RESUMO
In this work, we present the complete blood count data and PCR test results of a population of Ecuadorians from different provinces, primarily residing in the Andean region, especially in Quito. PCR was the standard test to detect Covid-19 during the pandemic since 2020. The data were obtained between March 1st and August 12th, 2021. Segurilab and Previne Salud laboratories performed the tests. The dataset contains about 400 clinical cases. Each patient agreed to participate in the study by sharing the results of their PCR (reverse transcription polymerase chain reaction) tests and CBC (complete blood count). CBC test measured several components and features of the blood, including red blood cells, white blood cells, hemoglobin, hematocrit, and platelets. The shared data are intended to provide researchers with input to analyze various events associated with the diagnosis of Covid-19 linked to potential diseases identified in the components measured in the CBC test. These data are helpful for pattern analysis of blood components in modeling prediction and clustering problems. The components measured in the complete blood count and CRP together can be helpful for the analysis of different medical conditions using machine learning algorithms.
RESUMO
Se realizó una investigación bajo el enfoque integrador transcomplejo en la búsqueda de una interpretación transdisciplinaria, multidimensionada y dinámica de la violencia juvenil delincuencial, cuyo propósito fue develar las posturas epistemológicas que subyacen en la lógica de intervención de los diversos sectores de las políticas públicas en relación a la violencia delincuencial, así como la resignificación, mediante un diálogo de saberes, con sujetos significantes y con los significados socioculturalmente construidos del contexto teórico disciplinario de la violencia juvenil delincuencial en el Estado Aragua , con el fin de aportar constructos teóricos que propicien un repensar de las políticas públicas desde una perspectiva transcompleja y transdisciplinaria. La Transmetódica se fundamentó en la transdisciplinariedad, la hermenéutica y la etnografía. Se llevó a cabo en cuatro etapas que confluyeron para desmontar el discurso de los informantes en relación a la realidad y contrastarlos con las corrientes del pensamiento que han sustentado la matriz epistemológica vigente, para luego develar desde una perspectiva transcompleja y multidimensionada los aspectos ocultos en el discurso; brindando la posibilidad de resignificar estos hallazgos hacia una alternativa epistemológica integradora. Se evidencia la necesidad de trascender las lógicas homogeneizadoras de las políticas de control social tradicionales fundamentadas en el etiquetamiento y exclusión social, mediante un proceso masivo de fortalecimiento axiológico y praxiológico de la institucionalidad social, para lograr un cambio paradigmático hacia una nueva visión multidimensionada y transcompleja de la lógica de las estrategias de prevención y control social de la violencia juvenil delincuencial, y su resignificación en un horizonte sociocultural de convivencia pacífica.
An investigation was carried out under the integrative transcomplex approach in the search for a transdisciplinary, multidimensional and dynamic interpretation of juvenile delinquent violence, whose purpose was to reveal the epistemological positions that underlie the intervention logic of the various sectors of public policies in relation to to criminal violence, as well as resignification, through a dialogue of knowledge, with significant subjects and with the socioculturally constructed meanings of the disciplinary theoretical context of juvenile delinquent violence in the State of Aragua, in order to provide theoretical constructs that promote a rethinking of public policies from a transcomplex and transdisciplinary perspective. Transmethodics was based on transdisciplinarity, hermeneutics and ethnography. It was carried out in four stages that converged to disassemble the informants' discourse in relation to reality and contrast them with the currents of thought that have sustained the current epistemological matrix, and then reveal the hidden aspects in the current epistemological matrix from a transcomplex and multidimensional perspective. speech; providing the possibility of resignifying these findings towards an integrative epistemological alternative. There is evidence of the need to transcend the homogenizing logics of traditional social control policies based on labeling and social exclusion, through a massive process of axiological and praxiological strengthening of social institutions, to achieve a paradigmatic shift towards a new multidimensional and trans-complex vision of the logic of the strategies of prevention and social control of delinquent juvenile violence, and its resignification in a sociocultural horizon of peaceful coexistence.
