RESUMO

PURPOSE: To evaluate the biocompatibility and osteogenesis of castor oil polymer doped with SiO2 or BaTiO3 nanoparticles. METHODS: Twenty four male rats Wistar were submitted to bone defect filled with castor oil polymer. The animals were distributed in two experimental groups had been formed with 12 animals each: Group 1 - Castor oil polymer doped with 0.30 grams of SiO2 replacing 0.30 grams of CaCO3. Group 2 - Castor oil polymer doped with 0.30 grams of BaTiO3 replacing 0.30 grams of CaCO3. Euthanasia occurred 30 and 60 days after surgery and the femurs were sent to histological analysis and MEV. RESULTS: The implants were biocompatible and allowed for progressive osteogenesis through osteoconduction in both observation periods. There was significant bone neoformation at 30 and 60 days in both groups within the histomorphometric evaluation, but group 1's osteogenesis was lesser in the 30 and 60-day periods observed when compared to the animals of group 2. The MEV morphometric evaluation evidenced a lesser percentage of osseous tissue filling within the BaTiO2-doped polymer. CONCLUSION: The castor oil polymer doped with SiO2 or BaTiO3 remained biocompatible and allowed for progressive osteogenesis in both observation periods.

Assuntos

RESUMO

PURPOSE: To evaluate the biocompatibility and osteogenesis of castor oil polymer doped with SiO2 or BaTiO3 nanoparticles. METHODS: Twenty four male rats Wistar were submitted to bone defect filled with castor oil polymer. The animals were distributed in two experimental groups had been formed with 12 animals each: Group 1 - Castor oil polymer doped with 0.30 grams of SiO2 replacing 0.30 grams of CaCO3. Group 2 - Castor oil polymer doped with 0.30 grams of BaTiO3 replacing 0.30 grams of CaCO3. Euthanasia occurred 30 and 60 days after surgery and the femurs were sent to histological analysis and MEV. RESULTS: The implants were biocompatible and allowed for progressive osteogenesis through osteoconduction in both observation periods. There was significant bone neoformation at 30 and 60 days in both groups within the histomorphometric evaluation, but group 1's osteogenesis was lesser in the 30 and 60-day periods observed when compared to the animals of group 2. The MEV morphometric evaluation evidenced a lesser percentage of osseous tissue filling within the BaTiO2-doped polymer. CONCLUSION: The castor oil polymer doped with SiO2 or BaTiO3 remained biocompatible and allowed for progressive osteogenesis in both observation periods. .

Assuntos

RESUMO

PURPOSE: To evaluate the biocompatibility and osteogenesis of castor oil polymer doped with SiO2 or BaTiO3 nanoparticles.METHODS: Twenty four male rats Wistar were submitted to bone defect filled with castor oil polymer. The animals were distributed in two experimental groups had been formed with 12 animals each: Group 1 - Castor oil polymer doped with 0.30 grams of SiO2 replacing 0.30 grams of CaCO3. Group 2 - Castor oil polymer doped with 0.30 grams of BaTiO3 replacing 0.30 grams of CaCO3. Euthanasia occurred 30 and 60 days after surgery and the femurs were sent to histological analysis and MEV.RESULTS:The implants were biocompatible and allowed for progressive osteogenesis through osteoconduction in both observation periods. There was significant bone neoformation at 30 and 60 days in both groups within the histomorphometric evaluation, but group 1's osteogenesis was lesser in the 30 and 60-day periods observed when compared to the animals of group 2. The MEV morphometric evaluation evidenced a lesser percentage of osseous tissue filling within the BaTiO2-doped polymer.CONCLUSION:The castor oil polymer doped with SiO2 or BaTiO3 remained biocompatible and allowed for progressive osteogenesis in both observation periods.(AU)

Assuntos

RESUMO

Cefovecin is the third generation semi synthetic cephalosporin. The drug is indicated for treatment of skin and urinary infections. The main difference between cefovecin and the others cephalosporins is the highest plasma protein binding, providing an extend action. Due to lack of laboratory studies demonstrating changes caused by the use of cefovecin, the aim of this study was to evaluate the influence of cefovecin therapy on the serum proteins, hemogram, urea and creatinine activities, blood gas, platelet distribution width (PDW) and platelet count. Ten healthy dogs (males n=4; females n=6), average weight of 10.03±3.54 kg were used. The animals were kept in individual cages all over the experiment. The animals were submitted to the clinical and laboratory examinations as an inclusion criterion for the experiment. Sodium cefovecin (Convenia®) was subcutaneously administered (8mg/ kg) to the dogs. Clinical evaluation and laboratorial analysis was performed prior and at 1, 2, 3, 7, 14 and 21 days post treatment (dpt). Despite to be in accordance with the reference values, it was observed a statistically significant (p 0.05) decrease in total serum protein, globulin, hemoglobin and packed cell volume at 21 dpt. The platelet distribution width (PDW) and platelet count were increased at seven and 21 days (p>0.05), respectively. No changes in urea and creatinine activities, blood gas and leukocyte values were observed in the dogs after the administration of cefovecin. In conclusion, cefovecin can be administered in healthy dogs without causing significant laboratory abnormalities.(AU)

