RESUMO
Histone deacetylases (HDACs) remove the acetyl groups of lysine residues of histone tails leading to chromatin compaction and transcriptional repression. In addition, HDACs can also influence transcription-independent events such as mitosis or deoxyribonucleic acid (DNA) repair and deacetylate nonhistone proteins involved in cell proliferation and death, altering their function. Histone deacetylase inhibitors (HDACi) constitute a promising treatment for cancer therapy due to their low toxicity. HDACi have been shown to induce differentiation, cell-cycle arrest, and apoptosis and to inhibit migration, invasion, and angiogenesis in many cancer cell lines. In addition, these compounds inhibit tumor growth in animal models and show antitumor activity in patients. HDACi alone and in combination with a variety of anticancer drugs are being tested in clinical trials, showing significant anticancer activity both in hematological and solid tumors. SAHA (vorinostat, Zolinza) was the first HDACi approved by the US Food and Drug Administration to enter the clinical oncology market for treating cutaneous T-cell lymphoma (CTCL) and is being tested for other malignancies.
Assuntos
Antineoplásicos/farmacologia , Inibidores Enzimáticos/farmacologia , Inibidores de Histona Desacetilases , Neoplasias/tratamento farmacológico , Neoplasias/enzimologia , Animais , Ensaios Clínicos como Assunto , Expressão Gênica/efeitos dos fármacos , HumanosAssuntos
Adenocarcinoma/diagnóstico por imagem , Asma/diagnóstico , Neoplasias Pulmonares/diagnóstico por imagem , Sons Respiratórios/etiologia , Adenocarcinoma/complicações , Adenocarcinoma/secundário , Asma/diagnóstico por imagem , Espasmo Brônquico/etiologia , Broncoscopia , Feminino , Humanos , Neoplasias Renais , Neoplasias Pulmonares/complicações , Neoplasias Pulmonares/secundário , Pessoa de Meia-Idade , Radiografia Torácica , Tomografia Computadorizada por Raios XRESUMO
This investigation presents the results of a multimodal therapeutic programme for the cessation of smoking. The programme included the following elements: self-control techniques, education on a variety of issues on tobacco effects, group dynamic techniques, medical check up and pharmacological support. There were two treatment conditions, one included twelve sessions, and the other eight sessions. All groups received four follow-up sessions in a six month period. Ninety four subjects initiated treatment and 69 (73.4%) completed it. Twenty one subjects (22.3%) stopped smoking and remained abstinent after six months, eleven (11.7%) stopped smoking and relapsed and fourteen (14.7%) stopped smoking but did not attend the last follow-up sessions. Twenty three subjects (24.5%) did not stop smoking but reduced their smoking rate in 50% from initial report. These results were considered as satisfactory when compared with others obtained in similar studies.
Assuntos
Terapia Comportamental , Educação em Saúde , Psicoterapia de Grupo , Prevenção do Hábito de Fumar , Adulto , Idoso , Terapia Combinada , Feminino , Seguimentos , Humanos , Entrevista Psicológica , Masculino , Pessoa de Meia-Idade , Reforço Psicológico , Terapia de RelaxamentoAssuntos
Pessoa de Meia-Idade , Humanos , Masculino , Fentanila , Anestesia Epidural , Frequência Cardíaca , LidocaínaRESUMO
Se presentan los resultados de un programa terapeutico multimodal para el control del tabaquismo. El programa incluyo tecnicas de autocontrol, educacion sobre diversos aspectos del tabaquismo, manejo de la dinamica del grupo, estudios medicos y apoyo farmacologico. Se impartieron 12 sesiones a unos grupos y 8 a otros y se llevaron a cabo cuatro seguimientos en un periodo de seis meses. Noventa y cuatro personas iniciaron el tratamiento, de las cuales 69 (73.4%) lo completaron. Veintiuna personas (22.3%) dejaron de fumar y siguieron sin fumar a los seis meses, once (11.7%) dejaron de fumar y reincidieron, catorce (14.5%) dejaron de fumar pero no completaron los ultimos seguimientos y vientitres (24.5%) no dejaron de fumar pero redujeron su tabaquismo un 50%. Estos resultados se consideraron satisfactorios al ser comparados con los de estudios similares
Assuntos
Adulto , Pessoa de Meia-Idade , Humanos , Masculino , Feminino , Terapia Comportamental , Educação em Saúde , Psicoterapia de Grupo , NicotianaRESUMO
This investigation presents the results of a multimodal therapeutic programme for the cessation of smoking. The programme included the following elements: self-control techniques, education on a variety of issues on tobacco effects, group dynamic techniques, medical check up and pharmacological support. There were two treatment conditions, one included twelve sessions, and the other eight sessions. All groups received four follow-up sessions in a six month period. Ninety four subjects initiated treatment and 69 (73.4
) completed it. Twenty one subjects (22.3
) stopped smoking and remained abstinent after six months, eleven (11.7
) stopped smoking and relapsed and fourteen (14.7
) stopped smoking but did not attend the last follow-up sessions. Twenty three subjects (24.5
) did not stop smoking but reduced their smoking rate in 50
from initial report. These results were considered as satisfactory when compared with others obtained in similar studies.
RESUMO
Se presentan los resultados de un programa terapeutico multimodal para el control del tabaquismo. El programa incluyo tecnicas de autocontrol, educacion sobre diversos aspectos del tabaquismo, manejo de la dinamica del grupo, estudios medicos y apoyo farmacologico. Se impartieron 12 sesiones a unos grupos y 8 a otros y se llevaron a cabo cuatro seguimientos en un periodo de seis meses. Noventa y cuatro personas iniciaron el tratamiento, de las cuales 69 (73.4%) lo completaron. Veintiuna personas (22.3%) dejaron de fumar y siguieron sin fumar a los seis meses, once (11.7%) dejaron de fumar y reincidieron, catorce (14.5%) dejaron de fumar pero no completaron los ultimos seguimientos y vientitres (24.5%) no dejaron de fumar pero redujeron su tabaquismo un 50%. Estos resultados se consideraron satisfactorios al ser comparados con los de estudios similares