RESUMO
Aim: The field of nanotechnology promotes the development of innovative and more effective cancer therapies. This work is aimed to develop a hybrid system that combines the capacity of boron nitride nanotubes (BNNTs) to be internalized by tumor cells and the ability of nickel ferrite nanoparticles to efficiently release heat by induced AC magnetic heating. Materials & methods: The systems studied were characterized by using x-ray diffractometry, transmission electron microscopy, vibrating sample magnetometry and Mössbauer spectroscopy. Results: The ferrite nanoparticles attached to BNNT were able to achieve the required temperatures for magnetohyperthermia therapies. After cellular internalization, AC induced magnetic heating of BNNT@NiFe2O4 can kill almost 80% of Hela cells lineage in a single cycle. Conclusion: This system can be a highly efficient magnetohyperthermia agent in cancer therapy.
Assuntos
Compostos de Boro/química , Nanopartículas/química , Nanotecnologia/métodos , Nanotubos/química , Compostos Férricos/química , Células HeLa , Humanos , Níquel/químicaRESUMO
BACKGROUND: This study aimed the use of mesoporous silica under the naturally transformable Neisseria meningitidis, an important pathogen implicated in the genetic horizontal transfer of DNA causing a escape of the principal vaccination measures worldwide by the capsular switching process. This study verified the effects of mesoporous silica under N. meningitidis transformation specifically under the capsular replacement. METHODS: we used three different mesoporous silica particles to verify their action in N. meningitis transformation frequency. RESULTS: we verified the increase in the capsular gene replacement of this bacterium with the three mesoporous silica nanoparticles. CONCLUSION: the mesouporous silica particles were capable of increasing the capsule replacement frequency in N. meningitidis.