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Modeling experts have been continually researching the interplay of human mobility and COVID-19 transmission since the outbreak of the pandemic. They tried to address this problem and support the control of the pandemic spreading at the national or regional levels. However, these modeling approaches had little success in producing empirically verifiable results at the neighborhood level due to a lack of data and limited representation of low spatial scales in the models. To fill this gap, this research aims to present an agent-based model to simulate human mobility choices in the context of COVID-19, based on social activities of individuals in the neighborhood. We apply the VIABLE model to the decision-making process of heterogeneous agents, who populate the system's environment. The agents adapt their mobility and activities autonomously at each iteration to improve their well-being and respond to exposure risks. The study reveals significant temporal variations in mobility choices between the groups of agents with different vulnerability levels under the Covid-19 pandemic. Agents from the same group with similar economic backgrounds tend to select the same mobility patterns and activities leading to segregation at this low scale. We calibrated the model with a focus on Porto Alegre in Brazil.

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This study evaluated the effects of chromium yeast and digestible lysine levels on the performance and carcass characteristics of finishing pigs. Sixty-four barrows with an initial weight of 72.77 ± 7.20 kg and final weight of 119.44 ± 9.47 kg were used, distributed in a 2 x 2 factorial scheme, with two levels of chromium yeast (Cr0: 0 ppb and Cr800: 800 ppb) and two levels of digestible lysine (L0: recommended level and L+10%: 10%). The recorded air temperature of 30.9 ± 3.7 ºC during the experimental period was considered as heat stress. Performance variables were not influenced (P>0.05); however, L+10% showed an increase (P<0.05) in daily digestible lysine intake. Carcass characteristics of the animals were not influenced (P>0.05) by the chromium or digestible lysine levels. Supplementation with 800 ppb of yeast chromium and a 10% increase in the level of digestible lysine, isolated or associated, did not improve the performance and carcass characteristics of finishing pigs, subjected to high ambient temperatures.

Realizou-se este estudo com o objetivo de avaliar os efeitos de níveis de cromo levedura e lisina digestível, desempenho e características de carcaça de suínos em terminação. Foram utilizados 64 machos castrados com peso inicial de 72,77 ± 7,20 kg e final de 119,44 ± 9,47 kg, distribuídos em esquema fatorial 2 x 2, sendo dois níveis (Cr0: 0 ppb e Cr800: 800 ppb) e dois níveis de lisina digestível (L0: nível recomendado e L+10%: 10%). A temperatura do ar registrada de 30,9 ± 3,7 ºC durante o período experimental foi considerada como de estresse por calor. As variáveis de desempenho não foram influenciadas (P>0,05), contudo L+10% aumentou (P<0,05) o consumo de lisina digestível diário. As características de carcaça dos animais não foram influenciadas (P>0,05) pelos níveis de cromo levedura e lisina digestível. A suplementação de 800 ppb de cromo levedura, e o aumento em 10% do nível de lisina digestível, isolados ou associados, não melhoram o desempenho e as características de carcaça de suínos em terminação submetidos a temperaturas ambientais elevadas.

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This study evaluated the effect of dietary net energy (NE) levels on growth performance and carcass characteristics of barrows from 30 to 70 kg of body weight (BW). Sixty barrows with initial body weight (IBW) of 31.94 ± 3.54 kg and final body weight (FBW) of 71.98 ± 5.99 kg were allotted to one of five dietary NE levels (2.40, 2.45, 2.50, 2.55, and 2.60 Mcal kg-¹), using a completely randomized block design with six replicates and two barrows per replicate. The experimental period was divided into phase I: 30 to 50 kg and phase II: 50 to 70 kg. The variables analyzed were average daily feed intake (ADFI), net energy intake (NEI), digestible lysine intake (LysI), average daily gain (ADG), feed conversion (FC), FBW, digestible lysine conversion:gain (LysI:G), Cost:Gain (C:G), loin eye area (LEA), muscle depth (MD), first backfat layer (BF1), second backfat layer (BF2), total backfat (BFt), lean meat percentage, and carcass bonus index (BI). In phase I, there was a linear increase (P < 0.05) in FBW, ADG, NEI, and LysI with increasing NE levels in the diet. In phase II, increasing dietary NE levels also increased (P < 0.05) FBW, ADG, NEI, LysI, and FC linearly. Overall, there was a linear increase (P < 0.05) in ADG, NEI, LysI, and FC with increasing NE levels in the diet. The other performance variables were not affected (P > 0.05) by the NE levels. There was an increase (P < 0.05) in BF2 with increasing NE levels, but the other carcass characteristics were not altered (P > 0.05). We recommended 2.60 Mcal of NE kg-¹ in the diet for growing barrows from 30 to 70 kg.

