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Cannabis sativa is a plant of the Cannabaceae family, whose molecular composition is known for its vast pharmacological properties. Cannabinoids are the molecules responsible for Cannabis sativa potential effects, especially tetrahydrocannabinol and cannabidiol. Scientific development has shown interest in the potential of cannabidiol in various health conditions, as it has demonstrated lower adverse events and great pharmacological potential, especially when administered topically. The present study aims to carry out a scoping review, focusing on the use of cannabidiol, in vivo models, for topical administration. Thus, the methodological approach used by the Joanna Briggs Institute was applied, and the studies were selected based on previously established inclusion criteria. Even though more information regarding the dose to achieve pharmacological potential is still needed, cannabidiol demonstrated potential in treating and preventing different conditions, such as glaucoma, atopic dermatitis, epidermolysis bullosa, and pyoderma gangrenosum.

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Consumer demand for natural, chemical-free products has grown. Food industry residues, like coffee pulp, rich in caffeine, chlorogenic acid and phenolic compounds, offer potential for pharmaceutical and cosmetic applications due to their antioxidant, anti-inflammatory, and antibacterial properties. Therefore, the objective of this work was to develop a phytocosmetic only with natural products containing coffee pulp extract as active pharmaceutical ingredient with antioxidant, antimicrobial and healing activity. Eight samples from Coffea arabica and Coffea canephora Pierre were analyzed for caffeine, chlorogenic acid, phenolic compounds, tannins, flavonoids, cytotoxicity, antibacterial activity, and healing potential. The Robusta IAC-extract had the greatest prominence with 192.92 µg/mL of chlorogenic acid, 58.98 ± 2.88 mg GAE/g sample in the FRAP test, 79.53 ± 5.61 mg GAE/g sample in the test of total phenolics, was not cytotoxic, and MIC 3 mg/mL against Staphylococcus aureus. This extract was incorporated into a stable formulation and preferred by 88% of volunteers. At last, a scratch assay exhibited the formulation promoted cell migration after 24 h, therefore, increased scratch retraction. In this way, it was possible to develop a phytocosmetic with the coffee pulp that showed desirable antioxidant, antimicrobial and healing properties.

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BACKGROUND: Given the rising occurrence of antibiotic resistance due to the existence and ongoing development of resistant bacteria and phenotypes, the identification of new treatments and sources of antimicrobial agents is of utmost urgency. An important strategy for tackling bacterial resistance involves the utilization of drug combinations, and natural products derived from plants hold significant potential as a rich source of bioactive compounds that can act as effective adjuvants. This study, therefore, aimed to assess the antibacterial potential and the chemical composition of Miconia albicans, a Brazilian medicinal plant used to treat various diseases. METHODS: Ethanolic extracts from leaves and stems of M. albicans were obtained and subsequently partitioned to give the corresponding hexane, chloroform, ethyl acetate, and hydromethanolic phases. All extracts and phases had their chemical constitution investigated by HPLC-DAD-MS/MS and GC-MS and were assessed for their antibiofilm and antimicrobial efficacy against Staphylococcus aureus. Furthermore, their individual effects and synergistic potential in combination with antibiotics were examined against clinical strains of both S. aureus and Acinetobacter baumannii. In addition, 10 isolated compounds were obtained from the leaves phases and used for confirmation of the chemical profiles and for antibacterial assays. RESULTS: Based on the chemical profile analysis, 32 compounds were successfully or tentatively identified, including gallic and ellagic acid derivatives, flavonol glycosides, triterpenes and pheophorbides. Extracts and phases obtained from the medicinal plant M. albicans demonstrated synergistic effects when combined with the commercial antibiotics ampicillin and ciprofloxacin, against multi-drug resistant bacteria S. aureus and A. baumannii, restoring their antibacterial efficacy. Extracts and phases also exhibited antibiofilm property against S. aureus. Three key compounds commonly found in the samples, namely gallic acid, quercitrin, and corosolic acid, did not exhibit significant antibacterial activity when assessed individually or in combination with antibiotics against clinical bacterial strains. CONCLUSIONS: Our findings reveal that M. albicans exhibits remarkable adjuvant potential for enhancing the effectiveness of antimicrobial drugs against resistant bacteria.

