RESUMO
It was obtained by synthesis a radioprogestin-iodine-131 and proved in two patients with hormono-dependent meningioma to progesterone with very good results in the scan of cerebral tumours localization; and in one patient in the treatment of this kind of tumour. No radiotoxicity or intolerance was present until today in six month of follow-up of this preliminary uses of radioprogestin in cerebral tumours hormono-dependent to progesterone; so it is proposed the use of this new radiopharmaco for the diagnosis and treatment of this tumours.
Assuntos
Radioisótopos do Iodo/uso terapêutico , Progestinas/uso terapêutico , Humanos , Masculino , Neoplasias Meníngeas/diagnóstico por imagem , Neoplasias Meníngeas/radioterapia , Meningioma/diagnóstico por imagem , Meningioma/radioterapia , Cintilografia , Indução de RemissãoRESUMO
Using antiestrogen labelled with iodine-131 we proved the useful as diagnostic and therapeutic tools to identified hormone dependent cancers in breast with very encorageous results in 7 cases of human cancer. The method was simple and safe and similar methods for scanning of prostate tumors dependent are in current research in our laboratory and will be object of other communications.
Assuntos
Neoplasias da Mama/tratamento farmacológico , Antagonistas de Estrogênios , Neoplasias Hormônio-Dependentes/tratamento farmacológico , Adulto , Neoplasias da Mama/química , Neoplasias da Mama/diagnóstico , Antagonistas de Estrogênios/uso terapêutico , Feminino , Humanos , Radioisótopos do Iodo , Pessoa de Meia-Idade , Neoplasias Hormônio-Dependentes/química , Neoplasias Hormônio-Dependentes/diagnósticoRESUMO
Using antibodies against Toxoplasma gondii labelled with indium-113 metaestable we obtained scan of rats infested with this disease in a simple and harmless way. Also using the same antibodies, but labelled with iodine-131, we destroyed by radiolysis the toxoplasmas of experimental animals with the Medial Lethal Dose obtained "in vitro" experiments. The experimental results are very encouraging and their use in human beings are in currently research in our laboratory and will be the object of a future communication.
Assuntos
Anticorpos/administração & dosagem , Índio/uso terapêutico , Radioisótopos do Iodo/uso terapêutico , Radioisótopos/uso terapêutico , Toxoplasmose/diagnóstico por imagem , Toxoplasmose/radioterapia , Animais , Rotulagem de Medicamentos , Técnicas In Vitro , Dose Letal Mediana , Cintilografia , RatosRESUMO
Using the same technique that gave such good results in cysticercosis and other parasitic diseases we obtained antibodies labelled against trichinosis and proved their diagnostic value by scan in infected rats. These same antibodies at lethal dose, median, (LD50) radiolysed trichina larvae without damage to the animal. Experimental results are very encouraging and their potential use in human subjects are undergoing research in our laboratory and will be the object of a future report.
Assuntos
Anticorpos/administração & dosagem , Radioisótopos do Iodo/uso terapêutico , Triquinelose/diagnóstico por imagem , Triquinelose/radioterapia , Animais , Rotulagem de Medicamentos , Dose Letal Mediana , Cintilografia , RatosRESUMO
Using the colorant proteic complex labell with Tc-99 m. we visualize--by the first time--the carotideal glomus in the human in 6 volunteers and one patient with tumor. The results are very encorageous: the method was simple and safe (one single dose endovenously) and hardless (no radiotoxicity presents in 3 months of clinical and laboratory controls) and there is a good visualization by scan of carotideal bodies "in vivo", in human being. We think this new method and labell compound could be useful in research and medical diagnoses.
Assuntos
Tumor do Corpo Carotídeo/diagnóstico , Cintilografia , HumanosRESUMO
The "nerve growth factor" is a polipeptide isolated from salivary glands of some mammals. Its main physiological effect is on the autonomic nervous system. The injection of antiserum in newborn animals leads to nearly total destruction of the sympathetic ganglia (immunosympathectomy). Anti-nerve growth factor labelled with Iodine-131 was injected in rats for the determination of organ distribution at different times (2,4,6,8 and 24 hours). A selective concentration in the adrenal medulla was obtained at 4 hrs. after intravenous administration of 50 uCi of anti-nerve growth factor with an specific activity of 0.001 g/mCi that permits, for the first time, the scan of the adrenal medulla. No intolerance or radiotoxicity was observed in the animals during a six-month follow-up period. The results are very encoragin, and the application of this new method in humans is at present under study.
Assuntos
Medula Suprarrenal , Cintilografia/métodos , Medula Suprarrenal/análise , Medula Suprarrenal/metabolismo , Animais , Sistema Nervoso Autônomo/metabolismo , Soros Imunes/metabolismo , Radioisótopos do Iodo , Camundongos , Fatores de Crescimento Neural/antagonistas & inibidores , RatosRESUMO
Two normal individuals (healthy volunteer) and one patient with pituitary adenoma were evaluated with estrogenic complex 131-I for pituitary scan. All of them receive 400 muCi of the radionuclide orally. The study was performed 24 hs. after the ingestion of the drug. The results obtained with this method were so encouraging: one side, any toxic reaction was detected through a period of three months, clinical nor laboratory; other side, we visualized directly and in an no invasive form, the pituitary gland with only one dose of the drug administered orally. It is necessary more investigation for a good evaluation of this.