RESUMO

We describe the case of a diabetic patient who developed a severe invasive fungal infection due to Rhizopus species postoperatively after a dual heart/kidney transplantation with subsequent intensive immunosuppressive therapy. No improvement was noted with amphotericin B (deoxycholate) therapy, but salvage treatment with the new azole antifungal posaconazole (200 mg orally 4 times daily) resulted in dramatic clinical improvement as early as 1 week after the initiation of therapy that continued through 23 weeks of treatment, with marked clinical, mycological, and radiological improvements and no adverse events.

Assuntos

Antifúngicos/uso terapêutico , Mucormicose/tratamento farmacológico , Complicações Pós-Operatórias/prevenção & controle , Triazóis/uso terapêutico , Antifúngicos/efeitos adversos , Complicações do Diabetes , Transplante de Coração , Humanos , Terapia de Imunossupressão , Transplante de Rim , Masculino , Pessoa de Meia-Idade , Triazóis/efeitos adversos