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CONTEXT: Acromegaly is a rare, chronic, debilitating disorder caused by prolonged hypersecretion of growth hormone (GH) and overproduction of insulin-like growth factor I (IGF-I). Medical therapies, including the somatostatin receptor ligand (SRL) pasireotide, are frequently used to restore biochemical control. OBJECTIVE: As patients often receive therapy over prolonged periods, long-term data from real-life settings are needed. METHODS: A retrospective analysis was performed using a prospectively maintained database of all patients with acromegaly from our primary care center who were enrolled in clinical studies with pasireotide (first visit November 2008). The main outcome measures were safety and biochemical control (age-adjusted IGF-I ≤ upper limit of normal). RESULTS: Patients (n = 50) entered 4 parental studies and 30 continued in the rollover; at data cutoff (June 2022), 27 were still receiving pasireotide. Overall, median (range) exposure was 58 (3-137) months. Normal IGF-I was achieved in 54%, and acromegaly symptoms and quality of life were improved with treatment. No predictors of pasireotide response were identified; however, controlled patients had smaller tumors and lower GH at baseline. Tumor volume reduction occurred in 63% of evaluable patients (n = 10/16). Most patients presented hyperglycemic events, including 63.2% of patients with normal glucose before treatment. Older patients and those with higher IGF-I, glucose, and HbA1c at baseline had higher glucose and HbA1c during pasireotide treatment. CONCLUSION: Pasireotide provided clinical benefit and was well tolerated for more than 11 years of treatment in acromegaly patients, most of whom were resistant to first-generation SRLs.

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The present study assessed the personality characteristics of children and adolescents with anxiety disorder from a maternal perspective. A total of 48 children and adolescents aged between 8 and 17 years participated in this study, which was organized as follows: a clinical group (24 children and adolescents with anxiety disorders and their respective mothers) and a control group (24 children and adolescents without psychiatric diagnosis and their mothers). The participants were submitted to the WASI, CBCL, MASC-2, and EPQ-J tests and their mothers to the SRQ-20 and PIC-2 tests. The results showed higher rates of internalizing symptoms in the clinical group. In addition, patients showed less interest in hobbies, less adherence to social organizations, impairment in social activities, and commitment to school performance compared to the control group. There was a positive correlation between the mothers' symptoms and each of the following PIC-2 domains: somatic concern (p < 0.01) and psychological discomfort (p < 0.01). In conclusion, youths with AD showed a withdrawn and reserved personality profile, involving distrust of impulses and avoidance of interactions with peers. Furthermore, psychoemotional problems of mothers adversely influenced the perception followed by anxiety and adjustment characteristics. More studies are needed to assess the maternal personality in youths with anxiety.

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Many plants are used by the population through popular knowledge passed from generation to generation for the treatment of various diseases. However, there is not always any scientific content supporting these uses, which is very important for safety. One of these plants is the fruit of the Spondias genus, which during its processing generates various residues that are discarded, but which also have pharmacological properties. The focus of this review is to survey the pharmacological activities that Spondias genus shows, as well as which part of the plant is used, since there is a lot of richness in its by-products, such as leaf, bark, resin, seed, and peel, which are discarded and could be reused. The main activities of this genus are antioxidant, anti-inflammatory, antidiabetic, antifungal, and antiviral, among others. These properties indicate that this genus could be used in the treatment of several diseases, but there are still not many products available on the market that use this genus as an active ingredient.

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Achieving the best possible outcome for the therapy is the main goal of a medicine. Therefore, nanocarriers and co-delivery strategies were invented to meet this need, as they can benefit many diseases. This approach was applied specifically for cancer treatment, with some success. However, these strategies may benefit many other clinical issues. Skin is the largest and most exposed organ of the human body, with physiological and psychological properties. Due to its exposition and importance, it is not difficult to understand how many skin diseases may impact on patients' lives, representing an important burden for society. Thus, this review aims to summarize the state of the art in research concerning nanocarriers and co-delivery strategies for topical agents' applications targeting skin diseases. The challenge for the medicine of the future is to deliver the drug with spatial and temporal control. Therefore, the co-encapsulation of drugs and the appropriate form of administration for them are so important and remain as unmet needs.

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This paper provides a review of the literature on the use of Pluronic® triblock copolymers for drug encapsulation over the last 10 years. A special focus is given to the progress of drug delivery systems (e.g., micelles, liposomes, micro/nanoemulsions, hydrogels and nanogels, and polymersomes and niosomes); the beneficial aspects of Pluronic® triblock copolymers as biological response modifiers and as pharmaceutical additives, adjuvants, and stabilizers, are also discussed. The advantages and limitations encountered in developing site-specific targeting approaches based on Pluronic-based nanostructures in cancer treatment are highlighted, in addition to innovative examples for improving tumor cytotoxicity while reducing side effects.

