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Oxidative stress (OS) induced by SARS-CoV-2 infection may play an important role in COVID-19 complications. However, information on oxidative damage in pregnant women with COVID-19 is limited. Objective: We aimed to compare lipid and protein oxidative damage and total antioxidant capacity (TAC) between pregnant women with severe and non-severe COVID-19. Methods: We studied a consecutive prospective cohort of patients admitted to the obstetrics emergency department. All women positive for SARS-CoV-2 infection by reverse transcription-polymerase chain reaction (RT-qPCR) were included. Clinical data were collected and blood samples were obtained at hospital admission. Plasma OS markers, malondialdehyde (MDA), carbonylated proteins (CP), and TAC; angiogenic markers, fms-like tyrosine kinase-1 (sFlt-1) and placental growth factor (PlGF); and renin-angiotensin system (RAS) markers, angiotensin-converting enzyme 2 (ACE-2) and angiotensin-II (ANG-II) were measured. Correlation between OS, angiogenic, and RAS was evaluated. Results: In total, 57 pregnant women with COVID-19 were included, 17 (28.9%) of which had severe COVID-19; there were 3 (5.30%) maternal deaths. Pregnant women with severe COVID-19 had higher levels of carbonylated proteins (5782 pmol vs. 6651 pmol; p = 0.024) and total antioxidant capacity (40.1 pmol vs. 56.1 pmol; p = 0.001) than women with non-severe COVID-19. TAC was negatively correlated with ANG-II (p < 0.0001) and MDA levels (p < 0.0001) and positively with the sFlt-1/PlGF ratio (p = 0.027). Conclusions: In pregnant women, severe COVID-19 is associated with an increase in protein oxidative damage and total antioxidant capacity as a possible counterregulatory mechanism.

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La obesidad es un problema de salud de primera magnitud debido al crecimiento de las ciudades industrializadas y a la dificultad de su tratamiento. Además la obesidad es responsable directa del incremento de la incidencia de diabetes mellitus tipo 2, resistencia a la insulina, hipertensión arterial y factores que desencadenan y aumentan el riesgo de enfermedad cardiovascular. En la presente investigación se mostraron los resultados de los procedimientos de cirugía bariátrica en el Hospital Médico Quirúrgico entre enero 2010 a diciembre 2014. El propósito principal es analizar la evolución clínica de los pacientes adultos asegurados, durante el primer año posterior a la cirugía y verificar pérdida ponderal y mejoría de las comorbilidades relacionados con la obesidad. Se pretende dar a conocer los resultados obtenidos en este estudio para demostrar el impacto sobre la salud del paciente obeso mórbido sometido a estos procedimientos. Un total de 468,609 procedimientos bariátricos se realizaron en todo el mundo en el año 2013 según la Federación Internacional para la Cirugía de la Obesidad y Enfermedades Metabólicas (IFSO) (10) y esta extraordinaria aceptación, tanto por los pacientes y médicos, se deriva de la eficacia de estos procedimientos para producir la pérdida de peso, sino también por los resultados en el tratamiento del síndrome metabólico en pacientes obesos mórbidos

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Dengue fever incidence and its geographical distribution are increasing throughout the world. Quality and timely information is essential for its prevention and control. A web based, geographically enabled, dengue integral surveillance system (Dengue-GIS) was developed for the nation-wide collection, integration, analysis and reporting of geo-referenced epidemiologic, entomologic, and control interventions data. Consensus in the design and practical operation of the system was a key factor for its acceptance. Working with information systems already implemented as a starting point facilitated its acceptance by officials and operative personnel. Dengue-GIS provides the geographical detail needed to plan, asses and evaluate the impact of control activities. The system is beginning to be adopted as a knowledge base by vector control programs. It is used to generate evidence on impact and cost-effectiveness of control activities, promoting the use of information for decision making at all levels of the vector control program. Dengue-GIS has also been used as a hypothesis generator for the academic community. This GIS-based model system for dengue surveillance and the experience gathered during its development and implementation could be useful in other dengue endemic countries and extended to other infectious or chronic diseases.

