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The objective was to estimate the growth curves and genetic parameters using random regression methodology for Nellore cattle raised in Pantanal, MS, Brazil (6974 calves; n = 53,233 weights), with at least four weighings per individual. The model considered direct and maternal genetic additives and maternal permanent environmental effects at random. Orthogonal Legendre polynomials of cubic order were used to fit the growth curve. Analyses of variance were performed using the GLM procedure. The model used contained the fixed effects of sex, year of birth, farm, and the covariates calf birth month (linear and quadratic) and cow age at calving (linear and quadratic). The adjusted mean weight at 120 days of age was 93.43 ± 19.78 kg, and for 205 days of age, it was 180.42 ± 26.58 kg. Animals born in the dry season had a higher average weight [kg] (219.57 vs. 211.78, 3.7% higher) and, consequently, had higher weights at 646 days of age. Estimates of direct heritabilities (h2a) ranged from 0.35 to 0.75 (high magnitudes), and maternal heritabilities (h2m) along the trajectory of low magnitudes ranged from 0.03 to 0.08, respectively. The use of random regression to evaluate beef animals allows for adjusting the growth curve and selecting the best animals to be the parents of future generations.

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Vismia japurensis Reichardt is a plant of ecological and chemical importance from which a variety of bioactive substances have been isolated. The current study aimed to establish in vitro cultures of this species as a source of secondary metabolites. Appropriate decontamination treatments and germination tests were performed and, after in vitro culture establishment, the propagated plants were multiplied in a sterile environment to increase the biomass of available experimental material. Seeds showed low contamination and a high germination percentage on Woody Plant Medium (WPM) supplemented with gibberellic acid (both at concentrations of 5 and 10 mg/L). V. japurensis nodal segments rapidly regenerated when first grown in WPM and then transplanted to Murashige and Skoog medium (MS). After 60 days in MS medium, the propagated plants were removed, lyophilized, and extracted with hexane and methanol. The hexane extract was fractionated via open column chromatography, and the substance isolated was purified by high performance liquid chromatography. Structural determination of the isolated substance was carried out using one and two-dimensional nuclear magnetic resonance and mass spectrometry. The isolated substance was identified as 1,8,10-trihydroxy-3,10-dimethyl-9(10H)-anthracenone, which, based on the conducted literature search, is reported for the first time.

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Esta pesquisa trata da questão dos ex-jogadores de futebol, particularmente, à condução de suas carreiras esportivas e a projeção de sua aposentadoria. Epistemologicamente, parte da concepção histórico dialética, entendendo como de suma importância reconstruir os cenários históricos e dialogá-los no seu movimento. Na construção da mesma, entrevistamos sete ex-atletas de futebol na região do Vale do Itajaí, que jogaram futebol profissionalmente por no mínimo dez anos, e que, no momento da pesquisa, já estivessem aposentados no mínimo cinco anos. Quanto a metodologia, trata-se de uma pesquisa de campo, de abordagem qualitativa e do tipo exploratória. Como instrumento de pesquisa, utilizamos a entrevista semiestruturada. Para análise do material qualitativo, utilizamos a Analise Narrativa. As considerações finais nos reportam a perceber as dificuldades encontradas pelos jogadores a conhecer o cenário exploratório ao qual estão imersos, sua condição de trabalhador assalariado, e a projeção de suas vidas pós a carreira esportiva.

This research addresses the issue related to former soccer players and their sports careers, as well as the projection of their retirement. Epistemologically, it is part of the historical dialectical conception, emphasizing the importance of reconstructing historical scenarios and engaging in dialogue about them. We interviewed seven former soccer athletes from the Vale do Itajaí region who played professionally for at least ten years. At the time of the research, they had been retired for five years. The methodology employed was exploratory field research with a qualitative approach. The research instrument used was the semi-structured interview. In the analysis, we employed Narrative analysis. The final considerations highlight the difficulties encountered by the players in understanding the exploratory scenario in which they are immersed, their status as employed individuals, and the projection of their lives after their sports career.

Esta investigación aborda el tema relacionado con los ex jugadores de fútbol, particularmente la conducta de sus carreras deportivas y la proyección de su retiro. Epistemológicamente, parte de la concepción dialéctica histórica, entendiendo como de suma importancia reconstruir los escenarios históricos y dialogarlos en su movimiento. Entrevistamos siete ex atletas de fútbol de la región de Vale do Itajaí, que jugaron profesionalmente durante al menos diez años y que, en el momento de la investigación, habían estado retirados durante cinco años. En cuanto a la metodología, se utilizó una investigación de campo con un enfoque cualitativo. Cuanto investigación, utilizamos la entrevista semiestructurada. Cuanto análisis de material cualitativo, utilizamos la Analise Narrativa. Las consideraciones finales nos dicen que percibamos las dificultades encontradas por los jugadores para conocer el escenario exploratorio en el que están inmersos, su condición de persona empleada y la proyección de sus vidas después de su carrera deportiva.

