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Chem Pharm Bull (Tokyo) ; 38(10): 2733-6, 1990 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-2127556

RESUMO

For several years we have screened natural products having aldose reductase (AR) inhibitory activity. 3,3',4-Tri-O-methylellagic acid 4'-sulfate potassium salt (2) was isolated from a Mexican herb "Sinfito" (Potentilla candicans) as a potent AR inhibitory active constituent. 2 was more potent (IC50 = 8.0 x 10(-8)M) than ellagic acid, which is one of the natural inhibitors of AR. So we examined the synthesis of ellagic acid derivatives and found that the sulfate group is one of the important function.


Assuntos
Aldeído Redutase/antagonistas & inibidores , Plantas Medicinais/análise , Aldeído Redutase/metabolismo , Animais , Técnicas In Vitro , Cristalino/enzimologia , México , Ratos
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