RESUMO

ABSTRACT Objective: Evaluated the antifungal effect of the incorporation of different concentrations of the essential oil Cymbopogon citratus (capim santo), into polymethylmethacrylate (PMMA) against Candida albicans. Methods: Fifty specimens were fabricated and divided into five groups: Group 1, PMMA + 10% essential oil (n=10); Group 2, PMMA + 15% essential oil (n=10); Group 3, PMMA + 20% essential oil (n=10); Group 4, PMMA + 25% essential oil (n=10); Group 5, PMMA (n=10). PMMA powder was mixed with the monomer and the mixture was placed in disc-shaped cavities measuring 15 mm in diameter, 2 mm thick. To evaluate the antifungal activity of the experimental specimens, the standard strain of Candida albicans was tested. After incubation, the colony count of each plate was performed using a digital colony counter, obtaining the number of colony forming units (CFU) and the Kruskal-Wallis test was applied. Results: There was statistically significant difference in the CFU count of Candida albicans as a consequence of the addition of Cymbopogon citratus essential oil to PMMA (p < 0.001) and values were significantly higher in comparison with those of all the other groups, when the essential oil was incorporated as incorporated into the PMMA in the concentration of 20%. In the other concentrations, no difference in values was observed in comparison with the Control Group without essential oil of Cymbopogon citratus. Conclusion: The acrylic resin with the essential oil incorporated into it in different concentrations provided no effect against development of the genus Candida.

RESUMO Objetivo: Avaliar o efeito antifúngico da incorporação de diferentes concentrações do óleo essencial Cymbopogon citratus (capim santo), em polimetilmetacrilato (PMMA) contra Candida albicans. Métodos: Cinquenta corpos de prova foram confeccionados e divididos em cinco grupos: Grupo 1, PMMA + 10% de óleo essencial (n=10); Grupo 2, PMMA + 15% de óleo essencial (n=10); Grupo 3, PMMA + 20% de óleo essencial (n=10); Grupo 4, PMMA + 25% de óleo essencial (n=10); Grupo 5, PMMA (n=10). O pó de PMMA foi misturado ao monômero e a mistura foi colocada em cavidades em forma de disco medindo 15 mm de diâmetro por 2 mm de espessura. Para avaliar a atividade antifúngica dos espécimes experimentais, foi testada a cepa padrão de Candida albicans. Após a incubação, foi realizada a contagem de colônias de cada placa por meio de um contador digital de colônias, obtendo-se o número de unidades formadoras de colônias (UFC) e para isso foi aplicado o teste de Kruskal-Wallis. Resultados: Houve diferença estatisticamente significativa na contagem de UFC de Candida albicans como consequência da adição do óleo essencial de Cymbopogon citratus ao PMMA (p < 0,001) e os valores foram significativamente maiores em comparação com todos os outros grupos, quando o essencial óleo foi incorporado como incorporado ao PMMA na concentração de 20%. Nas demais concentrações, não houve diferença nos valores em relação ao Grupo Controle sem óleo essencial de Cymbopogon citratus. Conclusão: A resina acrílica com o óleo essencial incorporado a ela em diferentes concentrações não apresentou efeito contra o desenvolvimento do gênero Candida.

RESUMO

INTRODUCTION/OBJECTIVES: Clinical evidence of skeletal muscle involvement is not uncommon in systemic lupus erythematosus (SLE). Because of the poor understanding of signaling pathways involved in SLE muscle wasting, the  aim of this study was to evaluate the effects of vitamin D supplementation on skeletal muscle in mice with pristane-induced lupus. METHODS: Balb/c mice with lupus-like disease induced by pristane injection were randomized into three groups: pristane-induced lupus (PIL; n = 10), pristane-induced lupus + vitamin D supplementation (PIL + VD; n = 10) and healthy controls (CO; n = 8). Physical function was evaluated on days 0, 60, 120 and 180. The tibialis anterior and gastrocnemius muscles were collected to evaluate myofiber cross-sectional area (CSA) and protein expression. RESULTS: The PIL + VD group showed lower muscle strength compared to the CO and PIL groups at different time points. PIL mice showed similar myofiber CSA compared to CO and PIL + VD groups. LC3-II expression was higher in PIL compared to CO and PIL + VD groups. MyoD expression was higher in PIL mice compared to PIL + VD, while myostatin expression was higher in PIL + VD than PIL group. Myogenin expression levels were decreased in the PIL + VD group compared with the CO group. The Akt, p62 and MuRF expressions and mobility assessment showed no significance. CONCLUSIONS: Changes in skeletal muscle in PIL model happen before CSA reduction, possibly due to autophagy degradation, and treatment with Vitamin D has a impact on physical function by decreasing muscle strength and time of fatigue.. Vitamin D supplementation has a potential role modulating physical parameters and signaling pathways in muscle during pristane-induced lupus model.

