RESUMO
BACKGROUND: Carcinomas of the external auditory canal are rare neoplasms (< 1% of all head and neck malignant neoplasms). OBJECTIVE: To evaluate the prognostic factors in 79 patients treated in a single institution. PATIENTS AND METHODS: The disease was staged as follows: 34 patients with stage T1 to T2 tumors; 43 patients with stage T3 to T4 tumors; 2 patients with stage TX tumors; 68 patients with stage N0 tumors; and 11 patients with stage N1 tumors. The initial treatment was surgery in 59 patients and radiotherapy in 9 patients. Eleven patients were not considered candidates for treatment. RESULTS: To date, 29 patients have experienced local recurrences and 2, neck metastases. The 5-year survival rates were 65% for patients who underwent surgery, 29% for patients who underwent radiotherapy, and 63% for patients who underwent a combination of surgery and radiotherapy. Univariate survival analysis showed statistical difference according to tumor type (P = .003), bone involvement (P = .002), and tumor stage (P < .001). CONCLUSION: Every effort must be undertaken to make an early diagnosis and perform radical surgical resection of squamous cell carcinomas in the external auditory canal. This study validates the staging system used for squamous cell carcinoma of the ear treated with surgery.
Assuntos
Carcinoma Basocelular/patologia , Carcinoma de Células Escamosas/patologia , Meato Acústico Externo , Neoplasias da Orelha/patologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Brasil/epidemiologia , Carcinoma Basocelular/mortalidade , Carcinoma Basocelular/radioterapia , Carcinoma Basocelular/cirurgia , Carcinoma de Células Escamosas/mortalidade , Carcinoma de Células Escamosas/radioterapia , Carcinoma de Células Escamosas/cirurgia , Terapia Combinada , Neoplasias da Orelha/mortalidade , Neoplasias da Orelha/radioterapia , Neoplasias da Orelha/cirurgia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Recidiva Local de Neoplasia/epidemiologia , Estadiamento de Neoplasias , Prognóstico , Taxa de Sobrevida , Fatores de TempoRESUMO
Human amniotic tissue previously treated with sodium hypochlorite and ethyl alcohol and stored in pure glycerol was employed to repair total and partial tympanic membrane perforations in 43 patients who underwent tympanoplasty or tympano-mastoidectomy. Follow-up varied from nine to 54 months. Closure of the perforation was obtained in 35 patients (81.4 per cent). Success rate was higher in tympanoplasty (84.8 per cent) than in tympanomastoidectomies (70 per cent). Functional improvement in hearing level was obtained in 65.7 per cent of the cases. In 25.7 per cent the hearing levels were unchanged and in 8.57 per cent they became worse. It was concluded that human amniotic tissue is an adequade material for tympanic membrane repair.
Assuntos
Humanos , Masculino , Feminino , Criança , Adolescente , Adulto , Pessoa de Meia-Idade , Âmnio/transplante , Perfuração da Membrana Timpânica/cirurgia , Seguimentos , Transplante Homólogo , TimpanoplastiaRESUMO
A case of cavernous hemangioma in the internal auditory canal was reported. There were no specific symptoms or physical or neurotological findings to differentiate from acoustic neuroma. The clinical and surgical aspects of this rare tumor were reviewed and discussed.
Assuntos
Neoplasias da Orelha , Hemangioma Cavernoso , Doenças do Labirinto , Adulto , Neoplasias da Orelha/diagnóstico , Neoplasias da Orelha/cirurgia , Hemangioma Cavernoso/diagnóstico , Hemangioma Cavernoso/cirurgia , Humanos , Doenças do Labirinto/diagnóstico , Doenças do Labirinto/cirurgia , Masculino , Osso TemporalRESUMO
This article describes cytogenetic findings in human small cell lung cancer (SCLC). Included is a summary of analyses performed by the authors on 17 tumors, each of which displayed numerous chromosomal alterations. Many of the recurrent changes involve losses at the locations of tumor suppressor genes, whose loss and/or inactivation may play a crucial role in tumorigenesis. Deletions of the short arm of chromosome 3 (particularly 3p21-25) were found in every case, providing additional evidence in support of the notion that this region harbors a tumor suppressor gene(s) critical in the pathogenesis of SCLC. Cytogenetic losses of 5q21, 13q14, and 17p13 (sites of the APC, RB1, and TP53 suppressor loci, respectively) also are common in SCLC. Double minutes are found in a minority of these tumors and are associated with oncogene amplification. The genetic complexity in SCLC underscores the need for greater preventive measures and early detection.