Assuntos
Humanos , Adolescente , Adulto Jovem , Violência/estatística & dados numéricos , Comunicação Interdisciplinar , Delinquência Juvenil/psicologia , Venezuela , Teoria SocialRESUMO
El cordón umbilical tiene una longitud de 50-60 centímetros en una gestación de término y constituye la comunicación entre placenta y feto. Entre las patologías de cordón están los nudos falsos (debidos a asas vasculares recubiertas por la acumulación de la gelatina de Wharton que se forma porque la longitud de los vasos supera a la del cordón) y reales. Este último es el que con más frecuencia lleva a muerte fetal intrauterina por causa funicular. Inexplicable cuando el producto se encuentra dentro del útero y evidenciable al producirse su posterior salida, como ocurrió en el caso presentado a continuación.
Assuntos
Humanos , Adulto , Feminino , Gravidez , Auscultação/instrumentação , Cordão Umbilical/irrigação sanguínea , Cordão Umbilical/patologia , Misoprostol/administração & dosagem , Morte Fetal/etiologia , Ocitocina/administração & dosagem , Ultrassonografia Doppler , Frequência Cardíaca Fetal , Misoprostol/farmacologia , Obstetrícia , Ocitocina/farmacologia , Prostaglandinas/uso terapêuticoRESUMO
La infección urinaria es una de las afecciones más importantes dentro de la urología pediátrica debido a su elevada frecuencia, dificultad diagnóstica, gran tendencia a recurrencias y posibilidad de generar insuficiencia renal. La relación varón/mujer aumenta con la edad y es mayor después de los 4 años 10:1. El 5-15 por ciento de los niños en edad escolar con una infección urinaria presentan anomalías renales que requieren intervención quirúrgica. Se revisaron 50 historias clínicas de niños hospitalizados con el diagnósticos de infección urinaria en el Hospital Tipo II, Padre Justo de Rubio, Estado Táchira, para el periodo 1998-2002. Se realizó un estudio retrospectivo incluyendo niños que presentaron clínica presuntiva de infección urinaria, con uroanálisis patológico y urocultivo positivo; para determinar a que porcentaje de niños se les cumplió el protocolo de estudio de infección urinaria encontrando: solo el 26 por ciento de los pacientes fueron estudiados, donde el sexo más afectado correspondio al femenino (53.84 por ciento), representado por el grupo etáreo de los preescolares., se les realizó Ultrasonografía renal y uretrocistografía miccional revelando anormalidades en el 15.4 por ciento y en el 54 por ciento respectivamente. El 15 por ciento ameritó urografía de eliminación y un 8 por ciento gammagrafía renal. Y solo el 46 por ciento ameritó tratamiento quirúrgico.
Assuntos
Humanos , Masculino , Feminino , Pré-Escolar , Protocolos Clínicos , Disuria/diagnóstico , Febre/diagnóstico , Infecções Urinárias/cirurgia , Infecções Urinárias/diagnóstico , Infecções Urinárias/patologia , Técnicas de Diagnóstico Urológico/instrumentação , Ultrassonografia , Nefropatias/etiologia , Doenças Urológicas/etiologia , Pediatria , Urografia/métodosRESUMO
In order to alleviate the shortage of human donors, the use of porcine islets of Langerhans for xenotransplantation in diabetic patients has been proposed as a solution. To overcome rejection, we have developed a procedure for protecting the islets by combining them with Sertoli cells and placing them in a novel subcutaneous device, that generates an autologous collagen covering. A type 1 diabetic woman was closely monitored for 10 months, and then transplanted in two devices with two months of difference and a third time after 22 months. Here we present a three-yr follow-up. The close monitoring induced a rapid decrease in exogenous insulin requirements, which stabilized between 19 and 28 IU/d for nine months. After transplantation, the requirements reduced further to below 6 IU/d and for some weeks she was insulin free. Glycosylated hemoglobin levels decreased concomitantly. Porcine insulin could be detected in the serum after a glucose challenge and insulin positive cells inside a removed device after two yr. No complications have arisen and no porcine endogenous retrovirus infection has been detected through PCR and RT-PCR. This case demonstrates the feasibility of using the xenotransplantation of porcine cells to alleviate metabolic complications and insulin requirements in type 1 diabetic patients.