Assuntos

RESUMO

Background: From late 2016 to early 2021, cases of Haff disease, a rare cause of rhabdomyolysis, possibly due to poisoning by palytoxin-like compounds in seafood, were detected in Salvador, Brazil. Surveillance was established to detect additional cases aiming at describing the clinical characteristics of the cases, identifying associated factors, estimating disease attack rate, and investigating the presence of biotoxins and trace metals in selected fish specimens obtained from cases. Method: Between December/2016-January/2021, surveillance investigated Haff disease suspected cases, and obtained clinical and fish samples to test. Findings: Of 65 cases investigated during the 2016-2017 outbreak, 43 (66%) had high creatine phosphokinase (CPK) levels. Among those with laboratory-confirmed rhabdomyolysis, 38 (88%) were hospitalized, 11 (26%) required intensive care, and three (7%) dialysis. Ingestion of marine fish 24h before disease onset was reported by 74% of the cases with elevated CPK and by 41% of those without CPK measurement (P=0·02). Attack rate for individuals who ate fish related to the outbreak was 55%. Following this outbreak, surveillance identified 12 suspected cases between 2017-2019, and a second outbreak in 2020-2021, with 16 laboratory-confirmed rhabdomyolysis patients (five required intensive care; one died). No traces of ciguatoxins and metals were detected in fish specimens obtained in 2016, found to be Seriola rivoliana. Some fish samples from 2020 were screened for palytoxin (PlTX)-like compounds and contained detectable levels of molecule fragments characteristics of isobaric PlTX, ovatoxin-a (OVTX-a), OVTX-b and OVTX-d. Interpretation: These findings support the hypothesis that compounds related to PlTX accumulated in marine fish may be the toxic agent causing the disease. Haff disease is a life-threatening condition, requiring clinical suspicion for patients with sudden-onset myalgia following fish ingestion. Suspected cases should be reported to health authorities for investigation.

RESUMO

Abstract Introduction/objectives: Clinical evidence of skeletal muscle involvement is not uncommon in systemic lupus erythematosus (SLE). Because of the poor understanding of signaling pathways involved in SLE muscle wasting, the aim of this study was to evaluate the effects of vitamin D supplementation on skeletal muscle in mice with pristane-induced lupus. Methods: Balb/c mice with lupus-like disease induced by pristane injection were randomized into three groups: pristane-induced lupus (PIL; n = 10), pristane-induced lupus + vitamin D supplementation (PIL + VD; n = 10) and healthy controls (CO; n = 8). Physical function was evaluated on days 0, 60, 120 and 180. The tibialis anterior and gastrocnemius muscles were collected to evaluate myofiber cross-sectional area (CSA) and protein expression. Results: The PIL + VD group showed lower muscle strength compared to the CO and PIL groups at different time points. PIL mice showed similar myofiber CSA compared to CO and PIL + VD groups. LC3-II expression was higher in PIL compared to CO and PIL + VD groups. MyoD expression was higher in PIL mice compared to PIL + VD, while myostatin expression was higher in PIL + VD than PIL group. Myogenin expression levels were decreased in the PIL + VD group compared with the CO group. The Akt, p62 and MuRF expressions and mobility assessment showed no significance. Conclusions: Changes in skeletal muscle in PIL model happen before CSA reduction, possibly due to autophagy degradation, and treatment with Vitamin D has a impact on physical function by decreasing muscle strength and time of fatigue.. Vitamin D supplementation has a potential role modulating physical parameters and signaling pathways in muscle during pristane-induced lupus model.

RESUMO

Introdução: Ouso de antibióticos na endodontia tem sido cada vez mais restrito e há uma preocupação quanto ao uso dessas drogas. Objetivo: Avaliar o conhecimento dos acadêmicos de Odontologia do Centro Universitário de João Pessoa - UNIPÊ, do sexto e décimo períodos, sobre a prescrição de antibióticos no tratamento endodôntico. Material e método: A amostra correspondeu a 105 participantes. O estudo apresentou uma abordagem descritiva e exploratória, utilizando um questionário. Os dados foram tabulados em uma plataforma do Microsoft Excel e analisados mediante estatística descritiva (valores de frequência absoluta e percentual). Resultados: Os estudantes relataram que esporadicamente apresentam dúvidas ao prescrever antibióticos sistêmicos. A maior parte dos alunos concluintes não soube identificar qual o tipo de receituário deve ser utilizado para prescrever e a validade da receita a partir da data de emissão. O medicamento de primeira escolha, indicado como coadjuvante ao tratamento endodôntico, foi descrito corretamente. Os participantes das duas turmas, não apresentaram certeza quanto aos casos que merecem a prescrição antimicrobiana e quais os pacientes de risco em que é preconizado a realização da profilaxia antibiótica. Conclusão: A maioria dos acadêmicos avaliados apresentaram conhecimento razoável evidenciando a necessidade contínua de atualização dos alunos quanto aos protocolos estipulados(AU)