Realizou-se este estudo com o objetivo de avaliar níveis de energia líquida (EL), mantendo a relação caloria: nutriente, no desempenho e características de carcaça de suínos dos 30 aos 70 kg. Foram utilizados 60 suínos machos castrados, com pesos iniciais de 31,94 ± 3,54 kg e finais de 71,98 ± 5,99 kg. Os animais foram distribuídos em delineamento experimental de blocos casualizados, em cinco níveis de EL (2,40; 2,45; 2,50; 2,55; 2,60 Mcal de EL kg-¹ de dieta), com seis repetições e dois animais por unidade experimental. O período experimental foi dividido em fase I: 30 aos 50 kg e fase II: 50 aos 70 kg. As variáveis analisadas foram os consumos de ração diária (CRD), energia líquida (CEL) e lisina digestível (CLdig), ganho de peso diário (GPD), conversão alimentar (CA), peso final (PF), conversão de lisina digestível: ganho (CLdig:G), custo: ganho (C:G), área de olho de lombo (AOL), profundidade de músculo (PM), espessura de toucinho da primeira camada (ET1), espessura de toucinho da segunda camada (ET2), espessura de toucinho total (ETt), percentual de carne magra (CM) e o índice de bonificação de carcaça (IB). Dos 30 aos 50 kg, verificou-se aumento linear (P < 0,05) do PF, GPD e dos CEL e CLdig com o aumento dos níveis de EL na dieta. Dos 50 aos 70 kg, o aumento dos níveis de EL na dieta promoveu melhora linear (P < 0,05) do PF, GPD, CEL, CLdig e da CA dos suínos. No período total, verificou-se aumento linear (P < 0,05) do GPD, CEL, CLdig e melhora linear (P < 0,05) da CA de acordo com o aumento do nível de EL na dieta. As demais variáveis de desempenho não foram afetadas (P > 0,05) pelos níveis de EL. Verificou-se aumento (P < 0,05) da ET2 de acordo com o aumento do nível de EL, porém sem alterar (P > 0,05) as demais características de carcaça. Recomenda-se o nível 2,60 Mcal de EL kg-¹ de dieta para suínos machos castrados dos 30 aos 70 kg.

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This study evaluated chromium supplements and energy restriction as substitutes for ractopamine in the diets of late finishing gilts. Sixty gilts were used, with initial weights of 98.87 ± 0.25 kg and final weights of 122.69 ± 10.97 kg, distributed in a randomized block design with five diets: control; yeast chromium (0.8 ppm); chromium picolinate (0.48 ppm); ractopamine (20 ppm) and energy restriction (reduction of 150 kcal of EM kg-1 of feed), with six replicates and two animals per experimental unit. Feeding diet containing ractopamine enabled better (P<0.05) feed conversion and greater weights of the hot carcass of the gilts. The diet containing ractopamine exhibited a lower (P<0.05) cost of feed per kilogram of gain and higher economic efficiency, when compared to diets containing chromium and energy restriction; these exhibited better outcomes, compared to the control diet. Diets supplemented with chromium and ractopamine resulted in a higher (P<0.05) percentage and quantity of lean meat and a higher rate of carcass bonus, when compared to the control diet and energy restriction. The energy reduction did not harm the gilts' responses, compared to the control diet. Ractopamine supplementation allowed for a better feed conversion, lower feed cost per kilogram of gain, and a higher economic efficiency index. Supplements of chromium and ractopamine increased the percentage and quantity of lean meat and the bonus index of the carcasses. Therefore, chromium picolinate and chromium yeast are potential substitutes for ractopamine for optimizing the gilts carcass characteristics.

Realizou-se este estudo com o objetivo de avaliar as suplementações de cromo e a restrição energética em substituição a ractopamina para leitoas em terminação tardia. Foram utilizadas 60 leitoas, com pesos inicial de 98,87±0,25 kg e final de 122,69 ± 10,97 kg, distribuídas em delineamento de blocos ao acaso com cinco dietas: controle; cromo levedura (0,8 ppm); picolinato de cromo (0,48 ppm); ractopamina (20 ppm) e restrição energética (redução de 150 kcal de EMkg-1 de ração), com seis repetições e dois animais por unidade experimental. A dieta contendo ractopamina proporcionou melhor (P<0,05) conversão alimentar e maior peso de carcaça quente das leitoas. A dieta contendo ractopamina apresentou menor (P<0,05) custo de ração por quilograma de ganho e maior índice de eficiência econômica em relação as dietas contendo cromo e restrição energética que, por sua vez, foram superiores em comparação a dieta controle. Dietas suplementadas com cromo e ractopamina apresentaram maior (P<0,05) percentual e quantidade de carne magra e maior índice de bonificação de carcaça em relação a dieta controle e restrição energética. Concluiu-se que a redução energética não prejudica as respostas das leitoas em relação a dieta controle. A suplementação de ractopamina possibilita melhor conversão alimentar, menor custo de ração por quilograma de ganho e maior índice de eficiência econômica. As suplementações de cromo e ractopamina expressam aumento do percentual e quantidade de carne magra e do índice de bonificação das carcaças. O picolinato de cromo e o cromo levedura são potenciais substitutos a ractopamina para otimizar as características de carcaça das leitoas.

