RESUMO

Introdução. Estudos têm explorado as possíveis conexões entre o consumo de laticínios e câncer de cabeça e pescoço (CCP), mas os resultados têm sido inconsistentes. Objetivos 1. Avaliar a associação entre consumo de leite e câncer de cabeça e pescoço; 2º. Avaliar a modificação no efeito do consumo de leite de acordo com consumo de álcool e tabagismo; 3º. Avaliar a associação entre consumo de queijo, manteiga, iogurte, sorvete e o câncer de cabeça e pescoço. Metodologia foram utilizados dados individuais de um total de 15 estudos caso-controle (12.998 casos e 9.510 controles) do consórcio Internacional Head and Neck Cancer Epidemiology (INHANCE). 1. A análise do leite incluiu 8.925 casos e 12.339 controles. As ORs e os intervalos de confiança de 95% foram calculados por meio de análise de regressão logística multinível aplicados às categorias do quartil de laticínios e ajustados para uso de cigarro e álcool. Modelos ajustados incluíram idade, sexo, nível de escolaridade, raça/etnia e centro de estudo. 2. Para avaliar heterogeneidades na associação entre o leite e o CCP, de acordo com o consumo de tabaco e de álcool, foram realizadas análises estratificadas por esses dois fatores 3. Para avaliar a associação entre o consumo de derivados do leite e CCP, realizamos análises de regressão logística multinível de efeitos aleatórios para queijo, manteiga, iogurte e sorvetes. Resultados 1. Foram encontradas ORs maiores do que a unidade para o quarto quartil de frequência de consumo de leite (em comparação com o primeiro quartil) para CCP em geral (OR=1,27 (IC 95%; 1,10-1,47) e para câncer da cavidade oral (OR= 1,25 1,07-1,47). 2. Não foi verificada alteração significativa das OR para o quartil IV versus o quartil I na análise estratificada por tabaco e álcool. 3º. O iogurte mostrou uma relação dose-resposta para todas as localizações anatômicas do estudo. Por outro lado, o consumo elevado de sorvete foi associado a uma maior chance de CCP, com p de tendência menor do que 0,05 para CEC de orofaringe (p=0,029) e CCP geral (p<0,001). Conclusão 1. O alto consumo de leite se associou ao CCP após ajuste por outras variáveis e essa relação parece apresentar dose-resposta. 2. Os resultados da presente investigação mostram que os comportamentos de beber e de fumar parecem não modificar o efeito do leite sobre o câncer de cabeça e pescoço. 3. Foram encontradas associações de magnitude e direção diferentes de acordo com o tipo de derivado do leite estudado. Iogurte e queijo apresentaram efeito protetor, enquanto o consumo aumentado de sorvete associou-se à maior chance de CCP.

Introduction. Studies have explored the possible connections between dairy consumption and head and neck cancer, but the results have been inconsistent. Objectives 1. To assess the association between milk consumption and head and neck cancer; 2. To evaluate the modification in the effect of milk consumption according to alcohol and smoking consumption; 3. To evaluate the association between cheese, butter, yogurt, ice cream consumption and head and neck cancer. Methodology individual data from a total of 15 case-control studies (12,998 cases and 9,510 controls) from the International Head and Neck Cancer Epidemiology Consortium (INHANCE) were used. 1. Milk analysis included 8,925 cases and 12,339 controls. ORs and 95% confidence intervals were calculated through multilevel logistic regression analysis applied to quartile categories of dairy and adjusted for cigarette and alcohol use; adjusted models included age, sex, education level, race/ethnicity, and study center. 2. Stratified analyses by tobacco and alcohol consumption were conducted to assess heterogeneity in the association between milk and HNC. 3. Multilevel random-effects logistic regression analyses were conducted for cheese, butter, yogurt, and ice cream consumption. Results 1. ORs greater than unity was found for the fourth quartile of milk consumption frequency (compared to the first quartile) for overall HNC (OR=1.27 (95% CI; 1.10-1.47)) and for oral cavity cancer (OR=1.25 (1.07-1.47)). 2. No significant alteration of ORs for quartile IV versus quartile I was observed in the analysis stratified by tobacco and alcohol. 3. Yogurt showed dose-response for all anatomical locations of the study. On the other hand, high ice cream consumption was associated with increased odds of HNC, with a trend p-value less than 0.05 for oropharyngeal HNC (p=0.029) And overall HNC (p <0.001). Conclusion: 1. High milk consumption was associated with HNC after adjustment for other variables, and this relationship seems to exhibit a dose-response. 2. The results of this investigation show that drinking and smoking behaviors appear not to modify the effect of milk on head and neck cancer. 3. Different magnitude and direction associations were found according to the type of milk derivative studied. Yogurt and cheese showed a protective effect, while increased ice cream consumption was associated with a higher chance of HNC.

