RESUMO
Schistosomiasis haematobia or urinary schistosomiasis is one of the main public health problems in Africa and the Middle East. A single dose of 40 mg praziquantel per kg body weight continues to be the treatment of choice for this infection. The aims of this follow-up were to study the post-treatment course of a patient infected with S. haematobium and not submitted to re-exposure, and to identify complications of the disease and/or therapeutic failure after praziquantel treatment by histopathological analysis. Treatments were repeated under medical supervision to ensure the correct use of the drug. In view of the suspicion of lesions in cystoscopy, the patient was submitted to bladder biopsy. The histopathological characteristics observed in biopsies obtained, after each treatment, indicated viability of parasite eggs and activity of granulomas.
Assuntos
Anti-Helmínticos/uso terapêutico , Praziquantel/uso terapêutico , Schistosoma haematobium/isolamento & purificação , Esquistossomose Urinária/patologia , Bexiga Urinária/parasitologia , Animais , Biópsia , Cistoscopia , Granuloma/parasitologia , Granuloma/patologia , Humanos , Masculino , Contagem de Ovos de Parasitas , Esquistossomose Urinária/tratamento farmacológico , Esquistossomose Urinária/urina , Falha de Tratamento , Bexiga Urinária/patologiaRESUMO
Schistosomiasis haematobia or urinary schistosomiasis is one of the main public health problems in Africa and the Middle East. A single dose of 40 mg praziquantel per kg body weight continues to be the treatment of choice for this infection. The aims of this follow-up were to study the post-treatment course of a patient infected with S. haematobium and not submitted to re-exposure, and to identify complications of the disease and/or therapeutic failure after praziquantel treatment by histopathological analysis. Treatments were repeated under medical supervision to ensure the correct use of the drug. In view of the suspicion of lesions in cystoscopy, the patient was submitted to bladder biopsy. The histopathological characteristics observed in biopsies obtained, after each treatment, indicated viability of parasite eggs and activity of granulomas.
A Esquistossomíase Hematóbica ou Esquistossomíase Urinária é um dos principais problemas de Saúde Pública na África e no Oriente Médio. Uma única dose de praziquantel 40 mg/kg de peso, continua sendo o tratamento de escolha para esta infecção. Os objetivos deste seguimento foram: avaliar o período pós-tratamento de um paciente infectado com Schistosoma haematobium e não submetido à re-exposição e, identificar as complicações da doença e/ou falha terapêutica, após o tratamento com praziquantel, por análise histopatológica de material obtido por biópsia vesical. O tratamento foi repetido sob supervisão médica para assegurar o uso correto do medicamento. Na presença de lesões suspeitas a cistoscopia, o paciente foi submetido a biópsia vesical. As características histopatológicas observadas nos materiais obtidos por biópsia, após cada tratamento, indicaram viabilidade de ovos e atividade dos granulomas.
Assuntos
Animais , Humanos , Masculino , Anti-Helmínticos/uso terapêutico , Praziquantel/uso terapêutico , Schistosoma haematobium/isolamento & purificação , Esquistossomose Urinária/patologia , Bexiga Urinária/parasitologia , Biópsia , Cistoscopia , Granuloma/parasitologia , Granuloma/patologia , Contagem de Ovos de Parasitas , Esquistossomose Urinária/tratamento farmacológico , Esquistossomose Urinária/urina , Falha de Tratamento , Bexiga Urinária/patologiaRESUMO
The assessment of urinary schistosomiasis in individuals coming from endemic areas often requires diagnostic resources not used in areas of exposure in order to determine complications or to establish more precise criteria of cure. Cystoscopy and 24-hour urine examination were performed, after treatments with praziquantel 40 mg/kg body weight, single dose, on 25 Brazilian military men who were part of a United Nations peace mission to Mozambique in 1994. The median age of the individuals was 29 years and all presented a positive urine parasitological exam. The alterations detected by cystoscopy were hyperemia and granulomas in the vesical submucosa in 59.1% of the individuals and only granulomas in 40.9%. A vesical biopsy revealed granulomas in all patients and viable eggs in 77.3% even after a period during which the patients no longer excreted eggs in urine. Cystoscopy after treatment, followed by biopsy and histopathological evaluation, performed in areas where the evolution of the disease can be better monitored, was found to be a safe criterion of parasitological cure.