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Co-encapsulation of anticancer drugs paclitaxel and imatinib in nanocarriers is a promising strategy to optimize cancer treatment. Aiming to combine the cytotoxic and antiangiogenic properties of the drugs, a liposome formulation targeted to folate receptor co-encapsulating paclitaxel and imatinib was designed in this work. An efficient method was optimized for the synthesis of the lipid anchor DSPE-PEG(2000)-folic acid (FA). The structure of the obtained product was confirmed by RMN, FT-IR, and ESI-MS techniques. A new analytical method was developed and validated for simultaneous quantification of the drugs by liquid chromatography. Liposomes, composed of phosphatidylcholine, cholesterol, and DSPE-mPEG(2000), were prepared by extrusion. Their surface was modified by post-insertion of DSPE-PEG(2000)-FA. Reaction yield for DSPE-PEG(2000)-FA synthesis was 87%. Liposomes had a mean diameter of 122.85 ± 1.48 nm and polydispersity index of 0.19 ± 0.01. Lyophilized formulations remained stable for 60 days in terms of size and drug loading. FA-targeted liposomes had a higher effect on MCF7 cell viability reduction (p < 0.05) when compared with non-targeted liposomes and free paclitaxel. On PC-3 cells, viability reduction was greater (p < 0.01) when cells were exposed to targeted vesicles co-encapsulating both drugs, compared with the non-targeted formulation. VEGF gene expression was reduced in MCF7 and PC-3 cells (p < 0.0001), with targeted vesicles exhibiting better performance than non-targeted liposomes. Our results demonstrate that multifunctional liposomes associating molecular targeting and multidrug co-encapsulation are an interesting strategy to achieve enhanced internalization and accumulation of drugs in targeted cells, combining multiple antitumor strategies.

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This study was conducted to evaluate nutritional plans of digestible phosphorus for barrows weighing between 30 and 100 kg. Eighty animals were distributed in a randomized block design with five nutritional plans containing 2.19-1.86-1.71, 2.57-2.23-2.09, 2.94-2.61-2.46, 3.32-2.99-2.84, and 3.70-3.36-3.32 g of digestible phosphorus kg−1 of diet, respectively, for the phases of 30 to 50 kg, 50 to 70 kg, and 70 to 100 kg, with eight replications and two barrows per experimental unit. The nutritional plans of digestible phosphorus had no effect on the final body weight, feed intake, daily weight gain, or feed conversion of barrows. The daily intake of digestible phosphorus increased with the dietary concentrations of digestible phosphorus. Of the carcass characteristics assessed, only muscle depth responded significantly to the highest concentration of digestible phosphorus, as assessed in barrows sequentially fed the 3.70-3.36-3.32 g kg−1 diet. The nutritional plans had no effect on backfat, rib eye area, or carcass lean tissue mass, percentage, and deposition. The nutritional plan containing 2.19-1.86-1.71 g kg−1 of digestible phosphorus meet the nutrient requirements for performance and carcass characteristics of barrows weighing from 30 to 100 kg.(AU)

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This study was conducted to evaluate the effects of net energy levels on the lipid profile of adipose tissue and muscle of swines. A total of 90 animals, with initial weight of 71.94±4.43kg, were used, and distributed in a randomized block design in five net energy levels (2,300, 2,425, 2,550, 2,675, and 2,800Kcal kg-1 feed), with nine replicates and two animals per experimental unit. Lipid profiles of adipose tissue and muscle were analyzed using gas chromatography. Increasing the levels of net energy using soybean oil, improved the lipid profile of adipose tissue and muscle, increased linearly (P 0.05) the concentrations of polyunsaturated fatty acids, especially linoleic and -linolenic acid, reduced linearly (P 0.05) the monounsaturated and saturated fatty acids and omega 6: omega 3. In adipose tissue was observed linear reduction (P 0.05) of atherogenic and thrombogenic indexes. In conclusion, increasing the level of net energy of the diet using soybean oil improved the lipid profile of adipose tissue and muscle.(AU)

Este estudo foi conduzido com o objetivo de avaliar o efeito dos níveis de energia líquida no perfil lipídico da gordura e carne suína. Foram utilizados 90 animais, com peso inicial de 71,94±4,43kg, distribuídos em delineamento de blocos ao acaso em cinco níveis de energia líquida (2.300, 2.425, 2.550, 2.675 e 2.800Kcal kg-1 de ração), com nove repetições e dois animais por unidade experimental. Foram analisados os perfis lipídicos da gordura subcutânea e da carne por cromatografia gasosa. O aumento do nível de energia líquida usando óleo de soja melhorou o perfil lipídico da gordura subcutânea e da carne, aumentando linearmente (P 0,05) a concentração dos ácidos graxos poli-insaturados, especialmente ácido linoleico e -linolênico, reduzindo linearmente (P 0,05) os ácidos graxos monoinsaturados e saturados e ômega 6: ômega 3. No tecido adiposo foi observado redução linear (P 0,05) dos índices aterogênico e trombogênico. Em conclusão, o aumento do nível de energia líquida da dieta, com a utilização do óleo de soja, melhora o perfil lipídico da gordura subcutânea e da carne suína.(AU)

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This study was conducted to evaluate the effects of net energy levels on the lipid profile of adipose tissue and muscle of swines. A total of 90 animals, with initial weight of 71.94±4.43kg, were used, and distributed in a randomized block design in five net energy levels (2,300, 2,425, 2,550, 2,675, and 2,800Kcal kg-1 feed), with nine replicates and two animals per experimental unit. Lipid profiles of adipose tissue and muscle were analyzed using gas chromatography. Increasing the levels of net energy using soybean oil, improved the lipid profile of adipose tissue and muscle, increased linearly (P 0.05) the concentrations of polyunsaturated fatty acids, especially linoleic and -linolenic acid, reduced linearly (P 0.05) the monounsaturated and saturated fatty acids and omega 6: omega 3. In adipose tissue was observed linear reduction (P 0.05) of atherogenic and thrombogenic indexes. In conclusion, increasing the level of net energy of the diet using soybean oil improved the lipid profile of adipose tissue and muscle.