Assuntos

RESUMO

Despite extensive research on overweight and obesity, there are few studies that present longitudinal statistical analyses among non-institutionalized older adults, particularly in low- and middle-income countries. This study aimed to assess the prevalence and factors associated with excess weight in older adults from the same cohort over a period of fifteen years. A total of 264 subjects aged (≥60 years) from the SABE survey (Health, Wellbeing and Aging) in the years 2000, 2006, 2010, and 2015 in the city of São Paulo, Brazil, were evaluated. Overweight was assessed by a BMI of ≥28 kg/m2. Multinomial logistic regression models adjusted for sociodemographic and health data were used to assess factors associated with excess weight. After normal weight, overweight was the most prevalent nutritional status in all evaluated periods: 34.02% in 2000 (95%CI: 28.29-40.26); 34.86% in 2006 (95%CI: 28.77-41.49%); 41.38% in 2010 (95%CI: 35.25-47.79); 33.75% in 2015 (95%CI: 28.02-40.01). Being male was negatively associated with being overweight in all years (OR: 0.34 in 2000; OR: 0.36 in 2006; OR: 0.27 in 2010; and OR: 0.43 in 2015). A greater number of chronic diseases and worse functionality were the main factors associated with overweight, regardless of gender, age, marital status, education, physical activity, and alcohol or tobacco consumption. Older adults with overweight and obesity, a greater number of chronic diseases, and difficulties in carrying out daily tasks required a greater commitment to healthcare. Health services must be prepared to accommodate this rapidly growing population in low- and middle-income countries.

Assuntos

RESUMO

OBJECTIVE: To analyze the relationship between health conditions and weight changes among elderly people monitored by the SABE Survey over a ten-year period in São Paulo/SP. METHODS: This was a longitudinal study that followed (2000-baseline, 2006 and 2010) change in body weight (outcome variable) and associated health conditions (exposure variables) in the elderly (n=571); multinomial logistic regression analyses were employed. RESULTS: Average weight increase in the evaluated period was 29.0%. 34.0% (2006) and 12.5% (2010) lost weight and 18.2% (2006) and 39.9% (2010) gained weight. Prevalence of chronic diseases increased from 34.1% (2000) to 51.9% (2006) and 60.1% (2010). Older people with weight gain also rated their overall health as poorer in 2006 (RR:3.15; 95%CI 1.21;8.17) and 2010 (RR:2.46; 95%CI 1.02;5.94). The higher numbers of diseases (RR:2.12; 95%CI 1.00;4.46) and hospitalizations (RR:3.50; 95%CI 1.40;8.72) were associated with a decrease in weight in 2010. CONCLUSION: Weight changes are related to poorer health status among the elderly.

Assuntos

RESUMO

Objetivo: Analisar a relação das condições de saúde com a mudança de peso entre idosos em um período de dez anos em São Paulo/SP. Métodos: Estudo longitudinal que acompanhou (2000-baseline, 2006 e 2010) a mudança do peso corporal (variável desfecho) e condições de saúde associadas (variáveis de exposição) em idosos (n=571); análises de regressão logística multinomial foram empregadas. Resultados: O aumento médio de peso no período foi de 29,0%. Perderam peso 34,0% (2006) e 12,5% (2010); e ganharam peso 18,2% (2006) e 39,9% (2010). A prevalência de doenças crônicas aumentou de 34,1% (2000) para 51,9% (2006) e 60,1% (2010). Idosos com aumento de peso avaliaram pior sua saúde geral em 2006 (RR:3,15; IC95% 1,21;8,17) e 2010 (RR:2,46; IC95% 1,02;5,94). Maior número de doenças (RR:2,12; IC95% 1,00;4,46) e internações (RR:3,50; IC95% 1,40;8,72) associaram-se a diminuição de peso em 2010. Conclusão: Mudanças de peso estão relacionadas a um pior estado de saúde entre idosos.

Objetivo: Analizar la relación entre las condiciones de salud y el cambio de peso entre adultos mayores durante un período de diez años en São Paulo/SP. Métodos: Estudio longitudinal (2000-baseline, 2006 y 2010) que siguió el cambio en el peso corporal (variable de resultado) y las condiciones de salud asociadas (variables de exposición) en adultos mayores (n=571); se emplearon análisis de regresión logística multinomial. Resultado: El aumento de peso promedio en el período evaluado fue del 29,0%. Un 34,0% (2006) y 12,5% (2010) perdieron peso; 18,2% (2006) y 39,9% (2010) ganaron peso. La prevalencia de enfermedades crónicas aumentó del 34,1% (2000) para 51,9% (2006) y 60,1% (2010). Las personas mayores con aumento de peso calificaron su salud general peor en 2006 (RR:3,15; IC95% 1,21;8,17) y 2010 (RR:2,46; IC95% 1,02;5,94). El mayor número de enfermedades (RR:2,12; IC95% 1,00;4,46) y hospitalizaciones (RR:3.50; IC95% 1,40;8,72) se asociaron con una disminución del peso en 2010. Conclusión: Los cambios de peso están relacionados con un peor estado de salud entre los adultos mayores.

