RESUMO

In the pathophysiology of spinal cord injury, the secondary biological processes involving changes in gene expression become more important day a day. Within these changes, the expression of different microRNAs has been involved in some of the pathophysiological processes of spinal cord injury. There are several studies that describe the transient expression of microRNA in spinal cord injury, some of them related to inflammation and apoptosis and others to functional recovery and regeneration. MicroRNA may be a potential target for the treatment of spinal cord injury, modifying the processes of inflammation, oxidation, apoptosis, functional recovery and regeneration. It is necessary to continue the study of microRNAs in spinal cord injury, as well as the identification of their target genes and signaling mechanisms involved in its neurological effects. With this, the ultimate goal is the development of effective and safe therapeutic and diagnostic strategies for patients with spinal cord injury.

Assuntos

MicroRNAs/genética , Medicina Regenerativa/métodos , Traumatismos da Medula Espinal/fisiopatologia , Ambystoma mexicanum , Animais , Apoptose/genética , Regulação da Expressão Gênica , Terapia Genética , Gliose/etiologia , Gliose/genética , Gliose/prevenção & controle , Humanos , Inflamação/genética , Camundongos , Camundongos Transgênicos , MicroRNAs/antagonistas & inibidores , MicroRNAs/biossíntese , Modelos Animais , Regeneração Nervosa/genética , Oligonucleotídeos/uso terapêutico , Oxirredução , Ratos , Recuperação de Função Fisiológica , Medula Espinal/metabolismo , Medula Espinal/fisiologia , Traumatismos da Medula Espinal/epidemiologia , Traumatismos da Medula Espinal/genética , Traumatismos da Medula Espinal/terapia