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Wound healing is known to be a complicated and intricate process and commonly classified as chronic or acute. Patients with chronic wounds are of public health concern, and require more attention onto skin lesions, including atopic dermatitis. Despite being a natural process, healing can be impaired by existing chronic de diseases such as diabetes, for example. Recently, wound dressings based in nanotechnology systems have emerged as a viable option to improve the healing process. Current advances in nanotechnology-based systems to release growth factors and bioactive agents represent a great opportunity to develop new therapies for wound treatments. It is essential that healthcare professionals understand the key processes involved in the healing cascade, to maximize care with these patients and minimize the undesirable outcomes of non-healing wounds. Therefore, this review aims to summarize the healing process phases and provide a general overview of dressings based in nanotechnology using biomaterials for the release of active agents in wound site.

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BACKGROUND: In the context of changing cannabis and other drug policy and regulation, concerns may arise regarding drug treatment access and use. We assessed cannabis/cocaine-related dependence and treatment in Argentina, Chile, and Uruguay. METHODS: Nationally representative cross-sectional household surveys of people ages 15-64 in Argentina (4 surveys, 2006-2017), Chile (7 surveys, 2006-2018), and Uruguay (4 surveys, 2006-2018) were harmonized. We estimated weighted prevalences of cannabis or cocaine-related (cocaine or cocaine paste) dependence, based on meeting 3+ past-year ICD-10 dependence criteria. We estimated weighted prevalences of past-year alcohol/drug treatment use (Argentina, Chile) or use/seeking (Uruguay) among people with past-year cannabis/cocaine-related dependence. We tested model-based prevalence trends over time and described individual-level treatment correlates by country. RESULTS: Cannabis/cocaine dependence prevalence increased in the region starting in 2010-2011, driven by cannabis dependence. Adjusted cannabis dependence prevalence increased from 0.7% in 2010 to 1.5% in 2017 in Argentina (aPD=0.8, 95% CI= 0.3, 1.2), from 0.8% in 2010 to 2.8% in 2018 in Chile (aPD=2.0, 95% CI= 1.4, 2.6), and from 1.4% in 2011 to 2.4% in 2018 in Uruguay (aPD=0.9, 95% CI= 0.2, 1.6). Cocaine-related dependence increased in Uruguay, decreased in Argentina, and remained stable in Chile. Among people with past-year cannabis/cocaine dependence, average alcohol/drug treatment use prevalence was 15.3% in Argentina and 6.0% in Chile, while treatment use/seeking was 14.7% in Uruguay. Alcohol/drug treatment prevalence was lower among people with cannabis dependence than cocaine-related dependence. Treatment correlates included older ages in all countries and male sex in Argentina only. CONCLUSION: Alcohol/drug treatment use among people with cannabis/cocaine-related dependence remained low, signaling an ongoing treatment gap in the context of growing cannabis dependence prevalence in the region. Additional resources may be needed to increase treatment access and uptake. Future studies should assess contributors of low treatment use, including perceived need, stigma, and service availability.

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Rosmarinus officinalis belongs to the Lamiaceae family, and its constituents show antioxidant, anti-inflammatory, antidepressant, antinociceptive, and antibacterial properties. The aim of this study was to develop a topical formulation with R. officinalis extract that had antimicrobial and antioxidant activity. Maceration, infusion, Soxhlet, and ultrasound were used to produce rosemary extracts, which were submitted to antioxidant, compound quantification, cell viability, and antimicrobial assays. Infusion and Soxhlet showed better results in the DPPH assay. During compound quantification, infusion showed promising metabolite extraction in phenolic compounds and tannins, although maceration was able to extract more flavonoids. The infusion and ultrasound extracts affected more strains of skin bacteria in the disk diffusion assays. In the minimum inhibitory concentration assay, the infusion extract showed results against S. aureus, S. oralis, and P. aeruginosa, while ultrasound showed effects against those three bacteria and E. coli. The infusion extract was chosen to be incorporated into a green emulsion. The infusion extract promoted lower spreadability and appropriated the texture, and the blank formulation showed high levels of acceptance among the volunteers. According to the results, the rosemary extract showed promising antioxidant and antimicrobial activity, and the developed formulations containing this extract were stable for over 90 days and had acceptable characteristics, suggesting its potential use as a phytocosmetic. This paper reports the first attempt to produce an oil-in-water emulsion using only natural excipients and rosemary extract, which is a promising novelty, as similar products cannot be found on the market or in the scientific literature.

