RESUMO
At least 30-35% of men with erectile dysfunction (ED) fail to respond to treatment with phosphodiesterase type 5 (PDE-5) inhibitors. Testosterone (T) has effects not only on sexual desire, but also on the anatomical and physiological substrate of erection. This study analysed the effects of T administration to men unsuccessfully treated for ED with PDE-5 inhibitors only. Twenty-nine men aged 36-75 years (mean 59 years) with ED were studied. They suffered from ED for a mean of 2.7 years and had subnormal plasma T levels (total T <3.5 ng ml(-1) ). They received parenteral testosterone undecanoate for 102 weeks. Changes of the domains of the International Index of Erectile Function (IIEF) were assessed. After 6 weeks of T treatment, the sexual desire domain of IIEF had improved (from 4.1 ± 1.4 to 7.2 ± 1.7) and erectile function as measured by IIEF started to improve, reaching a plateau after 30 weeks (from 9.1 ± 2.1 to 26.5 ± 2.3). Features of the metabolic syndrome also improved. There were no adverse effects of T administration. Addition of T to treatment of hypogonadal men unsuccessfully treated with PDE-5 inhibitors only, appeared useful and acceptably safe.
Assuntos
Disfunção Erétil/tratamento farmacológico , Hipogonadismo/complicações , Síndrome Metabólica/complicações , Inibidores da Fosfodiesterase 5/uso terapêutico , Testosterona/análogos & derivados , Adulto , Idoso , Disfunção Erétil/etiologia , Disfunção Erétil/fisiopatologia , Humanos , Hipogonadismo/fisiopatologia , Masculino , Síndrome Metabólica/fisiopatologia , Pessoa de Meia-Idade , Testosterona/uso terapêuticoRESUMO
Se prepararon seis lotes de vacuna tifoidica empleando el metodo de Zagred (M-I), los cuales se compararon con seis lotes producidos por el metodo empleado en el Instituto Nacional de Higiene (M-II). Se encontro que el metodo de Zagred reducia los tiempos de proceso y costo. Empleando el metodo tradicional se tenian problemas con el alto contenido de nitroseno, aun centrifugando la vacuna en algunos casos no resultaba suficiente antigenica siendo necesario adicionar antigeno "Vi" para elevar los titulos. En las vacunas producidas por el metodo de Zagreb, aun diluyendo al limite establecido de nitrogeno, se sobrepasan las 8 UP por mililitro