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Introduction: Zoonotic transmission is a challenge for the control and elimination of malaria. It has been recorded in the Atlantic Forest, outside the Amazon which is the endemic region in Brazil. However, only very few studies have assessed the antibody response, especially of IgM antibodies, in Neotropical primates (NP). Therefore, in order to contribute to a better understanding of the immune response in different hosts and facilitate the identification of potential reservoirs, in this study, naturally acquired IgM antibody responses against Plasmodium antigens were evaluated, for the first time, in NP from the Atlantic Forest. Methods: The study was carried out using 154 NP samples from three different areas of the Atlantic Forest. IgM antibodies against peptides of the circumsporozoite protein (CSP) from different Plasmodium species and different erythrocytic stage antigens were detected by ELISA. Results: Fifty-nine percent of NP had IgM antibodies against at least one CSP peptide and 87% against at least one Plasmodium vivax erythrocytic stage antigen. Levels of antibodies against PvAMA-1 were the highest compared to the other antigens. All families of NP showed IgM antibodies against CSP peptides, and, most strikingly, against erythrocytic stage antigens. Generalized linear models demonstrated that IgM positivity against PvCSP and PvAMA-1 was associated with PCR-detectable blood-stage malaria infection and the host being free-living. Interestingly, animals with IgM against both PvCSP and PvAMA-1 were 4.7 times more likely to be PCR positive than animals that did not have IgM for these two antigens simultaneously. Discussion: IgM antibodies against different Plasmodium spp. antigens are present in NP from the Atlantic Forest. High seroprevalence and antibody levels against blood-stage antigens were observed, which had a significant association with molecular evidence of infection. IgM antibodies against CSP and AMA-1 may be used as a potential marker for the identification of NP infected with Plasmodium, which are reservoirs of malaria in the Brazilian Atlantic Forest.

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AIM: This bibliometric study analyzed the characteristics of the 100 most cited articles on bone grafts in dentistry. MATERIALS AND METHODS: A database search was performed on the Web of Science Core Collection using a specific search strategy. Scopus and Google Scholar were also consulted for citation comparisons. Data extracted included: title, citation metrics, publication year, journal, study design, graft material, surgical technique, authors, institution, and country. Bibliometric networks were generated using VOSviewer. RESULTS: The identified articles were published between 1991 and 2019. Citation counts ranged from 120 to 1161 (mean: 240, 30). Clinical Oral Implants Research was the most cited journal (5175 citations; 25/100). Xenogeneic bone graft material was the most frequently used (5130 citations; 22/100). Europe had 62 articles (14,604 citations), and the United States was the most prominent country (5209 citations; 22/100). The University of Bern had the highest number of citations (2565 citations; 13/100), with Buser D as the author with the largest number of articles (2648 citations; 12/100). CONCLUSION: This study shows the scientific progress on bone grafts in dentistry. The use of xenogeneic grafts for horizontal and/or vertical ridge augmentation was the most prominent trend.

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Spotted fever caused by the bacterium Rickettsia parkeri, and canine rangeliosis caused by the protozoan Rangelia vitalii, are emerging or re-emerging tick-borne diseases in Brazil, where the main tick vectors are Amblyomma ovale and Amblyomma aureolatum, respectively. In the present study, we evaluated exposure to R. parkeri and R. vitalii infection among domestic (Canis lupus familiaris) and wild (Cerdocyon thous) canids sharing living areas within an Atlantic Forest area of southern Brazil. Four different domestic dogs and three different wild canids were captured. Most of the ticks collected from either domestic or wild canids were identified as A. ovale and A. aureolatum. DNA of R. parkeri was amplified from 14% of the A. ovale specimens. Two domestic dogs and two wild canids were seroreactive to R. parkeri antigens with high endpoint titers (>1024). Rangelia vitalii DNA was detected in two wild canids; one of them was resampled 93 days later, again infected by R. vitalii. We report exposure/infection of domestic dogs and wild canids to R. vitalii and/or R. parkeri-infected ticks in an Atlantic Forest area shared by both canid species, indicating that they also shared the same populations of the tick vectors, A. aureolatum and A. ovale. While A. ovale, A. aureolatum, R. parkeri, R. vitalii and C. thous, are all native to the Atlantic Forest, further studies are needed to evaluate the impact of an exotic canine species - C. lupus familiaris - on the enzootic cycles of R. vitalii and R. parkeri, as well as the possible role of domestic dogs in emergence and re-emergence of R. parkeri-spotted fever in humans and canine rangeliosis, respectively.

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This work aimed to assess the biomechanics, using the finite element method (FEM), of traditional titanium Morse taper (MT) dental implants compared to one-piece implants composed of zirconia, polyetheretherketone (PEEK), carbon fiber-reinforced PEEK (CFR-PEEK), or glass fiber-reinforced PEEK (GFR-PEEK). MT and one-piece dental implants were modeled within a mandibular bone section and loaded on an oblique force using FEM. A MT implant system involving a Ti6Al4V abutment and a cp-Ti grade IV implant was compared to one-piece implants composed of cp-Ti grade IV, zirconia (3Y-TZP), PEEK, CFR-PEEK, or GFR-PEEK. Stress on bone and implants was computed and analyzed while bone remodeling prediction was evaluated considering equivalent strain. In comparison to one-piece implants, the traditional MT implant revealed higher stress peak (112 MPa). The maximum stresses on the one-piece implants reached ~80 MPa, regardless their chemical composition. MT implant induced lower bone stimulus, although excessive bone strain was recorded for PEEK implants. Balanced strain levels were noticed for reinforced PEEK implants of which CFR-PEEK one-piece implants showed proper biomechanical behavior. Balanced strain levels might induce bone remodeling at the peri-implant region while maintaining low risks of mechanical failures. However, the strength of the PEEK-based composite materials is still low for long-term clinical performance.

