RESUMO
A case of amphicrine medullary carcinoma of the thyroid is presented. The patient was an 18-year-old female with nonhereditary MEN IIb, submucosal neuromas in the oral cavity, and a thyroid tumor that metastasized to regional lymph nodes. Histologically the thyroid tumor was composed of polygonal cells arranged in a solid/trabecular pattern admixed with mucus-producing goblet cells and displaying focal cytoplasmic lumen formation. Immunohistochemical stains were positive for calcitonin, carcinoembryonic antigen, and chromogranin. Electron microscopy demonstrated C-cells containing neurosecretory granules as well as intestinal-type microlumina. The presence of goblet cells and intestinal-type microlumina in medullary carcinoma of the thyroid is reminiscent of amphicrine tumors of the gastrointestinal tract and supports the hypothesis that the parafollicular C-cells of the thyroid may be of endodermal derivation.
Assuntos
Carcinoma Medular/patologia , Neoplasias da Glândula Tireoide/patologia , Adolescente , Biomarcadores/análise , Calcitonina/análise , Carcinoma Medular/química , Carcinoma Medular/ultraestrutura , Diferenciação Celular , Feminino , Humanos , Imuno-Histoquímica , Microscopia Eletrônica , Neoplasias da Glândula Tireoide/química , Neoplasias da Glândula Tireoide/ultraestruturaRESUMO
Colchiceine and ursodeoxycholic acid (UDCA) are drugs currently in use as therapy for different types of liver damage. We evaluated their ability to reverse the damage induced by carbon tetrachloride (CCl4) in rats. Six groups were analysed: (1) CCl4 (0.4 g kg(-1), i.p., three times a week) for 13 weeks; (2) CCl4 for 8 weeks followed by colchiceine (60 microg kg(-1)) + CCl4 for 5 weeks; (3) CCl4 for 8 weeks and thereafter UDCA (25 mg kg(-1)) + CCl4 for 5 weeks. Groups 4, 5 and 6 were appropriate controls of colchiceine, UDCA and vehicles respectively. Na+,K+- and Ca2+-ATPase activities and the cholesterol-phospholipid (CH/PL) ratio from erythrocyte and hepatocyte membranes were quantified. Membrane enzymatic activities and CH/PL ratios were affected more in group 1 than groups 2 and 3. We concluded that colchiceine and UDCA were effective drugs in this model of liver damage.
Assuntos
Tetracloreto de Carbono/toxicidade , Colchicina/análogos & derivados , Membrana Eritrocítica/efeitos dos fármacos , Cirrose Hepática Experimental/tratamento farmacológico , Fígado/efeitos dos fármacos , Fígado/patologia , Ácido Ursodesoxicólico/farmacologia , Animais , ATPases Transportadoras de Cálcio/sangue , ATPases Transportadoras de Cálcio/química , Colesterol/sangue , Colesterol/química , Colchicina/farmacologia , Colchicina/uso terapêutico , Membrana Eritrocítica/química , Membrana Eritrocítica/enzimologia , Cirrose Hepática Experimental/sangue , Cirrose Hepática Experimental/induzido quimicamente , Cirrose Hepática Experimental/patologia , Masculino , Fosfolipídeos/sangue , Fosfolipídeos/química , Ratos , Ratos Wistar , ATPase Trocadora de Sódio-Potássio/sangue , ATPase Trocadora de Sódio-Potássio/química , Ácido Ursodesoxicólico/uso terapêuticoRESUMO
A case is presented of an anterior mediastinal mass arising in a 64-year-old woman that showed on histologic, immunopathologic, and ultra-structural examination features of a poorly differentiated (insular) thyroid carcinoma. The tumor in this patient most likely arose from ectopically displaced thyroid tissue on the basis of a developmental defect. The clinicopathologic features and differential diagnosis of the lesion in the setting of its mediastinal location are discussed. Ectopic poorly differentiated (insular) carcinoma of the thyroid should be added to the list of mediastinal tumors showing a solid or insular growth pattern.