RESUMO
BACKGROUND: In the context of rheumatoid arthritis and its systemic inflammatory implications, there is an increasing interest in investigating the role of prolactin in the clinical and metabolic aspects of the disease. This study aimed to explore the potential links between serum prolactin levels, serum glucose levels, and the clinical manifestations of arthritis. METHODS: This exploratory, cross-sectional, observational study focused on women diagnosed with rheumatoid arthritis. The research involved assessing prolactin and blood glucose concentrations, alongside specific clinical traits such as disease-related inflammation, morning stiffness, and fatigue intensity. The presence of changes in serum prolactin (PRL) was initially compared among the groups based on disease activity intensity. Using a multinomial regression analysis, the study analyzed the impact of predetermined clinical and metabolic factors on various categories of prolactin concentration. RESULTS: Out of the 72 participants included in the study, hyperprolactinemia was detected in 9.1% of the sample. No differences in serum PRL were identified among the evaluated groups based on disease activity. Following multivariate analysis, no statistically significant differences were identified for the outcomes of inflammatory activity and morning stiffness within each PRL category when compared to the reference category for PRL. There was no increased likelihood of encountering blood glucose levels below 100 mg/dl among individuals with higher prolactin concentrations compared to those in the lowest prolactin category (OR 5.43, 95% CI 0.51-58.28). The presence of clinically significant fatigue revealed a higher likelihood of encountering this outcome among patients with intermediate PRL values (prolactin categories 7.76-10.35 with OR 5.18, 95% CI 1.01-26.38 and 10.36-15.29 with OR 6.25, 95% CI 1.2-32.51) when compared to the reference category. CONCLUSIONS: The study found no discernible correlation between prolactin concentrations and worse scores for inflammatory activity of the disease, nor between prolactin concentrations and serum glucose levels. The findings regarding fatigue should be approached with caution given the exploratory nature of this study.
Assuntos
Artrite Reumatoide , Glicemia , Hiperprolactinemia , Prolactina , Humanos , Prolactina/sangue , Artrite Reumatoide/sangue , Feminino , Estudos Transversais , Glicemia/análise , Pessoa de Meia-Idade , Hiperprolactinemia/sangue , Adulto , Índice de Gravidade de Doença , Fadiga/sangue , Fadiga/etiologiaRESUMO
Objective: To describe the methods used in a rapid review of the literature and to present the main epidemiological parameters that describe the transmission of SARS-Cov-2 and the illness caused by this virus, coronavirus disease 2019 (COVID-19). Methods: This is a methodological protocol that enabled a rapid review of COVID-19 epidemiological parameters. Findings: The protocol consisted of the following steps: definition of scope; eligibility criteria; information sources; search strategies; selection of studies; and data extraction. Four reviewers and three supervisors conducted this review in 40 days. Of the 1,266 studies found, 65 were included, mostly observational and descriptive in content, indicating relative homogeneity as to the quality of the evidence. The variation in the basic reproduction number, between 0.48 and 14.8; and the median of the hospitalization period, between 7.5 and 20.5 days stand out as key findings. Conclusion: We identified and synthesized 10 epidemiological parameters that may support predictive models and other rapid reviews to inform modeling of this and other future public health emergencies.
Assuntos
COVID-19/epidemiologia , COVID-19/transmissão , Previsões , Pandemias/estatística & dados numéricos , Saúde Pública/estatística & dados numéricos , Saúde Pública/tendências , Humanos , SARS-CoV-2RESUMO
Inflammatory myofibroblastic tumor or inflammatory pseudotumor was first described by Brunn in 1932. Umiker et al. named it so in 1954 for its ability to mimic malignancy clinically and radiologically [Med Pediatr Oncol 2000; 35(5): 484-7]. This tumor, characterized by its rareness, affects mainly the lung and the orbit. Histologically, the tumor is characterized by the presence of fibroblasts, myofibroblasts, polymorphs, lymphocytes, and neutrophils. This case report and review of literature present a male patient, 37 years old, with a bulky mediastinal lesion at the topography of the 4th rib. Histopathology reveals Hodgkin's Lymphoma (HL) concomitant with inflammatory myofibroblastic tumor (IMT). This report aims to emphasize the relevance of differential diagnoses to a better medical assistance. To the best of our knowledge, a case with this characteristic has never been seen before.