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This work provides a guide to design ultrasonic synthetic aperture systems for non-grid two-dimensional sparse arrays such as spirals or annular segmented arrays. It presents an algorithm that identifies which elements have a more significant impact on the beampattern characteristics and uses this information to reduce the number of signals, the number of emitters and the number of parallel receiver channels involved in the beamforming process. Consequently, we can optimise the 3D synthetic aperture ultrasonic imaging system for a specific sparse array, reducing the computational cost, the hardware requirements and the system complexity. Simulations using a Fermat spiral array and experimental data based on an annular segmented array with 64 elements are used to assess this algorithm.

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Cancer is the second leading cause of death worldwide and epidemiological projections predict growing cancer mortality rates in the next decades. Cancer has a close relationship with the immune system and, although Th17 cells are known to play roles in the immune response against microorganisms and in autoimmunity, studies have emphasized their roles in cancer pathogenesis. The Th17 immune response profile is involved in several types of cancer including urogenital, respiratory, gastrointestinal, and skin cancers. This type of immune response exerts pro and antitumor functions through several mechanisms, depending on the context of each tumor, including the protumor angiogenesis and exhaustion of T cells and the antitumor recruitment of T cells and neutrophils to the tumor microenvironment. Among other factors, the paradoxical behavior of Th17 cells in this setting has been attributed to its plasticity potential, which makes possible their conversion into other types of T cells such as Th17/Treg and Th17/Th1 cells. Interleukin (IL)-17 stands out among Th17-related cytokines since it modulates pathways and interacts with other cell profiles in the tumor microenvironment, which allow Th17 cells to prevail in tumors. Moreover, the IL-17 is able to mediate pro and antitumor processes that influence the development and progression of various cancers, being associated with variable clinical outcomes. The understanding of the relationship between the Th17 immune response and cancer as well as the singularities of carcinogenic processes in each type of tumor is crucial for the identification of new therapeutic targets.

