RESUMO
Lippia alba (Mill.) N. E. Brown Verbenaceae, known popularly as 'Juanilama' or 'Salvia Sija', is prized widely in folk medicine in Guatemala. Its leaves are employed as an infusion and decoction as a remedy for stomach problems, dysentery, colds and cough, febrifuge, as well as a sedative and in spasmolitic remedies. The present study reports the effects of the infusion of L. alba on the rat gastric mucosa. The following behavioural parameters were evaluated: (a) gastric irritancy test in Wistar rats; (b) antiulcer activity, short term and long term; (c) acid secretion; (d) measurement of total proteins; (e) estimation of total protein bound and nonprotein sulfhydryl groups. Ranitidine (100 mg/kg, p.o.) was used as the reference antiulcer drug. Oral treatment with the infusion (12.5 g dry plant/kg) did not cause gastric irritancy in the rats treated during five consecutive days. In addition, the oral administration of L. alba was found to be effective at preventing gastric ulceration induced by indomethacin (50 mg/kg, p.o.) in rats in the short term (1 day) and long term (5 days).
Assuntos
Antiulcerosos/farmacologia , Plantas Medicinais/química , Verbenaceae/química , Animais , Anti-Inflamatórios não Esteroides , Mucosa Gástrica/patologia , Guatemala , Indometacina , Masculino , Proteínas/química , Proteínas/metabolismo , Ratos , Ratos Wistar , Úlcera Gástrica/induzido quimicamente , Úlcera Gástrica/metabolismo , Úlcera Gástrica/prevenção & controle , Compostos de Sulfidrila/metabolismoRESUMO
The chemical composition, pharmacological activity and traditional uses of 52 species attributed to the genus Lippia (Verbenaceae) as used in the South and Central America, and Tropical Africa, were revised and compared. A survey of the available literature shows that these species are used mostly for the treatment of gastrointestinal and respiratory disorders and as seasoning. Additionally, some of these Lippia species showed antimalarial, spasmolitic, sedative, hypotensive and, anti-inflammatory activities. Generally, the essential oil or the phenolic compounds (flavonoids) from these plant extracts are assumed to be the active principles.
Assuntos
Medicina Tradicional , Fitoterapia , Plantas Medicinais , Verbenaceae/química , África , América Central , Gastroenteropatias/tratamento farmacológico , Humanos , Estruturas Vegetais/química , Plantas Medicinais/química , Doenças Respiratórias/tratamento farmacológico , América do Sul , EspeciariasRESUMO
The methanol extract of Pothomorphe peltata leaves, orally administered at the dose of 20 mg/kg (equivalent to 2.50 g dry plant/kg) body weight, exhibited a significant anti-inflammatory activity, comparable with phenylbutazone (80 mg/kg, p.o.), against adjuvant-carrageenan-induced edema in rats.
Assuntos
Anti-Inflamatórios não Esteroides/farmacologia , Edema/prevenção & controle , Magnoliopsida , Plantas Medicinais , Administração Oral , Animais , Anti-Inflamatórios não Esteroides/administração & dosagem , Anti-Inflamatórios não Esteroides/uso terapêutico , Carragenina , Edema/induzido quimicamente , Feminino , Humanos , Masculino , Fenilbutazona/farmacologia , Extratos Vegetais/farmacologia , Extratos Vegetais/uso terapêutico , Folhas de Planta , Ratos , Ratos WistarRESUMO
Ethanolic extracts from 15 plant species, representing eight different families, used in traditional medicine in Ecuador were evaluated for antiinflammatory and antioxidant activities. Conyza floribunda, Eupatorium articulatum, Bonafousia longituba, Bonafousia sananho, Tagetes pusilla and Piper lenticellosum extracts showed a significant antiinflammatory activity in vivo in the carrageenan-induced paw oedema model in mice. The extracts were also tested in vitro for their ability to inhibit lipid peroxidation and to scavenge superoxide and hydroxyl radicals. E. articulatum extract possesses both activities. Baccharis trinervis, E. articulatum and Phytolacca rivinoides extracts were active as antioxidants.