Introduction: The use of antibiotics in endodontics has been increasingly restricted and there is concern about the use of these drugs. Objective: The aim of this study was to evaluate the knowledge of the sixth and tenth semester dental students of the University Center of João Pessoa - UNIPÊ about the prescription of antibiotics in endodontic treatment. Material and method: The sample consisted of 105 participants and the study presented a descriptive and exploratory approach using a questionnaire. Data were tabulated on a Microsoft Excel platform and analyzed using descriptive statistics (absolute and percentage frequency values). Results: Students reported that they sporadically have doubts when prescribing systemic antibiotics. Most graduating students were unable to identifywhich type of prescription should be used for prescribing and the validity of the prescription from the date of issue. The drug of first choice, indicated as an adjuvant to endodontic treatment, was correctly described, as well as the correct interval between doses and penicillin substitutes in case of hypersensitivity. However, the participants in both groups were not sure about the cases that deserve the antimicrobial prescription and which patients are at risk for antibiotic prophylaxis. There was no statistically significant difference for the distribution of the students' responses, although the sixth period had the highest number of correct answers. Conclusion: Most of the evaluated students presented reasonable knowledge, evidencing the continuous need for updating students regarding the stipulated protocols(AU)

Introducción: El uso de antibióticos en endodoncia se ha restringido cada vez más y existe preocupación por el uso de estos fármacos. Objetivo: Evaluar los conocimientos de los estudiantes de Odontología del Centro Universitario de João Pessoa - UNIPÊ, del sexto y décimo período, sobre la prescripción de antibióticos en el tratamiento endodóntico. Material y método: La muestra correspondió a 105 participantes. El estudio presentó un enfoque descriptivo y exploratorio, utilizando un cuestionario. Los datos se tabularon en una plataforma Microsoft Excel y se analizaron mediante estadística descriptiva (valores absolutos y de frecuencia porcentual). Resultados: Los estudiantes informaron que esporádicamente tienen dudas a la hora de prescribir antibióticos sistémicos. La mayoría de los estudiantes graduados no pudieron identificar qué tipo de receta se debe usar para recetar y la validez de la receta a partir de la fecha de emisión. El fármaco de primera elección, indicado como complemento del tratamiento endodóntico, se describió correctamente. Los participantes de ambas clases no estaban seguros de los casos que merecen prescripción antimicrobiana y qué pacientes están en riesgo en los que se recomienda la profilaxis antibiótica. Conclusión: La mayoría de los académicos evaluados presentaron conocimientos razonables, evidenciando la necesidad continua de actualizar a los estudiantesen cuanto a los protocolos estipulados(AU)

Assuntos

RESUMO

A Síndrome da Apneia e Hipopneia Obstrutiva do Sono (SAHOS) é condição clínica importante com incidência crescente nos países desenvolvidos e em desenvolvimento. É condição negligenciada, com prevalência entre 30 e 56%, responsável por 80% dos casos de hipertensão arterial resistente, causa de sonolência diurna, hiperutilização de serviços de saúde, incapacidade laboral, sintomas depressivos, acidentes de trânsito e de trabalho e fator de risco para doenças cardiovasculares. Este artigo tem como objetivo atualizar informações e com isso alertar sobre a importância do rastreamento e manejo da SAHOS em população com hipertensão arterial sistêmica assistida na atenção primária à saúde.

Obstructive Sleep Apnea and Hypopnea Syndrome (OSAHS) is an important clinical condition with increasing incidence in developed and developing countries. It is a neglected condition, with prevalence between 30 and 56%, responsible for 80% of cases of resistant hypertension, causes daytime sleepiness, hyper-utilization of health services, work incapacity, depressive symptoms, traffic and work accidents, and risk factor for cardiovascular diseases. The aim of this article is to update information and thus alert about the importance of the screening and management of OSAHS in a population with high blood pressure assisted in Primary Health Care.

Assuntos

RESUMO

This study aimed to evaluate the effects of purple grape juice consumption in pregnancy on oxidative stress parameters in Wistar rat fetuses. Twenty-four pregnant rats were divided into five groups: control group, indomethacin group (received a single dose of indomethacin in DG20), group grape juice DG14 (received an amount for 14 days/first and second gestational trim), group grape juice DG20 (received a dose throughout the gestational period), group grape juice two doses (received two doses, at morning and afternoon). On the 20th day of pregnancy (DG20), rats were anesthetized, and a cesarean section was performed to obtain the fetuses. A sample of liver, heart, and total brain of fetuses was collected for oxidative stress analyses. Values P<0.05 were considered significant. In fetuses' heart, we observed that the grape juice two dose group decreased sulfhydryl and increased SOD. In the liver, the grape juice decreased TBARS and SOD. There was a decrease in carbonyl and sulfhydryl in the indomethacin and grape juice one dose groups in the brain. We conclude that indomethacin altered oxidative stress parameters only in the fetal brain, and grape juice was presented as an important modulator of antioxidant capacity when consumed in a dose.

