RESUMO

BACKGROUND AIMS: Advanced therapy medicinal products (ATMPs) are a class of biological products for human use that are based on gene, tissues or cells. ATMPs have peculiar characteristics when compared with traditional medicines. In this regard, long-term safety and efficacy follow-up systems of individuals treated with ATMPs have become necessary and may present unique challenges, because unlike conventional drugs and biologics, these products can exert their effects for years after administration. This work seeks to assess the requirements foreseen in the regulatory frameworks for the post-marketing authorization safety and efficacy surveillance for ATMPs in Brazil, European Union (EU), Japan and United States, which are some of the members of the International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use. METHODS: We reviewed the scientific literature and official documents of regulatory agencies (RAs) in Brazil, the EU, Japan and the United States. RESULTS AND CONCLUSIONS: RAs in the EU, US and Japan have developed regulatory guidelines for the post-marketing surveillance of ATMPs. These guidelines aim at implementing surveillance plans for monitoring adverse events, including late ones, after marketing authorization. All the ATMPs authorized by the RAs studied, submitted some type of post-marketing requirement to supplement safety and efficacy data, according to the regulations and terminology used by those jurisdictions.

Assuntos

RESUMO

A pericardite constritiva (PC) é uma condição na qual a cicatrização e perda de elasticidade do pericárdio resultam em enchimento ventricular prejudicado, disfunção diastólica e insuficiência cardíaca direita. O diagnóstico dessa patologia é desafiador, sendo frequente a necessidade de técnicas de imagem multimodal, dentre as quais a ecocardiografia representa a modalidade de imagem inicial para a avaliação diagnóstica, além de permitir a diferenciação da PC da cardiomiopatia restritiva (CMR) e outras condições que mimetizam constrição. (AU)

Constrictive pericarditis (CP) is a condition in which scarring and loss of elasticity of the pericardium result in impaired ventricular filling, diastolic dysfunction, and right heart failure. The diagnosis of this pathology is challenging, with frequent need for multimodal imaging techniques, among which echocardiography represents the initial imaging modality for the diagnostic evaluation, in addition to allowing the differentiation of CP from restrictive cardiomyopathy (RCM) and other conditions that mimic constriction. (AU)

Assuntos

RESUMO

BACKGROUND: Cancer chemotherapy using anthracyclines is associated with cardiotoxicity (CTX), and left ventricular ejection fraction (LVEF) analysis is not sensitive to early cardiotoxic changes. Left ventricular global longitudinal strain (LV GLS) monitoring helps screen subclinical CTX; however, the intervals at which it should be performed remain unclear. We aimed to evaluate the incidence of CTX in women with breast cancer and the associated factors and compare two echocardiographic monitoring strategies using two cutoff points for LV GLS variation. METHODS: Patients with breast cancer prescribed doxorubicin underwent serial LVEF and LV GLS assessments using two-dimensional echocardiography every 3 weeks for 6 months. RESULTS: We included 43 women; none developed a clinical CTX. Considering a relative reduction of LV GLS > 15%, subclinical CTX was present in 12 (27.9%) and six (14%) patients at 3-week and 3-month intervals, respectively (P = 0.28). Additionally, considering a reduction of > 12%, subclinical CTX was present in 17 (39.5%) and 10 (23.3%) patients (P = 0.16), respectively. There were no significant differences in either reference value at 3-week (P = 0.19) and 3-month intervals (P = 0.41). Age ≥ 60 years (P = 0.018) and hypertension (HTN) (P = 0.022) were associated with subclinical CTX in the univariate analysis. CONCLUSIONS: There was no difference in the incidence of subclinical CTX between the two cutoff points and no benefit in performing echocardiography every 3 weeks compared with quarterly monitoring. Advanced age and HTN were associated with the development of subclinical CTX.