Este estudo foi conduzido com o objetivo de avaliar o efeito dos níveis de energia líquida no perfil lipídico da gordura e carne suína. Foram utilizados 90 animais, com peso inicial de 71,94±4,43kg, distribuídos em delineamento de blocos ao acaso em cinco níveis de energia líquida (2.300, 2.425, 2.550, 2.675 e 2.800Kcal kg-1 de ração), com nove repetições e dois animais por unidade experimental. Foram analisados os perfis lipídicos da gordura subcutânea e da carne por cromatografia gasosa. O aumento do nível de energia líquida usando óleo de soja melhorou o perfil lipídico da gordura subcutânea e da carne, aumentando linearmente (P 0,05) a concentração dos ácidos graxos poli-insaturados, especialmente ácido linoleico e -linolênico, reduzindo linearmente (P 0,05) os ácidos graxos monoinsaturados e saturados e ômega 6: ômega 3. No tecido adiposo foi observado redução linear (P 0,05) dos índices aterogênico e trombogênico. Em conclusão, o aumento do nível de energia líquida da dieta, com a utilização do óleo de soja, melhora o perfil lipídico da gordura subcutânea e da carne suína.

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ABSTRACT: This study was conducted to evaluate the effects of net energy levels on the lipid profile of adipose tissue and muscle of swines. A total of 90 animals, with initial weight of 71.94±4.43kg, were used, and distributed in a randomized block design in five net energy levels (2,300, 2,425, 2,550, 2,675, and 2,800Kcal kg-1 feed), with nine replicates and two animals per experimental unit. Lipid profiles of adipose tissue and muscle were analyzed using gas chromatography. Increasing the levels of net energy using soybean oil, improved the lipid profile of adipose tissue and muscle, increased linearly (P<0.05) the concentrations of polyunsaturated fatty acids, especially linoleic and α-linolenic acid, reduced linearly (P<0.05) the monounsaturated and saturated fatty acids and omega 6: omega 3. In adipose tissue was observed linear reduction (P<0.05) of atherogenic and thrombogenic indexes. In conclusion, increasing the level of net energy of the diet using soybean oil improved the lipid profile of adipose tissue and muscle.

RESUMO: Este estudo foi conduzido com o objetivo de avaliar o efeito dos níveis de energia líquida no perfil lipídico da gordura e carne suína. Foram utilizados 90 animais, com peso inicial de 71,94±4,43kg, distribuídos em delineamento de blocos ao acaso em cinco níveis de energia líquida (2.300, 2.425, 2.550, 2.675 e 2.800Kcal kg-1 de ração), com nove repetições e dois animais por unidade experimental. Foram analisados os perfis lipídicos da gordura subcutânea e da carne por cromatografia gasosa. O aumento do nível de energia líquida usando óleo de soja melhorou o perfil lipídico da gordura subcutânea e da carne, aumentando linearmente (P<0,05) a concentração dos ácidos graxos poli-insaturados, especialmente ácido linoleico e α-linolênico, reduzindo linearmente (P<0,05) os ácidos graxos monoinsaturados e saturados e ômega 6: ômega 3. No tecido adiposo foi observado redução linear (P<0,05) dos índices aterogênico e trombogênico. Em conclusão, o aumento do nível de energia líquida da dieta, com a utilização do óleo de soja, melhora o perfil lipídico da gordura subcutânea e da carne suína.

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Abstract In this study, the potential antileukemic activity of grandisin, a lignan extracted from Piper solmsianum, was evaluated against the leukemic line K562. The cytotoxicity of grandisin (0.018 to 2.365 µM) was evaluated in K562 and normal peripheral blood lymphocytes by Trypan Blue Exclusion and MTT methods after 48h exposure to the drug. In both methods, cellular viability was concentration-dependent and the IC50 values were lower than 0.85µM. Analysis of K562 cells after treatment with grandisin showed that the cell cycle was arrested in the G1 phase with a 12.31% increase, while both S and G2 phases decreased. Morphological studies conducted after the exposure of K562 to grandisin revealed changes consistent with the apoptosis process, which was confirmed by anexin V stain and caspase activation. Thus, lignan grandisin showed antileukemic activities against the K562 cell line and the cell death process occurred via apoptosis.

