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1.
Genet Mol Res ; 14(1): 34-9, 2015 Jan 15.
Artigo em Inglês | MEDLINE | ID: mdl-25729933

RESUMO

The present study investigates the effects of electroacupuncture (EA) on urinary bladder pressure (UBP) in patients with acute gastrointestinal injury (AGI). Twenty patients with AGI admitted to the First Hospital of Jiaxing intensive care unit from December 2011 to June 2013 were evaluated. Conventional group patients (n = 10) were administered moderate enteral nutritional support, and electroacupuncture group patients (n = 10) were administered enteral nutritional support followed by EA at bilateral Zusanli (ST-36), Shangjuxu (ST-37), Hegu (LI-4), and QuChi (LI-11) acupoints. UBP was then measured every 6 h and the serum creatinine once daily for 7 days. There were no statistically significant patient demographic differences in the study groups (P > 0.05). The initial UBP of both patient groups was ≥12 mmHg. On days 6 and 7, the UBP significantly decreased in the EA group compared to the conventional group (P < 0.05). The serum creatinine concentration on day 7 was significantly lower in the EA group than in the conventional group (P < 0.05). Based on these results, electroacupuncture contributed to gastrointestinal motility recovery in patients with AGI. This procedure may reduce UBP and provide organ-protective effects in AGI patients.


Assuntos
Eletroacupuntura , Gastroenteropatias/fisiopatologia , Gastroenteropatias/terapia , Pressão , Bexiga Urinária/fisiopatologia , Doença Aguda , Creatinina/sangue , Feminino , Gastroenteropatias/sangue , Humanos , Masculino , Pessoa de Meia-Idade
2.
Genet Mol Res ; 13(4): 8258-67, 2014 Oct 20.
Artigo em Inglês | MEDLINE | ID: mdl-25366720

RESUMO

Sauvagesia rhodoleuca (Ochnaceae) is an endangered plant that is endemic to southern China. The levels of genetic variation and patterns of population structure in S. rhodoleuca were investigated using inter-simple sequence repeat markers. Eleven primers were used to amplify DNA samples from 117 individuals, and a total of 92 loci were detected. Our results indicated that genetic diversity was quite low both at the species level (percentage of polymorphic bands (PPB) = 41.30%, Nei's gene diversity (h) = 0.1331, and Shannon information index (I) = 0.2028) and the population level (PPB = 16.30-28.26%, h = 0.0496-0.1012, and I = 0.0756-0.1508). A high level of genetic differentiation among populations was detected based on Nei's genetic diversity analysis (0.4344) and analysis of molecular variance (47.03%). The low genetic diversity within population and high population differentiation of S. rhodoleuca were assumed to result largely from limited gene flow, genetic drift, inbreeding, and clonal growth. Conservation strategies for this endangered species are proposed based on the genetic data.


Assuntos
Variação Genética , Genética Populacional , Repetições de Microssatélites , Ochnaceae/genética , China , Espécies em Perigo de Extinção , Evolução Molecular , Geografia , Espécies Introduzidas
3.
Genet Mol Res ; 11(2): 1266-71, 2012 May 09.
Artigo em Inglês | MEDLINE | ID: mdl-22614355

RESUMO

Type 1 diabetes is a chronic progressive autoimmune disease characterized by mononuclear cell infiltration, with subsequent destruction of insulin-producing ß-cells. Studies have identified strong associations between type 1 diabetes and several chromosome regions, including 12q24. Association between type 1 diabetes and 12q24 arises from SNP rs3184504; rs3184504 is a nonsynonymous SNP in exon 3 of SH2B3 (also known as LNK). Nonobese diabetic (NOD) mice recapitulate many aspects of the pathogenesis of type 1 diabetes in humans and are therefore frequently used in studies addressing the cellular and molecular mechanisms of this disease. It is of interest to know whether there is a similar mutation of SH2B3 in NOD mice. We found that the SH2B3 mutation is absent in NOD mice. To our knowledge, this is the first report of the sequence and the protein levels of SH2B3 in NOD mice.


Assuntos
Diabetes Mellitus Tipo 1/genética , Peptídeos e Proteínas de Sinalização Intracelular/genética , Mutação , Proteínas Adaptadoras de Transdução de Sinal , Animais , Sequência de Bases , Primers do DNA , Feminino , Proteínas de Membrana , Camundongos , Camundongos Endogâmicos C57BL , Camundongos Endogâmicos NOD , Obesidade , Polimorfismo de Nucleotídeo Único
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