RESUMO
OBJECTIVE: The objective of this study was to assess the risk and prevalence of oral cancer in patients with systemic lupus erythematosus (SLE) or discoid lupus erythematosus (DLE). STUDY DESIGN: The review included observational cohort and cross-sectional studies that investigated the incidence or prevalence of oral cancer in adults with confirmed diagnoses of SLE or DLE. Studies were selected based on predefined eligibility criteria, including the use of specific diagnostic criteria for SLE and DLE. After searches in PubMed/MEDLINE, EMBASE, Scopus, Web of Science, LILACS, and LIVIVO databases and gray literature for relevant studies, the selection process was conducted by independent reviewers. RESULTS: A total of 5,545 articles were identified. After screening, 8 studies met the inclusion criteria. The pooled risk estimate indicated a significantly increased risk of oral cancer in patients with SLE (risk ratio = 2.69; 95% confidence interval, 1.75 to 4.16; I2 = 0%; P = .78) compared with the general population. The pooled prevalence of oral cancer in patients with DLE was 10% (95% ci, 0.03 to 0.13; I2 = 59%; P = .12). CONCLUSIONS: This review provides evidence supporting an elevated risk for individuals with SLE or DLE developing oral cancer. The findings highlight the importance of monitoring oral mucosa in patients with these conditions.
Assuntos
Lúpus Eritematoso Discoide , Lúpus Eritematoso Sistêmico , Neoplasias Bucais , Adulto , Humanos , Estudos Transversais , Prevalência , Lúpus Eritematoso Sistêmico/complicações , Lúpus Eritematoso Sistêmico/epidemiologia , Lúpus Eritematoso Sistêmico/diagnóstico , Lúpus Eritematoso Discoide/complicações , Lúpus Eritematoso Discoide/epidemiologia , Neoplasias Bucais/epidemiologiaRESUMO
Multicystic and unicystic ameloblastomas are benign odontogenic tumors that present distinct biological behavior. The investigation of stem cells has become an important branch of tumor biology, with several studies addressing the possible role of these cells in tumor growth, angiogenesis, progression, infiltration and invasiveness. This study evaluated the immunohistochemical expression of CD90(Thy-1) and P75NTR stem cell markers in multicystic and unicystic ameloblastomas. Seventeen (17) samples of ameloblastomas (multicystic, n = 10; unicystic, n = 7) were submitted to immunohistochemical reactions and graded semi-quantitatively. The Kolmogorov-Smirnov test was used to verify possible differences in CD90 and P75NTR expressions between multicystic and unicystic ameloblastomas (p < 0.05). CD90 immunostaining was observed in all multicystic ameloblastoma specimens (n = 10), in the cytoplasm of the fibroblasts and vascular endothelial cells of the tumor stroma, near the neoplastic odontogenic epithelia. The staining of stromal CD90 was significantly higher in multicystic than in unicystic ameloblastomas (p = 0.003). Nuclear P75NTR immunostaining was observed in all ameloblastoma specimens. A significant difference was seen in the epithelial staining of P75NTR between multicystic and unicystic types (p = 0.007). The increased expression of CD90 and P75NTR found in multicystic ameloblastomas suggests a behavioral biological difference between multicystic and unicystic ameloblastomas, as well as a difference in ameloblastoma development.
Assuntos
Ameloblastoma/metabolismo , Biomarcadores Tumorais/metabolismo , Neoplasias Mandibulares/metabolismo , Células-Tronco Neoplásicas/metabolismo , Proteínas do Tecido Nervoso/metabolismo , Receptores de Fator de Crescimento Neural/metabolismo , Antígenos Thy-1/metabolismo , Adolescente , Adulto , Ameloblastoma/patologia , Células Endoteliais/metabolismo , Feminino , Fibroblastos/metabolismo , Humanos , Imuno-Histoquímica , Masculino , Neoplasias Mandibulares/patologia , Pessoa de Meia-Idade , Células-Tronco Neoplásicas/patologia , Inclusão em Parafina , Estatísticas não Paramétricas , Células Estromais/metabolismo , Adulto JovemRESUMO
Abstract Multicystic and unicystic ameloblastomas are benign odontogenic tumors that present distinct biological behavior. The investigation of stem cells has become an important branch of tumor biology, with several studies addressing the possible role of these cells in tumor growth, angiogenesis, progression, infiltration and invasiveness. This study evaluated the immunohistochemical expression of CD90(Thy-1) and P75NTR stem cell markers in multicystic and unicystic ameloblastomas. Seventeen (17) samples of ameloblastomas (multicystic, n = 10; unicystic, n = 7) were submitted to immunohistochemical reactions and graded semi-quantitatively. The Kolmogorov-Smirnov test was used to verify possible differences in CD90 and P75NTR expressions between multicystic and unicystic ameloblastomas (p < 0.05). CD90 immunostaining was observed in all multicystic ameloblastoma specimens (n = 10), in the cytoplasm of the fibroblasts and vascular endothelial cells of the tumor stroma, near the neoplastic odontogenic epithelia. The staining of stromal CD90 was significantly higher in multicystic than in unicystic ameloblastomas (p = 0.003). Nuclear P75NTR immunostaining was observed in all ameloblastoma specimens. A significant difference was seen in the epithelial staining of P75NTR between multicystic and unicystic types (p = 0.007). The increased expression of CD90 and P75NTR found in multicystic ameloblastomas suggests a behavioral biological difference between multicystic and unicystic ameloblastomas, as well as a difference in ameloblastoma development.
