RESUMO
The cutaneous deposition disorders are a group of unrelated conditions characterized by the presence of either endogenous or exogenous substances within the dermis or the subcutis. Part I of this two-part series will focus on metabolic processes involved in the endogenous deposition in the various forms of amyloidosis, porphyria, colloid milium, and lipoid proteinosis. We will also review the clinical, histologic, biochemical, and ultrastructural findings relevant to each disorder. Basic mechanisms of pathogenesis, diagnostic modalities, and treatment options are also discussed.
Assuntos
Humanos , Amiloidose/complicações , Amiloidose/diagnóstico , Amiloidose/etiologia , Amiloidose/metabolismo , Amiloidose/patologia , Amiloidose/terapia , Dermatopatias Metabólicas/diagnóstico , Dermatopatias Metabólicas/etiologia , Dermatopatias Metabólicas/metabolismo , Dermatopatias Metabólicas/patologia , Dermatopatias Metabólicas/terapia , Dermatopatias/diagnóstico , Dermatopatias/etiologia , Dermatopatias/metabolismo , Dermatopatias/patologia , Dermatopatias/terapia , Lipidoses/diagnóstico , Lipidoses/etiologia , Lipidoses/metabolismo , Lipidoses/patologia , Lipidoses/terapia , Pele/metabolismo , Pele/patologia , Porfirias/diagnóstico , Porfirias/etiologia , Porfirias/metabolismo , Porfirias/patologia , Porfirias/terapia , Proteinose Lipoide de Urbach e Wiethe/diagnóstico , Proteinose Lipoide de Urbach e Wiethe/etiologia , Proteinose Lipoide de Urbach e Wiethe/metabolismo , Proteinose Lipoide de Urbach e Wiethe/patologia , Proteinose Lipoide de Urbach e Wiethe/terapiaRESUMO
Part II of the cutaneous deposition disorders focuses on cutaneous calcification and ossification, alkaptonuria and ochronosis, and gout. These disorders have in common the deposition of materials in the dermis or subcutis and often involve metabolic defects in hormonal and enzymatic regulation. The pathogenesis, clinical findings, and treatment of these diseases are discussed. Both the histologic and ultrastructural findings are reviewed.