Assuntos
Enterocolite Pseudomembranosa/tratamento farmacológico , Gentamicinas/administração & dosagem , Doenças do Recém-Nascido/tratamento farmacológico , Administração Oral , Ensaios Clínicos como Assunto , Escherichia coli/isolamento & purificação , Fezes/microbiologia , Feminino , Gentamicinas/efeitos adversos , Gentamicinas/sangue , Gentamicinas/metabolismo , Humanos , Recém-Nascido , Masculino , Distribuição AleatóriaRESUMO
Three newborn infants with congestive heart failure had hemodynamic, angiographic, and echocardiographic features of hypertrophic subaortic stenosis (hypertrophic obstructive cardiomyopathy). Treatment with digitalis and diuretic drugs was ineffective, but improvement occurred when these agents were withheld in one patient, and when treatment with propranolol was begun in two patients. Echocardiography was helpful in establishing the diagnosis in two patients and showed resolution of the condition during the first six months of life. Serial cardiac catheterizations confirmed resolution of the outflow obstruction in the third patient. Family studies revealed no evidence of familial cardiomyopathy, but the mothers of two infants had insulin-dependent diabetes mellitus and the mother of the third was presumed to be prediabetic.
Assuntos
Estenose Aórtica Subvalvar/etiologia , Cardiomiopatia Hipertrófica/etiologia , Gravidez em Diabéticas , Adulto , Estenose Aórtica Subvalvar/diagnóstico , Estenose Aórtica Subvalvar/fisiopatologia , Ecocardiografia , Feminino , Hemodinâmica , Humanos , Recém-Nascido , Masculino , GravidezRESUMO
During 1973 a nonendemic mucoid strain of Escherichia coli entered the nursery of a hospital in Houston. This organism caused septicemia and was associated with a high incidence of necrotizing enterocolitis. The illness was fulminant and characterized by apnea, abdominal distension, and shock. Diarrhea was not a feature of the symptom complex. The epidemic organism was nontypable. Assays for invasiveness, enterotoxin production, and Kl antigen were negative. Surveillance revealed a colonization rate of 14%, an attack rate in colonized infants of 19.5%, and a mortality rate of 87.5%. These data suggest that in certain instances the specific bowel flora may increase the incidence and severity of NEC.