RESUMO
Gastric cancer is one of the most frequent neoplasias in the digestive tract and is the result of premalignant lesion progression in the majority of cases. Opportune detection of those lesions is relevant, given that timely treatment offers the possibility of cure. There is no consensus in Mexico on the early detection of gastric cancer, and therefore, the Asociación Mexicana de Gastroenterología brought together a group of experts and produced the "Mexican consensus on the detection and treatment of early gastric cancer" to establish useful recommendations for the medical community. The Delphi methodology was employed, and 38 recommendations related to early gastric cancer were formulated. The consensus defines early gastric cancer as that which at diagnosis is limited to the mucosa and submucosa, irrespective of lymph node metástasis. In Mexico, as in other parts of the world, factors associated with early gastric cancer include Helicobacter pylori infection, a family history of the disease, smoking, and diet. Chromoendoscopy, magnification endoscopy, and equipment-based image-enhanced endoscopy are recommended for making the diagnosis, and accurate histopathologic diagnosis is invaluable for making therapeutic decisions. The endoscopic treatment of early gastric cancer, whether dissection or resection of the mucosa, should be preferred to surgical management, when similar oncologic cure results can be obtained. Endoscopic surveillance should be individualized.
Assuntos
Adenocarcinoma/diagnóstico , Adenocarcinoma/terapia , Neoplasias Gástricas/diagnóstico , Neoplasias Gástricas/terapia , Adenocarcinoma/epidemiologia , Adenocarcinoma/patologia , Terapia Combinada , Técnica Delphi , Detecção Precoce de Câncer/métodos , Detecção Precoce de Câncer/normas , Ressecção Endoscópica de Mucosa/métodos , Ressecção Endoscópica de Mucosa/normas , Gastroscopia/métodos , Gastroscopia/normas , Humanos , México/epidemiologia , Estadiamento de Neoplasias , Fatores de Risco , Neoplasias Gástricas/epidemiologia , Neoplasias Gástricas/patologiaRESUMO
INTRODUCTION AND AIM: Mantle cell lymphoma is an aggressive subtype of B-cell non-Hodgkin lymphoma and its incidence is 0.5/100,000 inhabitants. Gastrointestinal involvement at diagnosis is 15-30%. The aim of our study was to analyze the clinical and endoscopic characteristics of mantle cell lymphoma affecting the digestive tract. MATERIAL AND METHODS: A retrospective study was conducted, based on a case series of patients with mantle cell lymphoma affecting the gastrointestinal tract that were diagnosed over a 10-year period. RESULTS: Ten patients (11.7%) had gastrointestinal tract involvement. The upper endoscopic findings were polypoid lesions (66%), thickened folds (44%), and nonspecific changes in the mucosa (33%). At colonoscopy, polypoid lesions were viewed in 100% of the patients and ulcerated lesions in 40%. CONCLUSION: Polypoid lesions are the most common endoscopic characteristics in patients with mantle cell lymphoma of the gastrointestinal tract. Upper endoscopy and colonoscopy should be carried out on patients with mantle cell lymphoma, even those with nonspecific symptoms, to check their gastrointestinal status. Gastrointestinal involvement has an impact on disease staging.
Assuntos
Neoplasias do Sistema Digestório/patologia , Endoscopia Gastrointestinal , Linfoma de Célula do Manto/patologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos RetrospectivosRESUMO
We propose a novel synchronous phase-demodulation of pixelated interferograms using squared 3x3 phase-shifted unit-cells. This 3x3 unit-cell is tiled over the CCD image sensor to create a two-dimensional (2D) pixelated carrier. Our synchronous phase-demodulation uses this 2D carrier to demodulate the pixelated interferogram as in the standard 2x2 unit-cell case. The main motivation behind the use of a 3x3 pixelated carrier (instead of the usual 2x2) is its higher harmonic robustness, allowing one to demodulate intensity-distorted fringe patterns. The harmonic rejection robustness of our spatial 3x3 configuration equals the robustness of the temporal least-squares 9-step phase-shifting algorithm (PSA). In other words, extending from the usual 2x2 phase-shifting unit-cell to 3x3 unit-cells, one extends the harmonic rejection of the demodulation algorithm. Finally we also prove that our proposed 9-step, 3x3 pixelated carrier uses the 2D available spectral space more efficiently than using these 9-steps in a linear spatial-carrier configuration.