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O vírus SARS-CoV-2 foi detectado na cidade de Wuhan, na China, no final de 20191. Desde então, a alta transmissibilidade deste novo coronavirus e a elevada morbimortalidade relacionada à COVID-19, a infecção viral causada pelo SARS-CoV-2, cresceu exponencialmente em todo o planeta, culminando, primeiramente, em uma emergência de saúde pública de importância internacional e, logo em seguida, em uma grave pandemia2,3. A transmissão do vírus ocorre tanto por vias respiratórias quanto extrarrespiratórias e durante o período de desenvolvimento da COVID-19 no organismo humano a apresentação clínica inclui sintomas relacionados a alterações no olfato, paladar e complicações gastrointestinais, além do acometimento de forma mais acentuada do sistema respiratório.4 Em consequência dos sintomas da COVID-19, muitos pacientes precisam ser internados e, em alguns casos, são submetidos a procedimentos invasivos para garantir a condição fisiológica básica para a manutenção da vida. Durante o período de internação os pacientes desenvolvem condição clínica com debilitação fisiológica e a aptidão física geral reduz sensivelmente.5 Ao receber alta hospitalar, muitos desses pacientes precisam de tratamentos voltados à recuperação da condição física debilitada pela ação da doença.6 A Secretaria Municipal de Saúde Pública (SESAU) de Campo Grande/MS, na Região Centro-Oeste do Brasil, se mostrou atenta a esta demanda. O Serviço de Doenças Crônicas Não Transmissíveis (DANT), juntamente com a Coordenadoria de Atenção Especializada, estruturou no Sistema Único de Saúde (SUS) um serviço de reabilitação funcional destinado às pessoas com doenças crônicas não transmissíveis, que estiveram internadas por infecção pelo SARS-CoV-2 e precisam de atenção especializada para restabelecer a capacidade de trabalho e de realização das atividades da vida diária. O atendimento é realizado na Unidade Especializada de Reabilitação e Diagnóstico (UERD), que faz parte da Rede Municipal de Saúde (REMUS). Um projeto de reabilitação funcional foi elaborado pela equipe técnica da SESAU, para ser desenvolvido por meio de uma equipe multiprofissional formada por fisioterapeuta, profissional de educação física, nutricionista e psicólogo. As intervenções são realizadas com o uso de Projetos Terapêuticos Singulares (PTS), seguindo critérios de inclusão e exclusão pré-estabelecidos7, para pacientes com doenças crônicas não transmissíveis, em condição de pós-internação decorrente de COVID-19. O encaminhamento dos pacientes, vindos dos demais pontos da REMUS, é realizado por médicos dos três níveis de atenção à saúde (primária, secundário e terciário), via Sistema de Regulação (SISREG). Foi estabelecido um fluxo para as intervenções, sendo que no primeiro atendimento cada paciente passa por um acolhimento dado pela equipe multiprofissional (fisioterapeuta, profissional de educação física, nutricionista e psicólogo) em uma consulta compartilhada. Nesta etapa a equipe faz uma triagem e identifica a condição clínica da pessoa atendida. Posteriormente, os profissionais constroem, de forma coletiva, um PTS. Nos dias subsequentes, o paciente é contatado para iniciar o tratamento de reabilitação, por meio de agendamento nos dias e horários em que haja compatibilidade entre as vagas ofertadas e a disponibilidade do paciente. O protocolo do PTS consiste de intervenções com frequência de duas vezes por semana, com alternância entre os profissionais que desenvolvem as atividades. Os pacientes são atendidos, inicialmente, com um total de 10 sessões de 40 a 60 minutos cada, durante cinco semanas. Se a equipe identificar que há indicação de continuidade do tratamento, o paciente pode ser mantido no programa por mais sessões, com avaliação caso a caso. O processo de alta do paciente ocorre quando são finalizadas as sessões do PTS. Esse processo é caracterizado pelas orientações ao paciente e sua família/cuidador, com encaminhamento profissional para a contrarreferência da unidade de saúde à qual o paciente está vinculado na atenção primária, por meio de relatório de alta, com informações referentes ao tratamento e orientações, visando a integralidade do cuidado. Com isso, a atenção primária dará prosseguimento do cuidado em saúde ao usuário em seu território de abrangência. O programa de reabilitação funcional prevê uma abordagem multiprofissional, com longitudinalidade do cuidado e respeito às singularidades de cada paciente. Os propósitos são aliviar os efeitos das disfunções musculares e respiratórias, mitigar os danos do imobilismo após longo período de internação hospitalar, além de atenuar as sequelas psicológicas e necessidades nutricionais. Para obter a almejada melhora da saúde geral e da qualidade de vida das pessoas atendidas, cada área profissional envolvida no PTS intervém da seguinte forma: A Fisioterapia atua em duas vertentes: a) fisioterapia respiratória, com o objetivo de aumentar a capacidade pulmonar e recuperar disfunções referentes ao processo de respiração; b) fisioterapia motora, com o objetivo de corrigir e restabelecer as condições físicas do paciente. A abordagem do profissional de Educação Física é voltada à melhora dos componentes cardiorrespiratório e neuromuscular, visando a promoção da autonomia funcional, o controle dos fatores de risco para comorbidades, correção postural e manutenção do peso ideal. O atendimento inclui o treinamento aeróbio, o treinamento resistido, ações de educação em saúde, além de incentivo à continuidade da prática de atividades físicas após o término das sessões do PTS, para manutenção e ampliação dos ganhos obtidos. A Nutrição atua com o propósito de manutenção do bom estado do sistema imunológico dos pacientes e, para isso, realiza avaliação nutricional e orientações ligadas à promoção de uma alimentação saudável. A Psicologia disponibiliza suporte psicológico, com oferecimento de um espaço para que o paciente compartilhe seus sentimentos e necessidades, buscando a auto segurança. Com isso, objetiva-se minimizar o trauma psicológico decorrentes do período de internação, que pode ter gerado reações emocionais como medo, angústia, ansiedade e tristeza. O conjunto de intervenções propostas representa uma readequação do serviço de saúde, em função da demanda oriunda da pandemia de COVID-19. Para isso, são necessárias estratégias capazes de proporcionar recuperação físico-funcional e reintegração social dos indivíduos infectados pelo vírus SARS-CoV-2, uma vez que essa infecção pode prejudicar a capacidade de realizar atividades da vida diária e a funcionalidade dos indivíduos que passaram por internação hospitalar, além de alterar o desempenho profissional e dificultar a interação social, com possibilidade de aumento de fatores de risco para doenças crônicas não transmissíveis.8 Nesse sentido, o PTS realizado por uma equipe multiprofissional, como no programa relatado, é um dispositivo de cuidado que visa a resolutividade dos casos complexos por meio da corresponsabilização e utilização dos recursos de todos os envolvidos, por meio do desenvolvimento de ações terapêuticas a partir de uma reflexão sistematizada. Para isso, o PTS deve ser abordado em duas perspectivas, uma delas centrada na clínica ampliada e outra na recuperação da autonomia da vida afetiva do sujeito, tal como preconizado no SUS.9 Em ambas as perspectivas sempre são considerados o sujeito, as equipes de saúde, o território e a família onde o PTS é desenvolvido.10 A utilização do PTS no âmbito da saúde pública melhora não só o processo de trabalho como o vínculo entre todos os envolvidos ­ profissionais de saúde e pacientes, potencializando assim a assistência integral à saúde na produção do cuidado, em função da troca de saberes no âmbito multiprofissional.11-13 Nota-se, portanto, que o processo de tratamento dos pacientes com COVID-19 é fundamental não apenas durante a fase hospitalar, mas também após alta melhorada. Dentre as estratégias disponíveis para atender os pacientes na rede pública de saúde, o desenvolvimento de programas de reabilitação funcional, por meio de PTS e intervenções multiprofissionais, pode garantir a continuidade do acompanhamento, promovendo a recuperação de implicações provocadas pela doença, proporcionando mais qualidade de vida às pessoas no período pós-internação.

