RESUMO
BACKGROUND: Transepidermal drug delivery (TED) is a new potential method in dermatology. Permeability alterations induced by ablative fractional resurfacing have been described with the aim to increasing the delivery of different substances into the skin. OBJECTIVE: To evaluate clinical response and side effects of TED in areata alopecia (AA) treatment using ablative fractional methods associated with acoustic pressure ultrasound (US) to deliver triamcinolone solution into the skin. METHODS AND MATERIALS: Five cases of AA underwent treatment which comprised of 3 steps: 1) Ablative fractioned RF or CO2 laser 2) topical application of triamcinolone 3) acoustic pressure wave US. The number of sessions varied according to the clinical response, ranging from one to six sessions. RESULTS: All patients had complete recovery of the area treated. Two of them treated with ablative fractional RF + triamcinolone + US had complete response after three and six sessions. The other two treated with ablative fractional CO2 + triamcinolone + US had complete response after one session. CONCLUSION: Fractioned ablative resurfacing associated with acoustic pressure wave US is a new option to areata alopecia treatment with good clinical result and low incidence of side effects.
Assuntos
Alopecia em Áreas/tratamento farmacológico , Anti-Inflamatórios/administração & dosagem , Ablação por Cateter , Triancinolona/administração & dosagem , Terapia por Ultrassom , Administração Cutânea , Adolescente , Adulto , Alopecia em Áreas/terapia , Terapia Combinada , Procedimentos Cirúrgicos Dermatológicos , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Adulto JovemRESUMO
Lúpus eritematoso discoide é uma desordem autoimune benigna da pele e representa a forma clínica mais comum de lúpus eritematoso cutâneo. A apresentação do lúpus eritematoso discoide com acometimento palpebral exclusivo, como neste caso, é extremamente rara, o que dificulta o diagnóstico precoce da doença. O desconhecimento dessa apresentação de lúpus e o consequente retardo do seu diagnóstico podem contribuir com a progressão da doença e resultar em cicatrizes inestéticas, o que pode prejudicar a função palpebral.
RESUMO
La enfermedad de Hirschsprung o megacolon congénito es una anomalía rara, caracterizada por la ausencia de las células ganglionares del intestino. Esto genera una falla en su relajación distal, que impide la eliminación de la materia fecal y causa una obstrucción inmediata después del nacimiento. El tratamiento es eminentemente quirúrgico y a las semanas de la reanastomosis coloanal los pacientes presentan diarrea. Por su parte, la dermatitis de Jacquet es una forma infrecuente de la dermatitis del pañal por irritante primario, provocada por el contacto prolongado de la piel de esta región con la orina o heces acuosas. Comunicamos el caso de un niño con enfermedad de Hirschsprung que, luego de la intervención quirúrgica, presentó una dermatitis de Jacquet asociada a diarrea grave...
Hirschsprung´s disease, also known as congenital aganglionic megacolon, is a rare anomaly, marked by the absence of ganglionic cells of the large intestine, resulting in failure of its distal looseness, blocking evacuation and causing obstruction right after birth. The treatment is mainly surgical and weeks after coloanal reanastomosis, these patients develop diarrhea. Jacquet dermatitis is an unusual presentation of irritant diaper dermatitis, caused by prolonged contact of the skin of this region with urine and/or watery diarrhea. We report a case of a child with Hirschsprung´s disease that, after surgical treatment, presented Jacquet dermatitis as an outcome of severe diarrhea...