RESUMO
Complementary genetic and demographic analyses estimate the total proportion of European-American admixture in the Gila River Indian Community and trace its mode of entry. Among the 9,616 residents in the sample, 2,015 persons claim only partial Native American heritage. A procedure employing 23 alleles or haplotypes at eight loci was used to estimate the proportion of European-American admixture, m(a), for the entire sample and within six categories of Caucasian admixture calculated from demographic data, md. The genetic analysis gave an estimate of total European-American admixture in the community of 0.054 (95% confidence interval [CI] .044-.063), while an estimate from demographic records was similar, .059. Regression of m(a) on md yielded a fitted line m(a) = .922md, r = .959 (P = .0001). When total European-American admixture is partitioned between the contributing populations, Mexican-Americans have provided .671, European-Americans .305, and African-Americans .023. These results are discussed within the context of the ethnic composition of the Gila River Indian Community, the assumptions underlying the methods, and the potential that demographic data have for enriching genetic measurements of human admixture. It is concluded that, despite the severe assumptions of the mathematical methods, accurate, reliable estimates of genetic admixture are possible from allele and haplotype frequencies, even when there is little demographic information for the population.
Assuntos
Indígenas Norte-Americanos/genética , População Branca/genética , Alelos , Arizona , Demografia , Europa (Continente) , Frequência do Gene , Pool Gênico , Genética Populacional , Humanos , Hibridização Genética , MéxicoAssuntos
Antígenos de Grupos Sanguíneos , Eritrócitos/análise , Genética Populacional , Haptoglobinas/análise , Imunoglobulinas/análise , Indígenas Sul-Americanos , Cristianismo , Etnicidade , Feminino , Frequência do Gene , Deficiência de Glucosefosfato Desidrogenase/genética , Humanos , Isoanticorpos/análise , Masculino , Paraguai/etnologia , Fenótipo , Missões Religiosas , Federação Russa/etnologia , Seleção Genética , Talassemia/genéticaRESUMO
Serum IgG concentration was lower in Jamaicans than in Nigerians. The maternalfoetal IgG ratio was also lower in Jamaican sera than in Nigerian sera. It is suggested that endemic malaria in Nigeria may be responsible for these differences. The higher IgM concentration in the Nigerian cord sera may be further evidence of this. Eighteen new cases of myeloma were detected in Jamaicans between August 1966 and May 1967. Based on Gm typing, only two of these showed evidence of mixed white ancestry. All the others had the typical Gm groups of Negroes. Similarly, only two patients out of a total of 17 with malignant lymphoma showed evidence of mixed white ancestry. Twelve of the patients with myeloma showed serum proteins of the IgG type, five were IgA, and one had only light chains in the serum. The majority of the patients had myeloma protein of the kappa type. The Gm typing suggested that six patients had myeloma protein of the gamma1 heavy chain subclass, and one patient had a gamma3 subclass heavy chain, the remainder belonging most likely to the gamma2 heavy chain subclass since gamma2 occurs about four times as frequently as gamma4.
Assuntos
Linfoma/imunologia , Mieloma Múltiplo/imunologia , gama-Globulinas/análise , Negro ou Afro-Americano , Idoso , Proteína de Bence Jones/análise , População Negra , Feminino , Feto , Humanos , Imunoglobulina G/análise , Imunoglobulina M/análise , Jamaica , Malária/imunologia , Masculino , Pessoa de Meia-Idade , NigériaRESUMO
Serum IgG concentration was lower in Jamaicans than in Nigerians. The maternal foetal IgG ratio was lower in Jamaican sera than in Nigerian sera. It is suggested that endemic malaria in Nigeria may be responsible for these differences. The higher IgG concentration in the Nigerian cord sera may be further evidence of this. Eighteen new cases of myeloma were detected in Jamaicans between August 1966 and May 1967. Based on Gm typing, only two of these showed evidence of mixed white ancestry. All others had the typical Gm groups of Negroes. Similarly, only two patients out of a total of 17 with malignant lymphoma showed evidence of mixed white ancestry. Twelve of the patients with myeloma showed serum proteins of the IgG type, five were IgA, and one had only light chains in the serum. The majority of the patients had myeloma protein of the kappa type. The Gm typing suggested that six patients had myeloma protein of the y1 heavy chain subclass, and one patient had a y3 subclass heavy chain, the remainder belonging most likely to the y2 heavy chain subclass since y2 occurs about four times as frequently as y4.