Assuntos
Diabetes Mellitus Tipo 1/cirurgia , Transplante das Ilhotas Pancreáticas/métodos , Transplante Heterólogo , Adolescente , Animais , Hormônio Antimülleriano , Feminino , Seguimentos , Teste de Tolerância a Glucose , Hemoglobinas Glicadas/análise , Glicoproteínas/análise , Humanos , Imuno-Histoquímica , Insulina/administração & dosagem , Suínos , Hormônios Testiculares/análiseRESUMO
Con el propósito de determinar el valor predictivo para riesgo cardiovascular de los componentes del sindrome metabólico, según los criterios de la FID (2005) y ATP III (2001), se realizó un estudio descriptivo correlacional en 118 trabajadores de un Hospital tipo III del estado Aragua, a quienes se les determinó la prevalencia de los componentes del síndrome metabólico, el perfil lipídico, los antecedentes patológicos y el riesgo cardiovascular según el Score de Framingham. comparando la prevalencia de los componentes del sindrome metabólico con el riesgo cardiovascular encontrado, según los grupos de criterios diagnósticos de ambas clasificaciones, para estimar finalmente la correlación estadística de los mismos. En los resultados que este estudio encontró una alta prevalencia en los trabajadores, de Síndrome Metabólico según las definiciones de la FID y la ATP III. Al comparar estadís-ticamente la prevalencia por grupos de edad se encuentra una diferencia significativa para la clasificación de la ATPIII. Finalmente, se pudo observar, de acuerdo a los resultados de esta investigación, al Síndrome Metabólico como un factor independiente que se correlacionó significativamente con el riesgo cardiovascular, según la definición de la FID. Por lo que se concluye que ambas clasificaciones proveen beneficios en la detección y diagnóstico de Síndrome Metabólico.
As to determine the predictive value on cardiovascular risk of metabolic syndrome components, according to FID (2005) and ATP III (2001) criteria, a correlational descriptive study was performed on 118 workers of a type III Hospital in Aragua State. The determination of prevalence of the components of metabolic syndrome, lipidic profile, pathologic record and cardiovascular risk according to Framingham Score was determined a comparison between the prevalence of the components of metabolic syndrome with the cardiovascular risk assessed according to diagnostic criteria groups of both classifications allowed the estimation of its statistic correlation. As a result of the present research, a high prevalence of metabolic syndrome according to the FID and ATP III definitions was assessed. A statistical comparison of the prevalence among age groups indicated a significant difference as to the ATP III classification concerns. Finally, according to the results, Metabolic Syndrome appears as an independent factor significantly correlated with cardiovascular risk according to FID classification. Our conclusion is that both classifications are useful for the detection and diagnosis of Metabolic Syndrome.