RESUMO

Abstract Frailty is characterized as a set of factors related to the body structure that lead the subject to a process of physical vulnerability, increasing their dependence. The study aims to investigate the aggregation of factors related to physical frailty (PF) in elderly residents of a city with a low Human Development Index (HDI). This is a cross-sectional study carried out in the city of Ibicuí, state of Bahia, Brazil, and including a random 270 elderly people aged ≥ 60 years. The physical frailty condition was identified according to the criteria proposed by Fried and collaborators. In the data analysis, descriptive statistics, cluster analysis, and multinominal logistic regression procedures were used. The highest prevalence of aggregation was identified when the four risk factors were combined: weight loss, strength, walking speed and physical activity levels (O/E = 4.36; CI = 4.04 - 4.68). It was identified that older people (80 years old or more) with a lower level of education (unlettered) were more likely to have three or more risk factors for physical frailty (p <0.05). As for sociodemographic variables, those who were older and had lower levels of education were more likely to have three or more risk factors. The development of actions that encourage a healthier lifestyle to favor the prevention and treatment of physical frailty, as well as to increase health literacy and knowledge, may reduce the problems related to this condition in older adults, mainly thinking about the next generations.

Resumo A fragilidade é caracterizada como um conjunto de fatores relacionados à estrutura corporal que levam o sujeito a um processo de vulnerabilidade física, aumentando sua dependência. O estudo tem como objetivo investigar a agregação de fatores relacionados à fragilidade física (FP) em idosos residentes em um município com baixo Índice de Desenvolvimento Humano (IDH). Trata-se de um estudo transversal realizado na cidade de Ibicuí, estado da Bahia, Brasil, e incluiu aleatoriamente 270 idosos com idade ≥ 60 anos. A condição de fragilidade física foi identificada de acordo com os critérios propostos por Fried e colaboradores. Na análise dos dados, foram utilizadas estatísticas descritivas, análise de cluster e procedimentos de regressão logística multinominal. A maior prevalência de agregação foi identificada quando os quatro fatores de risco foram combinados: perda de peso, força, velocidade de caminhada e níveis de atividade física (O/E = 4,36; IC = 4,04 - 4,68). Identificou-se que idosos (80 anos ou mais) com menor escolaridade (analfabetos) apresentaram maior probabilidade de apresentar três ou mais fatores de risco para fragilidade física (p <0,05). Quanto às variáveis ​​sociodemográficas, aqueles que eram mais velhos e com menor escolaridade tinham maior chance de apresentar três ou mais fatores de risco. O desenvolvimento de ações que estimulem um estilo de vida mais saudável para favorecer a prevenção e o tratamento da fragilidade física, bem como aumentar a alfabetização e o conhecimento em saúde, pode reduzir os problemas relacionados a essa condição nos idosos, principalmente pensando nas próximas gerações.

RESUMO

We report the occurrence of the lizard Gymnophthalmus underwoodi in the municipality of Belém, state of Pará, Brazil. This is the first record of that species south of the Amazonas River, probably because of an accidental introduction by ships that dock in Belém, the same pathway suggested for the recent introduction of another species of exotic lizard recently recorded in the city. We also determined the identity of some specimens of Gymnophthalmus from the states of Amapá and Pará through external morphology and molecular data, confirming that, until now, G. vanzoi is the only Gymnophthalmus occurring in the savanna enclaves of those states. Finally, we provide a new distribution map for the species of Gymnophthalmus, including the new occurrence record for G. underwoodi for the state of Pará, where it can be considered as an invasive species.

Nós relatamos a ocorrência do lagarto Gymnophthalmus underwoodi no município de Belém, estado do Pará, Brasil. Este é o primeiro registro ao sul do Rio Amazonas, provavelmente como resultado de uma introdução acidental por navios que atracam em Belém, o mesmo caminho sugerido para a introdução de outra espécie exótica de lagarto recentemente encontrada na cidade. Nós também determinamos a identidade de alguns espécimes de Gymnophthalmus dos estados do Amapá e Pará, através de dados morfológicos externos e moleculares, confirmando que, até o momento, G. vanzoi é o único Gymnophthalmus ocorrendo nos enclaves de savana desses estados. Por fim, nós fornecemos um novo mapa de distribuição para as espécies de Gymnophthalmus, incluindo o novo registro de ocorrência de G. underwoodi para o estado do Pará, onde ela pode ser considerada como uma espécie invasiva.

Assuntos

RESUMO

ABSTRACT We report the occurrence of the lizard Gymnophthalmus underwoodi in the municipality of Belém, state of Pará, Brazil. This is the first record of that species south of the Amazonas River, probably because of an accidental introduction by ships that dock in Belém, the same pathway suggested for the recent introduction of another species of exotic lizard recently recorded in the city. We also determined the identity of some specimens of Gymnophthalmus from the states of Amapá and Pará through external morphology and molecular data, confirming that, until now, G. vanzoi is the only Gymnophthalmus occurring in the savanna enclaves of those states. Finally, we provide a new distribution map for the species of Gymnophthalmus, including the new occurrence record for G. underwoodi for the state of Pará, where it can be considered as an invasive species.