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RESUMO Objetivo: identificar os fatores relacionados aos sintomas depressivos em pessoas idosas com diabetes mellitus. Método: pesquisa transversal, com abordagem quantitativa e realizada com a participação de 144 pessoas idosas cadastradas em 72 Unidades Saúde da Família do município de João Pessoa, Paraíba, Brasil. Os dados foram coletados no período de setembro a dezembro de 2019, utilizando instrumento para a obtenção de dados referentes ao perfil sociodemográfico e clínico e a Escala de Depressão Geriátrica mediante estatística descritiva e inferencial. Resultados: observou-se que 75,7% dos idosos com diabetes não tinham sintomas depressivos. Foi evidenciada associação significativa entre a sintomatologia depressiva e as variáveis renda pessoal (p=0,044), tipo de renda (p=0,020), dislipidemia (p=0,038), complicações do diabetes (p=0,045) e a retinopatia (p=0,033). Conclusão: os fatores sociais, de saúde e relacionados ao diabetes podem influenciar negativamente a condição psíquica da pessoa idosa e favorecer o surgimento de sintomas depressivos.

ABSTRACT Objective: to identify the factors related to depressive symptoms in older adults with Diabetes Mellitus. Method: a cross-sectional study with a quantitative approach conducted with 144 older adults registered in 72 Family Health units from the municipality of João Pessoa, Paraíba, Brazil. The data were collected from September to December 2019, using an instrument to obtain information referring to the sociodemographic and clinical profile and the Geriatric Depression Scale by means of descriptive and inferential statistics. Results: it was observed that 75.7% of the diabetic older adults did not present depressive symptoms. There was a significant association between depressive symptoms and the following variables: personal income (p=0.044), type of income (p=0.020), dyslipidemia (p=0.038), diabetes complications (p=0.045) and retinopathy (p=0.033). Conclusion: the social and health factors, as well as those related to diabetes, can exert negative influences on older adults' psychological state and favor the onset of depressive symptoms.

RESUMEN Objetivo: identificar los factores relacionados con síntomas depresivos en ancianos con Diabetes Mellitus. Método: investigación transversal, de enfoque cuantitativo y realizada con la participación de 144 adultos mayores registrados en 72 unidades de Salud de la Familia del municipio de João Pessoa, Paraíba, Brasil. Los datos se recolectaron entre septiembre y diciembre de 2019, utilizando un instrumento para obtener datos sobre el perfil sociodemográfico y clínico y la Escala de Depresión Geriátrica mediante estadística descriptiva e inferencial. Resultados: se observó que el 75,7% de los ancianos que padecían diabetes no tenían síntomas depresivos. Se registró una asociación significativa entre los síntomas depresivos y las variables ingresos personales (p=0,044), tipo de ingresos (p=0,020), dislipidemia (p=0,038), complicaciones de la diabetes (p=0,045) y retinopatía (p=0,033). Conclusión: los factores sociales, de salud y relacionados con la diabetes pueden ejercer influencias negativas sobre el estado psicológico de los ancianos y favorece la aparición de síntomas depresivos.

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Este trabalho teve como objetivo a caracterização nutricional (umidade, proteínas, lipídeos, cinzas e açúcares totais), quantificação do Valor Energético Total (VET) e determinação do teor de carotenoides totais dos frutos de cajuzinho do cerrado (Anacardium humile A.St.-Hil.), curriola (Pouteria ramiflora (Mart.) Radlk) e inharé (Brosimum gaudichaudii Trécul), do Cerrado mato grossense. No intuito de oferecer uma alternativa de dieta nutritiva e incentivar o reaproveitamento de alimentos, foram analisadas polpas e cascas destes frutos. O cajuzinho do cerrado apresentou expressiva quantidade de carotenoides totais nas polpas (5,95 mg/100g) e cascas (6,55 mg/100g). Já a curriola apresentou um valor considerável de cinzas (0,66%) nas polpas e mostraram quantidade significativa de Valor Energético Total (80,96 Kcal/100g). O inharé destacou-se por apresentar elevado teor de proteínas nas cascas (3,76%) e polpas (3,19%). Estes resultados mostraram que polpas e cascas dos frutos analisados, podem ser utilizadas como fonte de nutrientes ou como ingredientes na elaboração de novos alimentos com potencial funcional. Este é o primeiro estudo que avalia o potencial nutricional e carotenoides totais nas cascas destes frutos do Cerrado mato grossense.(AU)