RESUMO
En el presente estudio se llevó a cabo una intervención educativa basada en la solución de problemas, con la finalidad de valorar su impacto en el aprendizaje del proceso de Enfermería y en el desarrollo de habilidades del pensamiento crítico en alumnos del Sistema Universidad Abierta (SUA). Objetivo: Evaluar el efecto de una intervención educativa con la enseñanza del Proceso de Enfermería para la solución de casos clínicos de los estudiantes que ingresan a la Licenciatura en Enfermaría del SUA. Metodología: Esta investigación de corte evaluativos, se inserta en la línea educativa y se considera Correlacional y Cuasiexperimental, en el que se utilizó el diseño de cuatro grupos de Solomon. Resultados; Los estudiantes que participaron en el seminario de proceso Atención de Enferme´ria tuvieron mayor habilidad en la solución de casos clínicos. Conclusiones: Este estudio nos hace pensar en que la forma de nuestro actuar docente puede y debe favorecer que los alumnos desarrollen las habilidades intelectuales, cognitivas e interpersonales que le ayuden a pensar y a realizar juicios críticos. Se debe considerar que los alumnos del SUA son personas adultas que requieren de un cambio en la metodología de la relación docente, donde no se reproduzcan los esquemas tradicionales de enseñanza, sino que fomente una relación dialógica, en donde puedan rescatar las experiencias de los estudiantes.
In the present study, an educational intervention baasada was carried out in the solution of problems, with the purpose of assessing its impact on the learning of the Nursing process and on the development of critical thinking skills in students of the Open University System (SUA). Objective: To evaluate the effect of an educational intervention with the teaching of the Nursing Process for the solution of clinical cases of the students who enter the Bachelor in Nursing of the SUA. Methodology: This evaluative research is inserted in the educational line and is considered Correlational and Cuasiexperimental, in which the design of four Solomon groups was used. Results; The students who participated in the seminar on the process of Attention to Disease had greater ability in the solution of clinical cases. Conclusions: This study makes us think that the way our teaching act can and should help students develop intellectual, cognitive and interpersonal skills that help them think and make critical judgments. It should be considered that the students of the SUA are adults who require a change in the methodology of the teaching relationship, where the traditional teaching schemes are not reproduced, but that foster a dialogical relationship, where they can rescue the students' experiences .
No presente estudo, uma intervenção educativa baasada foi realizada na solução de problemas, com o objetivo de avaliar seu impacto na aprendizagem do processo de enfermagem e no desenvolvimento de habilidades de pensamento crítico em estudantes do Sistema Universitário Aberto (SUA). Objetivo: Avaliar o efeito de uma intervenção educacional com o ensino do Processo de Enfermagem para a solução de casos clínicos dos alunos que inserem o Bacharel em Enfermagem da SUA. Metodologia: Esta pesquisa avaliadora é inserida na linha educacional e é considerada Correlacional e Cuasiexperimental, na qual o projeto de quatro grupos Salomão foi utilizado. Resultados; Os alunos que participaram do seminário sobre o processo de atenção à doença apresentaram maior capacidade na solução de casos clínicos. Conclusões: Este estudo nos faz pensar que a forma como o nosso ato de ensino pode e deve ajudar os alunos a desenvolver habilidades intelectuais, cognitivas e interpessoais que os ajudem a pensar e fazer julgamentos críticos. Deve-se considerar que os alunos do SUA são adultos que exigem uma mudança na metodologia da relação de ensino, onde os esquemas de ensino tradicionais não são reproduzidos, mas que promovam uma relação dialógica, onde podem resgatar as experiências dos alunos .