RESUMO
En la práctica odontológica se puede evidenciar una insatisfacción, de los profesionales de la odontología, al solo contar con una imagen diagnóstica de una radiografía panorámica y lo inaccesible que resulta adquirir otros equipos que puedan aportar información para estudiar las afecciones en la Articulación Témporo Mandibular (ATM). Esta investigación orientada al diseño de un dispositivo receptor de imagen que asemeja un arco facial y un audífono, el cual, a su vez posee cámaras para la obtención de imágenes. A su vez, apoyado por un software (matlab) que interpreta los cambios de la imagen como una línea de desplazamiento, arrojando valores que son llevados a formar parte de un diagnóstico, en el estudio de desórdenes témporomandibulares. Este proyecto se enmarco en la modalidad de proyecto factible, con enfoque tecnicistas. Se utilizó una encuesta como técnica de recolección de datos y como instrumento se uso un cuestionario estructurado con preguntas dicotómicas. El estudio se aplico a docentes de la asignatura Oclusión y Rehabilitación Protésica, del Departamento de Prostodoncia y Oclusión de la Facultad de Odontología de la Universidad de Carabobo. Se evidencio que la mayoría de los docentes manifestaron poca confianza en los métodos diagnósticos existentes, ya que no ofrecen imágenes dinámicas y son poco accesibles a la población. Además, se encontró que el 100% está de acuerdo que el desarrollo del dispositivo antes mencionado. Se encuentra que este dispositivo seria innovador y cómodo, además de encontrarse una amplia motivación hacia su aplicación...
The purpose of this research is to develop a design of a receiver device supported by software that interprets the changes in an image as a displacement line of the TMJ. This research aims to present a device as a diagnostic tool for the témporomandibular joint disorder to the professors of the Faculty of dentistry in Carabobo University. This project was delimited as a workable project with a technicist approach where it is used a survey, as data collection technique and a structured questionnaire with dichotomous questions, as instrument. The study was applied to the professors of occlusion and prosthetic rehabilitation subject of the Faculty of dentistry in Carabobo University having 15 professors. It was found that most of the professors manifest a lack of confidence on the methods to study the TMJ disorders, due to it is unable to show the condylar dynamics and are also expensive for most of the population. Plus, it was evidenced that 100% were agree on develop of the device mentioned before, It´s described as comfortable, being motivated for the application..
Assuntos
Humanos , Masculino , Feminino , Desenho de Equipamento , Transtornos da Articulação Temporomandibular/diagnóstico , Transtornos da Articulação Temporomandibular/reabilitação , Transtornos da Articulação Temporomandibular/terapia , Articulação Temporomandibular/anatomia & histologia , Articulação Temporomandibular/anormalidades , Tecnologia OdontológicaRESUMO
Se presenta el caso de un paciente de 65 años, con cuadro sospechoso de íleo biliar, que se resolvió en forma completa por laparoscopia. Se analiza aquí la técnica quirúrgica y los resultados postoperatorios.
Assuntos
Masculino , Humanos , Idoso , Cálculos Biliares/cirurgia , Laparoscopia , Fatores Etários , Cálculos Biliares/diagnóstico , Litíase/complicações , Procedimentos Cirúrgicos Minimamente Invasivos , Resultado do TratamentoRESUMO
Three random phage display peptide libraries were screened with sera from human papillomavirus (HPV)-infected patients to characterize the specificities of antibodies present in patients' sera and to identify molecules that correspond to or mimic natural epitopes; 141 phage clones were randomly selected in three rounds of bioselection and their binding properties were analyzed in ELISA using sera from 36 patients with confirmed HPV 16 infection and 24 healthy control female blood donors. Sixteen of 36 (44%) patients' sera reacted with at least 1 phage clone, and only 2 of 24 female donors' sera showed positive reaction with 1 of the selected clones. We conclude that the combination of various disease-specific epitopes generated by screening of phage display peptide libraries may potentially lead to a multicomponent diagnostic assay for the early detection of HPV infection and precancerous cervical lesions, making possible the prevention of one of the most common cancers in women.
Assuntos
Anticorpos Antivirais/genética , Anticorpos Antivirais/imunologia , Especificidade de Anticorpos , Papillomaviridae/genética , Papillomaviridae/imunologia , Infecções por Papillomavirus/imunologia , Infecções Tumorais por Vírus/imunologia , Anticorpos Antivirais/sangue , Ensaio de Imunoadsorção Enzimática , Feminino , Humanos , Epitopos Imunodominantes/genética , Epitopos Imunodominantes/imunologia , Infecções por Papillomavirus/sangue , Biblioteca de Peptídeos , Infecções Tumorais por Vírus/sangueRESUMO
GPIIb/IIIa, the human platelet glycoprotein complex, is the autoantigen most commonly recognized by autoantibodies in autoimmune thrombocytopenic purpura (AITP). Two murine monoclonal antibodies (mAbs), namely Y2/51 and 5B12, directed against gpIIIa and gpIIb/IIIa, respectively, and rabbit anti-human platelet polyclonal antibodies have been used to select AITP-related epitopes from a phage display peptide library expressing random dodecapeptides in the pIII coat protein of M13 phage. The selected phage clones were tested by ELISA for binding to rabbit anti-human platelet antibodies as well as to sera from AITP patients. Seven clones reacted strongly with rabbit anti-human platelet antibodies, and four clones reacted with sera from AITP patients. Some homology between peptide inserts sequences of selected clones and human platelet gpIIIa and gpIb were found.