This study aimed at performing the nutritional characterization (moisture, protein, lipid, ashes and total sugar), quantification of the Total Energy Value (TEV) and determination of carotenoid content of cajuzinho do cerrado (Anacardium humile A.St.-Hil.), curriola (Pouteria ramiflora (Mart.) Radlk) and inharé (Brosimum gaudichaudii Trécul), of the Midwestern Cerrado. Aiming at offering a nutritious alternative of diet and motivating the reuse of foods, the pulps and peels of fruits were analyzed. Cajuzinho do cerrado showed expressive amount of total carotenoids in the pulps (5.95 mg/100g) and peels (6.55 mg/100g). The curriola presented a considerable amount of ash (0.66%) in the pulps and a significant amount of Total Energy Value (80.96 Kcal/100g). On the other hand, the inharé had a high amount of protein in the peels (3.76%) and pulps (3.19%). These results showed that pulps and peels of the analyzed fruits can be used as source of nutrients or as ingredients in the manufacture of new functional foods. This is the first report which evaluates the nutritional potential and total carotenoids in peels of fruits from Midwestern Cerrado.(AU)

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In Brazil, there is a large diversity of species of small edible fruits that are considered sources of nutrients and functional properties. They present a high innovation domain for the pharmaceutical, cosmetic and food industries due to their health-promoting properties. Edible fruits from Brosimum gaudichaudii (Moraceae) are widely consumed and used in folk medicine and in feed by the population of the Brazilian Cerrado. Nevertheless, detailed information on the chemical fingerprint, antiradical activity and safety aspects of these fruits is still unknown. Thus, the aim of this work was to investigate the bioactive compounds of hydroethanolic extracts of fruits from Brosimum gaudichaudii using high-performance liquid chromatography combined with mass spectrometry using electrospray ionization (HPLC ESI-MS). Eighteen different compounds, including flavonoids, coumarins, arylbenzofurans, terpenoids, stilbenes, xanthones and esters, were detected. Moreover, the study indicated that the hydroethanolic extract of fruits from B. gaudichaudii presented low scavenging activity against 2,2-diphenyl-1-picrylhydrazyl radicals (IC50 >800 µg mL-1 ) and was cytotoxic (IC50 <30 µg mL-1 ) in Chinese hamster ovary cells (CHO-K1) by an in vitro assay. This is the first report of the chemical profile, antioxidant activity and cytotoxic properties of the hydroethanolic extract of fruits from B. gaudichaudii.

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Consumers are attracted to the latest fashion trends and different looks. This drives the search for novel hair treatments. Some chemicals present in hair treatment products can penetrate the hair shaft. These materials can either nourish or injure the hair cortex. Different techniques have been used to investigate the mechanism of molecule penetration and the conditions under which penetration occurs. This article reviews the techniques applied for this purpose. Various microscopy techniques are used to capture clear and colourful images to determine the diffusion pathways and the exact location of the molecules under study. However, the laborious sample preparation often leads to sample destruction since cross-sectioning is often required. While various other techniques have been successfully used for investigating the penetration methods, most of these require different amounts of work to be put in for sample preparation and instrumentation. Several spectroscopic techniques have been used to study the penetration of the molecules because of the high levels of accuracy and the quick response time of these techniques. Moreover, the samples are not damaged during the investigation.

Les consommateurs sont attirés par les dernières tendances et les différents styles de la mode. Cela stimule la recherche pour de nouveaux traitements capillaires. Certains produits chimiques présents dans les produits de soins capillaires peuvent pénétrer la tige du cheveu. Ils peuvent tantôt nourrir, tantôt endommager le cortex pileux. Différentes techniques ont été utilisées pour étudier le mécanisme de pénétration des molécules et les conditions dans lesquelles cette pénétration a lieu. Cet article examine les techniques appliquées à cette fin. Diverses techniques de microscopie sont mises en œuvre pour capturer des images claires et colorées afin de déterminer les voies de diffusion et la localisation exacte des molécules à l'étude. Cependant, la préparation laborieuse des échantillons conduit fréquemment à la destruction des échantillons, car une coupe transversale est souvent exigée. Si plusieurs autres techniques ont été utilisées avec succès pour étudier les méthodes de pénétration, la plupart d'entre elles nécessitent différents niveaux d'activité à mettre en œuvre pour la préparation des échantillons et l'instrumentation. Plusieurs techniques spectroscopiques ont été utilisées pour étudier la pénétration des molécules en raison de leurs niveaux élevés de précision et de leur délai de réponse rapide. De plus, les échantillons ne sont pas endommagés pendant l'investigation.