Assuntos
Humanos , Masculino , Feminino , Adolescente , Adulto , Adulto Jovem , Células-Tronco Neoplásicas/metabolismo , Ameloblastoma/metabolismo , Neoplasias Mandibulares/metabolismo , Biomarcadores Tumorais/metabolismo , Receptores de Fator de Crescimento Neural/metabolismo , Antígenos Thy-1/metabolismo , Proteínas do Tecido Nervoso/metabolismo , Células-Tronco Neoplásicas/patologia , Imuno-Histoquímica , Ameloblastoma/patologia , Neoplasias Mandibulares/patologia , Inclusão em Parafina , Células Estromais , Estatísticas não Paramétricas , Células Endoteliais/metabolismo , Fibroblastos/metabolismo , Pessoa de Meia-IdadeRESUMO
Introdução: Nos últimos anos, alguns estudos foram conduzidos com o objetivo de avaliar a aplicabilidade da análise de desenvolvimento dos terceiros molares na estimativa da idade humana. No entanto, há escassez de trabalhos em amostras populacionais da região Centro-Oeste do Brasil. Objetivo: Avaliar a relação entre estágio de desenvolvimento dos terceiros molares inferiores e a idade cronológica de indivíduos da região Centro-Oeste do Brasil. Material e Método: Trata-se de um estudo observacional transversal, com uma amostra constituída por 120 prontuários de pacientes entre 5 e 22 anos de idade, dos gêneros masculino e feminino, atendidos entre os anos de 2007 e 2012 na nossa instituição. O estágio de desenvolvimento dos terceiros molares inferiores foi avaliado pelo método descrito por Nolla e relacionado à idade cronológica do indivíduo por meio de regressão linear, sendo considerados significantes valores de tendência linear entre 0 e 1. Resultado: Pode-se observar que tanto a amostra composta por pacientes do gênero masculino (R2 = 0,7495) quanto do feminino (R2 = 0,8507) apresentaram correlação linear entre o estágio de desenvolvimento dos terceiros molares inferiores e a idade cronológica. Notou-se, ainda, que os estágios de desenvolvimento coincidiram com idades semelhantes em ambos os gêneros. Conclusão: Há relação entre a idade cronológica e o estágio de desenvolvimento dos terceiros molares inferiores na amostra estudada. Estes dados sugerem que este tipo de análise deve ser individualizada, de acordo com as características populacionais da região. .
Introduction: In recent years some studies have been taken to evaluate the applicability of the third molar development analysis in the estimation of human age. However, just a few studies with the population from Midwest Brazil were performed. Objective: The present study aim to analyze the relationship between the lower third molars development stage and the chronological age of individuals in Midwest Brazil region. Material and Method: This cross-sectional observational study comprised a total of 120 panoramic radiographies of patients aged 5-22 year-old, males and females, attended between 2007 and 2012 at our Institution. The third molars development stage was analyzed based on the method described by Nolla and related with the chronological age of the individual by linear regression. It was considered significant values for linear tendency between 0-1. Result: It was observed that both, male patients (R2 = 0.7495) and females (R2 = 0.8507), showed a linear correlation between the third molars development stage and chronological age. It was also noted that the development stages coincided with similar ages in both genders. Conclusion: There is a relationship between chronological age and developmental stage of the third molars in the sample studied. These data suggest that this type of analysis should be individualized according to the population characteristics. .