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OBJECTIVES: The aim of this work was to evaluate the biomechanical behavior of one-piece zirconia implants with a functionally graded bioglass (BG) layer as compared to monolithic zirconia and BG-coated implants, using the finite element method (FEM). METHODS: Zirconia disks were infiltrated with bioglass S53P4 and then morphologically inspected by scanning electron microscopy (SEM) followed by mechanical analyses on micro-indentation tests for further biomechanical validation using the finite element method (FEM). On modeling, zirconia dental implants anchored into mandibular bone were simulated on occlusal loading as recorded under mastication. Three types of implants were simulated: i) free of BG coating, ii) with 100 µm or 150 µm thick conventional BG coatings; and iii) with graded BG coatings involving 3 different chemical composition distributions. The stress state at both implant and bone were evaluated using the FEM. The mechanically-induced bone remodelling was analyzed through the bone strain results. RESULTS: Infiltration of BG into a zirconia structure resulted in a ∼100 µm thick layer with an exponential-like gradation of chemical composition and properties. Regarding the FEM calculations, the BG coating induced up to 30% decrease on stress in the implant body when compared to the monolithic zirconia implant. The gradient of chemical composition also improved the stresses' distribution. The stresses distribution towards the BG-coatings were significantly high and could lead to failure. Stresses on the bone were recorded down to its strength threshold, with insignificant influence of the coating layer. The bone strain values on all models indicates further bone remodelling although BG-coated and BG-graded zirconia implants showed the highest strain magnitude that may enhance the mechanical stimulation for bone maintenance. SIGNIFICANCE: Graded BG-zirconia dental implants showed enhanced overall biomechanical behaviour as compared to the BG-coated or monolithic zirconia dental implants. Also, such biomechanical improvements noticed for the BG-graded system should be considered in combination with the well-known osseointegration benefits of bioactive glasses.

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OBJECTIVE: The objective of this study was to evaluate the combined effect of the sulfuric acid etching and an acidic adhesive conditioning on the shear bond strength of PEEK to a resin-matrix composite. MATERIALS AND METHODS: Forty PEEK specimens were assigned randomly to 4 groups for H2SO4 etching followed by universal adhesive (pH at 2.5) conditioning for 0, 1, 3, and 5 min. Thirty PEEK specimens were divided into 3 groups for only acidic adhesive conditioning for 0, 1, 3, and 5 min. After the light-curing of the adhesive, a nanohybrid resin composite was applied onto the surfaces and then light-cured following the manufacturer`s guidelines. All specimens were stored in distilled water at 37 °C for 24 h mechanical testing. Shear bond strength tests were performed using a universal testing machine. Surfaces were analyzed by SEM, light interferometry, FTIR, and liquid contact angle measurement. Statistical analysis was performed by one-way ANOVA and Tukey's post hoc tests (p < 0.05). RESULTS: No adhesion was achieved between untreated PEEK a resin-matrix composite, regardless of the adhesive conditioning time points. Shear bond strength of H2SO4-etched PEEK to resin-matrix composite increased with time (0 mmin. 4.95 ± 2.86 MPa < 1 min: 9.35 ± 2.26 MPa < 3 min: 17.84 ± 2.82 MPa < 5 min: 21.43 ± 5.00 MPa). SEM images revealed a significant modification of PEEK surface topography after the H2SO4 etching. SIGNIFICANCE: The acidic adhesive was unable to modify the untreated PEEK surface to establish an effective adhesion although a synergistic effect was noticed when the universal (acidic) adhesive was applied over a H2SO4-etched PEEK surface, thus improving the PEEK to resin-matrix composite adhesion.

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The selection of animals with lower production costs can be achieved by using feed efficiency and growth curve information. Kleiber ratio (KR) is an alternative option for discriminating against the animals that have the greatest weight gain about their final weight. Alternative feed efficiency and growth curves for ostriches of the African Black (AB) and Red Neck (RN) breeds and their crossbreeds (CB) were investigated using KR and Gompertz equation. Univariate and multivariate analyses were used. The highest adult weight was identified in the RN and CB. AB was more precocious than the RN and CB individuals. Only AB animals reached 75% of their mature weight at one year of age. At 180 days, AB showed better KR. AB was different from the others, mainly for KR at 90 days and 180 days. Considering multivariate analysis, AB animals were different from the others, regardless of sex, mainly for KR at 90 days and KR at 180 days. Other subgroups separated the animals by sex. In a market preferring animals of minor structure (smaller cuts) and greater precocity, it would be suitable to opt for AB. When animals with greater body structure (larger cuts) are desired, males RN and CR is the best option, however, it will be slaughtered with greater age and lower value for KR (may generate a bigger production cost ). It is possible to obtain animals with precocity and high KR, being well represented by the AB breed.(AU)