Assuntos

Assuntos

RESUMO

Introdução: Hipertensão Pulmonar (HP), uma condição clínica grave, pode levar à disfunção sistólica do ventrículo direto (DSVD), com implicações prognósticas. Pacientes com suspeita de HP devem ser submetidos ao ecocardiograma transtorácico (ECOTT) para diagnóstico e avaliação, colocando-o como o principal exame de triagem e acompanhamento. Objetivo: Verificar a associação e a concordância das medidas referentes à pressão média no átrio direito (AD) e à disfunção sistólica do ventrículo direto (DSVD) ao (ECOTT) e ao cateterismo de câmaras direitas (CCD) em pacientes com (HP). Métodos: Foram incluídos indivíduos com diagnóstico de (HP). Todos os pacientes foram submetidos ao ECOTT e CCD. Avaliou-se pelo ECOTT: área do átrio direito (AAD), pressão média do átrio direito (AD) através por meio do diâmetro e da colapsabilidade da veia cava inferior (PMADECOTT ), strain AD (SAD), TAPSE (excursão sistólica do plano anular tricúspide), MAF (mudança da área fracional), SPLVD (strain da parede livre do VD) e onda s´ tricuspídea. Pelo CCD avaliaram-se pressão média do (PMADCCD ) e índice cardíaco (IC). Resultados: Dos 16 pacientes, 13 eram do sexo feminino. A idade média foi de 44,4 anos (±14,9). Constataram-se associação entre pressão média do átrio direito PMADCCD com área do átrio direito, PMADECOTT pressão média do átrio direito e SAD strain do átrio direito (r=0,845, r=0,621 e r=-0,523, respectivamente; p< 0,05). Verificou-se associação entre as categorias de risco de mortalidade, mensuradas pelas medidas AAD da área do átrio direito e pressão média do átrio direito PMADCCD (X2=10,42; p=0,003), com concordância moderada (k=0,44; p=0,012). DSVD A disfunção sistólica do ventrículo direto estava presente em dez pacientes. Houve associação entre disfunção sistólica do ventrículo direto DSVD (presente ou ausente) e índice cardíaco IC (r=0,522; p=0,04), com concordância moderada (k=0,43; p=0,037). Conclusão: As medidas do ecocardiograma transtorácico (ECOTT) e cateterismo de câmara direita (CCD) demostraram associação na avaliação da pressão média do átrio direito com melhor associação entre área do átrio direito AAD e pressão média do átrio direito (PMADCCD) . Houve associação com concordância moderada quanto à disfunção sistólica do ventrículo direto (DSVD) entre métodos. (AU)

Introduction: Pulmonary hypertension (PH), a serious clinical condition, can lead to right ventricular systolic dysfunction (RVSD) with prognostic implications. Patients with suspected PH should undergo transthoracic echocardiography (TTE) for diagnosis and evaluation as the main screening and follow-up exam. Objective: To verify the associations of and agreement between measurements of mean pressure in the right atrium (RA) and RVSD with TTE Method: Individuals diagnosed with PH were included. All patients underwent TTE and RCC. The following were evaluated by TTE: right atrial area (RAA), mean right atrial pressure through the diameter and collapsibility of the inferior vena cava (RMAPTTE), RA strain (RAS), tricuspid annular plane systolic excursion, fractional area change, RV free wall strain, and tricuspid s' wave. Mean RA pressure (RMAPRCC) and cardiac index (CI) were evaluated through the RCC. Results: Of the 16 patients, 13 were female. The mean patient age was 44.4 (±14.9) years. An association was found between RMAPRCC and AAD, RMAPTTE, and RAS (r=0.845, r=0.621, and r=-0.523, respectively; p<0.05). There was an association between the mortality risk categories measured by the RAA and RMAPRCC measures (X2=10.42; p=0.003), with moderate agreement (k=0.44; p=0.012). RVSDJ was present in 10 patients. There was an association between RVSD (present or absent) and CI (r=0.522; p=0.04) with moderate agreement (k=0.43; p=0.037). Conclusion: The TTE and RCC measurements showed an association in the assessment of mean right atrial pressure, especially between RAA and RMAPRCC. An association with RVSD and moderate agreement between methods were also noted. (AU)

Assuntos

RESUMO

RESUMO Objetivo: Descrever o perfil epidemiológico dos atendimentos pré-hospitalares realizados por um serviço móvel de emergência no município de Picos, Piauí, Brasil. Métodos: Trata-se de um estudo transversal, documental e retrospectivo com abordagem quantitativa, realizado nos meses de abril e maio de 2020. Foram analisados 4.220 registros com base nos atendimentos realizados pelo Serviço de Atendimento Móvel de Urgência às ocorrências que aconteceram no período de janeiro de 2019 a março de 2020. Os dados foram coletados das fichas de atendimento individuais da instituição, organizados por meio de um formulário e analisados à luz da estatística descritiva. Resultados: Foi observada frequência de ocorrências ligeiramente maior em indivíduos do sexo masculino (50,3%), predominância das faixas etárias de 20 a 30 anos (30,7%) e maior de 60 anos (34,2%), atendimentos realizados pela Unidade de Suporte Básico (65,9%). As ocorrências traumáticas provenientes de acidentes de transporte (68,5%) e as clínicas cardiológicas (18%) se apresentaram em maior percentual em relação às demais. As ocorrências traumáticas foram mais frequentes no período de outubro a dezembro e as clínicas nos meses de fevereiro e março. Conclusão: O perfil epidemiológico dos atendimentos corresponde à população do gênero masculino e faixa etária maior ou igual a 60 anos. Predominaram as ocorrências de natureza clínica, principalmente cardiológicas.

