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O presente trabalho teve como objetivo investigar a composição química e avaliar a atividade inseticida do extrato acetônico das raízes de Piper alatabaccum sobre Hypothenemus hampei. As raízes foram coletadas no campus da Universidade Federal de Rondônia, em Porto Velho-RO. Diluições de 100,0, 50,0, 25,0, 5,0 e 0,5 mg mL-1 foram utilizadas para exposição na superfície contaminada e aplicação tópica. No teste de repelência, utilizou-se as diluições de 25,0 e 100,0 mg mL-1. As avaliações ocorreram durante 48 horas após a exposição ao extrato. O extrato foi eficiente na mortalidade em aplicação tópica e superfície contaminada, não sendo eficiente no efeito de repelência. Estes resultados apontam para o elevado potencial inseticida do extrato de P. alatabaccum no controle de H. hampei. Identificou-se cinco compostos, sendo três amidas, dihydropiplartine piperovatina e piplartina, e duas flavona, 3',4',5,5',7 pentamethoxyflavone e 5,5',7-trimetóxi-3',4'-methylenedioxyflavone.

The purpose of this work was to investigate the chemical composition and to evaluate the insecticidal activity of the acetonic extract of Piper alatabaccum roots on Hypothenemus hampei. Roots of P. alatabaccum were collected at the University of Rondônia in Porto Velho-RO. Dilutions of 100.0, 50.0, 25.0, 5.0 and 0.5 mg mL-1 were used for exposition in the contaminated surface and for topical application. For the repellence test, 25.0 and 100.0 mg mL-1 dilutions were used. The evaluations occurred during 48 hours after exposure to the extract. The extract was efficient in terms of mortality, but no repellence was observed in the bioassays. These results pointed out the high insecticidal potential of the P. alatabaccum extract to control H. hampei. Five compounds, three amids, piperovatine, dihydropiplartine and piplartine, and two flavones, 3',4',5,5',7-pentamethoxyflavone and 5,5',7-trimethoxy-3',4' methylenedioxyflavone were identified.

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O óleo essencial das folhas de Schinus terebinthifolius foi obtido por hidrodestilação e analisado por CG-EM. O rendimento do óleo foi de 0,8%, sendo identificados 37 constituintes químicos. Os componentes principais foram germacreno D (25,0%), (E)-ß-cariofileno (17,5%) e δ -elemeno (10,5%). O óleo essencial foi diluído em acetona nas concentrações de 10-2 a 10-8 e aplicado aos insetos (Hypothenemus hampei) por aplicação tópica e exposição em superfície contaminada. As taxas de mortalidade foram avaliadas após 24 e 48 horas do início do experimento. A aplicação em superfície contaminada resultou em 25% de mortalidade no controle, enquanto nas diluições de 10-2 a 10-8 foram observados 100,0 a 30,0% de mortalidade. Na aplicação tópica, observou-se 27,5% de mortalidade no controle e 97,5 a 77,5% nas diluições de 10-2 a 10-8.

The essential oil from the leaves of Schinus terebinthifolius was obtained by hydrodistillation and was analyzed by GC-MS. The oil yield was 0.8%, and 37 chemical constituents were identified. The main components were germacrene D (25.0%), (E)-ß-cariophyllene (17.5%) and δ-elemene (10.5%). The essential oil was diluted in acetone in concentrations of 10-2 to 10-8 and it was applied to insects (Hypothenemus hampei) by topical application and exposure to contaminated surface. Mortality rates were evaluated after 24 and 48 hours. The contaminated surface application resulted in 25.0% of mortality in control while the dilutions of 10-2 to 10-8 resulted in 100% to 30.0% of mortality respectively. In the topical application, it was observed 27.5% of mortality in control and 97.5 to 77.5% of mortality in dilutions of 10-2 to 10-8

