RESUMO
BACKGROUND: Some cytokines are strongly implicated in the development of squamous cell carcinoma (SCC) such as the Macrophage migration inhibitory factor (MIF). The haplotype -794 (CATT)5-8 /-173G>C in MIF gene polymorphisms has been associated with some types of cancer. The aim of this study is to establish the possible association between the presence of this haplotype in the MIF gene and its subsequent soluble levels with the susceptibility of SCC in western Mexican population. METHODS: This study included 175 SCC patients and 175 age-sex-matched individuals as a reference group (RG) from western Mexico. Genomic DNA was extracted from peripheral blood leukocytes. Polymorphisms were genotyped by endpoint PCR and PCR-RFLP, and the determination of MIF serum levels was measured by ELISA. Clinical characteristics were evaluated by a group of dermatologists. RESULTS: Analysis of [-794(CATT)5-8 /-173G>C] MIF gene polymorphisms showed that the 5C (OR = 2.7, p = 0.02) and the 7G (OR = 3.39, p < 0.01) haplotypes are associated with susceptibility in SCC. MIF soluble levels in SCC patients showed a median of 13.93 ng/mL, whereas the reference group showed 6.000 ng/mL. CONCLUSIONS: Our findings suggest that 5C and 7G [-794(CATT)5-8 /-173G>C] MIF gene haplotypes are associated with susceptibility to SCC and that SCC patients present increased soluble levels of MIF.
Assuntos
Carcinoma de Células Escamosas , Fatores Inibidores da Migração de Macrófagos , Neoplasias Cutâneas , Humanos , Haplótipos , Carcinoma de Células Escamosas/genética , México , Predisposição Genética para Doença , Neoplasias Cutâneas/genética , Polimorfismo Genético , Fatores Inibidores da Migração de Macrófagos/genética , Oxirredutases Intramoleculares/genéticaRESUMO
Tinea capitis is an uncommon infection in adults, and predominantly affects women and the elderly with hormonal disorders and immunosuppression. Clinical features are often polymorphic and atypical. A kerion celsi case in an elderly female patient with type 2 diabetes mellitus and menopause is presented. The diagnosis was established by direct examination and the isolation of Trichophyton tonsurans in culture and typified by microculture. Treatment with prednisone and itraconazol was very successful. Recognizing the presentation of tinea capitis in adults will help clinicians to avoid delay in the diagnosis, awareness of the risk factors and provide early treatment to minimize sequelae of the disease.
Assuntos
Arthrodermataceae , Diabetes Mellitus Tipo 2 , Tinha do Couro Cabeludo , Adulto , Idoso , Feminino , Humanos , TrichophytonRESUMO
Abstract Trichosporon asahii is the causal agent of trichosporonosis. Patients with immunosuppression or hematological malignancies are at higher risk of infection. Skin and mucosal involvement appear as fast-growing papulonodular lesions and necrotic ulcers. Internal organ dissemination is lethal. Therapeutic success depends on the underlying disease. Here, the authors present the first case of disseminated mucocutaneous trichosporonosis in a patient with a post-mortem diagnosis of histiocytic sarcoma, a rare and aggressive haematolymphoid neoplasm. Regretfully, death occurred despite treatment with liposomal amphotericin B and supportive measures, showcasing the fatality of both diseases.
Assuntos
Humanos , Trichosporon , Sarcoma Histiocítico/tratamento farmacológico , Tricosporonose/diagnóstico , Tricosporonose/tratamento farmacológico , Basidiomycota , Antifúngicos/uso terapêuticoRESUMO
Trichosporon asahii is the causal agent of trichosporonosis. Patients with immunosuppression or hematological malignancies are at higher risk of infection. Skin and mucosal involvement appear as fast-growing papulonodular lesions and necrotic ulcers. Internal organ dissemination is lethal. Therapeutic success depends on the underlying disease. Here, the authors present the first case of disseminated mucocutaneous trichosporonosis in a patient with a post-mortem diagnosis of histiocytic sarcoma, a rare and aggressive haematolymphoid neoplasm. Regretfully, death occurred despite treatment with liposomal amphotericin B and supportive measures, showcasing the fatality of both diseases.
Assuntos
Sarcoma Histiocítico , Trichosporon , Tricosporonose , Antifúngicos/uso terapêutico , Basidiomycota , Sarcoma Histiocítico/tratamento farmacológico , Humanos , Tricosporonose/diagnóstico , Tricosporonose/tratamento farmacológicoRESUMO
La fascitis nodular es una masa subcutánea, benigna, autolimitada, que puede simular un sarcoma de tejidos blandos en su presentación clínica e histopatológica. Debido a que la mayoría de las descripciones de esta condición provienen de pacientes caucásicos, es necesario enfatizar su existencia en poblaciones poco representadas en la literatura. Se presenta el caso de un paciente mexicano, masculino, de 49 años, quien fue inicialmente mal diagnosticado y tratado como quiste epidérmico. Tras la recurrencia de la lesión, se realizó una adecuada técnica de biopsia y estudios de imagen, confirmando el diagnóstico de fascitis nodular. El presente reporte resalta la importancia de abordar con cautela las masas subcutáneas que puedan simular tanto tumores benignos como malignos para mejorar el pronóstico de los pacientes.
Nodular fasciitis is a benign, self-limited, subcutaneous tumor that may resemble a soft tissue sarcoma both clinically and histopathologically. Since most descriptions derive from Caucasian patients, further awareness is necessary in underrepresented populations. Here, we present a case of nodular fasciitis in a 49-year-old Mexican male who had been misdiagnosed and mistreated as an epidermal cyst. After recurrence, an adequate biopsy and imaging studies confirmed the diagnosis of nodular fasciitis. This case illustrates the importance of properly studying subcutaneous masses that can mimic a wide array of benign and malignant tumors to improve overall patient prognosis.
Assuntos
Humanos , Masculino , Pessoa de Meia-Idade , Fasciite/patologia , Fasciite/diagnóstico por imagem , Resultado do Tratamento , Cisto Epidérmico , Fasciite/cirurgia , Fasciite/epidemiologiaAssuntos
Humanos , Masculino , Adulto , Poroceratose/diagnóstico , Poroceratose/patologia , Poroceratose/terapiaRESUMO
A tinea capitis and tinea faciei case in an elderly female patient with diabetes mellitus type 2 is presented. Her dermatological illness began on her face and later disseminated to her scalp. She received multiple medications which aggravated her condition. The diagnosis was established by means of direct examination and the isolation of Trichophyton tonsurans in culture. Treatment with 200 mg daily dose of itraconazol for two months resulted in clinical and mycological cure.