RESUMO

We report the histological and biological behavior characteristics of a lung tumor (P07) that arose spontaneously in a Balb/c mouse. P07 is a moderately to poorly differentiated adenocarcinoma that secretes granulocyte-macrophage colony stimulating factor (GM-CSF) in culture supernatants. This tumor presents some paraneoplastic syndromes, such as leukocytosis, hypercalcemia and cachexia. taken together with the peripheral blood leukocyte (PBL) counts and serum calcium levels during s.c. tumor growth and after surgery, this study suggests that P07 may be a useful experimental model to study the biology of lung cancer and paraneoplastic syndromes.

Assuntos

Adenocarcinoma/fisiopatologia , Neoplasias Pulmonares/fisiopatologia , Síndromes Paraneoplásicas/fisiopatologia , Adenocarcinoma/patologia , Animais , Contagem de Células Sanguíneas , Peso Corporal , Medula Óssea/fisiologia , Cálcio/sangue , Modelos Animais de Doenças , Feminino , Fator Estimulador de Colônias de Granulócitos e Macrófagos/metabolismo , Hipercalcemia/etiologia , Leucocitose/etiologia , Neoplasias Pulmonares/patologia , Camundongos , Camundongos Endogâmicos BALB C , Síndromes Paraneoplásicas/patologia