RESUMO
Abstract Objective: To evaluate the rates of success and failure of ultrasound-guided percutaneous biopsy of lesions in hollow abdominal organs, as well as the influence of contrast enhancement on those rates. Materials and Methods: This was a retrospective, single-center study evaluating patients submitted to ultrasound-guided percutaneous biopsy of abdominal lesions in hollow organs between January 2017 and June 2018. Patient records were reviewed using a standardized data collection form. Results: We included 49 procedures performed in 48 patients, of whom 18 (38%) had a prior diagnosis of cancer. Malignancy was suspected in 44 cases (90%). Among those 44 cases, the suspicion was of a new neoplasm in 28 (64%), of relapse in 11 (25%), and of a metastatic lesion in 5 (11%). The histopathological findings were sufficient to make the diagnosis in all 44 of those cases, 33 (75%) of which were found to be malignant. The diagnosis was consistent with the clinical suspicion in 33 (75%) of the cases in which there was a definitive histological result. There were no complications resulting from the procedure. Conclusion: Ultrasound-guided percutaneous biopsy is a safe procedure that demonstrates high efficacy in providing a sufficient sample for the diagnosis. The main reason to perform such a biopsy is suspicion of a new neoplasm, followed by suspicion of a metastatic lesion. The histopathological results were concordant with the suspicion in the majority of the cases evaluated here.
Resumo Objetivo: Avaliar as taxas de sucesso e insucesso das biópsias percutâneas ecoguiadas de lesões em órgãos abdominais não sólidos e a influência da realização de contraste nessa técnica. Materiais e Métodos: Estudo retrospectivo que avaliou doentes submetidos a biópsias percutâneas ecoguiadas de lesões em órgãos abdominais não sólidos, entre janeiro de 2017 e junho de 2018. Os dados clínicos dos doentes foram revistos usando um método padronizado de colheita de dados. Resultados: Foram incluídos 49 procedimentos realizados em 48 doentes, dos quais 18 (38%) tinham diagnóstico prévio de câncer. Em 44 (90%) suspeitava-se de malignidade: 28 (64%) de suspeita de diagnósticos de novo de neoplasia, 11 (25%) de recidiva neoplásica e 5 (11%) de lesões metastáticas. Os resultados histopatológicos permitiram fazer o diagnóstico em 44 casos (90%), sendo 33 (67%) malignos. O diagnóstico foi concordante com a suspeita clínica em 33 (75%) dos casos com resultado histológico definitivo. Não ocorreram complicações resultantes das biópsias. Conclusão: A realização de biópsias ecoguiadas é segura e capaz de fornecer amostra suficiente para permitir o diagnóstico definitivo. O principal motivo para realizar biópsias ecoguiadas é a suspeita de neoplasia de novo, seguida da suspeita de metástases. Os resultados histopatológicos foram concordantes com a suspeita clínica na maioria dos casos.
RESUMO
The potential antihypertensive activity of Brazilian plants was evaluated in vitro by its ability to inhibit the angiotensin-converting enzyme (ACE). Forty-four plants belonging to 30 families were investigated. Plants were selected based on their popular use as antihypertensive and/or diuretics. The following plants presented significant ACE inhibition rates: Calophyllum brasiliense, Combretum fruticosum, Leea rubra, Phoenix roebelinii and Terminalia catappa.
Assuntos
Inibidores da Enzima Conversora de Angiotensina/farmacologia , Fitoterapia , Extratos Vegetais/farmacologia , Plantas Medicinais , Inibidores da Enzima Conversora de Angiotensina/administração & dosagem , Inibidores da Enzima Conversora de Angiotensina/uso terapêutico , Brasil , Calophyllum , Combretum , Humanos , Medicina Tradicional , Componentes Aéreos da Planta , Extratos Vegetais/administração & dosagem , Extratos Vegetais/uso terapêutico , Folhas de Planta , Caules de Planta , TerminaliaRESUMO
The vasodilator effect of the ethanolic extract of leaves from Hancornia speciosa Gomes (HSE) was studied in rat aortic rings. HSE produced a concentration-dependent vasodilatation (pIC(50)=5.6+/-0.1), which was completely abolished in endothelium-denuded vessels. The endothelium-dependent vasodilatation induced by HSE was abolished by l-NAME (100 microM), a nitric oxide (NO) synthase inhibitor, but not atropine (1 microM; pIC(50)=5.6+/-0.2), a muscarinic receptor antagonist, nor indomethacin (10 microM; pIC(50)=5.4+/-0.2), a cyclooxygenase inhibitor. The concentration-response curve of HSE was significantly shifted to the left by superoxide dismutase (SOD; 300U/mL). In addition, while SOD displaced the 3-morpholino-sidnonimine (SIN-1; P<0.05) concentration-effect curve to the left, HSE (50 microg/mL) had no effect. Finally, wortmannin (0.3 microM), an inhibitor of phosphatidyl-inositol 3-kinase (PI3K), dramatically reduced the vasodilator effect of HSE. Together, these findings lead us to conclude that HSE induces a NO- and endothelium-dependent vasodilatation in rat aortic preparations, likely by a mechanism dependent on the activation of PI3K.