RESUMO Nós relatamos a ocorrência do lagarto Gymnophthalmus underwoodi no município de Belém, estado do Pará, Brasil. Este é o primeiro registro ao sul do Rio Amazonas, provavelmente como resultado de uma introdução acidental por navios que atracam em Belém, o mesmo caminho sugerido para a introdução de outra espécie exótica de lagarto recentemente encontrada na cidade. Nós também determinamos a identidade de alguns espécimes de Gymnophthalmus dos estados do Amapá e Pará, através de dados morfológicos externos e moleculares, confirmando que, até o momento, G. vanzoi é o único Gymnophthalmus ocorrendo nos enclaves de savana desses estados. Por fim, nós fornecemos um novo mapa de distribuição para as espécies de Gymnophthalmus, incluindo o novo registro de ocorrência de G. underwoodi para o estado do Pará, onde ela pode ser considerada como uma espécie invasiva.

RESUMO

We report the occurrence of the lizard Gymnophthalmus underwoodi in the municipality of Belém, state of Pará, Brazil. This is the first record of that species south of the Amazonas River, probably because of an accidental introduction by ships that dock in Belém, the same pathway suggested for the recent introduction of another species of exotic lizard recently recorded in the city. We also determined the identity of some specimens of Gymnophthalmus from the states of Amapá and Pará through external morphology and molecular data, confirming that, until now, G. vanzoi is the only Gymnophthalmus occurring in the savanna enclaves of those states. Finally, we provide a new distribution map for the species of Gymnophthalmus, including the new occurrence record for G. underwoodi for the state of Pará, where it can be considered as an invasive species.(AU)

Nós relatamos a ocorrência do lagarto Gymnophthalmus underwoodi no município de Belém, estado do Pará, Brasil. Este é o primeiro registro ao sul do Rio Amazonas, provavelmente como resultado de uma introdução acidental por navios que atracam em Belém, o mesmo caminho sugerido para a introdução de outra espécie exótica de lagarto recentemente encontrada na cidade. Nós também determinamos a identidade de alguns espécimes de Gymnophthalmus dos estados do Amapá e Pará, através de dados morfológicos externos e moleculares, confirmando que, até o momento, G. vanzoi é o único Gymnophthalmus ocorrendo nos enclaves de savana desses estados. Por fim, nós fornecemos um novo mapa de distribuição para as espécies de Gymnophthalmus, incluindo o novo registro de ocorrência de G. underwoodi para o estado do Pará, onde ela pode ser considerada como uma espécie invasiva.(AU)

Assuntos

RESUMO

CONCLUSIONS: The prevalence of blood group antigens and phenotypes varies significantly in Brazil. To ensure a proper rare blood supply, it is essential to establish a local and regional database of rare donors connected to the national registry. The objective of this study was to create a database of rare blood donors in the northern region of southern Brazil. From November 2011 to December 2018, red blood cell (RBC) phenotyping and genotyping were performed on common and high-prevalence antigens in donors and patients in southern Brazil. During this study period, 17 patients and 33 blood donors with rare phenotypes were identified. Six patients had already been alloimmunized to clinically significant antigens. Patients with the following phenotypes (i.e., negative for highprevalence antigens) were found: Yt(a-), Jk(a-b-), Lu(a-b-), Oh (Bombay), Tc(a-), k-, and Fy(a-b-). Among the donors, Kp(a+b-), Fy(a-b-), Lu(a-b-), and k- phenotypes were identified. We also found four donors with the weak D type 18 phenotype. In conclusion, we observed that the prevalence of rare blood phenotypes in our region corresponds more to the prevalence found in the Caucasian population when compared with other regions in Brazil. Our results show the importance of continuous screening for rare donors in different regions of the country and the creation of a local database to support RBC transfusions in patients who need rare blood.

Assuntos

RESUMO

Method: An observational, retrospective, descriptive and cross - sectional study was carried out with data collected from Clínica Basegio, Brazil. The objective of this study was to analyze the importance of breast self-examination (BSE) as a diagnostic method for breast cancer in Passo Fundo, Rio Grande do Sul. A total of 320 patient records were selected from 1987 to 2017, among which 14 were excluded due to insufficient information. Results: BSE accounted for 48% of breast cancer diagnoses, followed by mammography and ultrasound. Imaging methods proved to be more effective in diagnosing early stage disease, while BSE detected more advanced tumors. This data was based on the histological characteristics of the tumors, with a significant difference (p<0.05) between tumor size and lymph node involvement when compared to BSE and imaging methods. Thus, the survival of the patients diagnosed by mammography and ultrasound was significantly higher than the patients diagnosed by BSE. Conclusion: Evidence from this retrospective study suggests that BSE is the prevalent diagnostic method for breast cancer in the State of Rio Grande do Sul. Despite detecting tumors in advanced stages, it is still a fundamental method within the Brazilian reality.

