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BACKGROUND: Androgenetic alopecia (AGA) affects up to 80% of men and 50% of women throughout their lifetime, causing significant discomfort. Minoxidil, finasteride, and low-level laser light therapy are the only Food and Drug Administration-approved treatments for AGA, and they have shown positive results in randomized controlled trials and meta-analyses. However, their efficacy is limited, and new therapies are needed. Injection of platelet-rich plasma (PRP), a minimally invasive technique, has been described by several authors as a promising treatment for AGA. Although many studies report beneficial effects of PRP on AGA, there is no standardized practice for PRP preparation and administration or a standard method to evaluate results. OBJECTIVE: The aim of this study was to evaluate the efficacy of manually prepared PRP in the treatment of male AGA. MATERIALS AND METHODS: We treated 20 male patients with AGA with 3 monthly injections of PRP and analyzed results by TrichoScan®. RESULTS: In this study, there was no statistically significant improvement in hair count or proportion of anagen hairs. CONCLUSIONS: This lack of response could be related to any of the variables during PRP preparation described above and also to the limited number of patients in the study.

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Introdução: O carcinoma basocelular (CBC) é a neoplasia maligna mais comum. Corresponde a 70- 80% dos tumores cutâneos. É diagnosticado pela suspeita clínica aliada à dermatoscopia, que permite definir os seus limites. Objetivo: Avaliar se critérios clínicos e dermatoscópicos podem ser suficientes para diagnóstico e tratamento do CBC primário e bem delimitado. Materiais e métodos: Revisão de suspeitas de CBCs primários, bem delimitados, operados por biópsia excisional (margem de 3mm) no serviço de Dermatologia da Universidade de Mogi das Cruzes (2017 a 2019). Aplicado o teste qui-quadrado para avaliar a significância das margens. Resultados: Foram 169 lesões avaliadas. Predominaram: sexo feminino, 8a década de vida. Resultaram no exame histopatológico 141 CBCs. Avaliando-se as margens de segurança para os casos de CBC houve 95% de margens livres (p=0,0004998). Discussão: Existem elementos dermatoscópicos comuns entre o CBC e outras neoplasias e lesões benignas, o que justifica outros diagnósticos encontrados. A margem cirúrgica de 3mm foi apropriada para CBCs primários bem delimitados, agilizando o processo de cura e reduzindo custos. Conclusão: Para suspeitas clínico-dermatoscópicas de CBC bem delimitados, a biópsia excisional mostrou-se eficaz quanto ao diagnóstico e às margens de segurança.

Introduction: Basal cell carcinoma (BCC) is the most common malign neoplasm. It corresponds to 70-80% of skin tumors. The diagnosis is made based on clinical suspicion combined with dermoscopy, which also allows defining its limits. Objective: To assess whether clinical and dermoscopic criteria are sufficient for the diagnosis and treatment of primary and well-defined BCC. Materials and methods: Review of suspected cases of well-defined primary BCC surgically approached by excisional biopsy (3 mm margin) at the Dermatology Service of the University of Mogi das Cruzes (2017 to 2019). The Chi-square test was applied to assess the significance of the margins. Results: 169 injuries were assessed, with a predominance of women in the 8th decade. The histopathological examination concluded on 141 BCCs. When evaluating the excision margins for BCC cases, there was 95% of free margins (p = 0.0004998). Discussion: There are common dermoscopic elements between BCC and other neoplasms and benign lesions, which justifies other diagnoses found. The 3 mm surgical margin was accurate for well-defined primary BCCs, speeding up healing time and reduces costs. Conclusion: For clinical-dermatoscopic suspicions of well-defined BCC, an excisional biopsy was effective in the diagnosis and clinical safety margins

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Os sarcomas indiferenciados são neoplasias de tecidos moles derivados do mesoderma. Relatamos um caso de sarcoma pleomórfico indiferenciado, sua dermatoscopia, seu estadiamento e sua abordagem terapêutica.

Undifferentiated sarcomas are neoplasms of soft tissues derived from the mesoderm. We report a case of undifferentiated pleomorphic sarcoma, its dermoscopy, staging, and therapeutic approach.