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RESUMO Objetivo: correlacionar a ansiedade, a depressão e o estresse com o bem-estar em cuidadores de pessoas com sequelas de acidente vascular encefálico. Método: estudo transversal e quantitativo realizado com 151 cuidadores informais primários de pessoas com sequela de acidente vascular encefálico. Dados coletados por meio de entrevistas realizadas em domicílios, utilizando-se instrumento estruturado para levantamento de informações sociodemográficas e as Escala de Ansiedade, Depressão e Estresse-21 e Bem-Estar Subjetivo. Realizou-se análise descritiva e inferencial com nível de significância de 5%. Resultados: a maioria dos cuidadores apresentou níveis normais de ansiedade (n=115), depressão (n=116) e estresse (n=120). A maior média de bem-estar subjetivo foi sobre as experiências negativas, refletindo bem-estar total negativo. Observaram-se correlações significativas (p≤0,05) entre o bem-estar subjetivo positivo e negativo e a ansiedade, depressão e o estresse. Conclusão: evidenciou-se que o bem-estar subjetivo dos cuidadores analisados apresentou correlação com os estados emocionais de ansiedade, depressão e estresse.

RESUMEN Objetivo: correlacionar la ansiedad, la depresión y el estrés con el bienestar de los cuidadores de personas con secuelas de accidente cerebrovascular. Método: estudio transversal y cuantitativo realizado con 151 cuidadores primarios informales de personas con secuelas de accidente cerebrovascular. Datos recolectados a través de entrevistas realizadas en hogares, utilizando un instrumento estructurado de relevamiento de información sociodemográfica y la Escala de Ansiedad, Depresión y Estrés-21 y Bienestar Subjetivo. Se realizó análisis descriptivo e inferencial con un nivel de significancia del 5%. Resultados: la mayoría de los cuidadores presentaron niveles normales de ansiedad (n = 115), depresión (n = 116) y estrés (n = 120). El promedio más alto de bienestar subjetivo se registró en experiencias negativas, lo que refleja un bienestar general negativo. Se observaron correlaciones significativas (p≤0.05) entre el bienestar subjetivo positivo y negativo y la ansiedad, depresión y estrés. Conclusión: se evidenció que el bienestar subjetivo de los cuidadores analizados se correlacionó con los estados emocionales de ansiedad, depresión y estrés.

ABSTRACT Objective: to correlate anxiety, depression, and stress with well-being in caregivers of people with stroke sequelae. Method: cross-sectional and quantitative study carried out with 151 informal primary caregivers of people with stroke sequelae. Data collected through interviews carried out in households, using a structured instrument for surveying sociodemographic information and the Scale of Anxiety, Depression and Stress-21 and Subjective Well-Being. Descriptive and inferential analysis was performed with a significance level of 5%. Results: most caregivers had normal levels of anxiety (n=115), depression (n=116) and stress (n=120). The highest average of subjective well-being was on negative experiences, reflecting negative overall well-being. Significant correlations (p≤0.05) were observed between positive and negative subjective well-being and anxiety, depression, and stress. Conclusion: it was evidenced that the subjective well-being of the analyzed caregivers was correlated with the emotional states of anxiety, depression, and stress.

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RESUMO Objetivo: associar a competência em comunicação interpessoal ao perfil clínico e os aspectos relacionados ao trabalho dos enfermeiros. Método: estudo transversal, com abordagem quantitativa, realizado com 152 enfermeiros de um hospital universitário em João Pessoa, Paraíba, Brasil. Os dados foram coletados mediante a utilização de um instrumento para obtenção dos dados sociodemográficos, condições de saúde e aspectos relacionados ao trabalho e da Escala de Competência em Comunicação Interpessoal. Foram realizados os testes Mann-Whitney e Kruskal-Wallis para avaliar associação/preditores. Resultados: os enfermeiros apresentaram médias elevadas de competência em comunicação interpessoal (61,50±7,31). Foram observadas associações significativas (p≤0,05) entre a competência em comunicação interpessoal e as variáveis prática de atividade física (p=0,027), consumo de bebidas alcoólicas (p=0,002), doenças do sistema osteomuscular e do tecido conjuntivo (p=0,001), transtornos mentais e comportamentais (p=0,021), uso de analgésicos (p=0,001), anti-inflamatórios (p=0,001), medicamentos que atuam no sistema digestivo (p=0,003) e treinamento (p=0,031). Conclusão: a competência em comunicação interpessoal é influenciada pelas condições de saúde dos enfermeiros e pelas características do trabalho desempenhado.