Método: Estudo observacional, retrospectivo, descritivo e transversal, com dados coletados na Clínica Basegio, Brasil. O objetivo deste estudo foi analisar a importância do autoexame das mamas (AEM) como método diagnóstico para o câncer de mama em Passo Fundo, Rio Grande do Sul. Um total de 320 registros de pacientes foram selecionados de 1987 a 2017, dos quais 14 foram excluídos devido a informações insuficientes. Resultados: O AEM foi responsável por 48% dos diagnósticos de câncer de mama, seguido pela mamografia e ultrassonografia. Os métodos de imagem mostraram-se mais eficazes no diagnóstico de doença em estágio inicial, enquanto o AEM detectou tumores mais avançados. Esses dados foram baseados nas características histológicas dos tumores, com diferença significativa (p<0,05) entre o tamanho do tumor e o comprometimento linfonodal quando comparados aos métodos de AEM e de imagem. Assim, a sobrevida dos pacientes diagnosticados por mamografia e ultrassonografia foi significativamente maior que a de pacientes diagnosticados por AEM. Conclusão: Evidências deste estudo retrospectivo sugerem que o AEM é o método diagnóstico prevalente para o câncer de mama no Estado do Rio Grande do Sul. Apesar de detectar tumores em estágios avançados, ainda é um método fundamental dentro da realidade brasileira.

RESUMO

OBJECTIVE: This study aims to perform a systematic review and meta-analysis of clinical trials in order to evaluate the clinical and radiographic success rates of primary teeth pulpotomy performed with biodentine, when compared to MTA. METHODS: Search strategies were conducted in nine databases on August 5th, 2017, update on February 14th, 2018. Clinical articles were selected, which were in accordance with the inclusion and exclusion criteria and the research objective. They were analyzed by meta-analysis at three time points (6, 12, and 18 months). RESULTS: Out of the 233 publications initially identified, only 9 studies that fulfilled the inclusion criteria were included in the review. The 6-month overall clinical (RR = 0.99; 95% CI = 0.96-1.02, p = 0.92) and radiographic success rates (RR = 0.96; 95% CI = 0.92-1.00, p = 0.28) showed that biodentine vs. MTA did not differ statistically. The 12 and 18-month overall clinical success rates, respectively (RR = 1.01; 95% CI = 0.97-1.04, p = 0.77; RR = 0.98; 95% CI = 0.92-1.05, p = 0.74) and radiographic success rates, respectively (RR = 0.97; 95% CI = 0.92-1.02, p = 0.11; RR = 1.00; 95% CI = 0.91-1.10, p = 0.56) also showed that biodentine vs. MTA did not differ statistically. CONCLUSION: There is no superiority of one material over the other, MTA versus biodentine. CLINICAL RELEVANCE: This systematic review comparing the performance of biodentine in relation to the MTA when used in the pulpotomy technique in primary teeth. Although MTA is considered the gold standard material for pulpotomy procedures, it has some drawbacks (poor handling, staining potential, long setting time); thus, it is important to evaluate the clinical performance of other calcium silicate-based cements like biodentine that overcome this drawbacks.

Assuntos

RESUMO

Frequentemente, as recessões gengivais (RG) estão associadas a lesões cervicais não cariosas (LCNC), defi nidas como a perda de estrutura dentária ao longo da margem gengival do dente, com a distinta característica de presença de tecido duro mineralizado em contraste com o tecido carioso. A partir de um ponto de vista topográfi co, a LCNC pode envolver apenas a coroa do dente (esmalte e/ou dentina coronal) ou somente a superfície radicular (cemento e/ou dentina radicular), ou pode localizar-se tanto na coroa como na raiz exposta. As principais indicações para o tratamento da LCNC são: 1) estética; 2) hipersensibilidade dentinária; 3) desenvolvimento de cáries; 4) acúmulo de biofi lme. Os procedimentos envolvem o tratamento restaurador e/ou cirúrgico, a depender do tipo de LCNC. Quando a LCNC atinge apenas a coroa do dente, o tratamento restaurador é mais indicado, enquanto uma lesão confi nada à raiz pode ser tratada preferencialmente com cirurgia plástica periodontal. Porém, a realidade clínica é geralmente complexa, o que torna o tratamento combinado mais favorável para certos casos. Portanto, o objetivo desse artigo foi realizar uma revisão da literatura concernente ao tratamento de recessões gengivais associadas a lesões cervicais não cariosas.

