RESUMO
In this work, was studied the adsorption and orientation of three dipyridinic derivatives 9,10-bis-((E)-2-(pyridin-4-yl)vinyl)anthracene (DPAC), 1,4-bis-((E)-2-(pyridin-4-yl)vinyl)naphthalene (DPNA-T) and 2,6-bis-((E)-2-(pyridin-4-yl)vinyl)naphthalene (DPNA-L) on gold nanoparticles, using Surface Enhanced Raman Scattering (SERS). Systematic modification in the shapes of the bifunctional systems (Cross-shape, T-shape and Linear-shape) shows changes significant in the preferential orientation of these analytes on the nanostructured gold surface. Additional data from UV-vis measurements and TEM images are in agreement with the Reaction Limited Colloid Aggregation (RLCA) mechanisms for DPAC and DPNA-T and Diffusion Limited Colloid Aggregation (DLCA) mechanisms for DPNA-L, showing that for the same analyte concentration, the aggregation mechanism depends on the molecular shape. These results allow us to rationalize the fundamental aspects involved in the development of devices based on plasmonic resonance with potential applications in the field of molecular electronics.
Assuntos
Ouro , Nanopartículas Metálicas , Adsorção , Coloides , Análise Espectral RamanRESUMO
Resumen Las experiencias infantiles adversas (EIAs) son un factor de riesgo para el desarrollo de las patologías mentales más prevalentes en la vida adulta, entre las que se incluye la depresión, y se asocian a una presentación clínica más compleja y severa que requiere de un abordaje diferenciado. En Chile, la depresión cuenta con garantías explícitas en salud y una guía ministerial de recomendaciones. Un 90% de los pacientes son tratados en la atención primaria de salud (APS). Un tercio de las muestras depresivas consultantes en la APS de la VII Región presenta una sintomatología caracterizada por mayor suicidalidad, exposición a EIAs e historia de violencia doméstica. Estos pacientes requieren de un tratamiento diferenciado que incorpore, al manejo de la depresión, los conocimientos de las consecuencias del trauma psíquico. Los resultados del Adverse Childhood Experiences Study, los hallazgos neurobiológicos derivados del estrés tóxico y el modelo de cuidado informado en trauma constituyen marcos de referencia que orientan la práctica clínica en consultantes con historia de EIAs en el contexto de los servicios de salud. El objetivo de este trabajo es revisar estas líneas conceptuales, en un intento por reformular un abordaje clínico y encauzar la investigación de este subgrupo de pacientes depresivos.
Adverse childhood experiences (ACEs) are a risk factor for the development of the most prevalent mental disorders in adulthood, including major depression, and are associated with a more complex clinical presentation and increased severity, which requires a unique approach. In Chile, depression is subject to explicit legal mandates ensuring access to and guidelines for clinical care issued by the government. Ninety percent of depressed patients are treated in primary care. A third of primary patients presenting with depression in the VII Region are characterized by increased suicidality and histories of exposure to ACEs and violence within the family. These patients require a specialized treatment that incorporates research findings in the field of trauma, as applied to the treatment of depression. Together, results from the ACE Study, neurobiological evidence from exposure to toxic stress and the model of trauma-informed care comprise a framework that can orient clinical practice in healthcare settings. The purpose of this article is to review the literature with the goal of update the clinical approach and suggest future research in this subgroup of depressed patients.