RESUMO
CC chemokine ligand (CCL)1/I-309 is a potent attractant for T-helper cell type 2 lymphocytes. The present study investigates whether this cytokine is released in the bronchoalveolar fluid (BALF) of asthmatic patients. Measurements of CCL1 using ELISA showed that levels of this cytokine were significantly elevated in BALF from asthmatics compared with normals (median (range) 193 (120-449) pg.mL(-1) versus 30 (21-55) pg.mL(-1)). Differential cell counts in BALF showed that either lymphocyte or eosinophil numbers were elevated in asthmatic compared with normal subjects (10.8 x 10(3).mL(-1) versus 1.0 x 10(3).mL(-1) and 1.7 x 10(3).mL(-1) versus 0.2 x 10(3).mL(-1), respectively). There was a trend towards a significant correlation between CCL1 levels and lymphocyte numbers in BALF. Separation of BALF using sequential CCL1 affinity column and reverse-phase high-performance liquid chromatography allowed detection of biologically active CCL1. Using immunohistochemistry, CCL1 immunoreactivity was localised predominantly to the airway epithelium. Interestingly, there was a significant correlation between CC chemokine ligand 1 levels and epithelial cell numbers in bronchoalveolar lavage fluid and between these cells and lymphocyte numbers. Moreover, interleukin-4, interleukin-13 and interferon-gamma stimulated primary bronchial airway epithelial cells to release CC chemokine ligand 1. These findings suggest that CC chemokine ligand 1 may play a role in lymphocyte recruitment in bronchial asthma.
Assuntos
Asma/patologia , Quimiocinas CC/metabolismo , Quimiocinas CC/fisiologia , Adolescente , Adulto , Líquido da Lavagem Broncoalveolar , Linfócitos T CD4-Positivos/metabolismo , Quimiocina CCL1 , Citocinas/metabolismo , Eosinófilos/metabolismo , Feminino , Humanos , Interferon gama/metabolismo , Interleucina-13/metabolismo , Interleucina-4/metabolismo , Masculino , Pessoa de Meia-IdadeRESUMO
Entomological surveys were conducted in five rural communities (138 domiciliary units [DUs]) in the southern Andes of Ecuador. Adobe walls and ceramic tile roofs were predominant construction materials. A 35% house infestation rate with Panstrongylus chinai (Del Ponte, 1929) (0.7%), Panstrongylus rufotuberculatus (Champion, 1899) (0.7%), Rhodnius ecuadoriensis (Lent & León, 1958) (27%), and/or Triatoma carrioni (Larrousse, 1926) (7%) was found. Adults and nymphs of R. ecuadoriensis and T. carrioni were found in intradomiciliary and peridomiciliary areas. Breeding triatomine colonies were present in 85% of infested DUs, and the average insect crowding was 52+/-113 triatomine bugs per infested house. T. cruzi-like organisms were found by microscopic examination in the feces or hindgut but not the salivary glands of 4% of examined R. ecuadoriensis and 12% T. carrioni. Serological tests detected a general anti-T. cruzi antibody seroprevalence of 3.9% (n = 1136). Only 2% of individuals had heard of Chagas disease, and although triatomines were reported as a major nuisance by the population they were not considered vectors of disease. Additional baseline field research is needed for the design and implementation of a Chagas disease control program in the region.
Assuntos
Doença de Chagas/transmissão , Habitação , Insetos Vetores/crescimento & desenvolvimento , Reduviidae/crescimento & desenvolvimento , Animais , Anticorpos Antiprotozoários/sangue , Doença de Chagas/imunologia , Doença de Chagas/parasitologia , Materiais de Construção , Equador , Humanos , Insetos Vetores/parasitologia , Panstrongylus/crescimento & desenvolvimento , Panstrongylus/parasitologia , Densidade Demográfica , Reduviidae/parasitologia , Rhodnius/crescimento & desenvolvimento , Rhodnius/parasitologia , População Rural , Triatoma/crescimento & desenvolvimento , Triatoma/parasitologia , Trypanosoma cruzi/isolamento & purificaçãoRESUMO
Infiltration of the airways by T helper type 2 (Th2) lymphocytes is a well-recognized feature of bronchial asthma. Monocyte-derived chemokine (MDC) is a potent attractant which activates Th2 lymphocytes via the chemokine receptor CCR4. We have investigated both leukocyte recruitment and MDC release into the airways of asthmatic patients. Differential cell counts in bronchoalveolar lavage (BAL) fluid showed that numbers of lymphocytes and eosinophils were elevated in asthmatics compared with normal subjects (median, 6.1 vs. 1.0 x 10(3)/ml, P < 0.005 and 1.4 vs. 0.24 x 10(3)/ml, P = 0.001, respectively). By enzyme-linked immunosorbent assay it was demonstrated that MDC concentrations were significantly elevated in BAL fluid from asthmatics compared with normals (medians 282 pg/ml, range 190-780 pg/ml vs. median 29 pg/ml range 17-82 pg/ml, P < 0.001). Interestingly, there was a significant correlation between MDC levels and the bronchoconstrictive response to methacholine [PC20 forced expiratory volume (FEV)1, r = -0.78, P = 0.001], suggesting that MDC may be involved in the severity of the disease. By immunohistochemistry, MDC was localized predominantly to the bronchial epithelium in bronchial biopsies derived from stable asthmatics. Moreover, primary human airway epithelial cells were found to release MDC upon cytokine stimulation. These findings suggest that MDC may play a major role in the pathogenesis of bronchial asthma.