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We have tested the hypothesis that restless leg syndrome (RLS) is related to quality of sleep, fatigue and clinical disability in multiple sclerosis (MS). The diagnosis of RLS used the four minimum criteria defined by the International Restless Legs Syndrome Study Group. Fatigue was assessed by the Fatigue Severity Scale (FSS >27), quality of sleep by the Pittsburgh Sleep Quality Index (PSQI >6), excessive daytime sleepiness by the Epworth Sleepiness Scale (ESS >10) and clinical disability by the Expanded Disability Status Scale (EDSS). Forty-four patients (32 women) aged 14 to 64 years (43 +/- 14) with disease from 0.4 to 23 years (6.7 +/- 5.9) were evaluated. Thirty-five were classified as relapsing-remitting, 5 as primary progressive and 4 as secondary progressive. EDSS varied from 0 to 8.0 (3.6 +/- 2.0). RLS was detected in 12 cases (27%). Patients with RLS presented greater disability (P = 0.01), poorer sleep (P = 0.02) and greater levels of fatigue (P = 0.03). Impaired sleep was present in 23 (52%) and excessive daytime sleepiness in 3 cases (6.8%). Fatigue was present in 32 subjects (73%) and was associated with clinical disability (P = 0.000) and sleep quality (P = 0.002). Age, gender, disease duration, MS pattern, excessive daytime sleepiness and the presence of upper motor neuron signs were not associated with the presence of RLS. Fatigue was best explained by clinical disability and poor sleep quality. Awareness of RLS among health care professionals may contribute to improvement in MS management.

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We have tested the hypothesis that restless leg syndrome (RLS) is related to quality of sleep, fatigue and clinical disability in multiple sclerosis (MS). The diagnosis of RLS used the four minimum criteria defined by the International Restless Legs Syndrome Study Group. Fatigue was assessed by the Fatigue Severity Scale (FSS >27), quality of sleep by the Pittsburgh Sleep Quality Index (PSQI >6), excessive daytime sleepiness by the Epworth Sleepiness Scale (ESS >10) and clinical disability by the Expanded Disability Status Scale (EDSS). Forty-four patients (32 women) aged 14 to 64 years (43 ± 14) with disease from 0.4 to 23 years (6.7 ± 5.9) were evaluated. Thirty-five were classified as relapsing-remitting, 5 as primary progressive and 4 as secondary progressive. EDSS varied from 0 to 8.0 (3.6 ± 2.0). RLS was detected in 12 cases (27 percent). Patients with RLS presented greater disability (P = 0.01), poorer sleep (P = 0.02) and greater levels of fatigue (P = 0.03). Impaired sleep was present in 23 (52 percent) and excessive daytime sleepiness in 3 cases (6.8 percent). Fatigue was present in 32 subjects (73 percent) and was associated with clinical disability (P = 0.000) and sleep quality (P = 0.002). Age, gender, disease duration, MS pattern, excessive daytime sleepiness and the presence of upper motor neuron signs were not associated with the presence of RLS. Fatigue was best explained by clinical disability and poor sleep quality. Awareness of RLS among health care professionals may contribute to improvement in MS management.

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RESUMO Hypothenemus hampei, é uma importante praga do café no Brasil e no mundo. A maioria dos trabalhos referentes à associação entre este inseto e fungos teve como alvo a parte aérea de plantas de Coffea canephora. Estudos de campo foram realizados em plantios de C. canephora, em Ouro Preto do Oeste, Rondônia, para levantar a micota associada à broca e frutos de café. Brocas e galerias foram obtidas a partir da dissecção de frutos de C. canephora brocados e não brocados. Os resultados mostraram que existe uma grande diversidade de fungos associados aos insetos. Nas brocas do solo foram encontrados 110 isolados (10 gêneros) e na parte aérea 91 isolados (10 gêneros). Em relação aos frutos brocados (galerias) foram registrados 5 gêneros no solo e 2 na parte aérea e nos frutos não brocados estes valores foram 6 e 5, respectivamente. O "ambiente" solo mostrou maior riqueza que a "parte aérea", tanto para brocas como para frutos brocados. Em relação aos frutos não brocados esta diferença não foi significativa revelando a ação da broca na dispersão destes microrganismos entre os dois ambientes. Este trabalho oferece uma descrição da micota associada à H. hampei em C. canephora e mostra a influência do ambiente na sua diversidade.

