RESUMO
Fourteen children admitted to the Hospital de Pediatría of the C.M.N. of the I.M.S.S. with the diagnosis of acute infectious laryngotracheobronchitis were divided into two groups with similar conditions for their study. The benefit derived from the application of recemic epinephrine with intermittent positive pressure was confirmed 15 and 30 minutes later by means of a double blind study; the improvement was swift and spectacular, but temporary; therefore, such treatment must be given only in hospitals, since relapses may show up two to four hours later, making in dangerous to send the patients home or to apply to ambulatory cases. The use of racemic epinephrine is proposed for hospitals having equipment and personnel trained in its management and the convenience of further studies is set forth to determine the period of effectiveness of racemic epinephrine and the advantage of giving repeated doses.
Assuntos
Epinefrina/uso terapêutico , Laringite/tratamento farmacológico , Respiração com Pressão Positiva , Racepinefrina , Traqueíte/tratamento farmacológico , Doença Aguda , Bronquite/tratamento farmacológico , Criança , Pré-Escolar , Avaliação de Medicamentos , Epinefrina/administração & dosagem , Feminino , Humanos , Lactente , MasculinoRESUMO
The study included 50 cases with this disease which were divided into 2 groups: above and under 2,500 g. A relationship was established among weight and bleeding site, type of delivery, prothrombin activity and lethality. It was found that those under 2,500 g. bled earlier than those above 2,500 g. With higher percentage, the bleeding site was the digestive tract in both groups. Most of both groups bled between the 2nd and 6th day and a group of special interest was made up of 8 patients who bled between the 10th and 28th day of life and that we included as hemorrhagic disease of the newborn because bleeding appeared within the neonatal stage; these patients fell within the group showing the lowest prothombin activity. Bleeding within the central nervous system was frequent and showed the highest lethality.
Assuntos
Sangramento por Deficiência de Vitamina K/diagnóstico , Fatores Etários , Peso ao Nascer , Testes de Coagulação Sanguínea , Doenças do Sistema Nervoso Central/diagnóstico , Feminino , Humanos , Recém-Nascido , Masculino , Gravidez , Prognóstico , Tempo de ProtrombinaRESUMO
The authors reviewed the clinical histories of 50 children admitted to the Emergency Department of Hospital de Pediatría, C.M.N., I.M.S.S. from 1971 through 1975, with the diagnosis of lomotil intoxication. No differences were found as to sex. Frequency was greater at ages from 2 to 3 years from accidental mechanism, which increased between 1973 to 1975. Lethality was similar to that reported by other authors. In the clinical picture, the depressive action of diphenoxylate and the anticholinergic action of atropine were outstanding, without being possible to establish the limits between the two, with somnolence and flushness as main symptoms. The treatment given followed the purpose to eliminate the toxic: emesis, gastric washing and in cases of respiratory depression, naloxone was given. Therefore, it is concluded that since the value of lomotil in the treatment of diarrhea has not been proved and that the risk of its administration is greater than the benefit, this product should be proscribed, specially for pediatric use.