RESUMO
BACKGROUND: The aim was to evaluate the frequency, clinicopathological features, and HPV status of oropharyngeal squamous cell carcinoma (OP-SCC) and benign HPV-related epithelial lesions of the oropharynx over the last 25 years. Moreover, a literature review was performed to investigate HPV frequency in OP-SCC samples diagnosed in Brazilian Centers. MATERIAL AND METHODS: A cross-sectional study analyzed OP-SCC, squamous papilloma, verruca vulgaris, and condyloma accuminatum, diagnosed from 1997 to 2021. HPV status of OP-SCC was determined by immunohistochemistry and "in situ" hybridization. Bivariate statistics were performed (p≤0.05). For the literature review, MEDLINE/PubMed, Web of Science, EMBASE, and Scopus were searched. Two independent reviewers assessed the studies for eligibility. RESULTS: Cross-sectional: 211 OP-SCC (63.0%) and 124 benign lesions (37.0%) were included. OP-SCC frequency increased gradually over time, whereas benign lesions had steady trends. OP-SCC affected more males (n= 171; 81.0%), though the relative frequency in females rose over time. Smoking (n= 127; 60.2%) was common in OP-SCC. Nineteen OP-SCC (13.0%) were positive for HPV. HPV-positive and HPV-negative tumors had similar clinicopathological features (p>0.05). Benign lesions predominated in middle-aged (n= 32; 26.7%) women (n= 71; 57.3%), in the soft palate (n=101; 81.5%). LITERATURE REVIEW: 32 studies were included, and in 60% of them, HPV frequency in OP-SCC was less than 25%. CONCLUSIONS: OP-SCC prevalence has been increasing, and it was mostly associated with smoking and alcohol rather than with HPV infection in Brazil. Benign lesions had a stationary frequency over the evaluated period.
Assuntos
Neoplasias Orofaríngeas , Infecções por Papillomavirus , Humanos , Estudos Transversais , Brasil/epidemiologia , Neoplasias Orofaríngeas/virologia , Neoplasias Orofaríngeas/epidemiologia , Neoplasias Orofaríngeas/patologia , Infecções por Papillomavirus/epidemiologia , Masculino , Feminino , Pessoa de Meia-Idade , Carcinoma de Células Escamosas/virologia , Carcinoma de Células Escamosas/epidemiologia , Carcinoma de Células Escamosas/patologia , Adulto , Idoso , Fatores de Tempo , Carcinoma de Células Escamosas de Cabeça e Pescoço/virologia , Carcinoma de Células Escamosas de Cabeça e Pescoço/epidemiologia , Carcinoma de Células Escamosas de Cabeça e Pescoço/patologiaRESUMO
Immuno-oncology studies the immune system in cancer. In recent decades, immunotherapy has shown a good response to the treatment of various locally advanced and metastatic cancers. The main mechanisms of action include stimulation of the patient's own immune system to enhance immune responses acting in tumor escape pathways. This review examined the literature related to immune system mechanisms in head and neck squamous cell carcinoma (HNSCC) and their application in immunotherapy using biomarkers. The PUBMED, LILACS, MEDLINE, WHOLIS, and SCIELO databases were searched using the terms squamous cell carcinoma, head and neck, immuno-oncology, immunotherapy, and immunology. The main drugs currently available for clinical use in patients diagnosed with HNSCC include pembrolizumab and nivolumab, both classified as check-point inhibitors. These immunobiological agents improve patient survival and quality of life. Many authors and clinical trials point out that the recommendation of these agents is linked to the dose of PD-L1 (ligand expressed primarily by tumor cells), which proved to be an unreliable biomarker in the patient selection. Recommendation of immunotherapy depends on reliable biomarkers that must be identified in order to achieve good therapeutic results.
RESUMO
Estudar o relacionamento conjugal e a avaliação da efetividade de intervenções com casais pode promover as habilidades de comunicação, afeto e resolução de problemas. Pesquisas com casais de namorados na literatura são incipientes e acredita-se que ampliar tais comportamentos pode ajudar esses casais. O presente estudo de caso avalia uma intervenção (quatro sessões de avaliação e dez sessões de grupo) com um casal de namorados num delineamento de sujeito único, considerando medidas de linha de base, pré-teste, pós-teste e seguimento, combinado com medidas processuais de expectativa e satisfação com o procedimento conduzido. Os resultados demonstram satisfação com o tratamento, generalização para outros relacionamentos e melhoria do relacionamento em comunicação, afeto e resolução de problemas. Discute-se implicações para a prevenção e futuras pesquisas (AU)
Assuntos
Humanos , Masculino , Feminino , Adulto , Comportamento Social , Terapia ComportamentalRESUMO
A. lacustris is a widely distributed species in the São Francisco and Paraná river basins, mainly in lentic waters. Specimens were captured monthly, over a whole year in a reservoir built by damming the Ribeirão Claro stream (SP). The stomach contents analyses showed a predominantly piscivorous diet. Feeding activity showed to be clearly less intense during winter, when all the sampling groups were compared. Despite the fact that the diet of A. lacustris presents a high diversity of prey-species, the prey size, their abundance and also behavior possibly determined a certain preference for some of them.
O peixe cachorro, Acestrorhynchus lacustris, encontra-se amplamente distribuído nas bacias do rio São Francisco e do alto rio Paraná, sobretudo nos locais de caráter lêntico. Ao longo de um ano, foram capturados mensalmente exemplares desta espécie no reservatório de captação de água do Ribeirão Claro. A análise do conteúdo estomacal dos exemplares capturados revelou uma dieta predominantemente piscívora. Durante o inverno, foi constatada uma diminuição acentuada da atividade alimentar do peixe-cachorro. Apesar de apresentar uma diversidade relativamente alta de espécies-presa, foi observada certa predileção por algumas, cujo tamanho, abundância e comportamento, foram os prováveis fatores determinantes.