RESUMO

A practical and efficient procedure for the enantioselective synthesis of mexiletine analogues with use of 10% of spiroborate ester 6 as chirality transfer agent is presented. A variety of mexiletine analogues were prepared in good yield with excellent enantioselectivities (91-97% ee) from readily available starting materials. The developed methodology was also successfully applied for the synthesis of novel beta-amino ethers containing thiophenyl and pyridyl fragments.

Assuntos

Antiarrítmicos/síntese química , Éteres/síntese química , Mexiletina/síntese química , Piridinas/química , Tiofenos/química , Boranos/química , Ésteres/química , Mexiletina/análogos & derivados , Modelos Químicos , Estereoisomerismo