RESUMO

BACKGROUND: Flavonoids from a variety of fruits, including açaí, have beneficial antioxidant activity in several diseases, including cancer. Breast cancer is the second most prevalent cancer among Brazilian women. Studies have shown the action of flavonoids on neoplastic cells, as well as on diabetes and neurodegenerative and cardiovascular diseases. OBJECTIVE: To analyze the relationship between the consumption of açaí and the presence of chronic diseases in women residing in the rural area of São Luís, Maranhão. METHODS: A convenience sample of 150 women residing in the Maracanã neighborhood in São Luís, Maranhão, was used; the collected data included sociodemographic characteristics, habits, sexual and reproductive history, consumption of açaí, and history of cancer and other chronic diseases. The sample was divided into women who consumed açaí at least once a week (cases) and women who did not consume açaí (controls). Statistical analysis was performed to assess the relationships between those variables and the consumption of açaí. RESULTS: A total of 141 women (94%) consumed açaí. Among these, 79.3% were aged between 20 and 50 years, 78.67% were farmers or housewives, 64.67% were Pardo (mixed race), 76.67% were nonsmokers, 70% were not receiving hormonal therapy, 40.67% had already undergone mammography, 28% had already undergone breast ultrasound, and 27.33% had a family history of cancer, with breast cancer being the second most prevalent cancer. There was a higher prevalence of hypertension among women who did not consume açaí than that among those who did; however, previous cancer, family history of cancer, heart disease, and diabetes were more prevalent among the consumers of açaí. There were no statistically significant relationships. CONCLUSION: Flavonoids are known to have a beneficial effect on some types of neoplastic cells and other diseases; therefore, larger studies are necessary to better evaluate the beneficial effects of consuming foods containing flavonoids on these diseases.

Assuntos

RESUMO

BACKGROUND: Familial cancer includes some types of cancer aggregation without a well-defined inheritance pattern. Cancer genetics is an essential component of clinical practice in oncology. In Brazil, breast cancer is the leading cause of death in women. In Maranhão, studies on genetic predisposition are necessary to investigate the incidence and mortality rates. The aim of this study was to investigate familial cancer among relatives of women who died of breast cancer in São Luís, Brazil, constructing a pedigree to identify families with a hereditary predisposition, an important step in the early diagnosis of malignant tumors. METHODS: The city of São Luís is located on the Island of Maranhão, northeastern Brazil, with a population of 997,098 inhabitants mainly comprising blacks and mulattoes, including descendants of runaway slaves from the Amazon region itself. Data for pedigree construction were obtained from the records of 54 patients seen at the Aldenora Bello Institute of Oncology, São Luís, between 2000 and 2007, as well as by interview with relatives of the patients. RESULTS: The mean patient age at diagnosis was 39.5 years. Most women were mulattoes (36/54, 66.6%). A history of cancer was observed in 18 families, with 16 families possessing cases of cancer among first-degree relatives and five among second-degree relatives. CONCLUSION: A concentration of cancer cases was found in families of patients diagnosed until the age of 40, a finding demonstrating the importance of a family history prior to genetic counseling.

Assuntos

RESUMO

Os tumores filoides são neoplasias fibroepiteliais raras de mama. Em sua forma menos agressiva, comportam-se semelhantemente ao fibroadenoma, diferenciando-se apenas pelo tamanho do tumor e/ou velocidade do crescimento. Relatou-se um caso de uma menor de idade, apresentando ginecomastia bilateral, submetida à mastectomia esquerda e quadrantectomia na mama direita. O diagnóstico anatomopatológico demonstrou proliferação estromal, compatível com tumor filoide, o que comprometeu toda a extensão das peças cirúrgicas, inclusive a pele da região areolar. O diagnóstico de tumor filoide é raro nas mamas de adolescentes. O caso relatado adquire grande importância em função da idade da paciente, da localização e da extensão da lesão.