A seleção de animais com custos de produção mais baixos pode ser alcançada usando a eficiência alimentar e informações da curva de crescimento. A razão de Kleiber (KR) é uma alternativa para discriminar os animais que apresentam maior ganho de peso em relação ao peso final. Eficiência alimentar alternativa e curvas de crescimento para avestruzes das raças African Black (AB) e Red Neck (RN) e seus cruzamentos (CB) foram investigadas usando a equação de KR e Gompertz. Análises univariadas e multivariadas foram utilizadas. O maior peso adulto foi observado no RN e no CB. AB foi mais precoce do que os indivíduos RN e CB. Apenas animais AB atingiram 75% de seu peso adulto até um ano de idade. Aos 180 dias, AB tem maior KR. AB foi diferente dos demais, principalmente para KR aos 90 dias e 180 dias. Considerando a análise multivariada, os animais AB diferiram dos demais, independente do sexo, principalmente pelos seguintes parâmetros: KR aos 90 dias, KR aos 180 dias. Outros subgrupos separaram os animais por sexo. Em um mercado que prefere animais de menor estrutura corporal (cortes menores) e maior precocidade, seria adequado optar pela AB. Para animais com maior estrutura corporal (cortes maiores), os machos RN e CR são a melhor opção, porém, serão abatidos com maior idade e menor valor para KR (pode gerar um maior custo de produção). É possível obter animais com precocidade e alto KR, sendo bem representados pelo AB.(AU)

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Objetivo: Investigar as naturezas do sofrimento psicológico ocasionado por problemas bucais. Métodos: Esta pesquisa adotou uma abordagem qualitativa e caráter exploratório-descritivo, utilizando-se da entrevista semiestruturada e da observação assistemática como instrumentos de coleta de dados. Para a análise dos dados da pesquisa foi utilizada a análise do conteúdo e a amostra da pesquisa foi de 25 participantes, entre homens e mulheres, que buscaram atendimento odontológico em uma clínica de Manaus, Amazonas, Brasil nos meses de maio e junho de 2020. Resultados: todos os participantes foram afetados psiquicamente pela existência de problemas bucais, o que gerou problemas de autoestima e autoimagem. Com o início do tratamento, os participantes relataram uma melhora na autoestima, não minimizando, contudo, outros tipos de sentimentos provenientes do problema bucal, como desconforto, dores e bullying. Conclusão: Problemas bucais podem gerar sofrimento psicológico aos pacientes, prejudicando sua autoimagem, acarretando, muitas das vezes, no isolamento e dificuldade em relacionar-se com outras pessoas. Portanto, um sorriso harmonioso é importante não somente por questões estéticas, mas para que o indivíduo se sinta bem consigo mesmo.

Aim:To investigate the nature of psychological distress caused by oral problems. Methods: This research adopted a qualitative approach and exploratory-descriptive design, employing, as data collection tools, a semi-structured interview and an unsystematic observation. For the research's data analysis, content analysis was used, and the research sample featured 25 participants, between men and women, who sought out dental care in a Manaus, Amazonas, Brazil dental clinic between May and June 2020. Results: All the participants were affected psychologically by the existence of oral problems, which led to self-esteem and self-image problems. With the start of treatment, the participants reported an improvement in self-esteem and self-image, not minimizing, however, other types of feelings that come with oral problems, like discomfort, pain, and bullying. Conclusion: Oral problems can cause psychological pain to the patients, harming their self-esteem and self-image, often leading to isolation and trouble interacting with other people. Therefore, a harmonious smile is important not only for esthetic reasons, but also for individuals to feel good about themselves.

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PURPOSE: The aim of this study was to evaluate the influence of different density and amplitude of electric current on the percentage of bone-implant contact (BIC) using the finite element method. MATERIALS AND METHODS: Numerical models were performed on commercially pure titanium grade IV implants connected to a 1.5 V battery with an electrical resistance (R) at 150 kΩ on 10 µA or at 75 kΩ on 20 µA. The percentage of simulated BIC was analysed by varying the electric current from 1 up to 60 µA. The variation of electric current application was simulated for coronal and apical peri-implant regions. RESULTS: The findings showed that a direct and constant electric current source below 10 µA does not provide a proper current density for osseointegration (BIC < 55%). Electric current sources ranging from 10 to 20 µA resulted in an increase in BIC above 60% while BIC reached 90% on 30 to 40 µA. Also, the application of the current source on 20 µA at the apical peri-implant region resulted in a high BIC percentage at around 86.1%. CONCLUSIONS: The location and intensity of the electrical current source can increase the resultant electrical current density at the implant-bone interface and enhance the bone healing process. Although the model is a simplified version of the biological process in the bone-implant interface, such findings can predict a magnitude of electrical current density required to stimulate osseointegration.