RESUMEN Objetivo: asociar la competencia en comunicación interpersonal con el perfil clínico y aspectos relacionados con el trabajo del enfermero. Método: estudio transversal con abordaje cuantitativo, realizado con 152 enfermeros de un hospital universitario de João Pessoa, Paraíba, Brasil. Los datos se recolectaron mediante el uso de un instrumento para la obtención de datos sociodemográficos, condiciones de salud y aspectos relacionados con el trabajo y la Escala de Competencia de Comunicación Interpersonal. Se realizaron pruebas de Mann-Whitney y Kruskal-Wallis para evaluar asociación / predictores. Resultados: los enfermeros presentaron altos promedios de competencia en comunicación interpersonal (61,50 ± 7,31). Se observaron asociaciones significativas (p≤0.05) entre la competencia en la comunicación interpersonal y las variables práctica de actividad física (p = 0.027), consumo de alcohol (p = 0.002), enfermedades del sistema osteomuscular y del tejido conjuntivo (p = 0.001), trastornos mentales y del comportamiento (p = 0,021), uso de analgésicos (p = 0,001), antiinflamatorios (p = 0,001), fármacos que actúan sobre el sistema digestivo (p = 0,003) y entrenamiento (p = 0,031). Conclusión: la competencia en la comunicación interpersonal está influenciada por las condiciones de salud de los enfermeros y las características del trabajo realizado.

ABSTRACT Objective: to associate competence in interpersonal communication with the clinical profile and aspects related to the nurses' work. Method: cross-sectional study with a quantitative approach, carried out with 152 nurses from a university hospital in João Pessoa, Paraíba, Brazil. Data were collected using an instrument to obtain sociodemographic data, health conditions and aspects related to work and the Interpersonal Communication Competence Scale. Mann-Whitney and Kruskal-Wallis tests were performed to assess association/predictors. Results: nurses had high averages of competence in interpersonal communication (61.50±7.31). Significant associations (p≤0.05) were observed between competence in interpersonal communication and the variables physical activity practice (p=0.027), alcohol consumption (p=0.002), musculoskeletal system and connective tissue diseases (p=0.001), mental and behavioral disorders (p=0.021), use of analgesics (p=0.001), anti-inflammatory drugs (p=0.001), drugs that act on the digestive system (p=0.003) and training (p=0.031). Conclusion: competence in interpersonal communication is influenced by the health conditions of nurses and the characteristics of the work performed.

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Este trabalho teve como objetivo a caracterização nutricional (umidade, proteínas, lipídeos, cinzas e açúcares totais), quantificação do Valor Energético Total (VET) e determinação do teor de carotenoides totais dos frutos de cajuzinho do cerrado (Anacardium humile A.St.-Hil.), curriola (Pouteria ramiflora (Mart.) Radlk) e inharé (Brosimum gaudichaudii Trécul), do Cerrado mato grossense. No intuito de oferecer uma alternativa de dieta nutritiva e incentivar o reaproveitamento de alimentos, foram analisadas polpas e cascas destes frutos. O cajuzinho do cerrado apresentou expressiva quantidade de carotenoides totais nas polpas (5,95 mg/100g) e cascas (6,55 mg/100g). Já a curriola apresentou um valor considerável de cinzas (0,66%) nas polpas e mostraram quantidade significativa de Valor Energético Total (80,96 Kcal/100g). O inharé destacou-se por apresentar elevado teor de proteínas nas cascas (3,76%) e polpas (3,19%). Estes resultados mostraram que polpas e cascas dos frutos analisados, podem ser utilizadas como fonte de nutrientes ou como ingredientes na elaboração de novos alimentos com potencial funcional. Este é o primeiro estudo que avalia o potencial nutricional e carotenoides totais nas cascas destes frutos do Cerrado mato grossense. (AU)