ABSTRACT Hypothenemus hampei is an important pest of coffee in Brazil and the world. The majority of thestudies concerning the association between this insect and fungus were lead in the aerial part of plants of Coffea canephora. Field studies were carried out on C. canephora, in Ouro Preto do Oeste, Rondônia, to determine the mycobiota associated with coffee berry borer and coffee fruits. Bored and unbored fruits were collected from plants of C. canephora and, borers and galleries were obtained from the disection of the infested fruits. The results that there is a great diversity of fungus associated to the insects. In the borers of the soil there were registered 110 isolates (10 genera) and in the aerial part there were found 91 isolates (5 genera). In relation to the bored fruits (galleries) there were registered 5 genera in the soil and 2 in the aerial parts of plants, and for unbored fruits these values were 6 and 5, respectively. The "soil environment" showed greater diversity than the "aerial part" as much borers as bored fruits. In relation to unbored fruits this difference was not significant, showing the action of the borer in the dispersion of these microorganisms between these two environments. This work offers a description of mycota associated to H. hampei in C. canephora and shows the influence of the environment in the diversity of this mycota.

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A modelagem da temperatura em tecidos humanos, quando os mesmos são sujeitos a ultra-som de terapia, é um aspecto essencial para um correto controle e calibração da instrumentação de terapia. A existência de modelos precisos possibilitaria um uso mais seguro e eficiente das terapias térmicas. O objetivo principal deste trabalho é a comparação entre a performance de um modelo linear e de um modelo não linear, na estimação pontual da temperatura num meio homogêneo. O objetivo final do trabalho é a construção de modelos para estimação in-vivo da temperatura. Os modelos lineares aplicados foram "autoregressive models with exogenous inputs" (ARX), enquanto que os modelos não-lineares aplicados foram "radial basis functions neural networks" (RBFNN). As melhores estruturas para as RBFNN foram selecionadas usando o "multi-objective genetic algoritm" (MOGA). A melhor estrutura RBFNN apresentou um erro máximo absoluto de 0,2ºC, que é inferior em uma ordem de grandeza ao erro cometido pelo melhor modelo ARX.

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Temperature modeling of human tissue subjected to ultrasound for therapeutic use is essential for an accurate instrumental assessment and calibration. Prior studies with a homogeneous medium are hereby reported. Nonlinear punctual temperature modeling is proposed by means of Radial Basis Functions Neural Network (RBFNN) structures...

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We report on the preliminary clinical and electrophysiological aspects of an in-patient possibly presenting epilepsia partialis continua (Koshevnikov). We discuss the different etiologies and emphasize on the possible idiopathic form in this case.

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We report on the clinical characteristics of amyotrophic lateral sclerosis (ALS) in Fortaleza (Northeastern Brazil). For this, we analyzed retrospectively (from 1980 to 1999) 78 cases of ALS from the Service of Neurology of the University Hospital of Fortaleza diagnosed clinically and laboratorially (EMG, muscle biopsy, myelography, blood biochemistry, muscle enzymes and cranio-cervical X-ray). The results showed that they were mostly sporadic ALS (76/78), and they were divided into definite (n = 36), probable (n = 20), possible (n = 15) and suspected (n = 7), according to the level of diagnostic certainty. They were also subdivided into juvenile (n = 17), early-onset adult (n = 18), age-specific (n = 39) and late-onset (n = 4) groups. Clinically, they presented as initials symptoms, principally, asymmetrical (30/78) and symmetrical (24/78) weakness of extremities, besides bulbar signs, fasciculations, and atrophy. Curiously, pain as first symptom occurred in an expressive fashion (17/78). The predominant initial anatomic site, in this series, was the spinal cord, and mainly affecting the arms. As to the symptom accrual from region to region, this occurs more quickly in contiguous areas, and fasciculations are predominant when bulbar region was associated.

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O edema cerebral constitui uma entidade bastante frequente na clinica neurologica e neurocirurgica. Os autores discutem os diferentes aspectos fisiopatologicos, clinicos e terapeutico do edema cerebral.Eles salientam as perspectivas e lacunas existentes na compreensao fisiopatologica do mesmo, e mostram as atuais e futuras tendencias de progresso terapeutico

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