Often, gingival recessions (GR) are associated with non-carious cervical lesions (NCCL), defi ned as the loss of tooth structure along the gingival margin of the tooth, with the distinctive feature of the presence of mineralized hard tissue, in contrast to the carious tissue. From a topographical point of view, NCCL may involve only the tooth crown (enamel and/or coronal dentin) or only the root surface (cementum and/or radicular dentin) or can be located both in the crown and exposed root. The main indications for the treatment of NCCL are: 1) aesthetic; 2) dentine hypersensitivity; 3) development of caries; 4) biofi lm formation. The procedures involve restorative treatment and/or surgery depending on the type of NCCL. When NCCL is located exclusively at the tooth crown, the restorative treatment is best suited while a lesion located at the root surface should be treated preferably with periodontal plastic surgery. However, clinical reality is often complex, which makes the combination treatment more favorable for some cases. Therefore, the aim of this article is to review the literature concerning the treatment of gingival recession associated with non-carious cervical lesions.

Assuntos

RESUMO

Um dos objetivos do tratamento endodôntico é a máxima desinfecção do sistema de canais radiculares, bem como, a prevenção da sua reinfecção. A terapia fotodinâmica surge como um método coadjuvante na etapa de desinfecção obtendo significativa redução microbiana. Objetivo: traçar um panorama do perfil de uso da terapia fotodinâmica na endodontia no Brasil com base num Congresso de Odontologia e analisar o protocolo utilizado na desinfecção do sistema de canais radiculares. Materiais e método: realizou-se um estudo transversal, por meio da observação indireta dos resumos publicados nos anais da Sociedade Brasileira de Pesquisa Odontológica acerca do uso da terapia fotodinâmica na endodontia nos anos de 2013 a 2016. A coleta foi realizada por dois examinadores e as informações foram organizadas e analisadas no programa Statistical Program Software e apresentadas por meio da estatística descritiva. Resultados: foram encontrados 97 trabalhos com 37,1% no ano de 2016; 26,8% no ano de 2014; 18,6% em 2015 e 17,5% em 2013. Observou-se que 40,2% correspondiam a estudos in vitro, 68% tendo finalidade antibacteriana. Em 25,8% associaram o hipoclorito de sódio com outras substâncias químicas auxiliares e 81,4% utilizaram o hidróxido de cálcio como medica- ção intracanal. O azul de metileno foi o fotossensibilizador mais descrito. Conclusão: a terapia fotodinâmica mostra-se promissora como coadjuvante ao tratamento endodôntico convencional. Fazem-se necessárias mais pesquisas, pois ainda não existe um protocolo padrão para o uso da terapia fotodinâmica na endodontia.

RESUMO

BACKGROUND: Gingival recession (GR) might be associated with patient discomfort due to cervical dentin hypersensitivity (CDH) and esthetic dissatisfaction. The aim is to evaluate the effect of root coverage procedure with a xenogenous collagen matrix (CM) and/or enamel matrix derivative (EMD) in combination with a coronally advanced flap (CAF) on CDH, esthetics, and oral health-related quality of life (OHRQoL) of patients with GR. METHODS: Sixty-eight participants with single Miller Class I/II GRs were treated with CAF (n = 17), CAF + CM (n = 17), CAF + EMD (n = 17), and CAF + CM + EMD (n = 17). CDH was assessed by evaporative stimuli using a visual analog scale (VAS) and a Schiff scale. Esthetics outcome was assessed with VAS and the Questionnaire of Oral Esthetic Satisfaction. Oral Health Impact Profile-14 (OHIP-14) questionnaire was used to assess OHRQoL. All parameters were evaluated at baseline and after 6 months. RESULTS: Intragroup analysis showed statistically significant reduction in CDH and esthetic dissatisfaction with no intergroup significant differences (P >0.05). The impact of oral health on QoL after 6 months was significant for CAF + CM, CAF + EMD, and CAF + CM + EMD (P <0.05). Total OHIP-14 score and psychologic discomfort, psychologic disability, social disability, and handicap dimensions showed negative correlation with esthetics. OHIP-14 physical pain dimension had positive correlation with CDH (P <0.05). OHIP-14 showed no correlation with percentage of root coverage, keratinized tissue width, or keratinized tissue thickness (P >0.05). CONCLUSION: Root coverage procedures improve patient OHRQoL by impacting on a wide range of dimensions, perceived after reduction of CDH and esthetic dissatisfaction of patients with GRs treated with CAF + CM, CAF + EMD, and CAF + CM + EMD.

Assuntos

RESUMO

BACKGROUND: Considering xenogeneic collagen matrix (CM) and enamel matrix derivative (EMD) characteristics, it is suggested that their combination could promote superior clinical outcomes in root coverage procedures. Thus, the aim of this parallel, double-masked, dual-center, randomized clinical trial is to evaluate clinical outcomes after treatment of localized gingival recession (GR) by a coronally advanced flap (CAF) combined with CM and/or EMD. METHODS: Sixty-eight patients presenting one Miller Class I or II GRs were randomly assigned to receive either CAF (n = 17); CAF + CM (n = 17); CAF + EMD (n = 17), or CAF + CM + EMD (n = 17). Recession height, probing depth, clinical attachment level, and keratinized tissue width and thickness were measured at baseline and 90 days and 6 months after surgery. RESULTS: The obtained root coverage was 68.04% ± 24.11% for CAF; 87.20% ± 15.01% for CAF + CM; 88.77% ± 20.66% for CAF + EMD; and 91.59% ± 11.08% for CAF + CM + EMD after 6 months. Groups that received biomaterials showed greater values (P <0.05). Complete root coverage (CRC) for CAF + EMD was 70.59%, significantly superior to CAF alone (23.53%); CAF + CM (52.94%), and CAF + CM + EMD (51.47%) (P <0.05). Keratinized tissue thickness gain was significant only in CM-treated groups (P <0.05). CONCLUSIONS: The three approaches are superior to CAF alone for root coverage. EMD provides highest levels of CRC; however, the addition of CM increases gingival thickness. The combination approach does not seem justified.