RESUMEN Objetivo: describir el perfil epidemiológico de la atención prehospitalaria realizada por un servicio de atención móvil de urgencia en el municipio de Picos, Piauí, Brasil. Métodos: se trata de un estudio transversal, documental y retrospectivo con enfoque cuantitativo, realizado en los meses de abril y mayo de 2020. Se analizaron 4.220 registros con base en las atenciones realizadas por el Servicio de Atención Móvil de Urgencia a los casos que ocurrieron en el período de enero de 2019 a marzo de 2020. Los datos fueron recolectados de las fichas de atención individuales de la institución, organizados por medio de un formulario y analizados a la luz de la estadística descriptiva. Resultados: fue observada frecuencia de casos ligeramente mayor en individuos del sexo masculino (50,3%), predominancia de las franjas etarias de 20 a 30 años (30,7%) y mayor de 60 años (34,2%), atenciones realizadas por la Unidad de Soporte Básico (65,9%). Los incidentes traumáticos provenientes de accidentes de transporte (68,5%) y las clínicas cardiológicas (18%) se presentaron en mayor porcentaje con relación a los demás. Los incidentes traumáticos fueron más frecuentes en el período de octubre a diciembre y las clínicas en los meses de febrero y marzo. Conclusión: el perfil epidemiológico de las atenciones corresponde a la población del género masculino y franja etaria mayor o igual a 60 años. Predominaron los incidentes de naturaleza clínica, principalmente cardiológicas.

ABSTRACT Objective: To describe the epidemiological profile of pre-hospital care performed by a mobile emergency service in the municipality of Picos, Piauí, Brazil. Methods: This is a cross-sectional, documentary and retrospective study with a quantitative approach, conducted in April and May 2020. We analyzed 4,220 records based on the visits performed by the Mobile Emergency Care Service to the occurrences that occurred between January 2019 and March 2020. Data were collected from the institution's individual care forms, organized through a form and analyzed in the light of descriptive statistics. Results: A slightly higher frequency of occurrences was observed in males (50.3%), predominance of the age groups from 20 to 30 years (30.7%) and higher than 60 years (34.2%), attendances performed by the Basic Support Unit (65.9%). Traumatic occurrences resulting from traffic accidents (68.5%) and cardiologic clinics (18%) were higher in percentage in relation to the other ones. Traumatic occurrences were more frequent from October to December and clinics in February and March. Conclusion: The epidemiological profile of the visits corresponds to the male population and age group greater than or equal to 60 years. Occurrences of a clinical nature, especially cardiac, predominated.

Assuntos

Assuntos

RESUMO

Purpose: This study aims to define which of the right ventricular myocardial deformation indices best correlates with the classic echocardiographic measurements and indices of right ventricular (RV) dysfunction in patients with stable chronic obstructive pulmonary disease (COPD). Patients and Methods: Ninety-one patients with stable COPD underwent clinical evaluation, spirometry, a 6-minute walk test, and echocardiographic examination. Patients were divided into two groups: "with RV dysfunction" (≥1 classic parameter) and "without RV dysfunction". We used speckle tracking to estimate myocardial deformation. For all analyses, results were considered significant if p < 0.05. Results: The mean age across all participants was 65 ± 9 years, with 53% (48/91) being male. Patients in the group with RV dysfunction were able to walk shorter distances and had higher estimated right ventricular systolic pressure (RVSP) and mean pulmonary arterial pressure (mPAP). The RV free wall longitudinal strain (RVFWLS) was the only deformation indices that showed a significant correlation with all classic measurements and indices in the diagnosis of RV dysfunction (Wald test, 10.24; p < 0.01; odds ratio, 1.61). In the ROC curve analysis, the absolute value <20% was the lowest cut-off point of this index for detection of RV dysfunction (AUC = 0.93, S: 95.8%, and E: 88%). Conclusion: In COPD patients, RVFWLS is the myocardial deformation index that best correlates with classic echocardiographic parameters for the diagnosis of RV dysfunction using <20% as a cut-off point.

