RESUMO

Along with three known drimanes, polygodial. 1-beta-(p-methoxycinnamoyl) polygodial and mukaadial, the sesquiterpene drimane named drimanial was isolated from the bark of Drimys winteri (Winteraceae). Its structure was elucidated based on spectroscopic evidence. Drimanial exhibited antinociceptive action against acetic acid induced pain, being about 3-fold less active than polygodial.

Assuntos

Analgésicos/farmacologia , Magnoliopsida/química , Sesquiterpenos/farmacologia , Espectroscopia de Ressonância Magnética , Sesquiterpenos Policíclicos , Sesquiterpenos/química , Análise Espectral