A cefovecina é a mais nova cefalosporina semissintética de terceira geração, indicada para tratamento de infecções de pele e do trato urinário de cães e gatos. O principal diferencial da cefovecina para as outras cefalosporinas é sua alta ligação às proteínas plasmáticas, o que lhe permite longo período de ação. Devido à ausência de trabalhos demonstrando alterações laboratoriais provocadas pelo uso da cefovecina, este trabalho teve o objetivo de avaliar a influência da terapia com cefovecina sobre as proteínas séricas e suas frações, valores do hemograma, atividade de uréia e creatinina, hemogasometria, distribuição do diâmetro das plaquetas (PDW) e contagem plaquetária em cães hígidos. Foram usados dez cães adultos (machos n=4; fêmeas n=6), com peso médio de 10,03±3,54 Kg, incluídos nos experimento mediante exames clínicos e laboratoriais. Os cães receberam por via subcutânea a cefovecina sódica (Convenia®), na dose de 8mg/Kg e foram acompanhados clínica e laboratorialmente nos dias 1, 2, 3, 7, 14 e 21 após o tratamento (dpt). Apesar de os valores permanecerem dentro da faixa de normalidade para a espécie, houve uma diminuição significativa (P 0,05) nos valores da proteína sérica, globulinas, hemoglobina e volume globular aos 21(dpt). O diâmetro das plaquetas (PDW), bem como sua contagem diminuíram aos 7 e 21 dias, mas sem diferença significativa (P>0,05), respectivamente. Não houve alterações nas atividades de uréia e creatinina, hemogasometria e valores leucocitários após a administração da cefovecina. Conclui-se que a cefovecina pode ser administrada em cães saudáveis sem causar alterações laboratoriais significantes.(AU)

Assuntos

RESUMO

Cefovecin is the third generation semi synthetic cephalosporin. The drug is indicated for treatment of skin and urinary infections. The main difference between cefovecin and the others cephalosporins is the highest plasma protein binding, providing an extend action. Due to lack of laboratory studies demonstrating changes caused by the use of cefovecin, the aim of this study was to evaluate the influence of cefovecin therapy on the serum proteins, hemogram, urea and creatinine activities, blood gas, platelet distribution width (PDW) and platelet count. Ten healthy dogs (males n=4; females n=6), average weight of 10.03±3.54 kg were used. The animals were kept in individual cages all over the experiment. The animals were submitted to the clinical and laboratory examinations as an inclusion criterion for the experiment. Sodium cefovecin (Convenia®) was subcutaneously administered (8mg/ kg) to the dogs. Clinical evaluation and laboratorial analysis was performed prior and at 1, 2, 3, 7, 14 and 21 days post treatment (dpt). Despite to be in accordance with the reference values, it was observed a statistically significant (p 0.05) decrease in total serum protein, globulin, hemoglobin and packed cell volume at 21 dpt. The platelet distribution width (PDW) and platelet count were increased at seven and 21 days (p>0.05), respectively. No changes in urea and creatinine activities, blood gas and leukocyte values were observed in the dogs after the administration of cefovecin. In conclusion, cefovecin can be administered in healthy dogs without causing significant laboratory abnormalities.

A cefovecina é a mais nova cefalosporina semissintética de terceira geração, indicada para tratamento de infecções de pele e do trato urinário de cães e gatos. O principal diferencial da cefovecina para as outras cefalosporinas é sua alta ligação às proteínas plasmáticas, o que lhe permite longo período de ação. Devido à ausência de trabalhos demonstrando alterações laboratoriais provocadas pelo uso da cefovecina, este trabalho teve o objetivo de avaliar a influência da terapia com cefovecina sobre as proteínas séricas e suas frações, valores do hemograma, atividade de uréia e creatinina, hemogasometria, distribuição do diâmetro das plaquetas (PDW) e contagem plaquetária em cães hígidos. Foram usados dez cães adultos (machos n=4; fêmeas n=6), com peso médio de 10,03±3,54 Kg, incluídos nos experimento mediante exames clínicos e laboratoriais. Os cães receberam por via subcutânea a cefovecina sódica (Convenia®), na dose de 8mg/Kg e foram acompanhados clínica e laboratorialmente nos dias 1, 2, 3, 7, 14 e 21 após o tratamento (dpt). Apesar de os valores permanecerem dentro da faixa de normalidade para a espécie, houve uma diminuição significativa (P 0,05) nos valores da proteína sérica, globulinas, hemoglobina e volume globular aos 21(dpt). O diâmetro das plaquetas (PDW), bem como sua contagem diminuíram aos 7 e 21 dias, mas sem diferença significativa (P>0,05), respectivamente. Não houve alterações nas atividades de uréia e creatinina, hemogasometria e valores leucocitários após a administração da cefovecina. Conclui-se que a cefovecina pode ser administrada em cães saudáveis sem causar alterações laboratoriais significantes.