Assuntos
Interferometria/instrumentação , Refratometria/instrumentação , Processamento de Sinais Assistido por Computador/instrumentação , Desenho de Equipamento , Análise de Falha de Equipamento , Luz , Tamanho da Amostra , Espalhamento de RadiaçãoRESUMO
Here, we present a fast algorithm for two-dimensional (2D) phase unwrapping which behaves as a recursive linear filter. This linear behavior allows us to easily find its frequency response and stability conditions. Previously, we published a robust to noise recursive 2D phase unwrapping system with smoothing capabilities. But our previous approach was rather heuristic in the sense that not general 2D theory was given. Here an improved and better understood version of our previous 2D recursive phase unwrapper is presented. In addition, a full characterization of it is shown in terms of its frequency response and stability. The objective here is to extend our previous unwrapping algorithm and give a more solid theoretical foundation to it.
Assuntos
Algoritmos , Processamento de Sinais Assistido por Computador , Razão Sinal-RuídoRESUMO
The standard tool to estimate the phase of a sequence of phase-shifted interferograms is the Phase Shifting Algorithm (PSA). The performance of PSAs to a sequence of interferograms corrupted by non-white additive noise has not been reported before. In this paper we use the Frequency Transfer Function (FTF) of a PSA to generalize previous white additive noise analysis to non-white additive noisy interferograms. That is, we find the ensemble average and the variance of the estimated phase in a general PSA when interferograms corrupted by non-white additive noise are available. Moreover, for the special case of additive white-noise, and using the Parseval's theorem, we show (for the first time in the PSA literature) a useful relationship of the PSA's noise robustness; in terms of its FTF spectrum, and in terms of its coefficients. In other words, we find the PSA's estimated phase variance, in the spectral space as well as in the PSA's coefficients space.
RESUMO
Recently a new type of spatial phase shifting interferometer was proposed that uses a phase-mask over the camera's pixels. This new interferometer allows one to phase modulate each pixel independently by setting the angle of a linear polarizer built in contact over the camera's CCD. In this way neighbor pixels may have any desired (however fixed) phase shift without cross taking. The standard manufacturing of these interferometers uses a 2x2 array with phase-shifts of 0, pi/2, pi, and 3 pi/2 radians. This 2x2 array is tiled all over the video camera's CCD. In this paper we propose a new way to phase demodulate these phase-masked interferograms using the squeezing phase-shifting technique. A notable advantage of this squeezing technique is that it allows one the use of Fourier interferometry wiping out the detuning error that most phase shifting algorithms suffers. Finally we suggest the use of an alternative phase-mask to phase modulate the camera's pixels using a linear spatial carrier along a given axis.
RESUMO
Recently, pixelated spatial carrier interferograms have been used in optical metrology and are an industry standard nowadays. The main feature of these interferometers is that each pixel over the video camera may be phase-modulated by any (however fixed) desired angle within [0,2pi] radians. The phase at each pixel is shifted without cross-talking from their immediate neighborhoods. This has opened new possibilities for experimental spatial wavefront modulation not dreamed before, because we are no longer constrained to introduce a spatial-carrier using a tilted plane. Any useful mathematical model to phase-modulate the testing wavefront in a pixel-wise basis can be used. However we are nowadays faced with the problem that these pixelated interferograms have not been correctly demodulated to obtain an error-free (exact) wavefront estimation. The purpose of this paper is to offer the general theory that allows one to demodulate, in an exact way, pixelated spatial-carrier interferograms modulated by any thinkable two-dimensional phase carrier.
Assuntos
Interferometria/métodos , Interferometria/normas , Modelos Teóricos , Dispositivos Ópticos/normas , Processamento de Imagem Assistida por Computador/métodos , Processamento de Imagem Assistida por Computador/normas , Reprodutibilidade dos Testes , Gravação em VídeoRESUMO
We present a theoretical analysis to estimate the amount of phase noise due to noisy interferograms in Phase Shifting Interferometry (PSI). We also analyze the fact that linear filtering transforms corrupting multiplicative noise in Electronic Speckle Pattern Interferometry (ESPI) into fringes corrupted by additive gaussian noise. This fact allow us to obtain a formula to estimate the standard deviation of the noisy demodulated phase as a function of the spectral response of the preprocessing spatial filtering combined with the PSI algorithm used. This phase noise power formula is the main result of this contribution.
Assuntos
Algoritmos , Interferometria/métodos , Modelos Estatísticos , Refratometria/métodos , Simulação por ComputadorRESUMO
In this work we analyze the frequency response, the spatial distribution and continuity of the recovered phase in Lateral Shearing Interferometry (LSI). This frequency content and topology of the recovered phase is analyzed for the forward LSI operator as well as its inverse LSI operator using one, two, or n two-dimensional sheared interferograms. The spatial frequency response of the shearing interferometer is well known and for the reader's convenience, it is briefly revisited in a new perspective. It is however less well-known and more interesting to analyze the spatial distribution of the sheared data as well as the spatial topology of the recovered phase produced by some inverse LSI operators. Also we define a useful space of functions S with the property that any sheared data available, along any direction, may be used to recovered a smooth continuous phase with the bonus property of fully covering the pupil of the wavefront being tested. These combined aspects allow us to find the best possible wave-front reconstruction from the available sheared data using one, two or n sheared interferograms.