Assuntos

RESUMO

Astrocytes are essential for lipid neuronal metabolism in long-distance uninterrupted migratory flights, when glucose is not available as the main source of energy. We previously demonstrated in Calidris pusilla that after uninterrupted 5 days transatlantic flight, astrocytes shrink and reduce its number in the hippocampal formation. Here we shifted our attention to the wintering period and tested the hypothesis that hippocampal astrocyte morphology of A interpres will change as the wintering period progresses towards the premigration window. To that end we used Arenaria interpres, which also crosses the Atlantic Ocean and reaches the mangroves of the Amazon River estuary for wintering. Birds were captured in September/October (closer to the arrival in the coast of Bragança, Para, Brazil for wintering) and in April/May (closer to the departure towards the breeding sites) and had their brains processed for selective GFAP-astrocyte immunolabeling. Three-dimensional reconstructions of the immunostained astrocytes were performed and morphological classification was done based on hierarchical cluster and discriminant analysis of multimodal morphometric features. We found two morphological phenotypes of astrocytes in the newcomers which differentially increased its morphological complexities as wintering period progresses towards the pre-migration window. Taken together, our findings demonstrate that the long-distance non-stop flight and wintering period differentially affected the two astrocytes morphotypes, suggesting distinct physiological roles for these cells. We suggest that morphological changes during the wintering period, may be part of the adaptive plasticity of the local hippocampal circuits of A. interpres in preparation for the long journey back to their breeding sites in the north hemisphere.

Assuntos

RESUMO

The sustainable use of soil requires a broad knowledge of its genesis, morphology, properties, and distribution in the landscape. Thus, the objective of this study was to characterize the pedogenetic attributes of representative soils from the cerrado-caatinga transition of the Gurguéia river basin to indicate their agricultural potential and limitations for the implementation of agroforestry systems. National and international soil classification systems were used to define the soil classes. The limiting factors and agricultural potential were characterized following the evaluation system of the agricultural potential of Brazilian land. In general, profiles 1, 3, 5, and 6 had a low nutrient budget and a sandy to loam texture. Profiles 2, 4, and 7 showed high clay content and nutrient budget. The soil profiles were classified as Ustic Quartzipsamments, Udic Haplusterts, Xanthic Haplustox, Arenic Kanhaplustults, Typic Haplustox, and Aridic Dystrustept based on their pedogenetic characteristics. Udic Haplusterts and Arenic Kanhaplustults soils display restrictions regarding the planting of forests owing to oxygen and soil depth limitations. The other soil classes had adequate physical properties for the implementation of agricultural systems and pastures, including good drainage and medium texture; however, they had low natural fertility, and thus require technologies for soil acidity correction and fertilization. Ustic Quartzipsamments and Ustic soils require the implementation of conservation systems, such as agroforestry, to avoid degradation.(AU)

O uso do solo de forma sustentável requer um amplo conhecimento sobre sua gênese, morfologia, propriedades e distribuição na paisagem. Dessa forma, objetivou-se com esta pesquisa realizar a caracterização pedogenética dos solos representativos da transição cerrado-caatinga da bacia hidrográfica do rio Gurguéia a fim de indicar sua aptidão e limitações para a implantação de sistemas agroflorestais. A caracterização baseou-se no estudo morfológico e na análise química e física dos horizontes de sete perfis de solos. Os sistemas de classificação de solos nacional e internacional foram utilizados para definir as classes de solos existentes na área pesquisada. Os fatores limitantes e a aptidão agrícola dos solos foram caracterizados conforme preposto no sistema de avaliação da aptidão agrícola de terras do Brasil. De forma geral, os perfis 1, 3, 5 e 6 apresentam baixa reserva de nutrientes e textura arenosa a média. Os perfis 2, 4 e 7 possuem maiores teores de argila e maior reserva de nutriente. Diante das características pedogenéticas dos perfis, pôde-se classificar os perfis de solo como NEOSSOLO QUARTZARÊNICO Órtico latossólico; VERTISSOLO HIDROMÓRFICO Órtico típico, LATOSSOLO AMARELO Distrófico típico, ARGISSOLO AMARELO Distrófico Abrúptico, LATOSSOLO VERMELHOAMARELO Distrófico argissólico e CAMBISSOLO HÁPLICO Tb Eutrófico típico respectivamente. Os VERTISSOLOS e CAMBISSOLOS presentam restrições a implantação de florestas devido à restrição de oxigênio e restrição a profundidade do solo. As demais classes de solos apresentaram propriedades físicas adequadas para a implantação de sistemas agrícolas e pastagens, incluindo boa drenagem e textura média; no entanto, tinham baixa fertilidade natural e, portanto, requerem correção da acidez do solo e adubação. Os solos NEOSSOLOS e ARGISSOLOS requerem a implementação de sistemas de conservação, como as agroflorestas, para evitar sua degradação.(AU)