Assuntos

RESUMO

This paper aims to report the presence of Dioctophyma renale in a rural region of Mato Grosso do Sul, as well as ways of diagnosis and treatment. The Dioctophyma renale is the largest known nematode and contamination to the host occurs after raw fish intake and oligochaetes harboring the infective larval form. The animals carrying the parasite do not have specific clinical signs, making it necessary to use other means of diagnosis such as an ultrasonography and urinalysis. A female dog was seen on a farm in Mato Grosso do Sul, with prostration, stiffness of the limbs and touch sensitivity in the abdominal area. After conducting laboratory tests it was possible to confirm the presence of parasite eggs in the urine and a cylindrical shape in the right kidney, visualized through the ultrasonography, suggesting the presence of adult worms. As a treatment the option chosen was the surgical removal of the parasite.(AU)

O trabalho tem como objetivo relatar a presença da Dioctophyma renale, em região rural de Mato Grosso do Sul, bem como as formas de diagnóstico e tratamento. D. renale é o maior nematoide conhecido e a contaminação ao hospedeiro ocorre após a ingestão de carne crua de peixe e oligoquetas albergando a forma larval infectante. Os animais portadores do parasita não apresentam sinais clínicos específicos, sendo necessária a utilização de outros meios de diagnósticos, como ultrassonografia e urinálise. Foi atendido um cão, fêmea, proveniente de uma propriedade rural de Mato Grosso do Sul, apresentando prostração, enrijecimento dos membros e sensibilidade ao toque em região abdominal. Após a realização de urinálise foi constatada a presença de ovos do parasita na urina e através da ultrassonografia foi visualizada uma forma cilíndrica no rim direito, sugerindo a presença do verme adulto. Como tratamento optou-se pela remoção cirúrgica do parasita. É possível concluir que os métodos de diagnóstico e tratamento empregado são eficazes para sobrevida do paciente.(AU)

Assuntos

RESUMO

This paper aims to report the presence of Dioctophyma renale in a rural region of Mato Grosso do Sul, as well as ways of diagnosis and treatment. The Dioctophyma renale is the largest known nematode and contamination to the host occurs after raw fish intake and oligochaetes harboring the infective larval form. The animals carrying the parasite do not have specific clinical signs, making it necessary to use other means of diagnosis such as an ultrasonography and urinalysis. A female dog was seen on a farm in Mato Grosso do Sul, with prostration, stiffness of the limbs and touch sensitivity in the abdominal area. After conducting laboratory tests it was possible to confirm the presence of parasite eggs in the urine and a cylindrical shape in the right kidney, visualized through the ultrasonography, suggesting the presence of adult worms. As a treatment the option chosen was the surgical removal of the parasite.

O trabalho tem como objetivo relatar a presença da Dioctophyma renale, em região rural de Mato Grosso do Sul, bem como as formas de diagnóstico e tratamento. D. renale é o maior nematoide conhecido e a contaminação ao hospedeiro ocorre após a ingestão de carne crua de peixe e oligoquetas albergando a forma larval infectante. Os animais portadores do parasita não apresentam sinais clínicos específicos, sendo necessária a utilização de outros meios de diagnósticos, como ultrassonografia e urinálise. Foi atendido um cão, fêmea, proveniente de uma propriedade rural de Mato Grosso do Sul, apresentando prostração, enrijecimento dos membros e sensibilidade ao toque em região abdominal. Após a realização de urinálise foi constatada a presença de ovos do parasita na urina e através da ultrassonografia foi visualizada uma forma cilíndrica no rim direito, sugerindo a presença do verme adulto. Como tratamento optou-se pela remoção cirúrgica do parasita. É possível concluir que os métodos de diagnóstico e tratamento empregado são eficazes para sobrevida do paciente.

Assuntos