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4-Nerolidylcatechol (1) is an isolated compound from Pothomorphe umbellata L. (Piperaceae) with promising antitumor cells properties. However it presents lability under light and room temperatures. Many efforts have been directed towards discovering anticancer agents endowed with cytotoxic activities. Here, we evaluated cytotoxic effects of 4-NRC analogues (LQFMs 2-6) and the cell death pathways induced by these compounds in multidrug-resistant K562 cells. Compounds (2-6) exhibited cytotoxic activities in a concentration-dependent manner against leukaemic cells, specially the compounds (3) and (5). Additionally, compounds (1), (3) and (5) promoted marked alterations on the cell morphology, including nuclear changes as demonstrated by Hoescht 33342 staining. Moreover, these compounds promoted apoptosis induction in K562 cells by phosphatidylserine exposure, increase of sub-G1 cells and modulation of the caspases-3/7, -8 and -9 activation. In addition, the pancaspase inhibitor z-VAD-fmk partially reduced the apoptosis induced by the compounds (1) and (5)-induced, suggesting caspase-dependent and caspase-independent cell death pathways. Compounds (1) and (5) also modified the cell cycle progression by G0/G1 and S arrest, respectively. Furthermore, compounds (1), (3) and (5) promoted mitochondrial dysfunction associated to accumulation of cytosolic cytochrome c and modulated the NF-ĸB activation. In addition, unlike their analogues, 4-NRC (1) also promoted a significant cyclin D1 inhibition. Together, these data suggest that the mechanism of cell death of 4-NRC and its analogues (3) and (5) occurs by apoptosis through mitochondrial mechanisms. Considering that LQFMs are biocompatible synthetic analogues produced by molecular simplification of (1) without the chiral centre, which is associated with the instability found in compound (1), we suggest that these compounds are promising candidates for further pre-clinical studies.

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Realizou-se este estudo com o objetivo de avaliar o desempenho técnico-econômico e determinar a lucratividade, por meio da análise de sensibilidade econômica, de suínos machos imuno (IM) e cirurgicamente castrados (MC). Foram realizados dois experimentos, em delineamento inteiramente casualizado, composto por dois tratamentos (IM e MC), com oito repetições de 10 animais cada, totalizando 160 suínos por experimento. Verificou-se que suínos IM apresentam menor consumo de ração e melhor conversão alimentar nas fases de crescimento em relação aos MC. Na fase de terminação, suínos IM apresentam melhor ganho de peso, conversão alimentar, rendimento de carcaça e porcentagem de carne em relação aos MC. A utilização de IM aumenta a lucratividade na produção de suínos. A análise de lucratividade entre suínos IM e MC deve considerar todas as fases de criação, uma vez que o desempenho diferencial dos suínos não castrados na fase de crescimento influencia economicamente os resultados da produção.

This study was conducted to evaluate the technical and economic performance and determine profitability through the economic sensitivity analysis of immune (IM) and male pigs surgically castrated (SC). Two experiments were conducted in a completely randomized design, consisting of two treatments (IM and SC) with eight replicates of 10 animals each, totaling 160 pigs per experiment. It was found that IM pigs have lower feed intake and feed conversion during the growth phases in relation to SC. In the finishing phases, IM have better weight gain, feed conversion, carcass yield and lean meat percentage in relation to SC. The use of IM increases the profitability in pig production. The analysis of profitability differential between IM and SC should consider all stages of creation, since the differential performance of not castrated pigs during growth influences economic results of production.

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BACKGROUND: Flutter VRP1, Shaker, and Acapella are devices that combine positive expiratory pressure (PEP) and oscillations. OBJECTIVES: To compare the mechanical performance of the Flutter VRP1, Shaker, and Acapella devices. METHODS: An experimental platform and a ventilator, used a flow generator at 5, 10, 15, 20, 26, and 32 L/min, were employed at angles of -30°, 0°, and +30° to evaluate Flutter VRP1 and Shaker, whereas Acapella was adjusted at intermediate, higher, and lower levels of resistance, including positive expiratory pressures (PEP) along with air outflow rates and oscillation frequencies. RESULTS: When the relationships between pressure amplitudes of all air flows were analyzed for the 3 devices at low and intermediate pressures levels, no statistically significant differences were observed in mean pressure amplitudes between Flutter VRP1 and Shaker devices. However, both devices had different values from Acapella, with their pressure amplitude values being higher than that of Acapella (P = .04). There were no statistically significant differences in PEP for the 3 angles or marks regarding all air flows. The expected relationships between variables were observed, with increases in PEP, compared to those of air flows and resistance. Nevertheless, there was a statistically significant difference in frequency of oscillation between these devices and Acapella, whose value was higher than those of Flutter VRP1 and Shaker devices (P = .002). At intermediate pressure levels, the patterns were the same, in comparison to low pressures, although the Acapella device showed frequencies of oscillation values lower than those of Flutter VRP1 and Shaker (P < .001). At high pressures, there were no statistically significant differences among the 3 devices for frequency of oscillations. CONCLUSIONS: The Flutter VRP1 and Shaker devices had a similar performance to that of Acapella in many aspects, except for PEP.