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OBJECTIVE: To develop an automated model for the operational regionalization needed in the planning of the health service networks proposed by the new Mexican health care model (Modelo Integrador de Servicios de Salud MIDAS). MATERIAL AND METHODS: Using available data for México during 2005 and 2007, a geospatial model was developed to estimate potential catchment areas around health facilities based on access travel time. The results were compared with an operational regionalization (ERO) study manually carried out in Oaxaca with 2005 data. RESULTS: The ERO assigned 48% of villages to health care centers further away than those assigned by the geospatial model, and 23% of these health centers referred patients to more distant hospitals. CONCLUSIONS: The model calculated by this study generated a more efficient regionalization than the ERO model, minimizing travel time to access health services. This model has been adopted by the General Department of Health Planning and Development of the Mexican Ministry of Health for the implementation of the Health Sector Infrastructure Master Plan.

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Objetivo. Desarrollar un modelo automatizado de regionalización operativa para la planeación de las redes de servicios de salud propuestas en el Modelo Integrador de Atención a la Salud (MIDAS). Material y métodos. Con información disponible para México en 2005 y 2007 se realizó un modelo geoespacial para estimar el área potencial de influencia alrededor de cada unidad de atención médica, con base en el menor tiempo de viaje. Los resultados se compararon con un Estudio de Regionalización Operativa (ERO) para Oaxaca llevado a cabo en 2005. Resultados. Comparado con el modelo geoespacial, el ERO asignó 48 por ciento de las localidades a centros de salud más lejanos y 23 por ciento de los centros de salud a hospitales más lejanos. Conclusiones. El modelo calculado en este estudio generó una regionalización más eficiente que el ERO de Oaxaca, minimizando el tiempo de viaje para el acceso a los servicios de salud. Este modelo ha sido adoptado por la Dirección General de Planeación y Desarrollo en Salud para la instrumentación del Plan Maestro Sectorial de Recursos para la Atención de la Salud.

Objective. To develop an automated model for the operational regionalization needed in the planning of the health service networks proposed by the new Mexican health care model (Modelo Integrador de Servicios de Salud MIDAS). Material and Methods. Using available data for México during 2005 and 2007, a geospatial model was developed to estimate potential catchment areas around health facilities based on access travel time. The results were compared with an operational regionalization (ERO) study manually carried out in Oaxaca with 2005 data. Results. The ERO assigned 48 percent of villages to health care centers further away than those assigned by the geospatial model, and 23 percent of these health centers referred patients to more distant hospitals. Conclusions. The model calculated by this study generated a more efficient regionalization than the ERO model, minimizing travel time to access health services. This model has been adopted by the General Department of Health Planning and Development of the Mexican Ministry of Health for the implementation of the Health Sector Infrastructure Master Plan.

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A 45 year old man, intravenous drug user, without history of systemic illness, presented with fever, chills and an anterior left thorax pulsatile mass. Echocardiogram showed an anterior mediastinal fluid collection with no apparent pericardial communication and without evidence of endocarditis. Chest tomography revealed a large left anterior mediastinal abscess with multiple pulmonary abscesses. Percutaneous aspiration and blood cultures were positive for Staphylococcus aureus. Surgical drainage with pericardiectomy was done.

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We present a case of a 52 y/o male with history of hypertension and high cholesterol who suffered an acute myocardial infarction. His catheterization revealed severe 3-vessel coronary artery disease with total occlusion of left anterior descending (LAD) artery at the mid segment with anterior and apical wall dyskinesia and estimated ejection fraction of 30%. After 3 years of medical therapy the patient had NYHA class II heart failure symptoms without angina. Enhanced external counterpulsation (EECP) therapy was offered as adjunctive therapy. After completing therapy patient started to develop angina and a new catheterization showed recanalization of LAD with TIMI I flow and normal ejection fraction without wall motion abnormalities. Patient underwent successful coronary artery bypass graft.

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A young male adult with significant aortic coarctation was initially referred to our clinics due to uncontrolled blood pressures. On evaluation the diagnosis of aortic coarctation was evident and confirmed with Magnetic Resonance Angiography (MRA). After discussing treatment options with the patient and his parents they opted for the least invasive procedure possible. Primary stenting of a simple discrete aortic coarctation was performed successfully. The following is a report on the methods used and immediate results.

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