Phyllodes tumors are rare fibroepithelial breast neoplasms. In a less aggressive form, they behave in a similar fashion to the fibroadenoma, and the only differences can be seen in the tumor size and/or speed of growth. We reported the case of an underage girl, with bilateral gynecomastia, who underwent left mastectomy and right breast quadrantectomy. The histopathological diagnosis showed stromal proliferation, consistent with phyllodes tumor that compromised the entire length of the surgical specimens, including the skin areolar region. Diagnosis of phyllodes tumor is rare in breasts of adolescents. The reported case is of great importance due to the patient?s age, and location and extent of the injury

RESUMO

A juçara, Euterpe oleracea Mart., fruta indígena da Amazônia Legal, é rica em fitoquímicos com atividades anti-oxidante, antiinflamatória e anti-câncer. Este estudo tem por objetivo analisar os efeitos do extrato hidroalcoólico da casca, caroço e fruto total da juçara em diferentes linhagens de células malignas humana. Os frutos foram coletados no Parque da Juçara, localizado no Maracanã, município de São Luís, seguida da confecção da excicata que se mantém registrada no Herbário Rosa Mochel do Núcleo de Estudos Biológicos da Universidade Estadual do Maranhão. Os extratos hidroalcoólicos da casca, caroço e fruto total foram extraidos no Laboratório de Farmacologia e Psicobiologia da UERJ. As linhagens celulares utilizadas nos ensaios foram MCF-7 (adenocarcinoma de mama), CACO-2 e HT-20 (adenocarcinoma colo retal) e adenocarcinoma na mama (MDA-MB-468). As linhagens foram tratadas com 10, 20 e 40µg/mL dos extratos por 24 e 48 horas e feitas às análises. Células MCF-7 controle apresentaram núcleo proeminente com nucléolos evidentes. Após tratamento com o extrato hidroalcoólico da casca da juçara, as células mostraram morfologia arredondada com retração do citoplasma. O ensaio de viabilidade com MTT ((3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide)) demonstrou uma redução na viabilidade das células. Após 48 horas, o tratamento das células com 20µg/mL do extrato da casca reduziu a viabilidade sendo que o efeito citotóxico do tratamento com 40µg/mL do extrato da casca foi potencializado. Células tratadas com 10µg/mL do extrato do caroço de juçara apresentavam-se arredondadas com consequente redução no volume celular. A concentração 20µg/mL de extrato hidroalcoólico do caroço, causou severa redução no volume das células e ocasionou o surgimento de vacúolos intracelulares. O mesmo foi observado após tratamento com 40µg/mL. O tratamento com 40µg/mL do extrato hidroalcoólico do fruto total, modificou drasticamente a morfologia das células MCF-7...

Juçara, Euterpe oleracea Mart., an indigenous fruit from Amazon, is rich in phytochemicals with antioxidant, anti-inflammatory and anti-cancer activity. This study aims to analyze the effects of the hydroalcoholic extract of the bark, seed and total fruit of juçara in different human malignant cell lines. Fruits were collected at the Maracana Ecological Park, in São Luís, followed by excicata manufacturing that remains registered in the Herbarium Rosa Mochel from the Nucleus of Biological Studies at the State University of Maranhão. The hydroalcoholic extracts of bark, seed and fruit were all obtained in the Laboratory of Pharmacology and Psychobiology UERJ. The cell lines used in the tests were MCF-7 and MDA-MB-468 (breast adenocarcinoma) and CACO-2 and HT-20 (colorectal adenocarcinoma). Strains were treated with 10, 20 and 40μg/mL of extracts for 24 and 48 hours. Control MCF-7 cells showed prominent nucleus with evident nucleoli. After treatment with the hydroalcoholic extract from the bark of juçara, the cells showed rounded morphology with retraction of the cytoplasm. The MTT viability assay showed a reduction in cell viability. After 48 hours, treatment of cells with 20μg/mL of bark extract reduced cell viability and the cytotoxic effect of treatment with 40μg/mL extract of the bark was potentiated. Cells treated with 10μg/mL of the bark extract were rounded with consequent reduction in cell volume. The concentration of 20μg/mL of bark extract caused severe reduction in volume of the cells and caused the appearance of intracellular vacuoles. The same was observed after treatment with 40μg/mL. Treatment with 40μg/mL of the hydroalcoholic extract of total fruit dramatically changed the morphology of the MCF-7 cells causing vacuolization and lysis with apparent loss of cytoplasmic contents. MTT assay showed a reduction in viability of MCF-7 cells treated with 20 and 40μg/mL after 24 hours of treatment. Analysis by electron microscopy showed the appearance...

Assuntos