RESUMO
One of the factors facilitating the global pandemic of Grigor'ev-Shiga dysentery is considered in detail. All Shigella dysenteriae 1 strains, irrespective of the geographical zone of their spread, showed medicinal resistance. As pandemic developed, the spectrum of medicinal resistance constantly increased in all hyperendemic foci. The presence of pronounced relationships between the strains circulating in each of three hyperendemic foci and the strains circulating in different hyperendemic foci could be observed. The necessity of paying greater attention to this dangerous infectious disease, and especially to the problems related to the medicinal resistance of its causative agents, is emphasized.
Assuntos
Surtos de Doenças/história , Disenteria Bacilar/história , Saúde Global , Shigella dysenteriae/efeitos dos fármacos , África Central , Sudeste Asiático , América Central , Reservatórios de Doenças , Resistência Microbiana a Medicamentos/genética , Disenteria Bacilar/epidemiologia , Disenteria Bacilar/microbiologia , Fezes/microbiologia , História do Século XX , Humanos , Shigella dysenteriae/genética , Shigella dysenteriae/isolamento & purificaçãoRESUMO
In this article, based on the data contained in literature, the development of the pandemic of Grigor'ev-Shiga dysentery, which began in 1960-ies, is followed. The stages of the formation of three powerful hyperpandemic foci in Central America, South-East Asia and Central Africa are characterized. The characterization of the epidemiological features of the spread of this disease and its clinical distinction are presented. The biological properties of the causative agent, and in particular its multiple medicinal resistance facilitating the spread of the disease throughout the world, is considered. The stable character of the foci of infection in developing countries, which actually present a threat also for this country, is pointed out. For this reason, the epidemiological surveillance on Grigor'ev-Shiga dysentery should be drastically strengthened.