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O objetivo do trabalho foi avaliar o desempenho e as características quantitativas de carcaça de suínos machos castrados e imunocastrados, sob alimentação à vontade ou restrição quantitativa. Foram utilizados 240 animais, com peso inicial de 91,49±3,26kg, distribuídos em delineamento experimental de blocos ao acaso, em esquema fatorial 2x2 (dois manejos alimentares e duas categorias), com quatro repetições e 15 suínos cada. Suínos sob restrição alimentar apresentaram consumo inferior (P<0,05) em relação aos alimentados à vontade. O consumo de ração não diferiu (P>0,05) entre castrados e imunocastrados. Suínos alimentados à vontade apresentaram maior (P<0,05) ganho de peso em relação àqueles sob restrição. Os imunocastrados apresentaram ganho de peso superior (P<0,05) aos castrados. Houve interação (P<0,05) entre manejo e categorias para conversão alimentar, em que a restrição melhorou a conversão alimentar dos castrados em relação aos imunocastrados. Além disso, os imunocastrados apresentaram melhor (P<0,05) conversão alimentar em relação aos castrados, independente do manejo alimentar. Não houve interação (P>0,05) entre os fatores sobre as características de carcaça. A restrição não afetou (P>0,05) as características de carcaça. Machos imunocastrados apresentaram menor (P<0,05) espessura de toucinho e maior percentual de carne magra na carcaça. A restrição alimentar melhora a conversão alimentar de machos castrados. A restrição alimentar piora o ganho de peso e não altera as características de carcaça dos machos castrados e imunocastrados. Suínos imunocastrados apresentam desempenho superior, menor espessura de toucinho e maior percentual de carne magra em relação aos castrados.

The objective of this study was to evaluate the performance and carcass quantitative characteristics of barrows and immunocastrated swine fed ad libitum or under quantitative feeding restriction. Two hundred and forty animals were used, with initial weight of 91.49±3.26kg, distributed in a randomized blocks design, in a factorial scheme 2x2 (two management and two food categories), with four replicates of 15 pigs each. Pigs submitted to dietary restriction had lower consumption (P<0.05) than those fed ad libitum. Feed intake did not differ (P>0.05) between castrated and immunocastrated. Pigs fed ad libitum had higher (P<0.05) weight gain over those submitted to restriction. The immunocastrated showed higher weight gain (P<0.05) than castrated. There was an interaction (P<0.05) between management and categories for feed, in which the restriction improved castrated pigs. Immunocastrated had better (P <0.05) feed conversion compared to castrated, regardless of feed management. There was no interaction (P>0.05) among the factors on carcass traits. The restriction did not affect (P>0.05) carcass traits. Immunocastrated pigs had lower (P<0.05) back fat thickness and higher percentage of lean meat. Dietary restriction improves feed conversion of castrated pigs. The dietary restriction affects weight gain and does not affect carcass characteristics of barrows and immunocastrated. Immunocastrated pigs have higher performance, lower back fat thickness and a higher percentage of lean meat compared to the castrated.

RESUMO

O objetivo do trabalho foi avaliar níveis de energia líquida (EL) e ractopamina na dieta de leitoas em terminação sob altas temperaturas ambientais (29,5±2,3°C). Foram utilizadas 40 leitoas (peso inicial de 69,3±2,8kg) distribuídas no delineamento de bloco ao acaso em esquema fatorial 2x4 (0 e 20ppm de ractopamina e 2.300; 2.424; 2.548 e 2.668kcal de EL kg-1 de ração), com cinco repetições de um animal cada. Houve interação (P<0,05) entre EL e ractopamina, sendo que a inclusão de 20ppm em dietas com 2.548 e 2.668kcal reduziu (P<0,05) a espessura de toucinho e aumentou (P<0,05) a percentagem de carne magra das carcaças. A ractopamina melhorou (P<0,05) a conversão alimentar e a quantidade de carne magra nas carcaças (P<0,05), independente dos níveis de EL. Concluiu-se que a ractopamina na dose de 20ppm propicia benefícios no desempenho e características de carcaça de leitoas sob estresse térmico e que esse efeito é mais positivo em dietas contendo níveis energéticos mais elevados (2.548 e 2.668kcal de EL).

The objective of this paper was to assess net energy (NE) levels and ractopamine in the diet of finishing gilts maintained under high temperature environment (29.5±2.3°C). Forty gilts were used, with initial weight of 69.3±2.8kg, distributed in a randomized block design, in a factorial scheme 2x4 (0 and 20ppm of ractopamine; and 2,300; 2,424; 2,548 and 2,668kcal/kg NE kg-1 of feed), and five replications and one animal each. There was interaction (P<0.05) between NE levels and ractopamine, and the inclusion of 20ppm of ractopamine in the diets containing 2,548 and 2,668kcal reduced (P<0.05) backfat thickness and increased (P<0.05) the percentage of lean meat of carcasses. The use of ractopamine improved (P<0.05) feed gain ratio and increased (P<0.05) the amount of lean meat in carcasses. It was concluded that ractopamine at a dose of 20ppm provides benefits in performance and carcass traits of gilts under heat stress and this effect is more positive in diets containing higher energy levels (2,548 and 2,668kcal of NE kg-1).

