RESUMO
Eight of the more than 80 known herpesviruses are human pathogens. Human herpes simplex virus (HSV) is a contagious infection with a large reservoir in the general population. It has a potential for significant complications in the immunocompromised host. In addition, psychological distress caused by the negative stigma associated with genital herpes and visible facial lesions in those experiencing frequent outbreaks renders it a challenging clinical dilemma. This article reviews the epidemiology, pathogenesis, and diagnostic features of HSV infections, providing the clinician with an up-to-date understanding of the available management strategies for mucocutaneous HSV-induced disease.
Assuntos
Infecções Sexualmente Transmissíveis/epidemiologia , Infecções Sexualmente Transmissíveis/fisiopatologia , Infecções Sexualmente Transmissíveis/virologia , Herpes Simples/epidemiologia , Herpes Simples/fisiopatologia , Herpes Simples/imunologia , Herpes Simples/parasitologia , Herpes Simples/virologia , Eczema/epidemiologia , Eczema/fisiopatologia , Eczema/virologia , Herpes Genital/epidemiologia , Herpes Genital/virologia , Herpes Labial/epidemiologia , Herpes Labial/virologiaAssuntos
Infecções por HTLV-I , Vírus Linfotrópico T Tipo 1 Humano/isolamento & purificação , Dermatopatias Infecciosas , Biomarcadores/análise , Criança , Pré-Escolar , Dermatite/diagnóstico , Dermatite/fisiopatologia , Dermatite/terapia , Diagnóstico Diferencial , Infecções por HTLV-I/diagnóstico , Infecções por HTLV-I/fisiopatologia , Infecções por HTLV-I/terapia , Humanos , Dermatopatias Infecciosas/diagnóstico , Dermatopatias Infecciosas/fisiopatologia , Dermatopatias Infecciosas/terapia , Clima TropicalRESUMO
The concept of verrucous carcinoma as a clinicopathologic variant of squamous cell carcinoma is worthy of recognition. It is known by a confusing array of names, such as Ackerman's tumor, Buschke-Loewenstein tumor, florid oral papillomatosis, epithelioma cuniculatum, carcinoma cuniculatum, and cutis papillomatosis carcinoides of Gottron. Its apparent clinical benignity may lead to lengthy periods of misdiagnosis, during which it is likely not to spread to distant lymph nodes, but rather to destroy a nose, mandible, or penis as it slowly but relentlessly extends into underlying tissue. Morphologically warty or verrucous, its relatively bland histologic features are often more suggestive of a verruca vulgaris or pseudoepitheliomatous hyperplasia than of squamous cell carcinoma to those unfamiliar with the diagnosis. Alternatively, when it extends into underlying tissues, it may be mistaken histologically for a benign adnexal tumor or even an epidermoid cyst. Therapy may also be challenging because recurrences are common and concerns about potential anaplastic transformation after radiotherapy are often expressed.
Assuntos
Humanos , Carcinoma Verrucoso/classificação , Carcinoma Verrucoso/diagnóstico , Carcinoma Verrucoso/epidemiologia , Carcinoma Verrucoso/etiologia , Carcinoma Verrucoso/terapia , Diagnóstico Diferencial , Incidência , Mucosa/patologia , Neoplasias Cutâneas/classificação , Neoplasias Cutâneas/diagnóstico , Neoplasias Cutâneas/epidemiologia , Neoplasias Cutâneas/etiologia , Neoplasias Cutâneas/terapia , Prognóstico , Terapia CombinadaRESUMO
A 29-year-old woman from Trinidad experienced the rapid onset of extensive lesions characteristic of erythema dyschromicum perstans following an x-ray study using orally administered contrast. Eleven months later a skin biopsy specimen showed few epidermal changes but extensive incontinence of melanin pigment and marked dilatation of lymphatics in the superficial dermis. Results of a systemic evaluation were normal. The available data on this disease are analyzed and conclusions offered regarding its nature and causes.