RESUMO
Zinc ions have been reported to stabilize cellular membranes, protecting the gastric mucosa against a wide variety of ulcerative agents. The treatment with zinc sulfate intragastrically administered as one dose (20 mg/kg body weight) daily for 30 consecutive days did not modify the normal aspect of rat gastric mucosa as observed by electron scanning microscopy. Furthermore, the X-ray microanalysis of the lysosome content performed on different gastric mucosa cells did not show the zinc element. These results suggest that zinc ion is a relatively nontoxic element for the rat gastric mucosa.
Assuntos
Mucosa Gástrica/efeitos dos fármacos , Zinco/toxicidade , Animais , Feminino , Mucosa Gástrica/ultraestrutura , Masculino , Ratos , Ratos Endogâmicos , Sulfatos/administração & dosagem , Zinco/administração & dosagem , Sulfato de ZincoRESUMO
Zinc ions have been reported to stabilize cellular membranes, protecting the gastric mucosa against a wide variety of ulcerative agents. The treatment with zinc sulfate intragastrically administered as one dose (20 mg/Kg body weight) daily for 30 consecutive days did not modify the normal aspect of rat gastric mucosa as observed by electron sanning microscopy. Furthermore, the X-ray microanalysis of the lysosome content performed on different gastric mucosa cells did not show the zinc element. These results suggest that zinc ion is a relatively nontoxic element for the rat gastric mucosa
Assuntos
Animais , Ratos , Masculino , Feminino , Mucosa Gástrica/ultraestrutura , Sulfatos/administração & dosagem , Zinco/administração & dosagem , Zinco/toxicidade , Membrana Celular/efeitos dos fármacos , Ratos Sprague-DawleyRESUMO
1. The present study was undertaken in order to demonstrate the protective action of zinc ions on the gastric mucosa of rats submitted to the ulcerogenic effect of ethanol. 2. Aqueous solutions of zinc sulfate (20 mg/kg) and/or ethanol/water (1:1, v/v) (10 ml/kg) were intragastrically administered to young adult rats. The fundus region of the stomach was submitted to scanning electron and light microscopy study. The control group received isotonic sodium sulfate by the same route. 3. The ulcerogenic action of ethanol was completely inhibited by intragastric pretreatment with zinc sulfate for 3 consecutive days. 4. The clinical use of zinc ions to protect the gastric mucosa merits consideration in the light of the present findings.
Assuntos
Etanol/farmacologia , Mucosa Gástrica/efeitos dos fármacos , Úlcera Gástrica/induzido quimicamente , Sulfatos/farmacologia , Zinco/farmacologia , Animais , Feminino , Mucosa Gástrica/ultraestrutura , Masculino , Ratos , Ratos Endogâmicos , Sulfato de ZincoRESUMO
1. The present study was undertaken in order to demonstrate the protective action of zinc ions on the gastric mucosa of rats submitted to the ulcerogenic effect of ethanol. 2. Aqueous solutions of zinc sulfate (20 mg/kg) and/or ethanol/water (1:1,v/v) (10ml/kg) were intragastrically administered to young adult rats. The fundus region of the stomach was submitted to scanning electron and light microscopy study. The control group received isotonic sodium sulfate by the same route. 3. The ulcerogenic action of ethanol was completely inhibited by intragastric pretreatment with zinc sulfate for 3 consecutive days. 4. The clinical use of zinc ions to protect the gastric mucosa merits consideration in the light of the present findings