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1.
Rev. bras. farmacogn ; 28(6): 673-677, Nov.-Dec. 2018. tab, graf
Artigo em Inglês | LILACS | ID: biblio-977745

RESUMO

ABSTRACT Leishmania infantum is an etiologic agent of visceral leishmaniasis. This disease is a neglected disease that can be fatal if not treated and additionally, the few therapeutic option present several drawbacks, including difficult route of administration and toxicity, which turn the search for new therapeutic alternatives necessary. Herein, we evaluated the leishmanicidal in vitro activity of the solanum extract from Solanum lycocarpum A. St.-Hil., Solanaceae, and the isolated alkaloids solasodine, solamargine and solasonine against promastigotes and intracellular amastigotes of L. infantum. Solasodine (IC50-pro = 4.7 µg/ml; IC50-ama = 10.8 µg/ml) and solamargine (IC50-pro = 8.1 µg/ml; IC50-ama = 3.0 µg/ml) exhibited interesting leishmanicidal ativity. Solasonine was approximately four-times (Selective Index 3.7) more selective to the parasite than to the host cells. This data suggest that solasonine might be considered as a potential drug candidate for leishmaniasis treatment.

2.
Nat Prod Res ; 31(24): 2905-2908, 2017 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-28368666

RESUMO

The composition of the essential oil (EO) from leaves of Vernonia polyanthes and the evaluation of its leishmanicidal potential are reported here for the first time. The oil obtained by hydrodistillation was analysed by combination of GC and GC/MS. Thirty-five compounds were identified, representing 91.8% of the oil composition. The oil consists primarily of monoterpenes (37.1%), sesquiterpenes (26.3%) and oxygenated sesquiterpenes (23.9%), myrcene (34.3%), zerumbone (15.8%), bicyclogermacrene (8.9%), α-humulene (4.8%) and germacrene D (4.3%) being the major constituents. Activity against Leishmania infantum was determined using the tetrazolium dye (MTT) colorimetric method. The oil, as well as zerumbone, one of its major constituents, showed significant leishmanicidal activity, with IC50 values of 19.4 and 9.0 µg/ml, respectively. Cytotoxicity in macrophages cells was evaluated using the MTT colorimetric assay. The EO showed the CC50 < 10 µg/ml to macrophages cells.


Assuntos
Antiprotozoários/isolamento & purificação , Leishmania infantum/efeitos dos fármacos , Óleos Voláteis/química , Vernonia/química , Animais , Antiprotozoários/química , Antiprotozoários/farmacologia , Cromatografia Gasosa-Espectrometria de Massas , Humanos , Macrófagos/efeitos dos fármacos , Monoterpenos/análise , Óleos Voláteis/uso terapêutico , Folhas de Planta/química , Sesquiterpenos/análise
3.
Bol. latinoam. Caribe plantas med. aromát ; 12(6): 618-621, nov. 2013. ilus, tab
Artigo em Inglês | LILACS | ID: lil-726596

RESUMO

The essential oil obtained by hydrodistillation from dry leaves of Capsicodendron dinisii (Schwancke) was analyzed using gas chromatography (GC) and gas chromatography/mass (GC/MS) spectrometry. According to GC and GC/MS analysis, the essential oil is mostly composed of sesquiterpene hydrocarbons (69.7 percent) and oxygenated sesquiterpenes (22.6 percent). Bicyclogermacrene (30.8 percent), E-caryophyllene (17.2 percent), spathulenol (13.5 percent) and germacrene D (7.6 percent) were the principal components identified in the essential oil.


El aceite esencial obtenido por hidrodestilación de hojas secas de Capsicodendron dinisii (Schwancke) se analizó mediante cromatografía de gases y cromatografía de gases/espectrometría de masas. De acuerdo con los análisis, el aceite esencial contiene un 69,7 por ciento de sesquiterpenos hidrocarbonados y 22,6 por ciento de sesquiterpenos oxigenados. Bicyclogermacreno (30.8 por ciento), E-cariofileno (17.2 por ciento), espathulenol (13.5 por ciento) and germacreno D (7.6 por ciento) fueron los componentes principales identificados en el aceite esencial.


Assuntos
Óleos Voláteis/química , Magnoliopsida/química , Folhas de Planta/química , Sesquiterpenos/análise , Brasil , Cromatografia Gasosa , Cromatografia Gasosa-Espectrometria de Massas
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