Assuntos

RESUMO

Abstract: Soil microorganisms present a great diversity, involving taxonomically distinct groups that play a role in the decomposition of organic matter, nutrient cycling, soil aggregation, among others. In this diversity, the fungi of the genus Trichoderma have been successful plant pathogen biocontrol agents, as plant growth promoters and as inducers of plant resistance to diseases. In addition, they are important in the sustainability of natural ecosystems. Aiming to verify the population density of Trichoderma fungi in natural environments and agroecosystems, in Cerrado area, samples of soils and roots from native vegetation and agroecological production system were collected in the Federal District, Brazil. The collection points were randomly selected, and each soil or root sample was individually wrapped. The soil adhered to the roots was removed for evaluations. Serial sample dilutions and number of Colony Forming Units (CFUs) of Trichoderma isolates were performed. The results showed that the number of CFU varied depending on the plant and location evaluated. The replacement of native vegetation by organic farming systems did not result in a significant reduction in this number.

Resumo: Os microrganismos de solo apresentam uma grande diversidade, envolvendo grupos taxonomicamente distintos que desempenham papel na decomposição da matéria orgânica, ciclagem de nutrientes, agregação dos solos, dentre outros. Nesta diversidade, os fungos do gênero Trichoderma tem apresentado sucesso como agentes de biocontrole de fitopatógenos, como promotores de crescimento de plantas e, ainda, como indutores de resistência de plantas a doenças. Além disso, são importantes na sustentabilidade dos ecossistemas naturais. Com o objetivo de verificar a densidade populacional de fungos do gênero Trichoderma em ambientes naturais e agroecossistemas, em área de Cerrado, amostras de solos e raízes oriundas de vegetação nativa e de sistema de produção agroecológica foram coletadas na região do Distrito Federal, Brasil. Os pontos de coleta foram selecionados aleatoriamente, e cada amostra de solo ou raiz foi acondicionada individualmente. O solo aderido às raízes foi removido para as avaliações. Foram realizadas diluições seriadas das amostras e contagem do número de Unidades Formadoras de Colônias (UFCs) de isolados de Trichoderma. Os resultados mostraram que o número de UFC variou dependendo da planta e da localidade avaliada. A substituição da vegetação nativa por sistemas de cultivo orgânicos não resultou em importante redução neste número.

RESUMO

Background: The metacarpophalangeal and metatarsophalangeal joints are very demanded during high intensity exercises,and may be affected by osteoarthritis, fractures, luxations and rupture of the suspensory apparatus. Thus, arthrodesis maybe indicated to restore joint stability and accelerate the ankylosis process. The most commonly used surgical techniqueshave been associated with postoperative complications, including infection and failure of the implants, so it is importantto develop procedures that are less invasive procedures and promoting stable fixation. Therefore, the aim of this work isto report the use of the modified steel basket technique for metatarsophalangeal arthrodesis in a foal with hyperextensionof the joint due to rupture of the digital flexor muscles.Case: A 2-day-old male foal was admitted to clinical care, presenting multiple cutaneous wounds caused by dogs bites,located in the tarsus and thigh of the hindlimb. The animal presented in standing position and had no difficulty of movement,being initially treated through daily cleaning of the cutaneous wounds and systemic antibiotic therapy. Hyperextension ofthe metatarsophalangeal joint was evidenced after 20 days, being approached through tenotomy and tendon shortening,followed by tenorrhaphy and immobilization for 30 days. Due to the failure of the treatment, it was opted for metatarsophalangeal arthrodesis by modified steel basket technique. The procedure involved the implantation of a steel basket of25.0 mm in diameter x 25.0 mm long in a 24.0 mm hole created on the dorsal surface between the third metacarpal andthe proximal phalanx. The basket was filled with bone extracted from drilling and fixed with two cortical screws at anangle of 25° toward proximoplantar and distoplantar direction. Immobilization of the limb was performed postoperativelywith synthetic plaster cast for 45 days and, due to the persistence of lameness...(AU)