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Improperly managed care conditions for reptiles can lead to clinical problems, including those of nutritional origin. A diagnostic tool to aid in the assessment of hepatic lipidosis is warranted. Evaluation of attenuation using quantitative computed tomography has a variety of indications in animals and permits the standardization of hepatic computed tomography (CT) reference values, aiding in the diagnosis of lipidosis. The objective of this paper was to estimate hepatic quantitative CT reference values for boas because of the lack of data in the literature for this species. CT scans were performed in 13 boas (Boa constrictor constrictor): 5 under managed care and 8 that were free ranging. Results show that the mean hepatic attenuation in the captive boa group was well below the mean for the free-ranging animals (P < 0.05) with respective values of 48.78 ± 6.57 and 61.76 ± 7.11 HU. These results suggest an influence of managed care on liver attenuation. These results were observed despite the lack of clinical or laboratory changes. This imaging technique is useful to detect early hepatic changes; however, clinical relevance is unknown at this point. Further studies and standardization of species-specific values for hepatic quantitative CT would contribute to better understanding of the physiologic, physiopathologic, environmental, and nutritional processes.

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Introdução:A utilização de fitoterápicos para os tratamentos de prevenção e de suporte de patologias situadas nos diversos órgãos e tecidos, caracteriza-se como uma prática amplamente disseminada no Brasil.Objetivo:Avaliar a ação antimicrobiana de 09 substâncias fitoterápicas utilizadas costumeiramentepara o tratamento de suporte em algumas afecções bucais no nordeste brasileiro. Materiais:O experimento in vitrofoi realizado no Laboratório de Microbiologia do Centro de Biociências da Universidade Federal do Rio Grande do Norte, e o preparo foi realizado por decocção em por um período de 10 minutos e para cada espécie de bactérias, foram utilizadas duas Placas dePetri com meio de cultura Agar Muller Hinton.Métodos:Para a realização da decocção, foi utilizadauma quantidade de 10 gramas eesperou-se os preparos atingir a temperatura ambiente (37º),aatividade antimicrobiana foi avaliada frente à duas cepas de bactérias,através de uma técnica de observação em laboratório, para cada espécie de bactéria.Foram utilizadas duas Placas de Petri com meio de cultura Agar Muller Hinton, onde a inoculação foi realizada por meio de Swabs, e sobre os quais foram realizadoscinco poços de aproximadamente 6 mm de diâmetro. Resultados:Os extratos da semente de manuscada, óleo de coco, casca de cajueiro, semente de sucupira, raiz de urtiga branca e gengibre, foram ineficazes contra o Streptococcus mutans,e Streptococcus mitis,por outro lado o extrato de româ exibiu eficácia para o Streptococcus mutanse a pedra hume exibiu eficácia parao Streptococcus mitis.Conclusões:Os extratos de casca de cajueiro, casca de romã, gengibre e de pedra hume foram eficazes antibacterianos sobre Streptococcus mutansquando comparado com o Periogard®, considerado padrão ouro nos estudos sobre os agentes antibacterianos na odontologia (AU).

Introduction:The use of herbal medicines for the prevention and support treatments of pathologies located in the various organs and tissues is characterized as a widespread practice in Brazil.Objective:To analyze, from the elaboration of antibiogramsof the species Streptococcus mutans and Streptococcus mitis, the antimicrobial activity of phytotherapeutic species in oral disorders.Materials:The in vitro experiment was carried out at the Microbiology Laboratory of the Biosciences Center of the Federal University of Rio Grande do Norte, and the preparation was carried out by decoction in a period of 10 minutes and for each species of bacteria, two plates were used Petri dish with Agar Muller Hinton culture medium.Methods:For the decoction, a quantity of 10 grams was used and the preparations were expected to reach room temperature (37º), the antimicrobial activity was evaluated against two strains of bacteria, using a laboratory observation technique, for each species of bacteria, two Petri dishes with Agar Muller Hinton culture medium were used, where the inoculation was performed by means of Swabs, and on which five wells of approximately 6 mm in diameter were made.Results:The extracts of the mamuscada seed, coconut oil, cashew bark, sucupira seed, white nettle root and ginger, were ineffective against Streptococcus mutans, and Streptococcus mitis, on the other hand, pomegranate extract showed efficacy for Streptococcus mutans and the hume stone showed efficacy for Streptococcus mitis. Conclusions:Cashew bark, pomegranate, ginger and hume stone extracts were effective antibacterials against Streptococcus mutans when compared to Periogard®, considered the gold standard in studies on antibacterial agents in dentistry (AU).