Assuntos
Asma/metabolismo , Líquido da Lavagem Broncoalveolar/química , Quimiocinas/metabolismo , Adolescente , Adulto , Asma/patologia , Líquido da Lavagem Broncoalveolar/citologia , Contagem de Células , Células Cultivadas , Feminino , Humanos , Imuno-Histoquímica , Interferon gama/farmacologia , Interleucina-13/farmacologia , Interleucina-4/farmacologia , Masculino , Pessoa de Meia-Idade , Mucosa Respiratória/efeitos dos fármacos , Mucosa Respiratória/metabolismoRESUMO
Eosinophil recruitment into the airways is a feature of asthma in children. However, the mechanisms by which these cells migrate into the airways are not fully understood. The present study investigated the presence of the eosinophil-activating chemokines regulated on activation, normal T-cell expressed and secreted (RANTES), monocyte chemotactic proteins (MCP)-3 and -4, and eotaxins-1 and -2 in the bronchoalveolar lavage (BAL) fluid obtained from both asthmatic (n=10, age 6-10 yrs) and normal children (n=10, age 5-10 yrs). Measurements of chemokines in BAL fluid showed that levels of RANTES, MCPs-3 and -4, and eotaxins-1 and -2 were significantly increased in fluid obtained from asthmatic children when compared with normal children. Among the different chemokines, RANTES was the cytokine released in greatest quantities in BAL fluid from asthmatic children. There was a significant correlation between the concentrations of MCP-4 and eosinophil numbers in BAL fluid and a trend between both chemokines MCP-3 and eotaxin-2 and eosinophils. Interestingly, the levels of most chemokines correlated with one another. These findings suggest that RANTES monocyte chemotactic proteins-3 and -4, and eotaxins-1 and -2 may regulate eosinophil trafficking into the airways of asthmatic children in a coordinated manner.
Assuntos
Asma/metabolismo , Quimiocina CCL5/metabolismo , Quimiocinas CC/metabolismo , Citocinas , Proteínas Quimioatraentes de Monócitos/metabolismo , Asma/patologia , Líquido da Lavagem Broncoalveolar/química , Líquido da Lavagem Broncoalveolar/citologia , Quimiocina CCL11 , Quimiocina CCL24 , Quimiocina CCL7 , Criança , Pré-Escolar , Eosinófilos/fisiologia , Feminino , Humanos , Contagem de Leucócitos , MasculinoRESUMO
Se realizó un estudio de tipo descriptivo y transversal donde se evaluaron 38 pacientes con diagnóstico de infarto de miocardio (IM) o angina inestable, basado en los criterios clínicos, electrocardiográficos y enzimáticos preestablecidos que ingresaron a la unidad de cuidados coronarios del Hospital Dr. Domingo Luciani desde julio hasta septiembre de 1992, descartándose en todos ellos a través del interrogatorio enfermedades alérgicas, asma bronquial, transfunsiones sanguíneas recientes, uso de glucocorticoides, presencia de mieloma IgE o un síndrome de hiper IgE; A través de un frotis de sangre periférica la presencia de eosinofília y mediante examen de heces especial la presencia de parasitosis intestinal. A todos los pacientes se les hizo una determinación de colesterol y triglicéridos a la semana del evento isquémico y de IgE sérica durante los días 1, 3, 8, 15 y 21 desde el ingreso del paciente, tomándose la primera muestra en un tiempo promedio de 11 horas, demostrándose una evidente asociación entre valores elevados IgE séricas y cardiopatía isquémica del tipo IM o angina inestable. Los valores séricos de IgE en nuestros pacientes isquémicos fueron superiores a los descritos en poblaciones normales tanto de estudios internacionales como de nuestro país; además, se demostró una diferencia estadísticamente significativa entre valores IgE sérica del grupo de paciente con IM y el grupo de pacientes con angina inestable estando más elevada en los primeros. En presencia de hábitos tabaquicos y edad superior a los 53 años, la tendencia a presentar niveles elevados de IgE sérica aumenta. De manera que niveles elevados de IgE, al igual que el tabaquismo y la edad pudieran representar un factor de riesgo adicional para cardiopatía isquémica