Assuntos

RESUMO

BACKGROUND: The ankle-brachial index (ABI) uses the ratio between systolic blood pressures at the ankle and the arm to diagnose peripheral arterial disease (PAD) noninvasively. Photoplethysmography (PPG) measures and records changes to the blood volume in the human body using optical techniques. OBJECTIVES: The objective of this study was to compare ABI with arterial stiffness and peripheral resistance parameters assessed using PPG in elderly patients and to propose a model for prediction of ABI. METHODS: A cross-sectional, quantitative study was conducted. The sample comprised elderly patients seen at a medical specialties clinic at the Universidade do Sul de Santa Catarina (UNISUL), Brazil. Age, sex, body mass index (BMI), comorbidities, smoking, and physical activity were recorded. The variables obtained using PPG and ABI were compared using bivariate and multivariate linear regression, with an α error of 0.05. RESULTS: A total of 93 elderly patients were assessed, 63.4% of whom were women. In 98.9% of cases, ABI was within normal limits. Comparison of ABI with variables acquired by PPG revealed significant associations with age. However, no significant associations were observed between ABI and PPG. The multivariate model indicated that only age, sex, and smoking were associated with ABI. CONCLUSIONS: In conclusion, ABI and PPG exhibited associations with arterial aging, considering its correlation with age. However, ABI was only related to age, sex, and smoking. More studies are needed to evaluate the potential uses of PPG for screening for vascular diseases in ambulatory settings.

RESUMO

Analisamos o processo de apropriação e consolidação do espaço de lazer e cultura "Zumbi dos Palmares", localizado em Teresina, capital do estado do Piauí. Destacamos e analisamos conflitos, lutas e movimentos realizados com o intuito de se apropriar deste espaço, antes de natureza escolar, hoje destinado a atividades de lazer, particularmente de diversas manifestações da cultura negra (coral em yorubá, oficinas de capoeira, percussão, dança, festas temáticas, cinema, biblioteca, exposições, etc). Atualmente a apropriação e consolidação deste espaço exerce um importante papel na difusão e valorização desta cultura no Piauí. A pesquisa foi realizada sob uma perspectiva qualitativa descritiva, tendo sido utilizada a entrevista semiestruturada como principal técnica de coleta de dados.

We analyse the appropriation and consolidation process of the leisure and cultural place called 'Zumbi dos Palmares' located in Teresina, capital of the State of Piaui. We pointed out and analyse some conflicts, struggles and movements which were made in order to appropriate this place, which it was once a school environment, nowadays it is a place intended for leisure activities, specially several manifestations of the black culture (Choir in Yorubá, Capoeira workshops, percussion, dancing, theme parties, cinema, library, expositions and so on). Nowadays the appropriation and consolidation of the place has an important role in spreading and valuating such culture in Piaui. This research was carried out from a qualitative and descriptive perspective, and made use of a semi structured interview as the main technique of data collecting.

Assuntos

RESUMO

O índice tornozelo-braquial (ITB) utiliza a razão entre a pressão arterial sistólica do tornozelo e do braço para diagnosticar de forma não invasiva a doença arterial periférica (DAP). A fotopletismografia (photoplethysmography, PPG) faz a medição e o registro das modificações de volume sanguíneo do corpo humano por meio de técnicas ópticas. Objetivos O objetivo deste estudo foi comparar o ITB com parâmetros de rigidez arterial e resistência periférica avaliados pela PPG em idosos e propor um modelo de predição para o ITB. Métodos Foi realizado um estudo transversal quantitativo. A amostra foi composta por idosos atendidos no ambulatório médico de especialidades da Universidade do Sul de Santa Catarina (UNISUL). Foram verificados: idade, sexo, índice de massa corporal (IMC), presença de comorbidades, tabagismo e atividade física. Para comparação das variáveis obtidas com a PPG com o ITB, foi realizada regressão linear bivariada e multivariada, considerando erro α = 0,05. Resultados Foram avaliados 93 idosos, sendo 63,4% mulheres. Em 98,9% dos casos, o ITB apresentou-se dentro da normalidade. Na comparação do ITB e variáveis derivadas da PPG em relação à idade, foram demonstradas associações significativas. Contudo, não foram observadas associações significativas entre ITB e PPG. O modelo multivariado indicou que apenas idade, sexo e tabagismo foram associados ao ITB. Conclusões Como conclusão, o ITB e a PPG demonstraram associação com o envelhecimento arterial, tendo em vista sua correlação com a idade; contudo, o ITB foi relacionado apenas com idade, sexo e tabagismo. Mais estudos são necessários para avaliar o potencial uso da PPG como rastreio de doenças vasculares em rotinas ambulatórias