RESUMO

Este estudo foi realizado com o objetivo de avaliar a duração da suplementação de ractopamina na dieta de leitoas em terminação, mantidas sob alta temperatura ambiente. Foram utilizadas 48 leitoas com peso inicial de 70,4±2,6kg, distribuídas no delineamento de blocos ao acaso, com seis tratamentos (suplementação de ractopamina por 0, 7, 14, 21, 28 e 35 dias pré-abate) e quatro repetições, sendo a unidade experimental constituída por dois animais. O peso final e o consumo de ração diário não foram influenciados (P>0,05) pelos tratamentos. O ganho de peso aumentou e a conversão alimentar reduziu linearmente (P<0,05) com o aumento do tempo de suplementação de ractopamina na dieta. As características quantitativas de carcaça (peso e rendimento de carcaça quente, espessura de toucinho, percentual de carne magra, profundidade de músculo e área de olho-de-lombo) não foram influenciadas (P>0,05) pela duração da suplementação de ractopamina na dieta. O peso dos pulmões, coração, fígado, rins e baço também não foi modificado (P>0,05) pelos tratamentos. Concluiu-se que a inclusão de 20ppm de ractopamina na dieta de leitoas em terminação, mantidas sob alta temperatura ambiente, durante 28 dias, maximiza a resposta de ganho de peso diário e, durante 35 dias, maximiza a resposta para conversão alimentar. Contudo, a inclusão do aditivo não altera as características quantitativas de carcaça e não afeta o desenvolvimento das vísceras.

The study was conducted to evaluate the duration of the supplementation of ractopamine in the diet of finishing gilts maintained under high temperature environment. Forty eight females, with initial weight of 70.4±2.6kg were used. The pigs were distributed in randomized blocks design of six treatments (supplementation of ractopamine for 0, 7, 14, 21, 28 and 35 days pre-slaughter) and four replications, each experimental unit consisted of two animals. The final weight and daily feed intake were not affected (P>0.05) by treatments. The weight gain increased and the feed conversion decreased linearly (P<0.05) according to the increased length of supplementation of ractopamine in the diet. The quantitative characteristics of carcass (weight and hot carcass yield, backfat thickness, percentage of lean meat, depth of muscle and loin eye area) was not influenced (P>0.05) by duration of supplementation of ractopamine in the diet. The weights of the lungs, heart, liver, kidneys and spleen were not modified (P>0.05) by treatments. It was concluded that inclusion of 20ppm of ractopamine in the diet of finishing gilts maintained under high temperature environment during 28 days maximizes the response of daily gain and during 35 days maximizes the response to feed conversion. However, the inclusion of the additive does not alter the quantitative characteristics of carcass and does not affect the development of the viscera.

RESUMO

O trabalho foi conduzido para avaliar o efeito de níveis de sódio sobre o desempenho zootécnico, produção e avaliação do pH das fezes e urina de leitões criados em câmara climática, com temperatura de conforto térmico (25 ± 2,7ºC). Foram utilizados 50 leitões, híbridos comerciais de alto potencial genético para deposição de tecido magro, com peso inicial de 9,06 ± 0,93kg e peso final de 25,2± 0,88kg, distribuídos em um delineamento experimental de blocos ao acaso com cinco tratamentos (0,13; 0,27; 0,41; 0,55 e 0,69% de sódio), cinco repetições e dois animais por repetição. Os níveis de sódio não influenciaram o peso final, o consumo de ração e o ganho de peso dos leitões. Houve efeito quadrático com ponto de mínima para a conversão alimentar com o melhor nível estimado em 0,36% de sódio. Não houve efeito sobre a produção de fezes. Houve aumento linear crescente no pH e produção de urina com o aumento dos níveis de sódio na dieta. O nível que melhorou a conversão alimentar para leitões em termoneutralidade foi 0,36% de sódio na dieta. (AU)

The study was conducted to evaluate the effect of sodium levels on zootechnic performance, production and evaluation of the pH of feces and urine of piglets reared in a climatic chamber under thermal comfort (25 ± 2.7°C). It were used 50 commercial hybrids piglets with high genetic potential for lean tissue deposition with initial weight of 9.06 ± 0.93kg and final weight of 25.2 ± 0.88kg, allotted to a completely randomized block design with five treatments (0.13; 0.27; 0.41; 0.55 and 0.69% of sodium), five replicates and two animals by replicate. Sodium levels did not influence the final weight, feed intake and weight gain of piglets. There was a quadratic effect with minimum point of the feed:gain with the best level estimated at 0.36% sodium. There was no effect on the production of feces. There was a linear increase in pH of urine, feces and urine production with increasing of sodium levels in the diet. The level of 0.36% of sodium in the diet improved feed:gain for piglets in thermoneutral environment.(AU)

Assuntos

RESUMO

O objetivo, neste estudo, foi avaliar o comportamento, as respostas fisiológicas e o desempenho de suínos mantidos em diferentes ambientes térmicos. Foram utilizados 30 suínos machos castrados, distribuídos em delineamento inteiramente ao acaso, composto por dois tratamentos (ambiente de conforto térmico, 21°C e de estresse por calor, 32°C). Suínos mantidos sob estresse por calor permaneceram menos tempo na posição em pé, mais tempo na posição deitado, menos tempo em alimentação, fuçando e mais tempo dormindo. O tempo em que os animais permaneceram em ócio e bebendo não foi influenciado pelos ambientes. O ambiente de estresse por calor provocou redução do consumo de ração, do ganho de peso e piorou a conversão alimentar dos animais. Por outro lado, a eficiência de utilização da energia e da proteína para ganho de peso não foi influenciada pelos ambientes. Suínos submetidos ao ambiente de estresse por calor apresentaram carcaças mais leves, com maior rendimento e menor percentual de carne, o que resultou em menor índice de bonificação. Ambientes térmicos que provocam estresse por calor afetam negativamente o comportamento, as respostas fisiológicas, o desempenho e as características quantitativas da carcaça de suínos em terminação. (AU)

