RESUMO
Justification and Objectives: dengue is one of the serious public health concerns in the world, due to the severity of its infection, which can lead to serious cases and death. The study aimed to analyze the epidemiological profile of dengue cases as well as their temporal distribution in the municipality of Jaboatão dos Guararapes-PE before and during the COVID-19 pandemic. Methods: this is an ecological time series study, with a descriptive character of suspected cases of dengue in the Notifiable Diseases Information System, from 2018 to 2021. Results: it should be noted that 2018 had the lowest dengue incidence rate of the years analyzed. The other years had high incidence rates, however 2020 had a decline in cases when compared to 2019. The year 2021 was marked by the highest number of cases in the study period. Conclusion: it was possible to observe a seasonal pattern of dengue in 2020 that was different from other years, with a more pronounced decrease in dengue cases following the arrival of COVID-19 in the municipality.(AU)
Justificativa e Objetivos: a dengue é um dos graves problemas de saúde pública no mundo, devido à gravidade de sua infecção, podendo evoluir para casos graves e a óbito. O estudo teve como objetivo analisar o perfil epidemiológico dos casos de dengue, bem como sua distribuição temporal no município do Jaboatão dos Guararapes-PE antes e durante a pandemia de COVID-19. Métodos: trata-se de estudo ecológico de série temporal, com caráter descritivo dos casos suspeitos de dengue no Sistema de Informação de Agravos de Notificação, de 2018 a 2021. Resultados: observou-se que o ano de 2018 apresentou a menor taxa de incidência de dengue dos anos analisados. Os demais anos tiveram altas taxas de incidência, no entanto 2020 teve um decréscimo dos casos quando comparado com o ano de 2019. Já o ano de 2021 foi marcado pela maior quantidade de casos do período temporal de estudo. Conclusão: foi possível observar um padrão de sazonalidade da dengue em 2020 diferente dos demais anos, com um decréscimo mais acentuado dos casos de dengue a partir da chegada da COVID-19 no município.(AU)
Justificación y Objetivos: el dengue se presenta como uno de los graves problemas de salud pública en el mundo, debido a la gravedad de su infección, que puede provocar casos graves y la muerte. El estudio tuvo como objetivo analizar el perfil epidemiológico de los casos de dengue, así como su distribución temporal en el municipio de Jaboatão dos Guararapes-PE antes y durante la pandemia de COVID-19. Métodos: un estudio de serie temporal ecológica, con carácter descriptivo de casos sospechosos de dengue en el Sistema de Información de Enfermedades de Declaración Obligatoria, del 2018 al 2021. Resultados: cabe señalar que el año 2018 tuvo la tasa de incidencia de dengue más baja de los años analizados. Los demás años tuvieron altas tasas de incidencia, sin embargo el 2020 tuvo una disminución de casos en comparación con el 2019. El año 2021 estuvo marcado por el mayor número de casos en el período de estudio. Conclusión: se pudo observar un patrón estacional del dengue en el año 2020 diferente a otros años, con una disminución más pronunciada de los casos de dengue tras la llegada del COVID-19 al municipio.(AU)
Assuntos
Humanos , Dengue/epidemiologia , Distribuição Temporal , COVID-19 , Saúde PúblicaRESUMO
BACKGROUND: The growing demand for agricultural products has led to the misuse/overuse of insecticides; resulting in the use of higher concentrations and the need for ever more toxic products. Ecologically, bioinsecticides are considered better and safer than synthetic insecticides; they must be toxic to the target organism, yet with low or no toxicity to non-target organisms. Many plant extracts have seen their high insecticide potential confirmed under laboratory conditions, and in the search for plant compounds with bioinsecticidal activity, the Lamiaceae family has yielded satisfactory results. OBJECTIVE: The aim of our study was to develop computer-assisted predictions for compounds with known insecticidal activity against Aphis gossypii and Drosophila melanogaster. RESULTS AND CONCLUSION: Structure analysis revealed ent-kaurane, kaurene, and clerodane diterpenes as the most active, showing excellent results. We also found that the interactions formed by these compounds were more stable, or presented similar stability to the commercialized insecticides tested. Overall, we concluded that the compounds bistenuifolin L (1836) and bistenuifolin K (1931), were potentially active against A. gossypii enzymes; and salvisplendin C (1086) and salvixalapadiene (1195), are potentially active against D. melanogaster. We observed and highlight that the diterpenes bistenuifolin L (1836), bistenuifolin K (1931), salvisplendin C (1086), and salvixalapadiene (1195), present a high probability of activity and low toxicity against the species studied.