The ankle-brachial index (ABI) uses the ratio between systolic blood pressures at the ankle and the arm to diagnose peripheral arterial disease (PAD) noninvasively. Photoplethysmography (PPG) measures and records changes to the blood volume in the human body using optical techniques. Objectives The objective of this study was to compare ABI with arterial stiffness and peripheral resistance parameters assessed using PPG in elderly patients and to propose a model for prediction of ABI. Methods A cross-sectional, quantitative study was conducted. The sample comprised elderly patients seen at a medical specialties clinic at the Universidade do Sul de Santa Catarina (UNISUL), Brazil. Age, sex, body mass index (BMI), comorbidities, smoking, and physical activity were recorded. The variables obtained using PPG and ABI were compared using bivariate and multivariate linear regression, with an α error of 0.05. Results A total of 93 elderly patients were assessed, 63.4% of whom were women. In 98.9% of cases, ABI was within normal limits. Comparison of ABI with variables acquired by PPG revealed significant associations with age. However, no significant associations were observed between ABI and PPG. The multivariate model indicated that only age, sex, and smoking were associated with ABI. Conclusions In conclusion, ABI and PPG exhibited associations with arterial aging, considering its correlation with age. However, ABI was only related to age, sex, and smoking. More studies are needed to evaluate the potential uses of PPG for screening for vascular diseases in ambulatory settings

Assuntos

RESUMO

Background: The metacarpophalangeal and metatarsophalangeal joints are very demanded during high intensity exercises,and may be affected by osteoarthritis, fractures, luxations and rupture of the suspensory apparatus. Thus, arthrodesis maybe indicated to restore joint stability and accelerate the ankylosis process. The most commonly used surgical techniqueshave been associated with postoperative complications, including infection and failure of the implants, so it is importantto develop procedures that are less invasive procedures and promoting stable fixation. Therefore, the aim of this work isto report the use of the modified steel basket technique for metatarsophalangeal arthrodesis in a foal with hyperextensionof the joint due to rupture of the digital flexor muscles.Case: A 2-day-old male foal was admitted to clinical care, presenting multiple cutaneous wounds caused by dogs bites,located in the tarsus and thigh of the hindlimb. The animal presented in standing position and had no difficulty of movement,being initially treated through daily cleaning of the cutaneous wounds and systemic antibiotic therapy. Hyperextension ofthe metatarsophalangeal joint was evidenced after 20 days, being approached through tenotomy and tendon shortening,followed by tenorrhaphy and immobilization for 30 days. Due to the failure of the treatment, it was opted for metatarsophalangeal arthrodesis by modified steel basket technique. The procedure involved the implantation of a steel basket of25.0 mm in diameter x 25.0 mm long in a 24.0 mm hole created on the dorsal surface between the third metacarpal andthe proximal phalanx. The basket was filled with bone extracted from drilling and fixed with two cortical screws at anangle of 25° toward proximoplantar and distoplantar direction. Immobilization of the limb was performed postoperativelywith synthetic plaster cast for 45 days and, due to the persistence of lameness...

Assuntos

RESUMO

Neste artigo, por meio de uma análise de conteúdo de um episódio do fi lme Boleiros - era uma vez o futebol, discutimos uma dimensão da complexa Teoria dos Papéis proposta por Peter Berger, pertinente à corrente sociológica Interacionismo Simbólico. Enfatizamos um de seus fundamentos: a exigência e necessidade de coerência do papel social. O episódio oportuniza a discussão sobre o papel e as expectativas de coerência social em torno de um árbitro de futebol cujo nome é Virgílio Paiva. Trata-se de uma pesquisa de natureza qualitativa que privilegia os aspectos pedagógicos, culturais e sociológicos presentes na obra de Berger relacionando-os a uma obra cinematográfi ca em que a fi cção dialoga com confl itos éticos e atitudinais reais. Dessa forma, a obra se torna um solo fértil para a discussão teórica à luz dos pressupostos de Berger e, portanto relevante para ser analisada sob o olhar científico....(AU)