This study aimed at performing the nutritional characterization (moisture, protein, lipid, ashes and total sugar), quantification of the Total Energy Value (TEV) and determination of carotenoid content of cajuzinho do cerrado (Anacardium humile A.St.-Hil.), curriola (Pouteria ramiflora (Mart.) Radlk) and inharé (Brosimum gaudichaudii Trécul), of the Midwestern Cerrado. Aiming at offering a nutritious alternative of diet and motivating the reuse of foods, the pulps and peels of fruits were analyzed. Cajuzinho do cerrado showed expressive amount of total carotenoids in the pulps (5.95 mg/100g) and peels (6.55 mg/100g). The curriola presented a considerable amount of ash (0.66%) in the pulps and a significant amount of Total Energy Value (80.96 Kcal/100g). On the other hand, the inharé had a high amount of protein in the peels (3.76%) and pulps (3.19%). These results showed that pulps and peels of the analyzed fruits can be used as source of nutrients or as ingredients in the manufacture of new functional foods. This is the first report which evaluates the nutritional potential and total carotenoids in peels of fruits from Midwestern Cerrado. (AU)

Assuntos

RESUMO

Este trabalho teve como objetivo a caracterização nutricional (umidade, proteínas, lipídeos, cinzas e açúcares totais), quantificação do Valor Energético Total (VET) e determinação do teor de carotenoides totais dos frutos de cajuzinho do cerrado (Anacardium humile A.St.-Hil.), curriola (Pouteria ramiflora (Mart.) Radlk) e inharé (Brosimum gaudichaudii Trécul), do Cerrado mato grossense. No intuito de oferecer uma alternativa de dieta nutritiva e incentivar o reaproveitamento de alimentos, foram analisadas polpas e cascas destes frutos. O cajuzinho do cerrado apresentou expressiva quantidade de carotenoides totais nas polpas (5,95 mg/100g) e cascas (6,55 mg/100g). Já a curriola apresentou um valor considerável de cinzas (0,66%) nas polpas e mostraram quantidade significativa de Valor Energético Total (80,96 Kcal/100g). O inharé destacou-se por apresentar elevado teor de proteínas nas cascas (3,76%) e polpas (3,19%). Estes resultados mostraram que polpas e cascas dos frutos analisados, podem ser utilizadas como fonte de nutrientes ou como ingredientes na elaboração de novos alimentos com potencial funcional. Este é o primeiro estudo que avalia o potencial nutricional e carotenoides totais nas cascas destes frutos do Cerrado mato grossense.

This study aimed at performing the nutritional characterization (moisture, protein, lipid, ashes and total sugar), quantification of the Total Energy Value (TEV) and determination of carotenoid content of cajuzinho do cerrado (Anacardium humile A.St.-Hil.), curriola (Pouteria ramiflora (Mart.) Radlk) and inharé (Brosimum gaudichaudii Trécul), of the Midwestern Cerrado. Aiming at offering a nutritious alternative of diet and motivating the reuse of foods, the pulps and peels of fruits were analyzed. Cajuzinho do cerrado showed expressive amount of total carotenoids in the pulps (5.95 mg/100g) and peels (6.55 mg/100g). The curriola presented a considerable amount of ash (0.66%) in the pulps and a significant amount of Total Energy Value (80.96 Kcal/100g). On the other hand, the inharé had a high amount of protein in the peels (3.76%) and pulps (3.19%). These results showed that pulps and peels of the analyzed fruits can be used as source of nutrients or as ingredients in the manufacture of new functional foods. This is the first report which evaluates the nutritional potential and total carotenoids in peels of fruits from Midwestern Cerrado.

Assuntos

RESUMO

Permeation of sunscreens agents reduces its effectiveness and safety, leading to systemic circulation and causing unknown adverse effects. In order to maintain the sunscreen efficacy and safety, the filters must stay on the skin surface, with minimum penetration through dermis. Even facing the possibility of filters permeation, the use of sunscreen is important to avoid skin damage as erythema, free-radicals formation, skin ageing and skin cancer, caused by ultraviolet radiation. Aiming potential side effects caused by topical absorption of sunscreens, studies are carried to improve formulation characteristics and stability, reduce skin permeation and evaluate sun protections factor (SPF). Current assays to detect the permeation of sunscreens involve in vivo or in vitro studies, to simulate physiological conditions of use. The aim of this review is to revisit sunscreen skin permeation data over the last decade and the factors that can enhance skin permeation or improve the sunscreen efficacy.

Assuntos