Assuntos
Humanos , Masculino , Feminino , Angina Instável , Hemoglobina E , Infarto do Miocárdio , Isquemia Miocárdica , VenezuelaRESUMO
La enfermedad de kawasaki es infrecuente en Venezuela; no así en comunidades de origen asiático. Para su diagnóstico no existe signo paraclínico o patogomónico, por lo que éste se sustenta en los criterios diagnósticos de la "America Heart Assocition" y la exclusión de otras enfermedades. Se informa este caso, pues en la literatura nacional son pocos los reportados, siendo éste el segundo en esta institución y el primero con afectación cardiovascular documentada. Se trata de una lactante menor femenina de 10 meses de edad, piel blanca, sin ascendentes asiáticos, quien presentó fiebre alta durante dos semanas, acompañada de congestión conjuntival, eritema labial, oral y faríngeo, diarrea sin moco ni sangre, edema y eritema de plamas, plantas y tronco, descamación periungueal y del pulpejo de los dedos, y adenopatías laterocervicales. Descartamos infección por estreptococos, estafilococos, rickettsias y sarampión, síndrome de Steven`s Johnson, reacción medicamentos y artritis reumatoidea juvenil
Assuntos
Humanos , Feminino , Lactente , Aneurisma Coronário , Síndrome de Linfonodos Mucocutâneos , Pediatria , VenezuelaRESUMO
Airway eosinophilia is a characteristic of bronchial asthma. Eosinophils are considered to cause tissue damage through the release of toxic proteases, lipid mediators, cytokines and oxygen free radicals. The discovery of chemokines and the demonstration that some members of this cytokine superfamily are implicated in the recruitment of eosinophils offers an opportunity for a novel therapeutic approach in asthma.
Assuntos
Asma/imunologia , Quimiocina CCL5/imunologia , Quimiocinas CC , Asma/virologia , Movimento Celular/efeitos dos fármacos , Quimiocina CCL11 , Quimiocina CCL5/farmacologia , Fatores Quimiotáticos de Eosinófilos/imunologia , Citocinas/química , Citocinas/metabolismo , Citocinas/farmacologia , Eosinófilos/efeitos dos fármacos , Eosinófilos/imunologia , Células Epiteliais/metabolismo , Humanos , Ligantes , Proteínas Quimioatraentes de Monócitos/imunologia , Proteínas Quimioatraentes de Monócitos/farmacologia , Receptores de Quimiocinas/metabolismo , Mucosa Respiratória/citologia , Mucosa Respiratória/imunologiaRESUMO
The objective was to analyse the levels of uric acid in the hypertensive disorders of pregnancy. The research involves the study of 137 patients that suffered any hypertensive disease associated with pregnancy, hospitalized on the Luis Castelazo Ayala Hospital. The patients were classified according to the ACOG. The levels of uric acid observed were measured and compared against one control group and between them. The levels of uric acid observed in any hypertensive state of pregnancy are superior to the ones observed in then control group. On patients with chronical hypertension complicated with preeclampsia, the levels of uric acid were above the levels observed on patients with chronic hypertension itself. It is not known with certainty, but some authors think that the problem es rather tubular than glomerular. There is not an exact explanation about uric acid's depuration. Nevertheless, the common characteristic is a reduction of renal perfusion. Uric acid is related with the degree of severity. Moreover, uric acid is a good indicator for the detection of hypertensive states of pregnancy.