Introducción: El uso de hierbas medicinales para la prevención y el tratamiento de apoyo de patologías localizadas en los diversos órganos y tejidos se caracteriza como una práctica generalizada en Brasil. Objetivo:analizar, a partir de la elaboración de antibiogramas de las especies Streptococcus mutans y Streptococcus mitis, la actividad antimicrobiana de las especies fitoterapéuticas en los trastornos orales.Materiales:Elexperimento in vitro se realizó en el Laboratorio de Microbiología del Centro de Biociencias de la Universidad Federal de Rio Grande do Norte, y la preparación se realizó por decocción en un período de 10 minutos y para cada especie de bacteria, se utilizaron dos placas. Placa de Petri con medio de cultivo Agar Muller Hinton. Resultados:los extractos de semilla de mamuscada, aceite de coco, corteza de anacardo, semilla de sucupira, raíz de ortiga blanca y jengibre, no fueron efectivos contra Streptococcus mutans y Streptococcus mitis, por otrolado, el extracto de granada mostró eficacia para Streptococcus mutans y el cálculo de húmero mostraron eficacia para Streptococcus mitis.Métodos:Para la decocción, se utilizó una cantidad de 10 gramos y se esperaba que las preparaciones alcanzaran la temperatura ambiente (37º), se evaluó la actividad antimicrobiana contra dos cepas de bacterias, utilizando una técnica de observación de laboratorio. Para cada especie de bacteria, se utilizaron dos placas de Petri con medio de cultivo Agar Muller Hinton, donde la inoculación se realizó por medio de hisopos, y en la cual se hicieron cinco pozos de aproximadamente 6 mm de diámetro.Conclusiones:los extractos de corteza de anacardo, granada, jengibre y cálculos de húmero fueron antibacterianos efectivos contra Streptococcus mutans en comparación con Periogard®, considerado el estándar de oro en estudios sobre agentes antibacterianos en odontología (AU).

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An amendment to this paper has been published and can be accessed via a link at the top of the paper.

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Introdução:A intrusão resulta no deslocamento do dente no sentido axial para o interior do osso alveolar, podendo causar injúrias à estrutura periodontal e ao tecido pulpar através do esmagamento e ruptura das fibras do ligamento periodontal e do aporte vascular.Objetivo:abordar a ocorrência de um traumatismo dentário do tipo intrusivo, na dentição decídua, descrevendo aspectos relacionados ao diagnóstico, tratamento e proservação da unidade dentária. Relato de caso:Paciente, quatro anos de idade, gênero feminino, apresentou traumatismo dentário condizente com o diagnóstico de luxação intrusiva, foi estabelecido um tratamento conservador, preservando o elemento dentário no arco até que ocorresse a esfoliação do mesmo. No presente caso, obteve-se um bom prognóstico, visto que foi percebida a reerupção do elemento dentário no período de dois meses.Conclusões:O conhecimento das técnicas de manipulação dos traumatismos dento-alveolares e dos tecidos moles é imprescindível para a realização de um tratamento adequado dessas condições. Desta maneira, é importante o cirurgião-dentista ter habilidades no manejo da criança para um correto diagnóstico, estabelecendo um adequado tratamento, para melhor prognostico da unidade dentária (AU).

Introduction:Intrusion results in axial displacement of the tooth into the alveolar bone and may cause damage to the periodontal structure and pulp tissue by crushing and rupturing the periodontal ligament fibers and vascular input.Objective:To address the occurrence of intrusive dental trauma in the deciduous dentition, describing aspects related to the diagnosis, treatment and proservation of the dental unit. Case report:Patient, four years old, female, had dental trauma consistent with the diagnosis of intrusive dislocation, a conservative treatment was established, preserving the dental element in the arch until exfoliation occurred. In the present case, a good prognosis was obtained, since it was noticed the re-erection of the dental element in the period of two months. Conclusions:The knowledge of the techniques of manipulation of dento-alveolar and soft tissue trauma is essential for the adequate treatment of these conditions. In this way, it is important for the dental surgeon to have skills in the management of the child for a correct diagnosis, establishing an appropriate treatment, for a better prognosis of the dental unit (AU).

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PURPOSE: The purpose of this paper is to evaluate the nonlinear impact of users' memories on their general evaluation of outpatient healthcare services by the integration of two methodologies: critical incidents technique (CIT) and penalty-reward contrast analysis (PRCA). DESIGN/METHODOLOGY/APPROACH: The authors carried out a survey with 356 respondents, users of seven outpatient clinics located in the city of Blumenau/SC, Brazil, during 2016. The participants were asked about their perceptions of positive and negative aspects of the service; and, using CIT, the answers were categorized according to the following dimensions: empathy, communication, facilities, access, promptness, medicines availability, complementary services, safety/confidentiality and service performance. Then, the authors evaluated the nonlinear impact of critical incidents on users' general evaluation of the service using the identified incidents as input variables in a PRCA. FINDINGS: The findings show that users of healthcare services tend to remember emotion and health aspects positively, while technical and formal aspects tend to be more negatively than positively remembered. On the other hand, PRCA identifies that incidents of three dimensions positively influence the overall perception of the service (empathy, complementary services and privacy) and five negatively (empathy, facilities, speed, drugs/pharmacy and health performance), explaining 26.3 percent of the variation in clients' general satisfaction. ORIGINALITY/VALUE: The present paper explores the integration of two methodologies, showing how we can use open listening to healthcare service users to identify the nonlinear impact of different incidents on their general evaluation of the service. The results show that what customers remember does not necessarily influence overall customer satisfaction. The present approach allows companies to improve the process of listening to customers. There are no other papers exploring this approach, particularly in relation to healthcare services.

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