RESUMO

Validation of transendocardial injection as a method for delivering therapeutic agents to the diseased heart is increasing. Puncture heart biopsies should re-emerge as a possible alternative method to allow access to the myocardium and implantable biomaterial for cell therapy. Therefore, this work aims to present a percutaneous puncture device for biopsy and intramyocardial biomaterial injection, standardize the technique and attest to the safety of the method. The adaptation consists of creating myocardial microlesions that allow for better fixation of stem cells. The objective of this technical note covers only the development of the needle and the histological quality of the biopsies. It has not been used in humans yet.

Assuntos

Biópsia por Agulha/métodos , Miocárdio , Agulhas , Transplante de Células-Tronco/métodos , Animais , Biópsia por Agulha/instrumentação , Humanos , Reprodutibilidade dos Testes , Transplante de Células-Tronco/instrumentação