Assuntos

RESUMO

Introduction: Oral candidiasis is considered one of the complications of antineoplastic therapy of head and neck. Studies show that herbal medicine has proven to be a promising alternative for the treatment of candidiasis. Objective: To evaluate the effectiveness of the gel Punica granatum Linn. in the prevention of oral candidiasis in patients undergoing radiotherapy with or without chemotherapy for squamous cell carcinoma of the head and neck, and adverse effects associated with its use. Material and method: It was performed a clinical trial, double blind, in the period 2012-2013, with patients seen at a referral hospital for cancer treatment. The sample consisted of 17 patients who did not have signs nor symptoms of oral candidiasis. These patients were divided into two groups: experimental (n=11): composed of patients who used the gel Punica granatum Linn. 6.25% since the beginning of the anticancer treatment and completed a week after the end of the treatment regimen; control (n=6): for patients who used the gel Miconazol 2%, following the same guidelines of the previous group. Data were tabulated and analyzed using descriptive statistics, the chi-square test and calculation of continuing Yates correction (p<0.05). Result: There was no oral candidiasis in 63.6% of patients in the experimental group and in none of the control group patients. Conclusion: Most patients who used the experimental gel showed no clinical signs of fungal infection, and there was no association of adverse effects.

Introdução: A candidíase oral é considerada uma das complicações da terapia antineoplásica de cabeça e pescoço. Estudos revelam que a fitoterapia vem se mostrando uma alternativa promissora para o tratamento da candidíase. Objetivo: Avaliar a efetividade do gel de Punica granatum Linn. na prevenção da candidíase oral, em pacientes submetidos à radioterapia associada ou não a quimioterapia para tratamento de carcinoma de células escamosas na região de cabeça e pescoço, e efeitos adversos associados ao seu uso. Material e método: Foi realizado um ensaio clínico, duplo cego, no período de 2012 a 2013, com pacientes atendidos em um Hospital de referência para tratamento oncológico. A amostra foi composta por 17 pacientes que não apresentavam os sinais e sintomas de candidíase oral, os quais foram divididos em dois grupos: experimental (n=11): composto por pacientes que utilizaram o gel de Punica granatum Linn. 6,25%, desde o inicio do tratamento antineoplásico e concluído uma semana após o término do esquema terapêutico; controle (n=6): por pacientes que utilizaram o gel de Miconazol 2%, seguindo as mesmas orientações do grupo anterior. Os dados foram tabulados e analisados por meio da estatística descritiva e usado os testes Qui-quadrado e Cálculo da Correção Continuada de Yates (p<0,05). Resultado: Não se observou a candidíase oral em 63,6% dos pacientes do grupo experimental, e em nenhum paciente do grupo controle. Conclusão: A maioria dos pacientes que fizeram uso do gel experimental não apresentaram os sinais clínicos da infecção fúngica, e não houve a associação de efeitos adversos.

Assuntos

RESUMO

Objetivo: avaliar a prevalência e a severidade da gengivite em escolares com higiene bucal deficiente, na faixa etária de 9 a 12 anos, e sua relação com possíveis fatores de risco locais. Sujeitos e método: foi realizado um estudo descritivo de corte transversal para avaliar as condições gengivais em escolares de duas escolas da rede pública de ensino, sendo a amostra composta por 36 escolares. Os índices aplicados foram: Índice de Higiene Oral Simplificado (IHO-S), Índice de Sangramento à Sondagem e Índice de Placa. O nível socioeconômico foi determinado pela classe socioeconômica a que pertencia a família. Os dados foram registrados no software SPSS para Windows®, versão 20.0, e analisados por meio de estatística descritiva e inferencial. Na análise bivariada, utilizou-se teste t de Student e a Análise de Variância (ANOVA). Resultados: foi observada uma prevalência de 100% de gengivite em todos os escolares, sendo a forma leve (97,2%) a mais frequente, havendo uma correlação positiva entre o IHO-S e o número de superfícies sangrantes. Conclusão: os escolares apresentaram elevada prevalência de gengivite na forma leve, relacionada à higiene bucal deficiente, o que evidencia a necessidade de realização de atividades preventivas que motivem a prática diária de higiene bucal efetiva.