Assuntos
Hipertensão/sangue , Complicações Cardiovasculares na Gravidez/sangue , Adulto , Feminino , Idade Gestacional , Humanos , Idade Materna , Gravidez , Terceiro Trimestre da Gravidez , Ácido Úrico/sangueRESUMO
The mycobacterial antigens and the factors related to protection for the development of active tuberculosis are not known. In a natural model of tuberculosis, we studied 10 patients with active pulmonary tuberculosis (non-protective immune response) and 38 healthy household contacts (protective immune response). We tested the lymphocyte proliferative response by T cell Western blotting to eight different antigen fractions and to two purified mycobacterial antigens of 30 and 64 kD. Patients with active tuberculosis recognized fractions with molecular weights of 80-114, 60-80, 28-41 and 14-19 kD. Household contacts recognized the same fractions except the 14-19 kD. The response to the 64-kD antigen was not significantly different between groups. In contrast, 10% of the patients with active tuberculosis and 73% of the household contacts responded to the 30-kD antigen. The humoral response against the 30-kD antigen by ELISA showed a significantly higher production of antibodies in tuberculosis patients compared with household contacts. We conclude that patients with active pulmonary tuberculosis develop an immune response characterized by poor proliferative response to the 30-kD antigen with a strong humoral response, whereas the opposite occurs in healthy subjects infected by Mycobacterium tuberculosis.
Assuntos
Anticorpos Antibacterianos/imunologia , Antígenos de Bactérias/imunologia , Mycobacterium tuberculosis/imunologia , Tuberculose Pulmonar/imunologia , Família , Humanos , Imunidade Inata , Ativação Linfocitária , Tuberculina/imunologiaRESUMO
El papel que los anticuerpos antitiroideos maternos pueden desempeñar en la etiopatogenia del hipotiroidismo congénito por atireosis es discutible. En este estudio se midieron los niveles séricos de antivuerpos antitiroideos en 12 pacientes hipotiroideos y en sus madres, con la finalidad de detectar la posible asociación entre enfermedad tiroidea autoinmune materna y displasia tiroidea fetal. En dos pacientes hubo anticuerpos antitiroglobulina, lo que apoya la teoría de la existencia de un proceso inmunológico contra la tiroides fetal en las primeras ocho semanas de festación, pero no descarta la existencia y/o coexistencia de otros factores etiopatogénicos
Assuntos
Humanos , Recém-Nascido , Lactente , Autoimunidade/imunologia , Hipotireoidismo/congênito , Hipotireoidismo/imunologia , Imunidade Materno-Adquirida/imunologia , Doenças da Glândula Tireoide/congênito , Doenças da Glândula Tireoide/patologia , Tiroxina/deficiênciaRESUMO
A case of primary amyloidosis located in the larynx in which Beta-2-microglobulin (beta 2m) was the main component of the tissue is presented. Indirect immunofluorescence performed with monoclonal anti-human beta 2 m antibody (BBM1) showed a positive reaction, as did Congo red stain, and both patterns were similar. A significant increase in serum beta 2 m was observed; however, the clinical condition associated with this elevation remains unclear. We suggest that beta 2m is not only the main component of secondary amyloidosis in terminal nephropathy patients undergoing hemodialysis for prolonged periods, but that it could be part of the structure of other types of amyloid--either primary or secondary.