In this article, through a content analysis of an episode of the movie "Boleiros - it was once the soccer", we discussed a dimension of the complex Theory of Social Roles presented by Peter Berger, who belongs to the sociological current "Symbolic Interactionism ".We emphasize one of his theories: the requirement and necessity of coherence of the social role. The episode allows a discussion about the role and expectations of social coherence around a football referee whose name is Virgílio Paiva. It is a qualitative research that privileges the pedagogical, cultural and sociological aspects presented in the Berger´s work and connects it to a cinematographic work in which fi ction establishes a dialogue with real ethical and attitudinal confl icts. This way, the work becomes a fertile soil for theoretical discussion in the light of Berger's assumptions and therefore relevant to be analyzed under the scientifi c view....(AU)

Assuntos

RESUMO

Como ocorre o lazer para as pessoas com deficiência? Esta é a pergunta central desta pesquisa, que ganha forma ao se reconhecer duas questões: a primeira, dos processos de exclusão desta parcela do gênero humano; e a segunda, relativa ao espaço urbano e o dialogo com seus territórios. Para respondê-la investigamos o acesso e participação social frente ao fenômeno do lazer. Com uma proposta metodológica de abordagem qualitativa em base exploratória e descritiva o estudo opera metodologicamente por meio de pesquisa documental, revisão bibliográfica e de campo em entrevistas a seis participantes. Resultados apontam ao acesso precário, poucas opções de atividades, barreiras financeiras, arquitetônicas, de respeito das pessoas e de transporte. A participação se mostra prejudicada pelo acesso e pelo reconhecimento das pessoas.

How does leisure for people with disabilities? This is the central question of this research, which gains form by recognizing two questions: the first, the processes of exclusion of this part of the human genre; and the second on urban space and dialogue with their territories. To answer it, we intend to investigate access and social participation in the face of the phenomenon of leisure. With a methodological proposal of qualitative approach on an exploratory and descriptive basis the study operates methodologically through documentary research, bibliographical and field review in interviews with six participants. Results point to precarious access, few options for activities, financial, architectural barriers, respect for people and transportation. Participation is hampered by access and recognition of people.

Assuntos

RESUMO

This work aimed to determine which non-linear model (Brody, Gompertz, logistic, von Bertalanffy or Richards) best represents the average growth curve of goats, in addition to evaluating the effect of the environment. The weight data of 40 Repartida goats reared in the Brazil Caatinga were included in this study. Weight data was collected every 30 days from birth until 270 days of age. The parameters of the models (A, mature body weight; B, constant of integration; k, maturation rate; m, inflection point) were estimated using the NLIN procedure of SAS. The logistic model showed a slightly higher average fit in comparison to the other models. The absolute growth rate suggests that the maximum growth rate was reached early. The effect of the contemporary groups was significant (P 0.05), but only for the estimated k parameter. The estimated correlation between the A and k parameters was significant and negative, indicating a lower probability of a high body weight in adulthood. Goats of the Repartida ecotype are characterized by their high birth weight and low weight at maturity, which combined with the nutritional deficit, suggests that these animals have adapted to the adverse conditions of the Brazilian Caatinga region.(AU)

Objetivou-se neste trabalho verificar dentre os modelos não-lineares seguintes, Brody, Gompertz, Logístico, Von Bertalanffy e Richards, qual representa melhor a curva média de crescimento de caprinos e, também, avaliar a influência do ambiente nos parâmetros estimados. Para a condução deste trabalho foram utilizados registros de peso de 40 caprinos do ecótipo Repartida criados na caatinga, coletados a cada 30 dias entre o nascimento até os 270 dias de idade. Os parâmetros dos modelos (A, peso à idade adulta; B, constante de integração; k, taxa de maturação; e m, ponto de inflexão) foram estimados com o procedimento NLIN do software SAS. O modelo Logístico apresentou ajuste médio ligeiramente superior aos demais modelos. Os resultados obtidos para taxa de crescimento absoluto indicam que a taxa máxima de crescimento foi alcançada precocemente. O efeito de grupos contemporâneos foi significativo (P 0,05) somente para o parâmetro k estimado. A correlação estimada entre os parâmetros A e k foi significativa e negativa, indicando menor probabilidade dos caprinos atingirem pesos elevados à idade adulta. Os caprinos do ecótipo Repartida são de alto peso ao nascimento e baixo peso à maturidade, o que pode indicar, além do déficit nutricional, a adaptação desses animais às condições adversas da caatinga.(AU)

Assuntos