RESUMO
Diffuse large B-cell non-Hodgkin's lymphoma (LDCGB) is one of the best examples of chemotherapy curable malignant diseases. This "Oncoguía SEOM" summarizes the basic directions of staging and recommended treatment options. The staging study should be thorough and includes clinical, laboratory, diagnostic imaging and nuclear medicine. Treatment depends on patient characteristics and comorbidity and on disease extension and prognostic factors. In localized cases, chemoimmunotherapy (CHOP-R) of short duration, followed by involved-field irradiation is the preferred option. In advanced stages, the association of CHOP-like chemotherapy and Rituximab has been a major breakthrough in terms of cure rate. It is important do not forget the supportive treatment in these patients.
Assuntos
Linfoma Difuso de Grandes Células B/terapia , Oncologia/métodos , Guias de Prática Clínica como Assunto , Algoritmos , Humanos , Oncologia/tendências , Sociedades Médicas , EspanhaRESUMO
An 80-year-old man was admitted to hospital with low-grade fever, weight loss, asthenia and anorexia. Physical examination revealed generalised ichthyosis with palmoplantar hyperkeratosis. CT scan showed retroperitoneal and inguinal lymph node enlargement. An inguinal lymph node biopsy revealed Hodgkin's disease (nodular-sclerosing subtype). The patient received chemotherapy, showing a clear improvement of both skin lesions and lymph nodes.
Assuntos
Doença de Hodgkin/diagnóstico , Ictiose/diagnóstico , Síndromes Paraneoplásicas/diagnóstico , Idoso de 80 Anos ou mais , Doença de Hodgkin/tratamento farmacológico , Doença de Hodgkin/patologia , Humanos , Ictiose/patologia , Linfonodos/patologia , Masculino , Síndromes Paraneoplásicas/patologiaRESUMO
Primary ovarian Burkitt lymphoma (BL) is a rare neoplasm in adults. We report a 30-year-old woman diagnosed with primary bilateral ovarian BL. She presented features of a twisted ovarian cyst and underwent bilateral salpingo-oophorectomy. The histopathologic evaluation yielded the diagnosis of BL and subsequently she received chemoimmunotherapy with CODOX-M-IVAC plus rituximab (anti-CD20 monoclonal antibody).