Assuntos
Algoritmos , Interferometria/métodos , Modelos Teóricos , Refratometria/métodos , Simulação por Computador , Luz , Espalhamento de RadiaçãoRESUMO
A robust algorithm for phase recovery from multi-phase-stepping images is presented. This algorithm is based on the minimization of an energy (cost) functional and is equivalent to the simultaneous application of a fixed temporal quadrature filter and a spatial adaptive quadrature filter to the phase-stepping pattern ensemble. The algorithm, believed to be new, is specially suited for those applications in which a large number of phase-stepping images may be obtained, e.g., profilometry with a computer-controlled fringe projector. We discuss the selection of parameter values and present examples of its performance in both synthetic and real image sequences.
RESUMO
A powerful technique for processing fringe-pattern images is based on Bayesian estimation theory with prior Markov random-field models. In this approach the solution of a processing problem is characterized as the minimizer of a cost function with terms that specify that the solution should be compatible with the available observations and terms that impose certain (prior) constraints on the solution. We show that, by the appropriate choice of these terms, one can use this approach in almost every processing step for accurate and robust interferogram demodulation and phase unwrapping.
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Most interferogram demodulation techniques give the detected phase wrapped owing to the arctangent function involved in the final step of the demodulation process. To obtain a continuous detected phase, an unwrapping process must be performed. Here we propose a phase-unwrapping technique based on a regularized phase-tracking (RPT) system. Phase unwrapping is achieved in two steps. First, we obtain two phase-shifted fringe patterns from the demodulated wrapped phase (the sine and the cosine), then demodulate them by using the RPT technique. In the RPT technique the unwrapping process is achieved simultaneously with the demodulation process so that the final goal of unwrapping is therefore achieved. The RPT method for unwrapping the phase is compared with the technique of least-squares integration of wrapped phase differences to outline the substantial noise robustness of the RPT technique.
RESUMO
The Hartmann test is a well-known technique for testing large telescope mirrors. The Hartmann technique samples the wave front under analysis by use of a screen of uniformly spaced array of holes located at the pupil plane. The traditional technique used to gather quantitative data requires the measurement of the centroid of these holes as imaged near the paraxial focus. The deviation from its unaberrated uniform position is proportional to the slope of the wave-front asphericity. The centroid estimation is normally done manually with the aid of a microscope or a densitometer; however, newer automatic fringe-processing techniques that use the synchronous detection technique or the Fourier phase-estimation method may also be used. Here we propose a new technique based on a regularized phase-tracking (RPT) system to detect the transverse aberration in Hartmanngrams in a direct way. That is, it takes the dotted pattern of the Hartmanngram as input, and as output the RPT system gives the unwrapped transverse ray aberration in just one step. Our RPT is compared with the synchronous and the Fourier methods, which may be regarded as its closest competitors.
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El presente trabajo estudia el efecto de la combinacion Captopril-Peroxido de Hidrogeno (H2O2) sobre el corazon de embrion de pollo durante etapas tempranas de la Cardiogénesis. Huevos fértiles White Leghorn de tres días de incubacion fueron divididos en tres grupos: a)controles solucion salina 0,15M. b)HýOý 0,1 ml, 10 mM y c)Captopril 0,1 ml 10 µg/ml + HýOý 0,1ml, 10 mM. A los 5 días se determino: a)el nivel de oxido reduccion del Verde Janus por incubacion en una solucion 0,2 mg/ml en PBS. b) el consumo de oxigeno por el método Polorográfico en funcion de la actividad de la catalasa endogena, c)los corazones fueron removidos y procesados para microscopia de luz. El HýOý produce a)una reduccion cualitativa de la poblacion de células de mesenquima del canal ario ventricular (cav), b)un mayor grado de reduccion del Verde Janus y c)una reduccion significativa del 20 por ciento de oxígeno consumido en comparacion al grupo control. La combinacion Captopril HýOý mantiene: a)cualitativamente estable la poblacion celular del tejido de mesenquima, b)una reduccion del colorante vital, en la region de cav, en escala similar a la de los controles y c)un 10 por ciento de diferencia en el consumo de oxígeno respecto al grupo control. El Captopril protege el estado de oxigeno-reduccion y porcentaje de saturacion de oxígeno en corazones embrionarios de pollo sometidos a estrés oxidativo y mantiene estable la poblacion celular del tejido de mesenquina durante etapas tempranas del desarrollo