Assuntos
Anti-Helmínticos/uso terapêutico , Praziquantel/uso terapêutico , Schistosoma haematobium/isolamento & purificação , Esquistossomose Urinária/diagnóstico , Bexiga Urinária/parasitologia , Adulto , África , Animais , Brasil , Cistoscopia , Granuloma/parasitologia , Granuloma/patologia , Humanos , Masculino , Militares , Contagem de Ovos de Parasitas , Esquistossomose Urinária/tratamento farmacológico , Esquistossomose Urinária/urina , Viagem , Bexiga Urinária/patologiaRESUMO
A avaliação de esquistossomose urinária em indivíduos procedentes de áreas endêmicas, freqüentemente requer recursos diagnósticos não usados nas áreas de exposição, para determinar as complicações ou estabelecer um critério de cura mais preciso. A cistoscopia e o exame de urina de 24 horas foram realizados, após tratamentos com praziquantel na dose de 40 mg/kg de peso, dose única, em 25 militares brasileiros que participaram de uma Missão de Paz pela ONU em Moçambique no ano de 1994. A idade média dos indivíduos foi de 29 anos e todos apresentavam exame parasitológico de urina positivo. As alterações detectadas pela cistoscopia foram hiperemia e granulomas na submucosa vesical em 59.1% dos indivíduos e somente granulomas em 40.9%. A biópsia vesical revelou granulomas em todos os pacientes e ovos viáveis em 77.3%, mesmo após um período durante o qual os pacientes não mais eliminavam ovos pela urina. Após o tratamento, a cistoscopia seguida por biópsia e avaliação histopatológica, realizada em áreas onde a evolução da doença pode ser monitorada melhor, demonstrou ser um critério mais seguro de cura parasitológica.
Assuntos
Adulto , Animais , Humanos , Masculino , Anti-Helmínticos/uso terapêutico , Praziquantel/uso terapêutico , Schistosoma haematobium/isolamento & purificação , Esquistossomose Urinária/diagnóstico , Bexiga Urinária/parasitologia , África , Brasil , Cistoscopia , Granuloma/parasitologia , Granuloma/patologia , Militares , Contagem de Ovos de Parasitas , Esquistossomose Urinária/tratamento farmacológico , Esquistossomose Urinária/urina , Viagem , Bexiga Urinária/patologiaRESUMO
Several cases of therapeutic failure of praziquantel used for the treatment of urinary schistosomiasis have been reported. Alternative drugs, like niridazol and metrifonate, have shown a lower therapeutic effect and more side effects than praziquantel. Twenty-six Brazilian military men (median age of 29 years) with a positive urine parasitological exam who were part of a United Nation peace mission in Mozambique in 1994 were treated with 40 mg/kg body weight praziquantel, single dose. They swam in Licungo river (Mocuba city, Mozambique) during the weekends. After this, they presented haematuria, dysuria, polakiuria, and lumbar pain. Control cystoscopy examinations carried out between 6 and 24 months after each treatment (including two additional treatments at a minimum interval of 6 months) revealed the presence of viable eggs. Granulomas in the vesical submucosa were observed in 46.2% (12/26) of the individuals. A vesical biopsy confirmed the presence of granulomas in all of these patients and the presence of viable eggs in 34.3% (9/26) of individuals who no longer excreted eggs in urine. The eggs filled with miracidia showed characteristics of viability. Histopathological examination using different strains demonstrated therapeutic failure and the need for repeated treatment. In this study, we demonstrated a low efficacy of praziquantel in the treatment of schistosomiasis haematobia, and the necessity of the urinary bladder biopsy as criterion of cure.
Assuntos
Anti-Helmínticos/uso terapêutico , Praziquantel/uso terapêutico , Esquistossomose Urinária/tratamento farmacológico , Bexiga Urinária/parasitologia , Adulto , África , Animais , Brasil , Cistoscopia , Granuloma/parasitologia , Granuloma/patologia , Humanos , Masculino , Pessoa de Meia-Idade , Militares , Contagem de Ovos de Parasitas , Esquistossomose Urinária/patologia , Esquistossomose Urinária/urina , Viagem , Falha de Tratamento , Bexiga Urinária/patologiaRESUMO
Several cases of therapeutic failure of praziquantel used for the treatment of urinary schistosomiasis have been reported. Alternative drugs, like niridazol and metrifonate, have shown a lower therapeutic effect and more side effects than praziquantel. Twenty-six Brazilian military men (median age of 29 years) with a positive urine parasitological exam who were part of a United Nation peace mission in Mozambique in 1994 were treated with 40 mg/kg body weight praziquantel, single dose. They swimmed in Licungo river (Mocuba city, Mozambique) during the weekends. After this, they presented haematuria, dysuria, polakiuria, and lumbar pain. Control cystoscopy examinations carried out between 6 and 24 months after each treatment (including two additional treatments at a minimum interval of 6 months) revealed the presence of viable eggs. Granulomas in the vesical submucosa were observed in 46.2 percent (12/26) of the individuals. A vesical biopsy confirmed the presence of granulomas in all of these patients and the presence of viable eggs in 34.3 percent (9/26) of individuals who no longer excreted eggs in urine. The eggs filled with miracidia showed characteristics of viability. Histopathological examination using different strains demonstrated therapeutic failure and the need for repeated treatment. In this study, we demonstrated a low efficacy of praziquantel in the treatment of schistosomiasis haematobia, and the necessity of the urinary bladder biopsy as criterion of cure.