Objective: To analyze the relationship between health conditions and weight changes among elderly people monitored by the SABE Survey over a ten-year period in São Paulo/SP. Methods: This was a longitudinal study that followed (2000-baseline, 2006 and 2010) change in body weight (outcome variable) and associated health conditions (exposure variables) in the elderly (n=571); multinomial logistic regression analyses were employed. Results: Average weight increase in the evaluated period was 29.0%. 34.0% (2006) and 12.5% (2010) lost weight and 18.2% (2006) and 39.9% (2010) gained weight. Prevalence of chronic diseases increased from 34.1% (2000) to 51.9% (2006) and 60.1% (2010). Older people with weight gain also rated their overall health as poorer in 2006 (RR:3.15; 95%CI 1.21;8.17) and 2010 (RR:2.46; 95%CI 1.02;5.94). The higher numbers of diseases (RR:2.12; 95%CI 1.00;4.46) and hospitalizations (RR:3.50; 95%CI 1.40;8.72) were associated with a decrease in weight in 2010. Conclusion: Weight changes are related to poorer health status among the elderly.

Assuntos

RESUMO

Introdução: A avaliação dos processos inflamatórios em pacientes com tumores de boca é assunto atual na literatura científica. Poucos estudos, entretanto avaliaram a expressão da Proteína Inibidora de Protease Secretada por Leucócito (SLPI), marcador específico de inflamação, em pacientes com câncer de boca Objetivos: 1.Descrever a frequência da concentração de SLPI salivar e sérica em pacientes com câncer bucal. 2. Avaliar a associação dessas concentrações com características clínicas, sociodemográficas e de estilo de vida. Metodologia: Realizou-se a quantificação de SLPI em soro por meio do teste ELISA em pacientes com carcinoma epidermoide da cavidade bucal atendidos no Hospital Heliópolis da Secretaria de Estado da Saúde do Estado de São Paulo no período entre 2011 e 2017. Dados relativos a estadiamento do tumor, características sócio demográficas dos pacientes, hábitos alimentares e estilo de vida foram coletados por meio de prontuários médicos e questionários aplicados aos pacientes. Foram realizados teste de correlação de Spearman e teste qui-quadrado para testar possíveis associações. Resultados: Foram encontradas: correlação positiva entre SLPI em saliva maços-ano de tabagismo (p=0,03) e correlação negativa entre SLPI bochecho para frequência no consumo de carne vermelha (p=0,01). A quantificação de SLPI em soro por quartis apresentou associação com significância estatística para escolaridade (maior proporção de pessoas com ensino médio completo no quartil mais baixo de SLPI), frequência de escovação dentária (maior proporção de pessoas que escovam os dentes mais do que uma vez por dia no quartil com maior SLPI) e estadiamento patológico (2º quartil com maior proporção de estadiamentos 3 e 4). Na avaliação de SLPI em saliva e bochecho, houve associação com o consumo de carne vermelha, havendo indivíduos com consumo mais baixo apenas nos quartis mais superiores de SLPI Conclusão: Este estudo concorda com a hipótese de que o SLPI em pacientes com câncer de boca se relaciona com estilo de vida e estadiamento da lesão

Introduction: The evaluation of inflammatory processes in patients with oral tumors is a current topic in the scientific literature. Few studies, however, have evaluated the expression of the Leukocyte Secreted Protein Inhibitor Protein (SLPI), a specific marker of inflammation in patients with oral cancer. Objectives: 1. To describe the frequency of salivary and serum SLPI in patients with oral cancer. 2. To evaluate the association of these concentrations with clinical, sociodemographic and lifestyle characteristics. Methodology: Serum SLPI was quantified by ELISA in patients with squamous cell carcinoma of the oral cavity treated at the Hospital Heliópolis of the State Health Department of the State of São Paulo in the period between 2011 and 2017. Data on staging of the tumor, socio-demographic characteristics of patients, eating habits and lifestyle were collected through medical records and questionnaires applied to patients. Spearman\'s correlation test and chi-square test were performed to test possible associations. Results: There was a positive correlation between SLPI in saliva and malnutrition SLPI (p = 0.03). The quantification of SLPI in serum by quartiles was associated with statistical significance for schooling (higher proportion of people with complete secondary education in the lowest quartile of SLPI), frequency of toothbrushing (a higher proportion of people brushing their teeth more than once per day in quartile with higher SLPI) and pathological staging (2nd quartile with a higher proportion of stages 3 and 4). In the evaluation of SLPI in saliva and mouthwash, there was an association with red meat consumption, with individuals with lower consumption only in the higher quartiles of SLPI. Conclusion: This study agrees with the hypothesis that SLPI in patients with oral cancer is related to lifestyle and staging of the lesion

Assuntos