RESUMO
Rural communities comprise around 20% of Caribbean and South American populations, but are under-represented in autosomal marker databases. That deficiency is problematic for forensic genetics, as it relies on accurate descriptions of genetic variation and population structure. Brazilian populations were shaped by an intense, complex and heterogeneous process of admixture encompassing mainly Amerindians, Sub-Saharan Africans and Europeans. Quilombos are Brazilian populations with significant African descent that have remained genetically isolated to some extent from surrounding populations. In the reported study, we analyzed three rural Quilombo populations: Kalunga; Riacho de Sacutiaba e Sacutiaba; and Mocambo, along with a dataset from the HGDP-CEPH panel. Aiming to contribute to representative genetic databases of forensic interest, we analyse the three rural Quilombos populations and investigate how their genetic makeup relates to their history by analyzing an established forensic test, comprising 46 ancestry-informative (AIM) Indels. The panel was chosen for its high power in differentiating the main contributing populations of Brazil. Parental populations were selected from HGDP-CEPH data available at the forInDel allele frequency browser based on historic patterns applicable to the study populations and the amount of variability observed within and between continents. Our results show the main admixture components in the Quilombos are African and European. Those estimates are in accordance with previous analyses for both uniparental and autosomal markers. PCA, structure analysis and ancestry estimates indicate a correlation between the extent of isolation and the degree of admixture in the Quilombos: Kalunga is the most isolated population and accordingly has a higher African admixture component (67.3%). Sacutiaba is the smallest and most impacted by migration, with the highest European component (46.8%). Mocambo neighbors a Native American population and therefore has the highest Amerindian contribution (12.2%). Our results are consistent with the history and demography of Quilombos. The heterogeneity observed in these populations stresses the genetic diversity that Latin American and Caribbean rural populations can have and reiterates the need to describe them in greater detail.
Assuntos
Etnicidade/genética , Genética Populacional , População Rural , Brasil , Cromossomos Humanos Y , Impressões Digitais de DNA , DNA Mitocondrial/genética , Frequência do Gene , Humanos , Mutação INDEL , Repetições de Microssatélites , Polimorfismo de Nucleotídeo Único , Análise de Componente PrincipalRESUMO
The aim of this study was to systematically review the use of medicinal plants for the treatment of varicose ulcers. The databases used in the search were: Medline/Pubmed, Scopus, Cinhal, Lilacs and Web of Science. The selection process was divided into two phases: the reading of titles and abstracts and the full reading of selected articles. The item description was compared with the checklist of the Consolidated Standards of Reporting Trials. The initial search produced 3505 articles and seven were selected for inclusion in the systematic review. Of the included studies, 7 (100%) evaluated the reduction of the ulcer area, 4 (57·14%) evaluated reepithelisation, 2 (28·57%) evaluated bacterial flora and 1 (14·28%) evaluated the oxygen pressure and percutaneous carbon dioxide. The level of evidence rating indicated that five studies (71·42%) were rated at level 2 and two (28·57%) were rated at level 3. The quality assessment was performed using the Jadad scale, which is prevalent in the literature. The quality score of the Jadad questionnaire ranges from 0 to 5; here, the studies analysed had an average of 2·5. A meta-analysis was performed on two studies that analysed the effects of Mimosa tenuiflora hydrogel in the treatment of venous ulcer and included 42 patients with a mean age of 60·5 years and a mean duration of treatment of 10·5 weeks. Heterogeneity was assessed using I2 ; we obtained a high value of 84%. We concluded that, despite the efficacy of the incorporation of Ageratina pichinchensis into the gel, the hydrogel that incorporated M. tenuiflora appeared to be a promising candidate for the management of venous ulcers.
Assuntos
Antibacterianos/uso terapêutico , Extratos Vegetais/uso terapêutico , Plantas Medicinais/química , Úlcera Varicosa/tratamento farmacológico , Cicatrização/efeitos dos fármacos , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Masculino , Pessoa de Meia-IdadeRESUMO
Constitui objetivo do presente trabalho a caracterizaçäo da prevalência do Diabetes Mellitus Auto-Referido(DMAR) no município de Säo Paulo, obtida a partir do inquérito domiciliar realizado pelo estudo multicêntrico sobre a prevalência do diabetes no Brasil, de 1986 a 1988. A amostra foi composta por 2007 indivíduos de 30 a 69 anos de idade, de ambos os sexos, selecionados em três áreas de distintas condiçöes sociais, nas quais estavam sendo implantados programas assistenciais aos diabéticos. A prevalência, obtida através de glicemia capilar, 2 h após sobrecarga de 75 g de glicose, foi de 9,7 por cento. A prevalência do DMAR foi de 4,7 por cento tendo sido observado aumento de acordo com a idade, e estreita relaçäo com o relato de história familiar de diabetes. Observou-se, ainda, diferença significante segundo o sexo (3,5 por cento na populaçäo masculina e 5,7 por cento na feminina), concentrando-se maiores valores nos níveis sócio-econômicos mais elevados, na populaçäo masculina, e, nos níveis mais baixos, na populaçäo feminina.