RESUMO
This report summarizes closed, family, and open studies conducted sequentially over a 10 month period with the Cendehill rubella virus vaccine in more than 16,000 children and adolescents. This strain of rubella was attenuated by serial propogation on primary rabbit kidney cell cultures. Inoculation of the Cendehill vaccine produced seroconversion in 97 percent of the 3589 susceptible (seronegative) vaccinated persons. There was no spread of the virus to susceptible controls living in close contact with those vaccinated. The vaccine was well tolerated. No arthritis or arthralgia occured in 860 female subjects 13-18 years of age who were included in the study. The Cendehill vaccine would appear to meet the requirements of an acceptable vaccine (Summary)
Assuntos
Humanos , Pré-Escolar , Criança , Adolescente , Adulto , Masculino , Feminino , Vírus da Rubéola/imunologia , Vacinas Virais , Formação de Anticorpos , Seguimentos , Testes de Inibição da Hemaglutinação , Placebos , Rubéola (Sarampo Alemão)/prevenção & controle , Vacina contra Rubéola , VacinaçãoRESUMO
Influenza virus undergoes continuous antigenic alterations which at times become so profound that the antigens in the available vaccines can not protect against newly emerging variants. Such a state of affairs makes it difficult if not impossible to furnish effective vaccines in adequate amounts during outbreaks caused by such variants. When vaccine is in short supply, one asks the question about the efficacy of reduced dosages. The present report relates information which shows that using proper spacing of injections, even small amounts of antigens, may engender antibody response in various age groups, including children (AU)