RESUMO

The effects of the selective histamine H1-receptor agonist, 2-(3-trifluoromethylphenyl)histamine, were studied in rats implanted with electrodes for chronic sleep recordings. 2-(3-Trifluoromethylphenyl)histamine (80-120 micrograms) injected into the left lateral ventricle increased wakefulness, whereas slow wave sleep was reduced. Pretreatment with pyrilamine (2.0 mg/kg) prevented the effects of the H1-receptor agonist on wakefulness and slow wave sleep. Our results further support the involvement of histamine in the modulation of the waking state.

Assuntos

Agonistas dos Receptores Histamínicos/farmacologia , Histamina/análogos & derivados , Vigília/efeitos dos fármacos , Animais , Relação Dose-Resposta a Droga , Eletrodos Implantados , Histamina/administração & dosagem , Histamina/farmacologia , Agonistas dos Receptores Histamínicos/administração & dosagem , Injeções Intraventriculares , Masculino , Pirilamina/farmacologia , Ratos , Ratos Wistar , Sono/efeitos dos fármacos