The objective in this study was to evaluate the behavior, physiological responses and the performance of the swine maintained in different thermal environments. Thirty barrows were used, distributed in a completely randomized design composed by two treatments (thermal comfort, 21°C and heat stress environment, 32°C). Pigs maintained under heat stress spent less time in the standing position, more time in the lying position, less time eating, rooting and more time sleeping. The period the animals remained in leisure and drinking was not affected by environment. The environment of heat stress caused a reduction of feed intake, weight gain and worsened feed: gain ratio. Moreover, the energy and protein utilization efficiency for weight gain was not affected by environments. Pigs submitted to environmental heat stress presented lighter carcasses, with higher values of carcass yield and lower percentage of meat, which resulted in lower bonus carcass index. Thermal environments which cause heat stress affect negatively behavior, physiological responses, performance and carcass quantitative characteristics of finishing swine. (AU)

Assuntos

RESUMO

O objetivo, neste estudo, foi avaliar o comportamento, as respostas fisiológicas e o desempenho de suínos mantidos em diferentes ambientes térmicos. Foram utilizados 30 suínos machos castrados, distribuídos em delineamento inteiramente ao acaso, composto por dois tratamentos (ambiente de conforto térmico, 21°C e de estresse por calor, 32°C). Suínos mantidos sob estresse por calor permaneceram menos tempo na posição em pé, mais tempo na posição deitado, menos tempo em alimentação, fuçando e mais tempo dormindo. O tempo em que os animais permaneceram em ócio e bebendo não foi influenciado pelos ambientes. O ambiente de estresse por calor provocou redução do consumo de ração, do ganho de peso e piorou a conversão alimentar dos animais. Por outro lado, a eficiência de utilização da energia e da proteína para ganho de peso não foi influenciada pelos ambientes. Suínos submetidos ao ambiente de estresse por calor apresentaram carcaças mais leves, com maior rendimento e menor percentual de carne, o que resultou em menor índice de bonificação. Ambientes térmicos que provocam estresse por calor afetam negativamente o comportamento, as respostas fisiológicas, o desempenho e as características quantitativas da carcaça de suínos em terminação.

The objective in this study was to evaluate the behavior, physiological responses and the performance of the swine maintained in different thermal environments. Thirty barrows were used, distributed in a completely randomized design composed by two treatments (thermal comfort, 21°C and heat stress environment, 32°C). Pigs maintained under heat stress spent less time in the standing position, more time in the lying position, less time eating, rooting and more time sleeping. The period the animals remained in leisure and drinking was not affected by environment. The environment of heat stress caused a reduction of feed intake, weight gain and worsened feed: gain ratio. Moreover, the energy and protein utilization efficiency for weight gain was not affected by environments. Pigs submitted to environmental heat stress presented lighter carcasses, with higher values of carcass yield and lower percentage of meat, which resulted in lower bonus carcass index. Thermal environments which cause heat stress affect negatively behavior, physiological responses, performance and carcass quantitative characteristics of finishing swine.

Assuntos

RESUMO

O trabalho foi conduzido para avaliar o efeito de níveis de sódio sobre o desempenho zootécnico, produção e avaliação do pH das fezes e urina de leitões criados em câmara climática, com temperatura de conforto térmico (25 ± 2,7ºC). Foram utilizados 50 leitões, híbridos comerciais de alto potencial genético para deposição de tecido magro, com peso inicial de 9,06 ± 0,93kg e peso final de 25,2± 0,88kg, distribuídos em um delineamento experimental de blocos ao acaso com cinco tratamentos (0,13; 0,27; 0,41; 0,55 e 0,69% de sódio), cinco repetições e dois animais por repetição. Os níveis de sódio não influenciaram o peso final, o consumo de ração e o ganho de peso dos leitões. Houve efeito quadrático com ponto de mínima para a conversão alimentar com o melhor nível estimado em 0,36% de sódio. Não houve efeito sobre a produção de fezes. Houve aumento linear crescente no pH e produção de urina com o aumento dos níveis de sódio na dieta. O nível que melhorou a conversão alimentar para leitões em termoneutralidade foi 0,36% de sódio na dieta.

The study was conducted to evaluate the effect of sodium levels on zootechnic performance, production and evaluation of the pH of feces and urine of piglets reared in a climatic chamber under thermal comfort (25 ± 2.7°C). It were used 50 commercial hybrids piglets with high genetic potential for lean tissue deposition with initial weight of 9.06 ± 0.93kg and final weight of 25.2 ± 0.88kg, allotted to a completely randomized block design with five treatments (0.13; 0.27; 0.41; 0.55 and 0.69% of sodium), five replicates and two animals by replicate. Sodium levels did not influence the final weight, feed intake and weight gain of piglets. There was a quadratic effect with minimum point of the feed:gain with the best level estimated at 0.36% sodium. There was no effect on the production of feces. There was a linear increase in pH of urine, feces and urine production with increasing of sodium levels in the diet. The level of 0.36% of sodium in the diet improved feed:gain for piglets in thermoneutral environment.

Assuntos